Conserved Protein Domain Family
fbt

?
TIGR00788: fbt 
folate/biopterin transporter
The Folate-Biopterin Transporter (FBT) Family (TC 2.A.71)The only functionally characterized members of the family are from protozoa and include FT1, the major folate transporter in Leishmania, and BT1, the Leishmania biopterin/folate transporter. A related protein in Trypanosoma brucei, ESAGIO, shows weak folate/biopterin transport activity. [Cell envelope, Other]
Statistics
?
PSSM-Id: 273268
Aligned: 8 rows
Threshold Bit Score: 438.832
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
?
Aligned Rows:
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
AAA96729        17 HPVSARVLRAAPFLGYIPVFsiairSFHPKVVVAICMQRLFEKGLAnGLMRLSMQPMLTGRYGLTGAMYQRLSTLYTLGW 96  Leishmania do...
AAC12874         1 MPDSTLSTVAKPTWQQRLLF-----GQEPSPELAAILLVYFVQGIL-GLSRLAVSFFLKDDLGLSPAQVSALTGIAALPW 74  Synechococcus...
AAD15400         1 -------------------------------------MVYFVQGVL-GLARLAVSFYLKDDLHLDPAETAVITGLSSLPW 42  thale cress
AAA53577        17 HPVSARVLRAAPFLGCIPVFsiairSFHPKVVVAICMQRLFEKGLAnGLMRLSMQPMLTGRYGLTGAMYQRLSTLYTLGW 96  Leishmania in...
AAC28092        23 HPVSARLLRAAPFLGYIPVFsiairSFHPNVVLAIFMQRLFEKGLAdGLMRLSIQPMLTGRYGLTGAMYQRLSTLYTLGW 102 Leishmania me...
CAA51968        96 HPDARALFQQLPCVWRIPVFgtaveAFGPRCVLALGLSELFGKGIAhDMIRTTLFPMFTYTFGADAKLYQRMGGMSSLGY 175 Trypanosoma b...
AAB80629         1 -----------------------------------------------MGEARPRRATTFACLSIRRRRNNNGVSEFEETA 33  thale cress
TIGR:At2g33280   1 ------------------------------------------------MVAKPLYGVLSDVLYIGGARR---VPYISVGV 29  thale cress
AAA96729        97 ALNAFITVMADTFALFGYTKRWYCVVSAVGGgafALLYGLLPAKESSAKPAAAFMFLAALFMSNIDVFAVALYSERIR-Q 175 Leishmania do...
AAC12874        75 MIKPAFGLLSDGFPLGGYRRRPYLIAAGLLG---STAWLGLGTVVHSPAMATLAIALSSLSVALSDVIVDSLVVERARqE 151 Synechococcus...
AAD15400        43 LVKPLYGFISDSVPLFGYRRRSYLVLSGLLG---AFSWSLMAGFVDSKYSAAFCILLGSLSVAFSDVVVDSMVVERARgE 119 thale cress
AAA53577        97 ALNAFITVMADTFALFGYTKRWYCVVSAVGGgafALLYGLLPAKESSAKPAAAFMFLAALFMSNIDVFAVALYSERIR-Q 175 Leishmania in...
AAC28092       103 ALNAFITVMADTFALFGYTKRWYCVVSAVGGsvfALLYGLLPAKELSAKPAAAFMFLAALFMSNIDVFAVALYSEQIR-R 181 Leishmania me...
CAA51968       176 AMKPFAAMFSDLFALFGYTKRWYLALSCVVGstvAIVYGSLPGELSYVPVAGILVFVMAFTKGILDILTQGHYSRLIR-R 254 Trypanosoma b...
AAB80629        34 RFEQVGGKGISVLCGLGYWVQGSRCFPWLALn--FHMVHSLALQPSTLQLVQYSCSLPMVAKPLYGVLSDVLYIGSGR-- 109 thale cress
TIGR:At2g33280  30 LLQGLAWGSLAIFPG------AREVLPSLMA---FILLSNLG--ASITEVSQ-D--A-LVAE--YGLRYQINGLQS---- 88  thale cress
AAA96729       176 RPAAGPALVSWMWGTALIGIMISSVIQGPLSDNRLTHLGVYITAAILLLSglLFVFNLFEErrnraarledamieflqnt 255 Leishmania do...
AAC12874       152 SRSESGSLQSLTWAVSALGGLVTAYLSGFLLQLFETRTLFLITATFPLIV--CLVAGWIAE------------------- 210 Synechococcus...
AAD15400       120 SQSVSGSLQSLCWGSSAFGGIVSSYFSGSLVESYGVRFVFGVTALLPLIT--SAVAVLVNEqr----------------- 180 thale cress
AAA53577       176 RPAAGPALVSWMWGTALIGIMISSVIQGPLSDNRLTHLGVYITAAILLLSglLFVFNLFEErrnraarledamieflqnt 255 Leishmania in...
AAC28092       182 RPAAGPALVSWMWGTALMGMMISSVIQGPLSDNGLTHFGVYITAGILLLSglLFVFNLFGErpnraarledamveflqhi 261 Leishmania me...
CAA51968       255 VPLAGPSLVSWVWWCVLTGSLIASSIVGPLTDKKLQRVAVFISAGIQFVPtiFFIMNWYGErrnreeraydltvlrkeql 334 Trypanosoma b...
AAB80629       110 ---------RVPYIAIGAGGVLGNLLGGYLLLTTPPKISFLVFSALLSLQ--LVVSLSSKEes----------------- 161 thale cress
TIGR:At2g33280  89 ----------YALMASAVGGILGNLLGGYCLLKTPPRILFLAFTALLSLQ--LIVSLSSKEes----------------- 139 thale cress
AAA96729       256 ksastdstagslpsphkpdghltidsrveeegddddhdeqkaaamdaqgfvRPRMdtylcgavemnrdvllrnwrmalfc 335 Leishmania do...
AAC12874       211 ---------------------------------------------------VPQT------------------------- 214 Synechococcus...
AAD15400       181 -------------------------------------------------vvRPASgqke-------------------ni 192 thale cress
AAA53577       256 ksastdstagslpsphkpdghltidsrveeegddddhdeqkaaamdaqgfvRPRMdtylcgavemnrdvllrnwrmalfc 335 Leishmania in...
AAC28092       262 ksvngdstagsppsp--skpdghltidsraeegeddddeqdttatdaqgfvRPRMdtylcgavemnrdailrnwrmalfc 339 Leishmania me...
CAA51968       335 ereada--------------------aglqgseetsgsldnpsdaeevaeaGTRIltcccgafevnrevfarnkkvvfyc 394 Trypanosoma b...
AAB80629       162 -------------------------------------------------fgLPRIae----------------------- 169 thale cress
TIGR:At2g33280 140 -------------------------------------------------vnLPRIgev---------------------- 148 thale cress
AAA96729       336 liLTLGvIANALVNILGTRWDIMyvcivvavvvcvssfftLpLAIAKAVVFMYFneilYLNLPGVLNTFYVAKPLCLPGG 415 Leishmania do...
AAC12874       215 --IQPG-LALIREQVGQIGQALR-----------------Q-RQIWMPTLFLFL----WQVTPSADSAFFFFSTNELHFE 269 Synechococcus...
AAD15400       193 tlLSPGfLQTSKQNMIQLWGAIK-----------------Q-PNVFLPTLFIFL----WQATPHSDSAMFYFTTNKLGFT 250 thale cress
AAA53577       336 liLTLGvIANALVNILGTRWDIMyvcivvavvvcvssfftLpLAIAKAVVFMYFneilYLNLPGVLNTFYVAKPLCLPGG 415 Leishmania in...
AAC28092       340 liLTLGvIANALVNILGTQWDIMyacivvavvvcvssfftLpLAIAKAVVFMYFnsifYLNLPGVLNTFYVATPSCLPGG 419 Leishmania me...
CAA51968       395 mlLTLGaMGMVLVTVLGTRLQLLitsvlasftlcglgfvaLpLVIAKANMFTFIsrvaYIQLPGAIDNVFMATPDCFPGG 474 Trypanosoma b...
AAB80629       170 ---tSSvLESVKKQISNLKEAIQ-----------------A-DEISQPLIWAVVs---IAMVPLLSGSVFCYQTQVLNLD 225 thale cress
TIGR:At2g33280 149 tpEISSvLGIVKKQFLDLKGIVQ-----------------V-DEISQPLIWIVSs---IALVPLLSGSVFCYQTQVLNLD 207 thale cress
AAA96729       416 PHFSYTFYNVMNgiLGSIAGIGGTMVFTHLFPhhsYRFVMGLSAVLLPAASMFDLLILKRWNLVIGIPDhAMYILGDAII 495 Leishmania do...
AAC12874       270 PEFLGRVRLVTN--LASLLGVWIFQRFLRGVP---IRRIFGWMIVVTTLLGLTSLILVTHLNRSWGISD-QWFSLGDSLI 343 Synechococcus...
AAD15400       251 PEFLGRVKLVTS--IASLLGVGLYNGFLKTVP---LRKIFLVTTIFGTGLGMTQVILVSGFNRQLGISD-EWFAIGDSLI 324 thale cress
AAA53577       416 PHFSYTFYNVMNgiLGSIAGIGGTMVFTHLFPhhsYRFVMGLSAVLLPAASMFDLLILKRWNLVIGIPDhAMYILGDAII 495 Leishmania in...
AAC28092       420 PHFSYTFYNAINgiLGNIAGIGGTMLFTHLFPnysYRLVMGLSAVLLPAASMFDVVILKRWNLAIGIPDhAMYIFGDAII 499 Leishmania me...
CAA51968       475 PNFSYFYYSTVGnmIGAVGGVIGVTLFRYVFSkrsYRLTFIVTTLIEIVSSIFDIIIVERWNRPY-VSDhVVFVLGDQII 553 Trypanosoma b...
AAB80629       226 PSVIGMSKVIGQ--LMLLCLTVVYDRYLKTLP---MRPLIHIIQLLYGLSILLDYILVKQINLGFGISN-EVYVLCFSSL 299 thale cress
TIGR:At2g33280 208 PSVIGMSKVIGQ--LMLLCLTVVYDRYWKKLP---MRALIHIVQLLYAFSLLFDYILVKQINLAFGISN-TAFVLCFSSV 281 thale cress
AAA96729       496 YEVCDMLLNMPMMMLMCRIAPRGSESMVFALLASIYHLGTSTSSAIGYLLMETIWpvv---tqGTCDYSNAPWLVITGHI 572 Leishmania do...
AAC12874       344 LTVAGQLSFMPVLILAARLCPSGIEATLFALLMSVLNLAHFGSVELGALLTHWLG--------VTESQFDRLWLLVLLTN 415 Synechococcus...
AAD15400       325 LTVLAQASFMPVLVLAARLCPEGMEATLFATLMSISNGGSVLGGLMGAGLTQAFG--------ITRDSFGNLSTLIILCN 396 thale cress
AAA53577       496 YEVCDMLLNMPMMMLMCRIAPRGSESMVFALLASIYHLGTSTSSAIGYLLMETIWpvv---tqGTCDYSNAPWLVITGHI 572 Leishmania in...
AAC28092       500 YEVCNMLLNMPMMMLMCRIAPRGSESMVFALLASIYHLGTSTSSAIGYLLMETIWpvv---tqGTCDYSNAPWLVITGHI 576 Leishmania me...
CAA51968       554 HQVCYMMHFMPTVILISRLCPSGYESAVYSVLAGCAHFGRSVSNTLGWLLMEYVWnvqsdikvGPCDFSNVKWLLLVGHF 633 Trypanosoma b...
AAB80629       300 AEILAQFKILPFAVRLASMCPQGCEGSVTSFLASTLCLSQIVSAFLGVGLANLIG--------ITSSNYSNLSSGILIQS 371 thale cress
TIGR:At2g33280 282 AEILAQFKILPFSVLLANMCPGGCEGSITSFLASTLCLSSVVSGFTGVGMANMIG--------ITSKNYSNLPAGILIQS 353 thale cress
AAA96729       573 VAPVFILPLAYvLLPsariSDHIDHTGRKVMEAALPETR 611 Leishmania donovani
AAC12874       416 LSSLLPLPLLG-LLP----AEEAETVPSDAIASAAPEPL 449 Synechococcus elongatus PCC 7942
AAD15400       397 LSSLLPLPLLG-LLP----RDSPDTLTKDDADVEMKSN- 429 thale cress
AAA53577       573 VAPVFILPLAYvLLPsariSDHIDHTGRKVMEAALPETR 611 Leishmania infantum
AAC28092       577 VTPVFIFPLAYvLLPsvriSDYIDHTGRKVMEVALPETR 615 Leishmania mexicana
CAA51968       634 ATPLISIPLVFlLIPaarlCDVLDENGK-AITKEAEDVR 671 Trypanosoma brucei
AAB80629       372 LAALAPLCFMH-LVPm--sEPVIEKEGKRGISKRSRRNR 407 thale cress
TIGR:At2g33280 354 LAALVPLWFIH-YVPm--lEPGFEREGKRAMSKKSRRNR 389 thale cress
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap