6KN5


Conserved Protein Domain Family
AF-4_C

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pfam18876: AF-4_C 
AF-4 proto-oncoprotein C-terminal region
This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.
Statistics
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PSSM-Id: 465894
Aligned: 30 rows
Threshold Bit Score: 372.464
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6KN5_A          2 SKPRRTKLVFDdRNySADHYLQEAKKLKHNADALSDRFEKAVYYLDAVVSFIECGNALEKNAqESKSPFPMYSETVDLIK 81  
XP_007495991  955 SKLMKHQVKFE-KQ-AADFHMKEAKRLKQKAESMSDKVGKAFKYLDAVLSYIECGIALESETpTPKSVYSTFSETVDFIK 1032
XP_012407494  950 SKPPKHQVKLE-KQ-VAAFHLKEAKKLKHKAESMSDKVGKAFKYLDAVLSFIECGIALESENpTSKSVYSMFSDTVDFIK 1027
XP_007658952  953 SKPAKPQVKCE-KQsEAEFHMKEAKRLKHKADSMSDKIGKAFKYLDAVLAFIECGIAMESETpTPKSGYTMFTETVDFVK 1031
4_pfamImport    3 AWSRRPLLRWEdRQfPVNHYIKEAKKLKHKADAESDKLCKAFSYVDAAMYFVESGIAMERDHqTSVSSYTMLAETVELLK 82  
1_pfamImport    3 ALSSRPLFRSDqRQyPVKHYIKEAKKLKHKADAESDKLSKAFNYLDAAMYFVESGIAMEKDPhISVSSYTMFAETVELLK 82  
XP_017202935  976 SKPGRPQVKRN-RQ-QADFHMKEAKKLKDKAETMTDKVGKAFKYLEAVLSFIECGIAMESESpACKAAYAVYSDTAELLK 1053
XP_004039129  958 SKPGKPQVKFD-KQ-QADLHMREAKKMKQKAELMTDKVGKAFKYLEAVLSFIECGIATESESqASKSAYSVYSETVDLIK 1035
XP_023493524  968 SKPGKPQMKFD-KQ-QADFYMKEAKKLKIKAETTTDKVGKAFKYAEAALSLIECGIAMESEGpAAKSAYSVYSETVDLIN 1045
XP_023369111  866 gmysessrsvalkI-QADFHMREAKKLKQKAELMTDKVGKAFKYLEAVLSLIECGIAMESESpASKSAYSVYSETVDLIK 944  small-eared g...
6KN5_A         82 YTMKLKNYLAPDATAADKRLTVLCLRCESLLYLRLFKLKKENALKYSKTLTEHLK-NSYNNSQAPSPG-LGsKAVGMPSP 159 
XP_007495991 1033 FILTLKYF--PDSPTQEKIFIVLCLRCQSILYMAMFRCKKDTAIKYSRTLNEHFK-SSSRLIQAASSG-GS-RNTSTPSP 1107
XP_012407494 1028 FILSLKSFPDSPPSTQEKIFIVLCMRCQSILYMAMFRCKKDTAIKYSRTLNEHFK-SSFRAAQAASSG-IS-RNISTPSP 1104
XP_007658952 1032 FIMSLKTFTDSSTPTQEKIFAVLCMRCQAILYMAMFRYKKDTAIKYSRTLNEHFK-NSSRVAQAPSPC-VA-RSTGTPSP 1108
4_pfamImport   83 FVLKLKNSVDASAPPSEKDFVALCLKCQSLLHMAMFRHKQKAAVKYSKTLTDHFS-NSAQRTQSPLVS-TP-KVSGTPSP 159 
1_pfamImport   83 FVLKLKNSVDASASPSEKDFLSLCLKCQSLLQMAMFRHKQKSALKYSKTLTDHFS-VSIKNSTTPDPSvVPfKVTVTPSY 161 
XP_017202935 1054 FIMSLKSF--SSATTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKYSRTLNEHFCtSSSKVAQAPSPC-IA-RSTGTPSP 1129
XP_004039129 1036 FIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKYSRTLNKHFE-SSSKVAQAPSPC-IA-RSTGTPSP 1112
XP_023493524 1046 FVLSLKSFSDVTTPLPGKIFAVLCMRCQSILNMAMFRCKKDTAIKYSRTLNEHFK-ISSKVAQAPSPC-VA-RSTGTPSP 1122
XP_023369111  945 FIMSLKSFSDATTSTQEKIFAVLCLRCQSILNMAMFRCKKDIAIKYSRTLNEHFM-SSSRVAQAPSPC-IA-RSTGAPSP 1021 small-eared g...
6KN5_A        160 VSPKLSPGNSGNY-SSGA----SSASASGSSVTIPQKIHQMAASYVQVTSNFLYATEIWDQAEQLSKEQKEFFAELDKVM 234 
XP_007495991 1108 LSPMTS-ASSGFV-QPGSsassTGNGGVSSTVSTPIVIQNMTSSYVTITSHILNAYDLWEQADMLARKNTEFFTELSTSV 1185
XP_012407494 1105 LSPMPSPASSGVS-QPGSgagsAGNGGVSSTVSTPVVIQNMTSSYVTITSHILNAYDLWEQADILARKNTEFFTELSASV 1183
XP_007658952 1109 HSPLPSPASSASScQPGSn---ANGGGAAGTVSTPVQIQNMTSSYVTITSYFLNSYELWEQADALARKNKEFFAELSTAA 1185
4_pfamImport  160 MPSLPSPAPSSAG-ACSS----HSGDPVSSFVSVPQAIEQVAFSYVNITSLFLRAYEIWEKAEELARAGSGLLTELDTAL 234 
1_pfamImport  162 TPYMPSPATTSSS-SSHSg---LGVDPVGSTVLIPHAIGQVAFNYVNITVLFVSAHDIWEQAEELALTGSGMLTELDAVM 237 
XP_017202935 1130 LSPMPSPASCLGS-QSSAg--sVGSSGMTATVSTPVTIQNMTSSYVSITSHILTAFDLWEQAEALARRNKEFFAQLSTNV 1206
XP_004039129 1113 LSPMPSPASSVGS-QSSAg--sVGSSGVAATISTPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNV 1189
XP_023493524 1123 LSPMPSPASSIGS-QASAg--sVGSSGMPATISTPVTIQNMTSSYVTITSHILTAFDLWEQAEFLTRNNKEFFAQLSTSE 1199
XP_023369111 1022 LSPTPSPASSVGS-QSSSg--sVGSSGMAATISTPVTIQNMTSSYVTITSHVLTAFDLWEQAEVLTRKNKEFFAQLSTNV 1098 small-eared g...
6KN5_A        235 GPLIFNASiMTDLVRYTRQGLHWLRQDAKLI 265 
XP_007495991 1186 CTLALNSS-LMELVLYTRQALQQLRQVAKML 1215
XP_012407494 1184 CALVLNSS-LMELVLYIRQALKQLRQMAKPL 1213
XP_007658952 1186 CSLTMNSS-LTELVHYMKQGLQWLRLATKMP 1215
4_pfamImport  235 GPLNLMSS-MAFMVRYTRQGVHWLRLDCRRG 264 
1_pfamImport  238 GPLSLASS-MSSMVAYARQAVHWLRLDSQKG 267 
XP_017202935 1207 GTLALNSS-LVDLVHYTRQGFQRLKQLTRTP 1236
XP_004039129 1190 CTLALNSS-LVDLVHYTRQGFQQLQELTKTP 1219
XP_023493524 1200 RALALNSS-LEDLVRYTRQGFQRLKQVTKTP 1229
XP_023369111 1099 CALALNSS-LADLVHYTRQGFQQLK------ 1122 small-eared galago
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