1US4,1US5


Conserved Protein Domain Family
PBP2_TtGluBP

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cd13567: PBP2_TtGluBP 
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Substrate binding domain of Thermus thermophilus GluBP (TtGluBP) of TAXI family of the tripartite ATP-independent periplasmic transporters; contains the type 2 periplasmic binding protein fold.
This subgroup includes TtGluBP of TAXI-TRAP family and closely related proteins. TRAP transporters are comprised of an SBP (substrate-binding protein) and two unequally sized integral membrane components. Although TtGluBP is predicted to be an L-glutamate and/or an L-glutamine-binding protein, the substrate spectrum of TAXI proteins remains to be defined. A sequence-homology search also shows that TtGluBP shares low sequence homology with putative immunogenic proteins of uncharacterized function.
Statistics
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PSSM-Id: 270285
Aligned: 30 rows
Threshold Bit Score: 304.519
Created: 23-Sep-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
chemical
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:chemical substrate binding site [chemical binding site]
Evidence:
  • Structure:1US4; Thermus thermophilus putative periplasmic glutamate/glutamine-binding protein in complex with L-glutamate, contacts at 4A.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           #    ###                              ###                 #               
1US4_A     20 FITIGSGSt-tGVYFPVATGIAKLVndan-----vgiRANARSTGGSVANINAINAGEFEXALAQnDIAYYAyqgccipa 93  Thermus thermophil...
NP_693988  44 MLTLVTGGt-sGTYYPLGGEMATNInnn------tdvQVDAISSNASAENVLAIENGEAQLGFIQtDVIAHAveginaf- 115 Oceanobacillus ihe...
ADU92125   70 FVTIATGGa-sGPYNIIATTLADEYnka------ygvNSKTQTTGASIENANLVENGKVEMAFLMsDIVSDAvkgens-- 140 Taylorella equigen...
CAM75975   25 FVNVLTGGt-sGVYYPLGVALSNIYgki------pevKASVQATKASVENLNLLSQGRGEIGFTLgDSLSQAwdgneev- 96  Magnetospirillum g...
NP_716093  29 FINILTGGt-sGVYYPIGVALSQLYgtgi-----egaKTSVQATKASVENLNLLQAGRGELALALgDSVAAAyqgdada- 101 Shewanella oneiden...
YP_572447  68 SLIFGTGGt-gGTYYPIGGALKSVFeasd-----lidDVQVVSTGASVQNINNITDGLNQVAIVMsDVAYDAvngenq-- 139 Chromohalobacter s...
NP_148408  34 RLVMGTGSp-gGIYNPLGFKIAEVVskys-----dkvEIEAQESGASVANAKGIKAGDYQLAMMQsDVAFFAyngkllkd 107 Aeropyrum pernix K1
ADC65290   52 IVTIYTGSgpgSVYFAVGSMFAKVLnkks-----dliEAKGVTSGASVANAKAIGKGEALAAIIQnDVTYYAwngkfqf- 125 Ferroglobus placid...
NP_069469  40 EVTILTGGs-aGTYYPIGGAMAQAItefa-----pgiKATAVTSGASVVNARKVGAGEAEFGLMQnDVAYYAyngiemf- 112 Archaeoglobus fulg...
AEK72645   18 SVEIYTGGt-sGVYYPLGSAYANILnqyskdeagikiEARAVTSGASVANAQAIGEGRAQAAIMQnDVAYYAfhgttlea 96  Thermococcus sp. 4557
Feature 1                      #                             ###                              
1US4_A     94 fegkpvkTIRALAALYPEvVHVVARKdagirtVADLKGKRVVVGdvGSGTEQNARQILEAYGltfddlgQAIRVSas-qG 172 Thermus thermophil...
NP_693988 116 -dgepveKVQAIGSLYPEtIQIVTTAdsgissVEDLAGKKVSVGapGSGTYINAEQILEIHGmsm-ddvEAQNLDfg-eS 192 Oceanobacillus ihe...
ADU92125  141 -fkapvkNINQMAVLYPNfVQVVTSKdsgietLADIKGKRVSVGapGSGTEVNARNLIQGFGmty-ddiKVDYLGya-eS 217 Taylorella equigen...
CAM75975   97 gfkakqdKLRSIAGIYPNyIQIVAAAdsgiktLADLKGKKISVGapKSGTELNARAIFAAAGmtykdfaRVEYLPfg-eS 175 Magnetospirillum g...
NP_716093 102 gfkkpldKVRVLAAAYPNyIQIVASKesgiktLADLKGKRISVGapKSGTELNARAIFKAAGlsyedmgKVEFLPya-eS 180 Shewanella oneiden...
YP_572447 140 -fdgqpaDIQALAGLYPNvVQVVATEdsgiesISDLAGKRVGVGkvGSGVEQSAAKVIESAGlsyddlaQVSHTGya-dS 217 Chromohalobacter s...
NP_148408 108 fegnpveDLRALAALYPEpIQIVARAgagietIWDLEGKRVAVGnpGSGLYATAYTILSALGlwd--kiDKVEFGfa-eA 184 Aeropyrum pernix K1
ADC65290  126 -egkpikELRGIGTLYPEpVQIVVRAdsdiytLEDLRGKKVVVGaaGSGVAATAERVLKAAGvwd--diEPVYQTfs-eA 201 Ferroglobus placid...
NP_069469 113 -kdnkidKLRGVATLYPEiIQIVTLKesgiktVYDLKGKKVAVGapGSGTAVDALQILNAAGide--snTDIRYLdfkeV 189 Archaeoglobus fulg...
AEK72645   97 fqgkavtKIRGVAALYPEtIQFVVKAdsniktLEDLKGKKVAVGaaGSGTAVAAQQILEAAGvwn--dvDKVYLKfs-eA 173 Thermococcus sp. 4557
Feature 1                  ##                                                                 
1US4_A    173 IQLXQDKrADALFYTvglgaSAIQQLALTtpIALVavdlnri--qaiakkyPFYVGFNIPGGTYKg--vDVTTPTvavQA 248 Thermus thermophil...
NP_693988 193 TGGIQDGnIDAAFITsgtptGAVEGLAASvdISIVpiaedkv--eelveayPYYASDVITGGTYGg--lDEDVQTvavLA 268 Oceanobacillus ihe...
ADU92125  218 ADALKTGkVDVAFLTsglpnASLLELSKSfpLKLVsippekl--keiadkaPYFSSMEVPTGTYGi---DKPVTTaviRN 292 Taylorella equigen...
CAM75975  176 VDLMKNRqIDATLQSaglgvASIRDLSNSvsIVIVpipmet----itkvgdPAYIAAIIPAGTYGg--qTADVPTaavQN 249 Magnetospirillum g...
NP_716093 181 VELIKNRqLDATLQSsglgmAAIRDLATTmpINFVevpedv----ilkinnPAYQHGVIPASTYEg--qTADVSTvaiQN 254 Shewanella oneiden...
YP_572447 218 VTGMSNGnLDAAFFTsgvpnSSITGLMQStdITFVpvtgeva--dklleayPYYETYTLPAGAPErydlDAEVDTvaiRN 295 Chromohalobacter s...
NP_148408 185 SSAMKQGtVDVLFIVagvptPKIEEIATQvdVVLVkvpddaiqklkdaglgNLYLKYTIPAGSYDf--qKEDVTTltvTA 262 Aeropyrum pernix K1
ADC65290  202 AQSLVLGqVDAEFTViaypaPAIDQIAVKvpVRLIpipdeviq-klhdegyPFYVKVVVPANTYNg--qTEDVQTiavKA 278 Ferroglobus placid...
NP_069469 190 ADALKDRtIDAGFIVagiptSAVSDVAAVreVAIVevpdeiy--qklkeqyPFYTQVTIPAGTYPg--vDEDVKTvavLA 265 Archaeoglobus fulg...
AEK72645  174 AQQLKLGqIDAAVIVsgaptPAIDQIAVQtpVRVLpigedilk-klkddgyIFYVSQTLPKDTYKg--mTEDTPTlavKA 250 Thermococcus sp. 4557
Feature 1                                                                
1US4_A    249 XLIASErlSEETVYKFXKAVFGNleafkkihpnlerffglekavkglpiPLHPGAERFY 307 Thermus thermophilus HB8
NP_693988 269 MLAVSSdlSEELVYDMTKAIYDNadkishakgefi---tidsaldgigiDLHPGAQKYF 324 Oceanobacillus iheyensis HTE831
ADU92125  293 AIIVSSklSEDDVYKLTKTFIEKlpalqnshqaika-vdaksaqegmvaPIHPGAKKYY 350 Taylorella equigenitalis MCE9
CAM75975  250 FLVTHAgvSDQLAYDMTKGLFENldqlqaahaaaka-ialteaavkspvPLHPGAAKYY 307 Magnetospirillum gryphiswaldense MSR-1
NP_716093 255 LFVTQTgvSDDLAYQMTKLMFEHldrlgnahsaaka-iqldkatknlpaPLHPGAERYF 312 Shewanella oneidensis MR-1
YP_572447 296 MLIVGSdmRDDVAEELTARFYDYlnsenvsvgalkq-fdpetmnqnlvaPVHPGAQAFY 353 Chromohalobacter salexigens DSM 3043
NP_148408 263 LLVIDKdvPEDIAYEIVKTMFEHldeiktvharaq--disldkapivpiPLHPGAEKYY 319 Aeropyrum pernix K1
ADC65290  279 TLAVHKdlPEEVVYEMTNVLYENidelakahqvakq-idmnkafeglmiPLHPGAVKYY 336 Ferroglobus placidus DSM 10642
NP_069469 266 MLATNAdlPEDLVYEVTKAIFEHrdileaahkraad-itletalegmpiPLHPGAEKYY 323 Archaeoglobus fulgidus DSM 4304
AEK72645  251 ILVVSAdvPDDVVYAMTRLLFLHvdelrqvhakaqy-isfdtaldgmsiPLHPGAVKYY 308 Thermococcus sp. 4557

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