6HXR,4F0D


Conserved Protein Domain Family
ARTD15_N

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pfam18084: ARTD15_N 
ARTD15 N-terminal domain
This is the N-terminal domain of poly ADP-ribose polymerase (PARP16 also known as ARTD15) present in homo sapiens. ARTDs catalyze the formation of branched or unbranched chains of ADP-ribose units on protein side chains. The N-terminal domain of ARTD15 does not share any obvious sequence similarity with the regulatory domains of ARTD1-4. The N-terminal domain arrangement in both ARTD15 and ARTD1-3 suggests a regulatory role through different mechanisms.
Statistics
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PSSM-Id: 465641
Aligned: 52 rows
Threshold Bit Score: 47.567
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6HXR_A        30 EAAGR-DMLAADLRCSLFASALQSYKRDSVLRPFPASYARGD--CKDFEALLADAS-KLPNLKEL-----LQSSGDNHKR 100
XP_004351416 416 DRIQK-SLTECDLMISLFYTSASSQRRTAVCEPFPFRFKDTVtlNKQFDRLLEALN-HIPHLQSIkn--dKQLLHRLPSD 491
CBN75069     169 AAIKE-DPLGADLVLALLSMAVSSYRRDTVSTPFPKQLESPGgsKRAYAAFISCLE-GIPSMLEMsrwtdAAQVLKLPPV 246
XP_005850123   8 AVLQAaDPWATDLLLSALAAAAASRRRATCTTPFPTSLFQTAdgERDYDALLENVQ-TLPPAGPL-----AAALDGLSRQ 81 
XP_008199398  45 KEIKD-NVWGCDLILCLFISALNSYRSDRCLRPFPPSYVNEE--GKNFTGLRSTCD-SIPPLTTI-----LNEPNKCSHD 115
XP_019754954  53 DLIRK-NLPGCDLVLCIFIAALKSFRADKCLRPFPQYFVNEKd-EKDFVSLKKSFD-KIPPLSEFl---rIPAQ-NIPQD 125
XP_001841848  12 NAIDR-DHTAADLRISLVVAAAKSFKYDSCLLPFPADYIVNK--EKKIDELNQVLD-SLPALSEI-------VLEELDEP 80 
KFB51656      14 ETIAR-DPPAADLRLSLFVSAARSFRFDSCLQPFPPKFIVNG--EKNIDELCRVIE-TIPPVAEL-----TAGLEGLDES 84 
ETN66314      19 EAISR-DPAAADLRFSLFVSAARSFRYDSCLQPFPPDFIVKG--EKNIDQLCRVIE-TIPPISELan-dlTGGLGADDER 93 
4_pfamImport   1 KFIGK-NLEAADLKINLYVTACNKH----CLSPYPSYIIEES--AIGMESL-VLINdFIPPVGLLkhylkGTNKFTPNEH 72 
6HXR_A       101 AWDLVSWIL 109
XP_004351416 492 TIYLIDYII 500
CBN75069     247 AVVALHLVL 255
XP_005850123  82 QASLLHWLL 90 
XP_008199398 116 VKKLLMWLF 124
XP_019754954 126 VADLLLWLF 134
XP_001841848  81 QLELLYWIL 89 
KFB51656      85 TVGLLYWVL 93 
ETN66314      94 AVSLLHWIF 102
4_pfamImport  73 VINVLHWLL 81 
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