1E4G


Conserved Protein Domain Family
ASKHA_NBD_FtsA
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cd24048: ASKHA_NBD_FtsA 
nucleotide-binding domain (NBD) of cell division protein FtsA and similar proteins
FtsA is an essential cell division protein that assists in the assembly of the Z ring. It may serve as the principal membrane anchor for the Z ring. It is also required for the recruitment to the septal ring of the downstream cell division proteins FtsK, FtsQ, FtsL, FtsI and FtsN. FtsA binds ATP. FtsA interacts with FtsZ. This interaction plays an essential role in cell division.
Links
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Statistics
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PSSM-Id: 466898
Aligned: 86 rows
Threshold Bit Score: 282.883
Created: 14-Jan-2023
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
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nucleotide
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:nucleotide binding site [chemical binding site]
Evidence:
  • Structure:1E4G; Thermotoga maritima FtsA in complex with MgATP, contacts at 4A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  #### #                          #                                    #  
1E4G_T           8 VFYTSIDIGSRYIKGLVLGkr-dQEWEALAFSSVKSRGldEGEIKDAIAFKESVNTLLKELEeqlqKSLRSDFVISFSs- 85  Thermotoga ma...
O07325           4 HYYVSIDIGSSSVKTIVGEkf-hNGINVIGTGQTYTSGikNGLIDDFDIARQAIKDTIKKASia-sGVDIKEVFLKLPi- 80  Staphylococcu...
jgi:Theth_1232   5 KKYVLIDVGNHYVKCLVIGetsqREYELLKNFTARTRGieNGETKDVVSFREVLEKVISEVEev-aKLETSEIVVSTScg 83  Pseudothermot...
BAH06285        23 GYIIGIDIGSSNICAAAGKvernGRMQILGITSSGCNGvkKGIVVDIDKTSESIKNCISSLErm-iDIKINEAYISLPg- 100 Clostridium k...
CDB31734         5 DIIVGVHIGTTKVAVVVGEvnnfEQIETICSTSYKCSGlkKGKIINEEEISLSLAKTIQDAEde-tNLKINSAYVTIPg- 82  Clostridium s...
CDC78373         5 DIIVGLDLGATKISCVIGQvnkfSEIEVIGYGLSDSSGikKGRILDPQSVANAVRNAVDAAEev-sDLIVNSTYVNIKg- 82  Clostridium s...
OFX80709         3 NYVAAIDLGTTKVVTLVGErt-dSGYRIVAFREAPSKGvlRGEVVNIQSVLDSLQPTIEDIKke-eAIEINEVYVGIAg- 79  Bacteroidetes...
OGH99146         8 NSIIGLDLGTSKICASLCTfdenGQIHIAGVGTSITEGinKGSITNTDLLIKAIKRAITRAEri-aKISSKSVIIGLAs- 85  Candidatus Ma...
PMP62889         5 KIFVSLDVGSSKIATIFADidetGTMYVIGLGESQSKGidKGNIISSADAIKSIKESISLGEaa-aGFKVNGIFINIGg- 82  Sulfurihydrog...
CCZ99594         7 NYIVAIDLGSGSVTAAAGSkdpdGRLNIIDMVSKPMQGmsCGEVINIEQVTGAVRAAVGELEeh-lGIKVTEAYAGISg- 84  Alistipes sp....

Feature 1                                                                                          
1E4G_T          86 -vSFEREDTVIERDFGeekrsitLDILSEXQSEALEK--LKENGKTPLHIFSKRYLLDDERIVFNPld-xkASKIAIEYT 161 Thermotoga ma...
O07325          81 -iGTEVYDESNEIDFYedt--eiNGSHIEKVLEGIREk-NDVQETEVINVFPIRFIVDKENEVSDPkeliaRHSLKVEAG 156 Staphylococcu...
jgi:Theth_1232  84 kfNLRSVEKEVVLSENekk--piDETTVEQLREAILD--EFQTTERPLHIFAKRYIIDKSKVVFNPqd-mlANSLAAEFN 158 Pseudothermot...
BAH06285       101 -gISELIWNKGVIAVSsed-reiRYNDVKRVLKAAKIi-TIPNDKEVIGVIPEQYIIDGYDNIKDPig-mnGLRLEVDAQ 176 Clostridium k...
CDB31734        83 -kYVTIVQNSITKEVKdky-agvSIRDVQNAIMQVKDi-EIPDGKTLIDIVPDKIVLENGTVVADPvg-slSSSFTISAQ 158 Clostridium s...
CDC78373        83 -mNTRIEKVTIETEVEkpn-dgmSINDIYNSYSRAQMavNMTNNEQIIDLLPIEYTVNGRKYKEEPig-afCKSFSLEAQ 159 Clostridium s...
OFX80709        80 -qNIKCVSQRLSRNRGkad-nliSDSEIDDMMREMSNs-RVNAGEKILHVIPQSFNVDDHIGVDNAkg-mtGTRIEGDYK 155 Bacteroidetes...
OGH99146        86 -pTYKTKQASGVISLPdsr-dhiTTEDKISVIKKARQl-TDIKDYSVIHTVPQKFFIDDKLCNSDPig-tfGSSLKADIL 161 Candidatus Ma...
PMP62889        83 -hHVESKKEKESITFSmpn-keiDQDDINALIEKINSk-YKNESTTILHIIPTKYILDDEDLVYDPig-liGNKLTGEFT 158 Sulfurihydrog...
CCZ99594        85 -hDIKCADSSYFVYVSged-heiCEEDVAKLHESMNSl-QPPEGICILDRTPQKYVIDSREETMQPvg-rfGQQLEATFN 160 Alistipes sp....

Feature 1                                                              ###                      #  
1E4G_T         162 SIVVPlKVYEXFYNFLQDTvkSPFQLKs-SLVSTAEGVLTTPEKDRGVVVVNLGYNFTGLIAYKNGVPIKISyVPVGXKH 240 Thermotoga ma...
O07325         157 VIAIQkSILINMIKCVEAC--GVDVLDvySDAYNYGSILTATEKELGACVIDIGEDVTQVAFYERGELVDADsIEMAGRD 234 Staphylococcu...
jgi:Theth_1232 159 LVTVE-RSSGSVLDFLEETfpPETDFAv-SVISACEGILTDIEKETGTCVIDLGYSSTSVTIYSHGVPIRLEfIPLGIKH 236 Pseudothermot...
BAH06285       177 IILARsTIINNIFKSVNKAgiKVLGIVf-QPIAISQVVLKEEEIQRGVALVDVGSESINIYIYEGGILRSIStIALGGSI 255 Clostridium k...
CDB31734       159 VILAEkDYIRQLTNIFKKAglEIDGIVp-ETLAERNLILDKNELHDNIAIIDVGAENTDIGVFEGSTFVYTNsIPLGGDN 237 Clostridium s...
CDC78373       160 VVIANgEYIAGVQRVLKLAglRLDGLIl-ETLATSNIVLMPEEKDMGVLLVDIGGGHTDISVYKNNIIEFYTtLPVGGDH 238 Clostridium s...
OFX80709       156 LFIGKiNSVEHSKLVINRAglRLRELIl-EPVASAKAVLSEDETELGVAMIDIGGGTTDLLIYHNNIIRHTAvIPFGGNS 234 Bacteroidetes...
OGH99146       162 TIQYRnNDIELIKAIFDKLnlSILAIVa-SPLATSKIALTTSELNTSVALIDIGGGTTQLAYYQNNIIRHLTiLPIGGDH 240 Candidatus Ma...
PMP62889       159 VVTIKsSAYNNLKKVVESVgiRVLDLAv-NPIASATSVLYPEEKELGVALIDIGGGLSDIAIYKNGSLEMLKsIPIGGHL 237 Sulfurihydrog...
CCZ99594       161 FILANrGSLERLNKAFLRLgiVQRRLFt-NAQASAAAVLTEDEKELGAAVIDIGAGCTDICIWQDNIMRYVGvLPVGSDA 239 Alistipes sp....

Feature 1           #              #   #                                                           
1E4G_T         241 VIKDVSAVLdtsFEESERLIITHGnavyndlkee----eiqyrgldgnTIKTTTAKKLSVIIHARLREIXSKSKKFFREv 316 Thermotoga ma...
O07325         235 ITDDIAQGLntsYETAEKVKHQYGhafydsasdqd---iftveqvdsdETVQYTQKDLSDFIEARVEEIFFEVFDVLQDl 311 Staphylococcu...
jgi:Theth_1232 237 VIKDISFVLntsLDEAERLLKTHGcavfgetsfvq--qtieykgldgmTAKTTTKDFLSRIIHARLREILTKARRIYREe 314 Pseudothermot...
BAH06285       256 ITNDIAVCLklpFSEAEKLKIKYGsvsadpgkks-----lkievnadyNKVKVDYDILVQIMEARVEELFSIIDKEIRVs 330 Clostridium k...
CDB31734       238 ITNDIALVLnisEEEADKLKRQYGlalksfidndn--diilntckdnnKNKIIKSSELIEIIEARIEEMFLIINKELTNq 315 Clostridium s...
CDC78373       239 ITNDIAMTLditSDEAEKLKRQYNlaimamiannh---dvklntkmtgENEVIRCSEIVQIIEARVKEIYQLIKKMISDn 315 Clostridium s...
OFX80709       235 ITEDLRQGCgvsLKNAEQMKIQYGscyseyapenk---tviipgiggrESREVSFKVIAGIIEARVEEILEAVMYEIENs 311 Bacteroidetes...
OGH99146       241 ISSDIKIILktsTGEADRLKILYChlnkehydennt-ieyimkdndkeLKTNTSEDYLSQIIKARLEEIFKLISQELKKa 319 Candidatus Ma...
PMP62889       238 ITKDIAYRFkisRGLAENIKIQYGlatldyldvdd---hidipsregdENIRIDRKDLVETIEWRLREIFEILKKELEKs 314 Sulfurihydrog...
CCZ99594       240 INRDIRSIAi-pERFIEKLKTTHGyavaaqipeekrsqnikikgrtqrENKEISFYNLAQIIEARLLDIVENVMEEIKEs 318 Alistipes sp....

Feature 1                             ##   ##                                       #          
1E4G_T         317 eakiveegeigiPGGVVLTGGGa-KIPRINELATEVFk-SPVRTGCYansdrpsiinadevandPSFAAAFGNVFA 390 Thermotoga maritima
O07325         312 gl-------tkvNGGFIVTGGSa-NLLGVKELLSDMVs-EKVRIHTPsqmg----------irkPEFSSAISTISS 368 Staphylococcus au...
jgi:Theth_1232 315 tskfseiglkglPGGIILSGGGa-KVPRLLDVAIDVFk-NPVRIGTYntssnvqiknadevidePLYNAALGNFVS 388 Pseudothermotoga ...
BAH06285       331 ey-------ydkLSGIVLVGGGiaTIKGIEDFGKNLLe-KFMRIGTTkyig----------assPLYVTAVGIVKD 388 Clostridium kluyv...
CDB31734       316 gi-------kpkINNVVLTGQGi-VNISKSDVAGKINlnIPVKISTGrlig----------atkPTYRTSYALVRY 373 Clostridium sp. C...
CDC78373       316 kl-------ngkIDCMVLTGQGisNIVGAQELAMLILkiNQVRVCNPklin----------vikPQHATVFGMVRY 374 Clostridium sp. C...
OFX80709       312 gym------dklGAGIVITGGGs-QLTNLRQFIKIKTg-YDARIASPinnisyd---tpsdicrPGSSTAFGLIML 376 Bacteroidetes bac...
OGH99146       320 ig-------nkaPEIIVITGGTs-NLPGIDDYATNFFk-IPVRIGIPkdkke--------viesQNYATSIGLVVY 378 Candidatus Margul...
PMP62889       315 gfy------dklTSGIVLTGGVs-NTPYIKELAEEIFe-KDVRIGRPkdfkcf-----teklysPQYATGVGVLQF 377 Sulfurihydrogenib...
CCZ99594       319 gya------dklGSGIVLTGGGa-YLKDIDTLFRERTk-YDVRTGSAypelvndr--slpaaddMHLSSAIGLLLL 384 Alistipes sp. CAG...

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