Conserved Protein Domain Family
LpxK

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COG1663: LpxK 
Tetraacyldisaccharide-1-P 4'-kinase (Lipid A 4'-kinase) [Cell wall/membrane/envelope biogenesis]
Tetraacyldisaccharide-1-P 4'-kinase (Lipid A 4'-kinase) is part of the Pathway/BioSystem: Lipid A biosynthesis
Statistics
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PSSM-Id: 441269
Aligned: 544 rows
Threshold Bit Score: 232.379
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_012375811   1 Mswwkrkfnal---------elytidvilgR--Radt--------------------gaaV--------------Y-GAF 34 
WP_013506875   1 Mslrdryl----------------yggglwH--------------------------------------------LpRLA 20 
NP_221074      1 Miklly-------------------pqfwqE--Rn-------------------------I--------------I-AYL 19 
WP_013951005   1 Memnflskve-----------hlmvdrlwrQ--Nl-------------------------F--------------I-NKL 27 
WP_079891516   1 MlkklisnqlepinsmtvqlesyitdhiegR--Rks-----------------------sL--------------V-RGV 40 
WP_081579033   1 Magpglafsss----------agtdeksgeE--RengaekpggfccttgsspaddgaskaVfgrdvsspkedrfvIpRPW 68 
WP_075260599   1 Mknlnr-------------------prfwqQ--Fn-------------------------W--------------L-TLC 19 
WP_032124446   1 --------------mlvkkfevyvkevikgQ--Krgg--------------------vptL--------------I-KWM 29 
WP_083498605   1 Mwkkkrtykesclkr--khasrtpfkalhsKvnQwgy--------------------snnT--------------V-YKL 43 
WP_106874662   1 Mypk-----------------------fwnS--Ks-------------------------I--------------I-STL 15 
WP_012375811  35 LQALSWLFNGIAQLRLWLYRHRILHDQPLGCL-VVVVGNLTVGGTGKTPVVEKFARALRDRGRKVAILSRGYKSKSapfw 113
WP_013506875  21 LLPLSLLYPLIGAWRYRL-----ATPRRFPFF-TISLGNLVAGGTGKTPLTIVLARLLTEHGLKVGILSRGYGGSY---- 90 
NP_221074     20 LLPISLIYQFLSYLRASL-----AYPVILPAQ-VICVGNCSVGGTGKTQIVIYLAKLLKAKNVPFVIITKAYGSHI---- 89 
WP_013951005  28 LRPFSWIYIIVHTIKVFF-----TEKQKANMP-VICVGNLTVGGSGKTPIVIAIGRLLKKHKKNLAFIGHGYKANL---- 97 
WP_079891516  41 LHGLSKLFKFGVTLRNFAFDYHLIKESKVDIP-VISIGNIIAGGTGKTALIQKLGKDLSR-NKRVSVLLRGYRSEI---- 114
WP_081579033  69 LSPFSLAYAGGLYLWEEGYRRGILSTKKLSIP-VIGVGSIMVGGAGKTPATICILESLIRMGLSPGVLTRGYGRRK---- 143
WP_075260599  20 LLPLSFIYRFIVYVKYII-----SKPNKMNIP-VICVGNIVVGGAGKTPTVIAIAEFLQSTGKKVAIISRGYKGSL---- 89 
WP_032124446  30 LLPLSWAYRLIVVVRNWLYDQGWMRRYVPPVSlVMSVGNIVAGGTGKTPVTLLIANAFYE-RFDLAILSRGYRSKA---- 104
WP_083498605  44 LYPLSCFYRLAVNTRNILYDQKFLQVQKLPVP-TISVGNITLGGTGKTPLVIGLCKYLKELDYNPCVLSRGYGRKR---- 118
WP_106874662  16 LLPLTHIYVWFSERRKRL-----ANPIHFGIK-TICVGNITVGGTGKTQFVMWLVQRL--KNIKTVIVSKGYKSNF---- 83 
WP_012375811 114 kkwwyalnhaeEp--P---PR-IVSD-GTrvllDSEQAGDEPYMLARNLpGVIVLVDKNRVKSGAYAIKKFGCDTLVLDD 186
WP_013506875  91 -----------R---E---PY-LVVTeST----PWRECGDEPLLMARRT-AAQVVVSRQRIPGALYLQ-QQGVDVVLLDD 146
NP_221074     90 -----------K---S---TT-IIQK-GH----TALEVGDEGIMLARYG----TVIAAKYVKDILPLINELKPDVIIVDD 142
WP_013951005  98 -----------L---KhsiCI-AVDLkMH----NVSNVGDEAILLSN---FAPTYIAQKRIQGVFAAQa-DDFDVVVLDD 154
WP_079891516 115 -----------EkvgG---SLhLIDrs----riTPNVCGDEAYLLWKTLpELKLFIGKDRRLNAQRAAYH-EAELVLLDD 175
WP_081579033 144 -----------E---Na-ePF-LFRS-GDn--lSPERVGDEPAMMAERFpETLFCISRDRAIGGTFLE-TAGVDVVLLDD 203
WP_075260599  90 -----------S---TnkeAT-LVQ--DH----SAYEVGDEALVLSK---IASVYINRDRFLAALRAQr-DGAEVIIMDD 144
WP_032124446 105 -----------EkldN---PI-VLCE-GQgpifPASYCGDEPYIYAQRFpKAIVVVGGNRKKASFLAA-KAGAQIILLDD 167
WP_083498605 119 -----------K---E---EI-LVCD-GKrilaSASESGDEPFLIATKT-KAIVAVGSDRYKAFKLA-ENLSPDVVILDD 177
WP_106874662  84 -----------I---D---PQ-IVGK-YD----SPELVGDEPKLMSK---ITDVIVAKNPADASDLVAq-INPDLVILDD 136
WP_012375811 187 GFQYLPLKGRLNLLLVDKTNPFGN----GHLLPRGILREPIK-HLRR-ASYVFLTKSNGHR---DEELERLIKQhn---- 253
WP_013506875 147 AFSNHKLVKDFEILLLDHRRPLGN----GLPIPSGLLREFPS-AIAR-ADLVIRTRVEE-----------HFa------- 202
NP_221074    143 FLQNPYLHKDFTIVSVDSQRLFGN----RFLIPAGPLRQNPKqVLDA-ADLIFLVSSNQDQ------IPNEL-------- 203
WP_013951005 155 GLQDNSIHKDLSILVIDSEYMFGN----LLLLPAGPLRELPVcALGR-ADLVIVSGINEDK------IKETINFinyrfs 223
WP_079891516 176 GMQYRRLHRDLEIVMLHADDLYGK----GFYLPRGYLRDSPK-RLKE-ADFVIINHVR--DqdhFEELKKDVEQq----- 242
WP_081579033 204 GFQSLELHQDLRVVILPSEVPSGGpgsvFQLLPAGNLRDFPS-RLKE-ADVLVNVRESwRk----EDYDKEF-------- 269
WP_075260599 145 GLQNYTLEKDFSILVIDSNYGLGN----HQLLPAGALRESLSlALKK-ADCIVYTGDGKTN------IINt--------- 204
WP_032124446 168 AMQHRRLARDFDIVVIDGGDPFGQ----GYFLPRGFLREDIR-SLNR-ANLLILNHITDSEq--fKNVKNQLKHy----- 234
WP_083498605 178 GFQHRKIERDLDLCLIDGTRCFGN----GHLLPAGPLREPIK-SLHR-CDAIIITKQKNL-----SCFEKTVGIl----- 241
WP_106874662 137 FMQNPYVTKDFNILIIDADRNFGN----NRLLPAGPLRQTFE-SAKNqIGLIIAIGSSPQ---------R---------- 192
WP_012375811 254 pDVD-------------IIE-CAHRP---QY-LQRWhgrlahdarpdpvgapnavpstiaaaapvhGQDarateftggtp 315
WP_013506875 203 gDAP---------------A-AHYa------------------------------------------------------- 211
NP_221074    204 --TPyi---------dkLIN-AQIVP---SNn------------------------------------------------ 220
WP_013951005 224 kTIP-------------LLK-TKITSciiTPk------------------------------------------------ 241
WP_079891516 243 tSAS-------------LIG-MQMVP---ET----I------------------------------EGKn---------- 261
WP_081579033 270 --TPqekwtsfcgreavILE-ATIKP---SG----Ve------------------------------------------- 296
WP_075260599 205 -KLP-------------TFT-AKTIV---Kn------------------------------------------------- 217
WP_032124446 235 tTAP-------------MIG-VKGVV---CH-RRDLk------------------------------------------- 253
WP_083498605 242 sQKP-------------VFFfT---P---TTeLTSI------------------------------CDRe---------- 262
WP_106874662 193 ---Pnnl-------ldgAFY-AQITS---ESe------------------------------------------------ 210
WP_012375811 316 vppkpgsgrEP-LSFLk------gRRVLAFSGIATPESFEKFLRDLGALIvARERFLDHYRYTDEDFGALFAAAKe---- 384
WP_013506875 212 ---------MS-CSAdr------aFPISAYSALGNNRAFFEGLQQMGYRLeRTLALPDHGVPTDDQLEALSA-------- 267
NP_221074    221 ------------IDk--------nKNYFAFSGIGNPQRFFLTLENYRLNIvGYKIFPDHYNYLQADLENLYSLAKe---- 276
WP_013951005 242 ----------G-IEEFk------dKDFFAIIGIAHPKKFLETAKKYNIKVkESAIFSDHYMFGESELDAIYNHANv---- 300
WP_079891516 262 ---------rEiWDEVq------gMRAAVFCGLGKPKSFFKTIEKMGIEIaETLILPDHIPPTRRQLIDLAILAEe---- 322
WP_081579033 297 ---------kN-LEEIrrthqsreLAVVLVSGIARPRRFFHMVESLNHTIlGHLTLPDHVRYSPDVLLKIELWVKkiekk 366
WP_075260599 218 ------------SERLq------dKIFIALCGIASPEKFFTTLKSLNITCaEKFIFGDHHNYSREEIEVIVGLANk---- 275
WP_032124446 254 --------gRE-IENLq------gQRVGMFCAIAHPEYFKRTLESEGVIVvAESCLPDHDEIKEKDLENFAQQCKq---- 314
WP_083498605 263 ---------HP-------------SKPTFITAIANPEAALEELKKKDINPyKVITFADHHWFTEKEFDYV---------- 310
WP_106874662 211 ------------LDt--------nKKYLAFAGVGNPERFFSCISHL--NIvRKVTYSDHHNYLSQELYSLQKAADk---- 264
WP_012375811 385 nK-A-ECLVTTEKDAVRIPENYvCPLPLYYLRLEIDI--I-R-GAaDFDEAVGRI--Cf----P-QT 438
WP_013506875 268 -G-G-HPLVTSEKDHLKLSTH--WQPRVMPVGLALKL--L-NtDa-pLEN-LLQR--Ik----R-HQ 317
NP_221074    277 hN---AILITTRKDYVKFNY---LNDEIICLDVELSI--N-N-Pd-lLNEKIFKKakIl----N--- 325
WP_013951005 301 lK---CSVITSSKDFVRLPKK--YQSLTQVLEIEAEF--P-N-Ie-lVENMLAKIks---------- 347
WP_079891516 323 kG-C-EILLCSEKDWVKLPEPLkLSLPIAYVKASLQV--V-A-QPeNYDELLKKI--Ltl--tQgTS 379
WP_081579033 367 tGrAiEKILVTEKDWVKLSRQNdLDPRIQPIGIRMGW--K-E-Dr-pWADILSRK--Fg---wKi-- 421
WP_075260599 276 lN---LEIITTSKDIVKIPLT--YHTfIEVVEIEYIF--P-Ne----FYNLISKA--Tn----K-TD 323
WP_032124446 315 lG-A-QWLICTEKDRVKLPDQLvLSLPIAWIQIELAV--I-E-GEeEWKAFLAKA--Ea----K-IS 368
WP_083498605 311 ---G-DEIITTEKDLVKFPESIkKQKKIWVLRF-VEV--LpE-D---LKTFIRER--LcllkgK-SD 363
WP_106874662 265 lG---ATLLTTPKDAVKLVNK--LKfEVFEPKLQFENptD-E-------EKILSI--Ls----Q--- 309
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