Conserved Protein Domain Family
DUF4284

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pfam14112: DUF4284 
Immunity protein 22
A predicted immunity protein with an alpha+beta fold and conserved tryptophan,tyrosine and an acidic residues. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, which usually contains toxin domains of the ColD/E5, Tox-REase-4, Ntox49 or Ntox14 families. The domain is also found in heterogeneous polyimmunity loci.
Statistics
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PSSM-Id: 433726
Aligned: 12 rows
Threshold Bit Score: 90.1022
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CAS:CtCNB1_3929       66 HFWIGDTPlGEAEFGRYFdyaDSY--------WELEvedIESSSedvtgCGFCQDLGRQFlFDEDLLLMIW-LPEPVPVA 136
jgi:CAETHG_4059        8 SIWLAKCE-DIKDLQHYL---QVN--------YSNF---GDYLN-----SKFEKNFNVEC-FDEELKEINFiERDSDLFS 66 
jgi:Jden_2532         18 SVWGGRFR-DADAFMTYL---DIT---------SRE---GKPMS-----SDFLTDVRLGD-YNLDAAEAVHgDINAGLIR 75 
WP_007634979          22 SIWASQHP-YADIPDEYF---EET--------FFKK---GTRAR-----NTWSDNYKINY-FSPQQMETNGaHTGTIDIH 80  Paragla...
WP_013626631           8 SLWLGTAP-DADALNEYI---GLS--------YDDN---GELIA-----SSFMLDFSLLY-WDEDFREADHlETACQSVA 66  Rubinis...
zhongguo:PM3016_5818  12 SLWLGSWS-SEEAAKAYV---EGS--------YTED---GDYVP-----SPFERDFAFR--YDPDFIELNFkETPAADWE 69 
Q5LEK8                 5 MIWVGQFD-SEADFEKYM---DQSafrqwwkeYDED---NKELR-----CQFCKELGVMD-YDEDSLIMKY---SSEGLE 68  Bactero...
Q5LEL3                 5 MIWVGQFD-SEADFEKYM---DQSafrqwwkdYDED---NKELR-----CQFCKELGVMS-YDEDFLIMKF---TSDGLA 68  Bactero...
WP_014085268           8 FLWLGIFNgSKNEFNLYF---DQSk------gYLLDeygNDRLPeeielSQFSKDLGEDFtYDEDFIGYLL-FPNSIEIL 77  Flavoba...
faib:Ccan_20570       13 HIWIGSFVgTDKEFEVYFeqkNEA-------------------------CQFCLDIGIDE-YDEDLIGIIPpITNYVNIS 66 
jgi:Cpin_2614         20 AVWLANFN-HEKELRNYL---EVK--------YDED---GNSL------SAFGDAVGMRH-FDIDFLEHASfTNAMKP-E 76 
WP_012685631           6 TVWGTTLQ-SADELADFL---TPV--------YDED---GEVIP-----SGFLTASGLEW-VDEDFFEVHEvQDAEAR-A 63  Breviba...
CAS:CtCNB1_3929      137 ALVSQSTLDSNTsLALIVQACaAQGIH----TANAMFVYADPS-----------EPITDPDKlYNGLSYIGLF 194
jgi:CAETHG_4059       67 DIMKDQSFSQNI-ISDYSKKF-SDKLDr---KYNSIILLYNFNyd--------gSIGEDQDN-SVYVKFIGSF 125
jgi:Jden_2532         76 -LSHARSFANAV-RAQLPENG----------KINALYAIYDLD-----------ASDVRVVE-QSRMQLLGVF 124
WP_007634979          81 EAAGGCSCSSSF-IVNLMSKAkKNKMQ----QVTWIILLFEQEy---------sVKLSGVAS-DEYTTFLGAF 138 Paraglaciecola...
WP_013626631          67 EVLSGFSYDSRL-IEQYQQQL-GRTLPa---EVNAVVLLYNYRhq--------pTAVPQTSG-DVRLEFVGTA 125 Rubinisphaera ...
zhongguo:PM3016_5818  70 SLLQGHSYDEEI-IPAFMEEI--GPLSr---SFNTVILVYNLAyd--------aEHLRSGTA-AGELEYIGQA 127
Q5LEK8                69 NLLNVIPADTD----KIKEILrAKKIT----VANAAIMYNSHE-----------GISLQKATnTVSVSFLGSF 122 Bacteroides fr...
Q5LEL3                69 GLLNLIPADTQ----KISLSMaDKNIT----MANAVICYNCRE-----------GISPKKAEnTTTMTYLGTF 122 Bacteroides fr...
WP_014085268          78 EILEEVPINHSE-KESVIKKCiELGLN----DANAVYWYSD-------------EITPNPNIsYNGLKYIGEY 132 Flavobacterium...
faib:Ccan_20570       67 ELLEKIPVDESE-ISNIIIKCkDLRIN----KVNAIFYYLDST-------------ISIIGNrFNQLQYIGKF 121
jgi:Cpin_2614         77 EIINGVSFSEYF-KDDLTPLInHDILY----HHNTIIFLYGKQdrygainehifTLANMPQR-QLPFSFIGTV 143
WP_012685631          64 DFFMYLENEYAM-NATLDRKEwPEKLTeeigKYPHVILLYGNEsrygpineklfDLTEGGQEkDSPLVLLAKL 135 Brevibacillus ...
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