Conserved Protein Domain Family
PLN03223

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PLN03223: PLN03223 
Polycystin cation channel protein; Provisional
Statistics
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PSSM-Id: 215637
Aligned: 4 rows
Threshold Bit Score: 2371.15
Created: 9-Dec-2010
Updated: 16-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
255074031   89 MGSKNDVLNWIDSVVTTSWVEPQCGDGRCEAPFEFPEYGRFGCKADCNIINSKMNITKIQIDLYYNFSHPKGSVSPIDLM 168 
159484705    1 MQDTDAVYSWLNGLLTEVWKDPVCGDGLCEAPFEFASYSRFGCRADCGKLSEVQNLTKIQIDIYYDFSHPVGSIPASDLM 80  
302842417   54 MQNTDEVYDWLKKLLTEVWKDPVCGDGLCEAPFEFASYSRFGCRADCGKLNEVQNLTTIQLDVYYDFSHPVGSIPASDLM 133 
303290174  173 LQSGNEVRQWISAFVKKSWTDPRCGDGRCEMPFEYPEYGRFGCKADCDLLTVKAKVTPIQVDVYYNFSHPKGSVSPIDLM 252 
255074031  169 NDAKWNLCPLEMDenigp-kkifHGADCYYEEDQGFEDQVGHIIRQIDDVPDGDWTIVVKKDIFLKVAGAVRPRVNVTKE 247 
159484705   81 QQASWNLCPLATA----------YSSDCYFDADKEFDRLSGVQNFVLDDAPDGDWNLVVRRDIFNKIRGAVRDTTLVYAS 150 
302842417  134 QQASWNLCPVSTP----------YSSDCYYDSDINFERLSGEQHFTLDDAPDGEWNLVVKRDIFNKIRGAVRDATLVKIA 203 
303290174  253 NDASWNLCPMEVDdvlggtnkiyHGADCYYEKDQKFDTQVGHQSRVIEDVPDGEWTIVVKKDIFKKVGGAVRVRANVVKE 332 
255074031  248 ATHKRLLMAAHYAQTYRKIELDKYNKILSDLAETNATHAHDKINITFLVDSQNYNN-TWKSERDGWNKTLQAEltkeANA 326 
159484705  151 AFYYKIYVAAAAARAEQAFEISLLNQAINITSQDFWTYANSVIMAGYPNATEYDAAvGWVKNATCFCDSVANDtvasGTP 230 
302842417  204 GYYYKIYVAIAAAASEQAFEKTLLQQAASFSSMDFWTYANSSIRAGYPNETEYLAAyTWVRNATCTCSTVDNN----GTA 279 
303290174  333 ADNKRLLLASHYAQLRRKTELAAYDATLTTLGKSNQTLALEYLEKLYLAE------------------------------ 382 
255074031  327 ANSSNATLValmegnLANSTNTKEEAMIWrqkyrvnndTMVDWALRANGYCQTNFPdLMNSTRYKYGFNH---SNAWTAN 403 
159484705  231 FTPEALMLY------LNQSVSATDPNAPF---------SYTLTQYKNDPYYCASGP-FDPREWRGRNVTV---NSTAVNA 291 
302842417  280 FGETNMTLF------LNQSVSATDANKPF---------NLTYSEYIANPYYCPSSSaIQPYIWKTYNDSA---------- 334 
303290174  383 ----NTTIYarndagLAGNKTANEAAWALn-------kTLVNGAYEAAGYCVANSVrLRTAMATGGTYANwydHSKFTTQ 451 
255074031  404 FSNTGIALGNTYPDDNLFNVSMMTNTTCR---CVPVAGIDECFCYEAGLSDvfsategtcdkcekakelaCAETMRWIMR 480 
159484705  292 TANSTASSGNVTWTKELVTINMANQTALR---DWCVGGLNLSIAWRTNMTN-------------------TVQRLLIDRR 349 
302842417  335 ----------GNWTRTLMPVNTTNGTAYR---DWCAGGLALSLTWRTNMTN-------------------TVQRLLIDRR 382 
303290174  452 CTTPNGASGCVWNERGHIKVLVGGAYVNKnpaCTCNAGPPISCQCYSGLTPtggaaavs---sadakdiaCVETFRWIDQ 528 
255074031  481 MWDSRLKTAFTQNVNLRTDAKKDADDDFELVKswlsseSPVTFFEINQIKGTDPKKLEEASLDTLKDDNVinEYNLDPAA 560 
159484705  350 LGDQRTTGKIAQRNNVNDRMLAFIRANRPELV------APVFNAPRGTVALQDPINARLEYLYPLYVDGV--KYSTEPQR 421 
302842417  383 LGDQKTTGKIAMRNNVSASLRTDIIANYPELF------GPVFSDPSGTVALQDPISARLDYLMPLYVDGT-----ISPQA 451 
303290174  529 LWVTTLAQLWTDTNNVVTTTKATADAEFASVLlalqtqSPVTHYEINKMVGTNAQDLKTASLNVLKDADVlkEHNADATH 608 
255074031  561 AAVVAARQ---ADLVYKDPLIDLITARRNGLADPKISTPIFKYPAL----Y----PFNFTQINATAV--KYVAPLFPGYD 627 
159484705  422 AALNMTRRivyNTTVHLLSLRPRAAARIAEVQEQIADVRAIALPTPitsyQ----NYTFPNATVGDVydAFINAGATSFS 497 
302842417  452 ASLNMTRRfvyGSNVHLLDLGPRALARMQEVDTIQAQVLGFPIPAPrarySgtdkNYTFSNLTVGDVwsTFILAAANTTR 531 
303290174  609 AAVIAARS---SSTPYWEQLRDIITPRRNSLQNVQKSTPIYPSPVT----S----AFTFTANAAAV---GYVRANYPGYG 674 
255074031  628 LTAEVDLDL----VEFNPAVLERKDYAFMTCNLEDRADSYAGQCTNVKKYLEDAT-------------AGVISTPVVINP 690 
159484705  498 VPAPTNSSLgafqVSYNLVEWLGNTTAYMRCDLADRGAEYEGECVAMNNTCIATTndtvpynctdltnNGATITGNLSNP 577 
302842417  532 VPPPTSDALgsmsVKYNLVAWAGNTTAYMRCDLKTRAPAYIGLCVAMNNTCVATVndtvpy-ncedvaTGAAIPGSLANQ 610 
303290174  675 LTDVLTLSL----KEWNPSVLLRQDYAFTQCELPSRLPEVVGACKT----------------------PASVTTPTVANP 728 
255074031  691 ENPTAPKEPVLKQFRfqklCHSICYCGr----QGCnrkgwdpadtpvsnivdVDGDLCVCEMCLKPAQYDYVDYPLASTk 766 
159484705  578 DYRMRCETPCDRRFD----CNTICECY-----GTC-----------------AATEYCECDACIQLNVNAAADTQFVDI- 630 
302842417  611 TYRLNCEVPCDRRFD----CNTICECF-----STC-----------------LPTEYCECEACKALQRDATSDNQFVDI- 663 
303290174  729 ANTAQMQ-PFLQQTRfqklCDAVCDCAvatngAGC-----------------AAGSHCVCPVCSVTNQFANVIYPTGYTg 790 
255074031  767 peetstckavasrRKLLQEGAQVAESVRPHFHKSHHDMHRtranvfgRRHLLQES--A--DDKLTTILDSVKALSTTQTA 842 
159484705  631 -------------RSIVQDQAAASASIASIGLSGTVNRRA-------SRRLLTTN--EeiAAQLSNVLTQVGTVSTQQGS 688 
302842417  664 -------------RSLVTGQAAAAVTIASLGDVSSSSRRSmq---asGRQLQQTNssAdiQATLNNVLSQVGTVATTQAT 727 
303290174  791 ------------rRKLLEHEYVDAGDVGDVAAAPKYDFTAp-----yRRRLQ--------AATLDSIQTAISTLTTKQTS 845 
255074031  843 LDTKIEQVKTSQQLQAQEAADHHADNSLETIIKAGFDDMKRGQDALGASLEEILAKQQQALAAAQESLLIQQRTNALADS 922 
159484705  689 IATQMATLKAQVDRANQLAEARANDNRLIDLINAGRADIQAGQARVEAKLDEIIGKQNQALAAAEDAAKALSAIQGLAER 768 
302842417  728 ISQQMDALKVQVDRANAIAEARAKDDTVLNAINAGRTEIAAGQAAVEKKLDEILGKQQEALLAAQSAAAALSAIKGLAER 807 
303290174  846 LDTAITTIQTTQTNANVQANAHHADTALDTLITRGFTDVNNANAALQTTMNTILSKQQLALDKVTESLAIQQRTETLAAK 925 
255074031  923 NAKAIEKLAKAVEKQRDSINSAyCSGAFADVAMYIGIQEQAIITREQKAKENFLSNMPCQMK-VMYYPFSIDNfQNAPPP 1001
159484705  769 QVAAQRALETAVTNQLSAIKTA-TYQSIITLTQALALWKRARRDKALTLKAAKLANVPCTSDpVSTNTFTLDN-GNIVDT 846 
302842417  808 QAAAQANLEQAVNSQLSAIKVA-TYREIISLTQALALWKRARRDRALTLKAAQLANTPCNSApTASNTFKLDN-QNEVDT 885 
303290174  926 GVAQIEKLALAVEKQTASISAAwAAGAFTSIDQYVQIQENAVVTREVTAKTNSLSNSPCTTQ-EQFNNFELDNhENVYAK 1004
255074031 1002 IAYRERFIGMNNRVLAGMLVYVERKNLQACDSSRFDNIDKTCSGGRDISSYGVDPVFKMGSPLFKADYLNEQTMLSPNLY 1081
159484705  847 TTSRERNVGLTNRVIGGLLLHQTRTNETLCPESKFDKIQKTCTGPQTVASFGVDPIFKRGTTLYNPDYDDVNGTKVLDFY 926 
302842417  886 TTSRERNVGLTNRVISGLLLHQTRTNVTECPKSKFDKIQKTCTGPQTIASFGVDPVFKRGTTSYNPDFDDVNDAKVLEVY 965 
303290174 1005 DAFRERYIGLNNRVIAGMLIYTKRKNLVKCDSNRFEKIDDACSEGRDVSSYGVDPVFKLGTPMYKPTYDNKPT--VTKVY 1082
255074031 1082 NCTEMANPEAGIYPTYNNSGkwvyefsecapptekcnkcasvlgpevaegecmgkipgtlgvpgncwnascvfnptvgnn 1161
159484705  927 NCSVLSSPTYNVSFLNQTVN------------------------------------------------------------ 946 
302842417  966 NCTKLSAPTYDITFLNQTTN------------------------------------------------------------ 985 
303290174 1083 NCSELNNPSEGISPTYNPPGstd--------------------------------------------------------- 1105
255074031 1162 nyevfnikgetIGGYCKELFNPQGTPYGFRHKNLPGYADGFPYFFDINLSAAEARRWLDVMIYGLMIDDvKTEKVTAQVV 1241
159484705  947 -----------PAPYCAELYNPQELPYAFHFFPLSGKDDGFPVWFDINLSQDGAQTWFTYLQEGLYLDQ-NTRTMTAEMV 1014
302842417  986 -----------LKPYCAELYNPQKLPYAFHFFPLEGKEDGFPIYFDINLSQQGAQAWYTYINEGLYLDQ-NTRQMTAELV 1053
303290174 1106 ---------gnKYPYCKELFNPRDIPYGFRVKSIPGYADGFPYIFDINLSAKEAETWVDYMEYGLMIDDvKTDVVSAQVV 1176
255074031 1242 VYNAELGYFGNVMVFFEFTDGGKIEVSHSVNTIRVELYETPEDWGRFAMELLLAVGAVYSVYEEAMDFISSKKNHGSYMA 1321
159484705 1015 TYNAPLRIFSYFYIKFYFSDGGSIKVTYRLNTARVELQNSYEDDVRFGFEIILSIWISLLLLINFWDIGNCQKTKGNFLK 1094
302842417 1054 TYNAQLRIFSYYFIRFFFSDGGSIKITHRLNTVRVELYNSYSDDVRFAFEIILSMIIFGMLIYNLFQIGYTQVTRGNFLK 1133
303290174 1177 VYNAELGYFGNVVVYFEFTDGGKIEVTYGIDTIKVELYETIQDWIRLAMECLLAIGAAHSVYAEIMDFMDSKKTRGSYLA 1256
255074031 1322 YFASMWNYIDVASIAIHLATIMMWFIFSWSRARAFEPDIHYDIYKNIEASAFVTKLRIPNE-FPDMGDMFLEMKNLVDYM 1400
159484705 1095 YFLSGWNWVEFCSNGLLFSCMVMWWVISSKYASKFEIPIRRDVYAGLSAEANFLALQSNGAwLNEANNDFEELKQLVDMF 1174
302842417 1134 YFLSGWHWVEFASNGLLTACMIIWWVFKEEYAKTFNIMLRYDVYNSLSPSANFLALNANGTqLIAANAAFSDLRELVDML 1213
303290174 1257 YFQSAWNYVDIVSIFVHVLTIFMWFSYAWAMATAFAPSIHYKIYKNLAASAHITNLKVPNE-MDEMASMFLEMKSLVTYF 1335
255074031 1401 QLYMTLSGINIILILGRILKLMDFQPRLGVITHTLSLAFADLMHFFVIFIMVFMGYAFIGHVIFGFQSVHFSDMTHSTNS 1480
159484705 1175 NWYFALNGINILLLIARVLKLMDFQPRLGVVTRSLWLAGPDLCHFAIVAGMVFVGYAMMGHLIFGNAIPAFATFGDAINT 1254
302842417 1214 NWYFALNGINILLLIARVLKLMDFQPRLGVVTRSLWLAGPDLVHFAIVAGMVFVGYAMMAHLIFGNAIVAFATFGDSINT 1293
303290174 1336 QMYMTLSGINIILMLGRILKLMDFQPRLGVITRTLALATADLAHFFVIFALVFVGYAFIGHVIFGYASEHFSDMTSSINS 1415
255074031 1481 LFQNLLGDITyFLEDFKNATGITFFV--------------------------GMIYFYSFNIFVFMILFNFLLAIICDAF 1534
159484705 1255 CFEILLGNID-VNSDLRALGGLQSVA--------------------------GALWFWSYELLVYMVLLNFLLAIIVDAF 1307
302842417 1294 CFEILLGNID-VNDDLRALGGLQSVAavrlrgrdcrrltrllmampilpmspGALFFWSYELLVFMVLLNFLLAIIVDAF 1372
303290174 1416 LFMNLLGDITyFMEDLKNLTGMIFWV--------------------------GMIYFYTYNIFVFMILFNFLLAIICDAF 1469
255074031 1535 GEVKANAAESVSVVTELVPMLRDSWRTMFkGWLYKQHVPEARVRRQLRIWKGENPDEEEEEAFDEEPEPVFKYGD--KEL 1612
159484705 1308 SEVKEKTHETVGIHTELFQLMRDKWRSLL-GSFSPNYISDAKLGDLLRQWAGEGDDKDDSPEVREEKRKLLTILN--EDM 1384
302842417 1373 SEVKEKTQETVGIHTELFTLLRDKWRSMM-GRCSSNYISDAKLGDLLRQWAGEEDTDRDDKATLADKRKLLTILN--EDM 1449
303290174 1470 GEVKANASEAVSVTAEIGPMLRDKWRSVWrPLFYRDHIPEERVRRQLRIWKGEDPDEPEYEEDRRPKERVFTYANgeKEL 1549
255074031 1613 DMAGLKRVLRRCVIETYQKTNDSK---FLLTTRVGNFGKGKkkeTLATADEIDRAARMLMDQVGQEPEDEAEDEA----- 1684
159484705 1385 DEETLREVFEECLRDAPAADPKAKqgnVLARLFKRNVGAGD---TDATKKEIEQAAHYIVERFGAVPDDYDEDEDddqeq 1461
302842417 1450 DEETLLEIFKECLRDAPDTTDRSK---VASRSLLSRMFPRRkvgVEATEEELAQAAHYIVDRFGMVPDDDDDDDDsddgr 1526
303290174 1550 DAAGLKRVLRRCVIETYQNSDKTF---NTYLLRPNGVGSSK---ALATAAEIDQAAAMLMRQVGHRPKRGPDGEGgv--- 1620
255074031 1685 --------------------------MSEVDRLQQSLTDLLRAQERLITNQVKVIEGQARMAERQDRLSSLEEkilgvlE 1738
159484705 1462 lqaapqqaimggggmpaapgareavlEKERDQLAQALERLAEVQRELAEGQRNLMSGQKQLAEQQSKLVQLMN------E 1535
302842417 1527 qdspplppaapaaavgalgpsreavlEKERDQLAQALERLAEVQRELAEGQRNLMNGQKQLSEQQSKLVQLMN------E 1600
303290174 1621 ------------------------ghENEVQTLQRSLERLIKSQQKLVEGQVKVIDGQSKMASRQERLSDLEHkilgvlE 1676
255074031 1739 KPPS 1742
159484705 1536 TPPQ 1539
302842417 1601 QPPA 1604
303290174 1677 KPPG 1680
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