Conserved Protein Domain Family
7tmA_EBI2
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cd15159: 7tmA_EBI2 
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors
Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.
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Statistics
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PSSM-Id: 320287
Aligned: 10 rows
Threshold Bit Score: 445.258
Created: 18-Nov-2008
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                               #  ##            ###### #
NP_004942     32 IVMPLHYSLVFIIGLVGNLLALVVIVQNRKkinSTTLYSTNLVISDILFTTALPTRIAYYAmgfdWRIGDalCRITALVF 111 human
XP_001231944  38 IILSVFYSLILILGVLGNTIALTVIFKNRKkinSTTLYSTNLVFSDLLFCIALPTRIAYYAlgfhWPFGEalCRITALLF 117 chicken
NP_001092711  28 YFLPAMYSLICIVGLLGNVLALHVIWPNLKkinSTTLYSANLVVSDILFSLALPLRVVYYArgfdWPMGEglCKAVALLF 107 zebrafish
XP_001506459  32 IVLSIFYIGVLVFGFLGNFLAFCIIGCKRKr-nSTDLYLLNLSMSDLLFTLALPGRISYFIqafsWNFGDwaCRLTALLF 110 platypus
XP_001376949  29 VALLLFYSVLLVISSFGNILAIYIASQKKKm-nSTDLYLINLAVSDILFTLALPGRIAYYIldfnWPFGDwlCRVIAFVF 107 gray short-tail...
NP_001122272  34 ILFPLFYCLIFVISVAGNSLVLCITCQKRQkmnSTTIYLINLAISDALFTLALPGRITYYIrgfdWPFGDflCRLTAMIF 113 zebrafish
NP_001133697  38 VLMPLFYCIVFFVGLLGNALAFHIIRPNVKkinSTTLYSANLVISDILFTLSLPLRIIYYAlgfhWPLGEtlCKIVGLIF 117 Atlantic salmon
NP_001124284  25 VLIPLVYSIICPVGLLGNALALHVVISSTTkinSITLYSANLAVSDILFCLSLPLRAVYYGlgfhWPMGEvlCKAIALLF 104 zebrafish
EMP29757      34 VIFSFFYTVLLVFGSCGNVLALYVTFHRGKkinSTDLYLINLAVSDALFTLALPGRIAYYIlefnWPFGDwfCRVTAFIF 113 green seaturtle
ELK36701      29 VTLCLFYTVLLVFSTLGNTLALFLACQKDKkinSTSVYLVHLAVSDLLFTLALPGKITYYAldfsWPFGEglCRLTAFIF 108 Myotis davidii

Feature 1        #  #                                             # #####                        
NP_004942    112 YINTYAGVNFMTCLSIDRFIAVVHPl-RYNKIKriEHAKGVCIFVWILVFAQTLPLLInpmsk-qeaerITCMEYpnfe- 188 human
XP_001231944 118 YINTYAGVNFMTCLSIDRFFAVVHPf-RYKIRRi-KYAKGICVFIWFLVFSQTFPLLIqpmth-eenerTTCMEYpnfe- 193 chicken
NP_001092711 108 YINMYAGVNFMTCLSVDRFIAVVLPlrFSRFRKv-QKVRYICGVVWVVVLMQTLPLLSmpmtnieqsghITCMEYpnfe- 185 zebrafish
XP_001506459 111 FMNTYGSIYLMTFVSVDRYIAVVSTrrCHNLRKv-GVVRWICAFAWGLAFLLNVPLLLrpits-kmgdrVACMDLnnie- 187 platypus
XP_001376949 108 YVNTYGSVYLMTCISIDRYIAVIHThqNHKFRHa-GWAKYICITVWSLASLQTMPVLFmpltk-kmgdkLSCMEYasie- 184 gray short-tail...
NP_001122272 114 YSNTYVSIAFMTCISVDRYLAMLHRqrCQRLRKt-KVVKAVCVLVWVVVLLETSPLLFksime-nrpghRTCMEFsnfd- 190 zebrafish
NP_001133697 118 YINTYAGVNFMTCLSVDRFIAVVLPlrFARFRKv-SNVRYICVGVWLLVLMQTLPLLSmpmtneepdgfITCMEYpnfe- 195 Atlantic salmon
NP_001124284 105 YLNCYAGVNFMTCLAVDRFVALVFParLAKLRKa-KNVRFVCLAIWLLVLAQTLPLLTigltktepdssITCMEYpnfeg 183 zebrafish
EMP29757     114 YMNTYVGIYFMTCVSVDRYIAVVHTrrLGRFRKv-SRVKYICMLIWFIVFLQTISLLFrpmtk-kigdkLTCMEYfnfe- 190 green seaturtle
ELK36701     109 YMNTYGGIYLMTCVSVDRYLAVVRThqRPQLRSa-NRARLVCMAVWALAGLQTVPLLLitltg-pvagkVTCMEYasve- 185 Myotis davidii

Feature 1            #  ### ### ##                                                   #  ## ##  # 
NP_004942    189 etksLPWILLGACFIGYVLPLIIILICYSQICCKLfrtakqnplteksGVNKKALNTIILIIVVFVLCFTPYHVAIIQHM 268 human
XP_001231944 194 kiahLPFILLAACLVGYLIPLGIILFCYSQISCKLfqtakenplteksGINKKAINTILFVIIVFIICFTPYHVAIIQHM 273 chicken
NP_001092711 186 kidnLPVMLIGAVVLGFGIPVITILVCYTALCLKLrhlaksnklteksGRSSKAIGVICTVILVFVVCYSPYHVDLLQYM 265 zebrafish
XP_001506459 188 gifkHPLIVLISCIIVFSVPVGIILFCYVKITLKLirsarrnslpkriGNDKKACVVSMMVLIIVVVCFSPYHLIVIQFM 267 platypus
XP_001376949 185 kilsLPLLLLGGCVLGFFGPVGIILFCYVKITLKLcriaqensvmcksDHQKKACLVILLVLMAVIICFSPYHFNISQFV 264 gray short-tail...
NP_001122272 191 -skrMAYVLLFACVIGFFMPLGLILCSYSRVSCKLyktakenpltnksGGHTRAKNMILLILLSFVVCFSPYHINIMQFV 269 zebrafish
NP_001133697 196 pvpnISYILIGAVFLGYGVPVVTILVCYSILCCKLrlaakanqltdksGRSQKAIGVICCVSLVFVVCFSPYHIDLLQYM 275 Atlantic salmon
NP_001124284 184 vfkgLPYMLIVAVVLGFGIPVMTIIACYSILTHKLhqaaksnqltersGKTKKARGVIAGVVFVFVVCFSPYHIDILQYM 263 zebrafish
EMP29757     191 eipkLPFILLGACMIGFCLPVGIILVCYVQINLKLcraakenpltdknGHHRKAFTIILVVLLAVVICFSPYHLNIIQFM 270 green seaturtle
ELK36701     186 kvfrLSLIILGACVVGFWVPLGVMLFCYVQITVKLcrtardnpltsekGHHRRACLLTLVVLVAVLVCFSPYHLNIAQFM 265 Myotis davidii

Feature 1                         ## ###  #  ##                     
NP_004942    269 IKklrfsnflecsqrhsFQISLHFTVCLMNFNCCMDPFIYFFACkgYKRKV 319 human
XP_001231944 274 IKklqyqpl--cnenqiFQKSLHYTVFLMNFNCCLDPFIYFFACkgYKRTV 322 chicken
NP_001092711 266 IKklrydpd--cselhkFQISLHITVCFMNLNSCLDPFIYFFACkgYKKKV 314 zebrafish
XP_001506459 268 IRmityqts--cseqvkFKVSLQITMMIMNANCCIDPIIYFFACksYKKKL 316 platypus
XP_001376949 265 IRelfsqst--caekkaFKVSLQVTVCFMNMNCCVDPIIYFFASqgYKKQF 313 gray short-tailed opossum
NP_001122272 270 VRrlyheps--ceelkaLKLSLQVTVAMMNLNSCLDPIIYFFAIrtYKQRV 318 zebrafish
NP_001133697 276 IRkliytpd--caeltaFQISLHFTVCLMNLNSCLDPFIYFFACkgYKTKV 324 Atlantic salmon
NP_001124284 264 IRkllyetd--ckelqsFQISLHITVCLMNLNSCLDPFVYFFACkgYKQKV 312 zebrafish
EMP29757     271 VRkilyqps--csaqkaFKMSLQITVAFMNMNCCIDPIIYFFAFrgYKRRL 319 green seaturtle
ELK36701     266 VRqmlylps--cpeqsaFKVSLQLTVSLMNMNCAIDPLIYFFAStrYREWL 314 Myotis davidii

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