2ZO4,2Q0I


Conserved Protein Domain Family
TTHA1429-like_MBL-fold
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cd07725: TTHA1429-like_MBL-fold 
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uncharacterized Thermus thermophilus TTHA1429 and related proteins; MBL-fold metallo hydrolase domain
Includes the MBL-fold metallo hydrolase domain of uncharacterized Thermus thermophilus TTHA1429 and related proteins. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.
Links
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Statistics
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PSSM-Id: 293811
Aligned: 21 rows
Threshold Bit Score: 157.075
Created: 9-Jun-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     # # ##      
2ZO4_A                  8 LYLLPVPipy-plkTVNLYLLQga-geVALVDTALgtraARGALELHLaelg----lcfQDVKTILLTHHHPDHYGLSGF 81  Thermu...
NP_604176               9 IYLVEVPlpknplrALNCYFIKng-enILVVDSGFdheeSEKAFFEALeel-----gakVGKTDMFLTHLHADHSGLALK 82  Fusoba...
BAA79285               10 VVNVWIPiqs--lgSVNVTVFKkdageVDLVDAGMy---SARSVHDLLakiksrirgkiRDVDKIVITHFHVDHMSGAAI 84  Aeropy...
DSMZ:AFULGI_00005430    9 IYRIEVPlkgsplrYTNSYLVMdg-deALLIDTGF----NRESCYRSIkgal---eelnVRNFRVFCTHMHADHMGLAAK 80  Archae...
AAY80462                2 ITTLSLPmpg-plkHINSYVIRdg-ddTLLIDTGLpiedDAVVLKEFIek--------sGYPDYVLITHYHPDHIGQARL 71  Sulfol...
PRJNA279939:SULB_0317   3 IFTLKLPmqg-plkYINSYLVKgn-eeSVLIDTGLptqeDVTTLSNYLka--------yGYPNFVVITHYHPDHMGLVRL 72  Sulfol...
jgi:M1425_0819          9 LFKLSIKlpdlaigSLNAYLLTlg-dkNILIDTGSpsygSISSLVEELenlg----mkiSDINEIIITHFHIDHIGLAYL 83  Sulfol...
BAA81602                8 RVEAWIPigd--lgSVNVYAFTdg-asTVLVDSGMf---SGKSVYTLLkglrr-vgvdpRSVERIVVTHYHVDHLTGAAI 80  Aeropy...
AAL64875                3 FFRISLPlpgmelgHVNVYVVKcs-dgYGLIDAGLatydAALSLLRGLkslg----ikpSEITKVFITHYHADHITLAQF 77  Pyroba...
AAT43707                1 MRLLKVPveipalrTANIYLND-----NFIIDSGMsr-ySYDYIKSSIn---------vDDIDFIVISHMHIDHIGGALY 65  Picrop...

Feature 1                                                                                                 
2ZO4_A                 82 FEg--lGARVFLHeeefarghrfwrepeafaeaswrlfl----dhgtpegalqgiretvektrervhppQNPLPLRDGEA 155 Thermu...
NP_604176              83 FKn--kYQGKVYCsqidtdyinqmkhelyadrfvptlk-------vmgidpdfkffethpglvycvkgkLETTIVKDGDK 153 Fusoba...
BAA79285               85 LRe--vFEPTVFIgigelelplrsgspdvfvdniltlyrehgvpepvlesirrshpvfrtvlayrafssLDLKPIYPGDI 162 Aeropy...
DSMZ:AFULGI_00005430   81 LAdevlMGETEAKivretmveedywrdllkfyikn------------gfpakeaekilslhpgrnfwvkDDVEFVAVGEV 148 Archae...
AAY80462               72 FKk---SRILLNQeelqfitdviegvheremkdyllr--------ngfpenflqrifsqraffkelladIEFEGVKDGDK 140 Sulfol...
PRJNA279939:SULB_0317  73 FKd--kSIILISDreleyvtyllseeyekemrkylla--------ngfpeefiqrmfrnrsrfseiidgVNFNTVKDGDV 142 Sulfol...
jgi:M1425_0819         84 LS----KLAKVKIiignveynfikrfkyrydemikilklng-asqqlldiafdftsgfraniysrvgelNNVETVNDSQQ 158 Sulfol...
BAA81602               81 LCe--aLGAELMLargdlelllrvgveeyfrralellalag-tprevleeikryspavrvaeaygavaeLGPKPLGEGDI 157 Aeropy...
AAL64875               78 IAe--vASPDFYIgegevsevatsfedlarlyaeeyrrhg--apaevaeaflkihpmsryrkafedvwkLPWKRVKDGEL 153 Pyroba...
AAT43707               66 FQk--eNNIDVYIginelkyienideyidfyrslikd---------sgapdaiiekiisdniigkyidyYREINLKPLNY 134 Picrop...

Feature 1                                 ##                 #                                           #
2ZO4_A                156 LEva-gkRLRVLWTPGHADGHAAFYLEeeGVLLAGDALLEKVSPNVGlwaytreNPLKDFLRSLDRLADLg-aRVAYAGH 233 Thermu...
NP_604176             154 IDfg-dyHFEVVDLSGHTPGQMGIYDRehKILFSGDHILNKITPNISfwefkyeDILGIYLKNLDKVYNMe-vDIIYAAH 231 Fusoba...
BAA79285              163 LRlg-eaSYRALPAPGHTPGHIVLESLdgTHAIVGDTLLERITPSVIlyd-eehDPLGSYLRTLEMLAQKk-yLVAYPGH 239 Aeropy...
DSMZ:AFULGI_00005430  149 VRvg-sfRLKAIETPGHSPGHTCLYDEsrKIFFSGDHVLIDITPNITwwp-fleDSLSSYLQSLEKVENLd-vKLVLPGH 225 Archae...
AAY80462              141 IVig-gnEAEVIWTPGHTVGHSCVKYG--ENLFCGDHILPNVTPNVSlha-pydDPLGRYLDSLDKIEKLe-iNTIYPAH 215 Sulfol...
PRJNA279939:SULB_0317 143 IKlg-qeQMRVLLTPGHTMGHICLVYE--KVVFCGDHILQDITPNISllr-ledNPLKAYLESLDKVQKLd-iELLYPAH 217 Sulfol...
jgi:M1425_0819        159 LY-----NLKFLFTPGHTIGHICIYDEenKLLLSGDTLLADITPNVSlye-ensNPLNEYLKSLKRISSLe-vKKFLPAH 231 Sulfol...
BAA81602              158 IEmpghgDYLVLETPGHTPGHIVLVSHgkREVLLGDTVLPDITPHVSlhs-idsDPLGNYMSSLSRIATEtagYLGLPGH 236 Aeropy...
AAL64875              154 LDc----GLKALSTPGHTPGHTVYIYR--DGVFTGDHILPKITPNISwypkkgfNPLKAYLNSLRKVYIK---AKGYPAH 224 Pyroba...
AAT43707              135 IN-----GYSIIDTPGHSPGSICIYDSynERLFSGDHVLERITPNVSmy---ygNPLDDYIKSLEKLKNIs-iRSIYPGH 205 Picrop...

Feature 1                           
2ZO4_A                234 FGPIADVRQR 243 Thermus thermophilus HB8
NP_604176             232 RGVIKNPKLR 241 Fusobacterium nucleatum subsp. nucleatum ATCC 25586
BAA79285              240 GNPIISPAER 249 Aeropyrum pernix K1
DSMZ:AFULGI_00005430  226 RRRWNDLKTR 235 Archaeoglobus fulgidus DSM 8774
AAY80462              216 GEPFTNVKER 225 Sulfolobus acidocaldarius DSM 639
PRJNA279939:SULB_0317 218 GEVLKDVSKR 227 Sulfolobus solfataricus
jgi:M1425_0819        232 GRIIENTEER 241 Sulfolobus islandicus M.14.25
BAA81602              237 GNPMKDVAAR 246 Aeropyrum pernix K1
AAL64875              225 GDEISDITTR 234 Pyrobaculum aerophilum str. IM2
AAT43707              206 GNVINNVGNR 215 Picrophilus torridus DSM 9790

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