Conserved Protein Domain Family
PRK09694

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PRK09694: PRK09694 
CRISPR-associated helicase/endonuclease Cas3
Statistics
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PSSM-Id: 182031
Aligned: 13 rows
Threshold Bit Score: 1306.71
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
16130668    1 MEPFKYICHYWGKSSKSLTKGND-IHLLIYHCLDVAAVADCWWDQSVVLQNTFCRN---EMLSKQRVKAWLLFFIALHDI 76 
170082336   1 MEPFKYICHYWGKSSKSLTKGND-IHLLIYHCLDVAAVADCWWDQSVVLQNTFCRN---EMLSKQRVKAWLLFFIALHDI 76 
238901898   1 MEPFKYICHYWGKSSKSLTKGND-IHLLIYHCLDVAAVADCWWDQSVVLQNTFCRN---EMLSKQRVKAWLLFFIALHDI 76 
292489288   1 MNSQPEYYRYWGKATAATPEGETaCHLLPWHCLDVAAVAARWWDSSPSLRSQFST----ELSPVSQLRAWVLFFVALHDF 76 
292898483   1 MNSQPEYYRYWGKATAATPEGETaCHLLPWHCLDVAAVAARWWDSSPSLRSQFST----ELSPVSQLRAWVLFFVALHDF 76 
39996486    3 SLTVPEYVWYWGKAEKDAGG----YHLLPYHCLDVAAVAAVWWDASPTIRRSFSSH---ASCSEVQSRAWLLFFVALHDY 75 
170018993   1 MEPFKYICHYWGKSSKSLTKGND-IHLLIYHCLDVAAVADCWWDQSVVLQNTFCRN---EMLSKQRVKAWLLFFIALHDI 76 
288940397   1 -MLSKDYWRYWAKADTGVEGANK-WHPFAYHSLDAAVIAATFWRDSSAVRRTLMAAfdvEEAEIQRLLAWILFFVALHDI 78 
259907480   1 MNSPPGYYRYWGKAIAVTPEGETaCHLLPWHCLDVAAVAARWWDNSPSLRSQFSA----ESSPAPQVRAWVLFFVALHDF 76 
157162211   1 MEPFKYICHYWGKSSKSLTKGND-IHLLIYHCLDVAAVADCWWDQSVVLQNAFCRN---EMLSKQRVKAWLLFFIALHDI 76 
119945303  12 DEKINTYFMYWGKAKSESQATGAdYHLLPYHCLDVTAVADVWLEESNILLSQISCY---LDTTQDQAKRICLFFILLHDL 88 
218547719   1 MEPFKYICHYWGKSSKSLTKGND-IHLLIYHCLDVAAVADCWWDQSVVLQNAFCRN---EMLSKQKVKAWLLFFIALHDI 76 
47104065   15 FMSSATYFKYWGKVEKDSEQADIgYHLLPYHCLDVAAVADKWLTRSNVLLKQISAH---IGKTEQEARSIVLFFVLLHDF 91 
16130668   77 GKFDIRFQYKSAESWLKLNP-ATPSLNGPSTQMCRKFNHGAAGLYWFNQDSLS----EQSLGDf-fSFFDAAPHPYESWF 150
170082336  77 GKFDIRFQYKSAESWLKLNP-ATPSLNGPSTQMCRKFNHGAAGLYWFNQDSLS----EQSLGDf-fSFFDAAPHPYESWF 150
238901898  77 GKFDIRFQYKSAESWLKLNP-ATPSLNGPSTQMCRKFNHGAAGLYWFNQDSLS----EQSLGDf-fSFFDAAPHPYESWF 150
292489288  77 GKFDIRFQAKAPAALRILNP-DGEKISGRLPP----WDHGKGGVLCLREDFRA----NAVSDDsllAFLDEPPHSKRAWF 147
292898483  77 GKFDIRFQAKAPAALRILNP-DGEKISGRLPP----WDHGKGGVLCLREDFRA----NAVSDDsllAFLDEPPHSKRAWF 147
39996486   76 GKFDLRFQLKVREVWEKLHPlAGQGASLPSQFDINQYQHGESGLFWFKKDFFAlngcEPTADS---LFIDDEPLQWSNWK 152
170018993  77 GKFDIRFQYKSAESWLKLNP-ATPSLNGPSTQMCRKFNHGAAGLYWFNQDSLS----EQSLGDf-fSFFDAAPHPYESWF 150
288940397  79 GKLHALFQIKAPHILPQIWP--DLASTKLIDTSGGHYDHGREGYRLSMAELRG-------------WFKPASRHALKAWS 143
259907480  77 GKFDIRFQAKAPAALRILNP-DGLNISGRLPP----WDHGKGGVLCLRNDFRE----NPASDDsllSFLDEAPHSKQAWF 147
157162211  77 GKFDIRFQYKSAESWLKLNP-ATPSLNGPSTQMCRKFNHGAAGLYWFNQDSLS----EQSPGDf-fSFFDAAPHPYESWF 150
119945303  89 GKFDARFQNFREDIRQILQG-DDWEIEPDPTY----YSHGSCGYRQFSEMFDT----NEA-------------------- 139
218547719  77 GKFDIRFQYKSAESWLKLNP-ATPSLNGPSTQMCRKFNHGAAGLYWFNQDSLS----EQSPGDf-fSFFDAAPHPYESWF 150
47104065   92 GKFDARFQNFVESIRIKLQG-NEYEVESEA------YSHGSFGYLHFRKVHGN----NEA-------------------- 140
16130668  151 PWVEAVTGHHGFILHSQDQDKSRWEMPASLASYAAQDKQAREEWISVLEALFLTPAGLSINDIPPDC----SSLLAGFCS 226
170082336 151 PWVEAVTGHHGFILHSQDQDKSRWEMPASLASYAAQDKQAREEWISVLEALFLTPAGLSINDIPPDC----SSLLAGFCS 226
238901898 151 PWVEAVTGHHGFILHSQDQDKSRWEMPASLASYAAQDKQAREEWISVLEALFLTPAGLSINDIPPDC----SSLLAGFCS 226
292489288 148 PWMEAVAGHHGYVVREYHLPDEMMNYPPGLQGWADADRQARMAWLQALEGLFLQPVGLSLQDNPPPV----SPLLAGFCS 223
292898483 148 PWMEAVAGHHGYVVREYHLPDEMMNYPPGLQGWADADRQARMAWLQALEGLFLQPVGLSLQDNPPPV----SPLLAGFCS 223
39996486  153 PWVEAVTGHHGHVKQAEYASDASLSVSVD-GRFAEIDQTARKEWLKALEQLFLRPAGLSLDNAPPPP----SPLLAGFCS 227
170018993 151 PWVEAVTGHHGFILHSQDQDKSRWEMPASLASYAAQDKQAREEWISVLEALFLTPAGLSINDIPPDC----SSLLAGFCS 226
288940397 144 SWLAAVTGHHGEIPDNDDPLPAYAE-----ATILEQDANARRAWIQEAADLFLHPAGLSLEDPPPPCvteaRNLLAGFCS 218
259907480 148 PWMEAVAGHHGYVVREYDLSDEVMNYPPGLQGRADADRQARMAWLQALERLFLQPVGLCLQDNPPPV----FPLLAGFCS 223
157162211 151 PWVEAVTGHHGFILHSQDQDKSRWEMPASLASYAAQDKQAREEWISVLEALFLTPAGLSINDIPPDC----SSLLAGFCS 226
119945303 140 --MKAVAGHHGSCDTSQPYHD-----PDADDELLELDEQARKEWVEFSLDFCQLKEVPDVGDIP---------MLAGLCS 203
218547719 151 PWVEAVTGHHGFILHSQDQDKSRWEMPASLASYAAQDKQAREEWISVLEALFLTPAGLSINDIPPDC----SSLLAGFCS 226
47104065  141 --MKAVAGHHGYCDVSLDPFSPEAE-PDADDELIELDKHAREEWVKFCLEWTGLSQIPDVGEIP---------MLAGLCS 208
16130668  227 LADWLGSWTTTNTFLFNedapSDINALRTYFQDR-QQDASRVLELSGLVSNKRCYEGVHALLDNGYQPRQLQVLVDALPV 305
170082336 227 LADWLGSWTTTNTFLFNedapSDINALRTYFQDR-QQDASRVLELSGLVSNKRCYEGVHALLDNGYQPRQLQVLVDALPV 305
238901898 227 LADWLGSWTTTNTFLFNedapSDINALRTYFQDR-QQDASRVLELSGLVSNKRCYEGVHALLDNGYQPRQLQVLVDALPV 305
292489288 224 ISDWLGSWSSEETFCYR----SSVEPPDNYFARRyASDAAIVLERSGLVAQIKPWSGVAALLEKGHAPRQLQTLVDRLPE 299
292898483 224 ISDWLGSWSSEETFCYR----SSVEPPDNYFARRyASDAAIVLERSGLVAQIKPWSGVAALLEKGHAPRQLQTLVDRLPE 299
39996486  228 VSDWLASRCDDTNFSFH----QSPLSISDYFTQKfSQDAPAILAFSGLNGTAKSYGGISDLLPAIATPRPLQTKVDQLPL 303
170018993 227 LADWLGSWTTTNTFLFNedapSDINALRTYFQDR-QQDASRVLELSGLVSNKRCYEGVHALLDNGYQPRQLQVLVDALPV 305
288940397 219 LCDWIGS--NVDVFAYAppalSPNDYLHSRLEQIrRDD---ILRHFGLIATPLAYQGIPALLKTDEHPRGTQVMIDDLPL 293
259907480 224 VSDWLGSWSSEETFRYQ----SSVESLDNYFAQRyACDAAIVLERSGLVAQVKPWSGVAALLEKGHAPRQLQTLVDRLPE 299
157162211 227 LADWLGSWTTTDTFLFKedapSGIQALRTYFQDR-QQDACRVLALSGLVSNKRRYDGVHALLDNGYQPRQLQVLVDALPA 305
119945303 204 VADWVGSSITNFTT-------DPSINLQQYYQDT-LLRARKALVDTGMIEKSQ--GAGFAYLFNGYRPRGIQTLLSEMPL 273
218547719 227 LADWLGSWTTTDTFLFKedapSGIQALRKYFQDR-QQDACRVLELSGLVSNKRSYDGVHALLDNGYQPRQLQVLVDALPT 305
47104065  209 VSDWIGSSITNFTQ-------EPDLDLYQYYKQI-LPKADAALIESGMVQVLS--GAGFEFLFNGYTPRGIQTLIEQIPQ 278
16130668  306 APGLTVIEAPTGSGKTETALAYAWKLIDQQIADSVIFALPTQATANAMLTRMEASASHLFS-SPNLILAHGNSRFNHLFQ 384
170082336 306 APGLTVIEAPTGSGKTETALAYAWKLIDQQIADSVIFALPTQATANAMLTRMEASASHLFS-SPNLILAHGNSRFNHLFQ 384
238901898 306 APGLTVIEAPTGSGKTETALAYAWKLIDQQIADSVIFALPTQATANAMLTRMEASASHLFS-SPNLILAHGNSRFNHLFQ 384
292489288 300 QPGLTLIEAPTGSGKTEAALAFAWRLLASGQADSIIFALPTQATANAMYARLERLAVQLFD-RPNFILAHGYARFNPAFD 378
292898483 300 QPGLTLIEAPTGSGKTEAALAFAWRLLASGQADSIIFALPTQATANAMYARLERLAVQLFD-RPNFILAHGYARFNPAFD 378
39996486  304 QDGLTIIEAPTGSGKTEAALAHAWRLLATGQADSIIFALPTQATANAMLGRLESLAERIFTnSPNLLLAHGNARFNRTFT 383
170018993 306 APGLTVIEAPTGSGKTETALAYAWKLIDQQIADSVIFALPTQATANAMLTRMEASASHLFS-SPNLILAHGNSRFNHLFQ 384
288940397 294 VPGLTIVEAPTGSGKTEAALAYAWRLIDAGLAESIVFALPTQATANAMLGRCETFSKSAFG-RANLVLAHGHSRLNQAYQ 372
259907480 300 QPGLTLIEAPTGSGKTEAALAYAWRLLAGGQADSIIFALPTQATANAMYSRLERLATQLFE-RPNFILAHGYARFNPVFG 378
157162211 306 APGLTVIEAPTGSGKTETALAYAWKLIDQQLADSVIFALPTQATANAMLSRMEANASRLFT-SPNLILAHGNSRFNHLFQ 384
119945303 274 KAGLTLVESDTGSGKTEFALAYASSLIEAGLADGVVFGLPTQATANGLFSRVGDAAKKLFP-DTKTTLAHGKSKYLMSDE 352
218547719 306 APGLTVIEAPTGSGKTETALAYAWKLIDQQLADSVIFALPTQATANAMLSRIEANASRLFT-SPNLILAHGNSRFNHLFQ 384
47104065  279 QPGLTIVESDTGSGKTEFALAYASRLIENKLADGIVFGLPTQATANGLFDRIGDAAEKLFP-DSTVTLAHGKSRYILKDK 357
16130668  385 SIKSRAI--TEQGQEEAWVQCCQWLSQSNKKVFLGQIGVCTIDQVLISVLPVKHRFIRGLGIGRSVLIVDEVHAYDTYMN 462
170082336 385 SIKSRAI--TEQGQEEAWVQCCQWLSQSNKKVFLGQIGVCTIDQVLISVLPVKHRFIRGLGIGRSVLIVDEVHAYDTYMN 462
238901898 385 SIKSRAI--TEQGQEEAWVQCCQWLSQSNKKVFLGQIGVCTIDQVLISVLPVKHRFIRGLGIGRSVLIVDEVHAYDTYMN 462
292489288 379 AVKQRAA--NVQQAEEGWAQCCEWLSRGNKRAFLGQIGVCTVDQVLISVLPVKHRFIRGFGLGRSVLLVDEVHAYDSYMY 456
292898483 379 AVKQRAA--NVQQAEEGWAQCCEWLSRGNKRAFLGQIGVCTVDQVLISVLPVKHRFIRGFGLGRSVLLVDEVHAYDSYMY 456
39996486  384 DLKRRGY--SDVADPDGWTQCGEWLAESRKRVFLGQIGVCTIDQVLISVLPVKHRFVRGLGVGRSVLIVDEVHAYDAYMY 461
170018993 385 SIKSRAI--TEQGQEEAWVQCCQWLSQSNKKVFLGQIGVCTIDQVLISVLPVKHRFIRGLGIGRSVLIVDEVHAYDTYMN 462
288940397 373 RLIEAGSkrTAQGETEAGVQCAAWLASSRKRVFLGQIGVCTVDQVLLSVLPVRHNFVRAFGLHRSVLIVDEVHAYDAYMN 452
259907480 379 AVKQRAA--NVQQAEEGWAQCCEWLSRGSKRAFLGQIGVCTVDQVLISVLPVKHRFIRGFGLGRSVLLVDEVHAYDSYMY 456
157162211 385 SIKSRAF--TEQGQEEAWVQCCQWLSQSNKKVFLGQIGVCTIDQVLISVLPVKHRFIRGLGIGRSVLIVDEVHAYDTYMN 462
119945303 353 S---------------------GFLQQSNKRAFLGSMSVATIDQILMGVLGIRHQFVRSFGTRKSVLVLDEIHSFDAYML 411
218547719 385 SIKSRAF--TEQGQEEAWVQCCQWLSQSNKKVFLGQIGVCTIDQVLISVLPVKHRFIRGLGIGRSVLIVDEVHAYDTYMN 462
47104065  358 YLSPDEN---------------GFLHRSNKRAFLGSMSVATVDQILMGVLSIKHQFIRSFGTRKSVLILDEIHSFDAYMY 422
16130668  463 GLLEAVLKAQADVGGSVILLSATLPMKQKQKLLDTYGLHtDPVENNSAYPLINWRGVNGA-QRFDLLAHPEQLPPRFSIQ 541
170082336 463 GLLEAVLKAQADVGGSVILLSATLPMKQKQKLLDTYGLHtDPVENNSAYPLINWRGVNGA-QRFDLLAHPEQLPPRFSIQ 541
238901898 463 GLLEAVLKAQADVGGSVILLSATLPMKQKQKLLDTYGLHtDPVENNSAYPLINWRGVNGA-QRFDLLAHPEQLPPRFSIQ 541
292489288 457 GLLEAVLRAQSAAGQSALLLSATLPAHLKQRLLNTYPGD-PAAELSSAYPLVTWRGQRQQ-LHFDLSATPEHLPAESALL 534
292898483 457 GLLEAVLRAQSAAGQSALLLSATLPAHLKQRLLNTYPGD-PAAELSSAYPLVTWRGQRQQ-LHFDLSATPEHLPAESALL 534
39996486  462 GLLEEVLRQQRQCGGSAILLSATLPATLKQQLAAAWGDQrTECNPSAAYPLLTWLGNVDF-PPISLARH--ETPKPVTVE 538
170018993 463 GLLEAVLKAQADVGGSVILLSATLPMKQKQKLLDTYGLHtDPVENNSAYPLINWRGVNGA-QRFDLLAHPEQLPPRFSIQ 541
288940397 453 GLLIEVLKRQKAVGGSAILLSATLPASIRGKLLESWGH--EPVADVANYPAIWNTAALSE-SDSPLSLPDTERPAQRTIE 529
259907480 457 GLLEAVLRAQSAAGQSALLLSATLPGHLKQRLLATYPVD-NAAQLSSEYPLVTWRGQTQQ-RHFDLSATPEHLPAETTLL 534
157162211 463 GLLEAVLKAQADVGGSVILLSATLPMKQKQKLLDTYGLHtDPEENNSAYPLINWRGVNGA-QRFDLLAHPEQLPPRFSIQ 541
119945303 412 GLIEQVLKGQHQAYSSVILLSATLPNTLKEKLLSTYKGK----SLNNAYPLVSHTDLFATtQEFTLPKQ----ATNKTIT 483
218547719 463 GLLEAVLKAQADVGGGVILLSATLPMKQKQKLLDTYGLHtDPEENNSAYPLINWRGVNGA-QRFDLLAHPEQLPPRFSIQ 541
47104065  423 GLIEQVLKGQHQAFSSVILLSATLPNTQKNKLLRPYGGS----TQSDCYPLITHTSVEGEtNEFTLTTG----TVRKQIK 494
16130668  542 PEPICLADMLPDLTMLERMIAAANAGAQVCLICNLVDVAQVCYQRLK----ELNNTQVDIDLFHARFTLNDRREKENRVI 617
170082336 542 PEPICLADMLPDLTMLERMIAAANAGAQVCLICNLVDVAQVCYQRLK----ELNNTQVDIDLFHARFTLNDRREKENRVI 617
238901898 542 PEPICLADMLPDLTMLERMIAAANAGAQVCLICNLVDVAQVCYQRLK----ELNNTQVDIDLFHARFTLNDRREKENRVI 617
292489288 535 LQPRYLAGGEPDDLLLQQMMAAAAAGAQVCLICNLVDVAQKTWQRLS----AYG--QAEVMLFHARFTLTDRIAKEQQVL 608
292898483 535 LQPRYLAGGEPDDLLLQQMMAAAAAGAQVCLICNLVDVAQKTWQRLS----AYG--QAEVMLFHARFTLTDRIAKEQQVL 608
39996486  539 IEALRLEGMEPDQTLLARLVRAAESGAQVAVICNMVNDAQRIAAALR----EMT--SAPVGLFHARYRFKDRQIRESEVI 612
170018993 542 PEPIYLADMLPDLTMLERMIAAANAGAQVCLICNLVDVAQVCYQRLK----ELNNTQVDIDLFHARFTLNDRREKENRVI 617
288940397 530 VSLSKLGGACPDEPLIQRIIDAAESGALVGIVMNTVDDAQQLWIQLH----KNA--QVPVDLFHARFRLQDRQRIEQRVI 603
259907480 535 LEHRYLAESEPDELLLQEMVDAAAAGAQVCLICNLVDVAQKTWQRLM----AYG--QAEVLLFHARFTLTDRIAKEQQVL 608
157162211 542 PEPIYLADMLPDLTMLERMIAAANAGAQVCLICNLVDVAQVCYQRLK----ELNNTQVDIDLFHARFTLNSRREKENRVI 617
119945303 484 LKTWCSDDLLPSINQRKKMIDWVSQGAMVGVICNTVKDAQRLYHQIK-----IANPELKIELFHARFTFGDRKKREDQVL 558
218547719 542 LEPIYLADMLPDLTMLERMIAAANAGAQVCLICNLVDVAQVCYQRLK----ELNNTQVDIDLFHARFTLNDRREKENRVI 617
47104065  495 AEKWCSATLLPNQQQQQQLLNWAMKGAMVGVICNTVNDAQKLYLSLQevlpKDQGPELDIDIFHARYTFADRAKIEKSVL 574
16130668  618 SNFGKNGKRNVGRILVATQVVEQSLDVDFDWLITQHCPADLLFQRLGRLHRHHR-----KYRPAGFEIPVATILLPDGE- 691
170082336 618 SNFGKNGKRNVGRILVATQVVEQSLDVDFDWLITQHCPADLLFQRLGRLHRHHR-----KYRPAGFEIPVATILLPDGE- 691
238901898 618 SNFGKNGKRNVGRILVATQVVEQSLDVDFDWLITQHCPADLLFQRLGRLHRHHR-----KYRPAGFEIPVATILLPDGE- 691
292489288 609 ECFGPHGNRQQGRILVATQVVEQSLDVDFDWLITQLCPVDLLFQRSGRLHRHQR-----NRRPAGFSQPMLTVLLPDAE- 682
292898483 609 ECFGPHGNRQQGRILVATQVVEQSLDVDFDWLITQLCPVDLLFQRSGRLHRHQR-----NRRPAGFSQPMLTVLLPDAE- 682
39996486  613 DCFGPSGKREQGRILVATQVVEQSLDLDFDWLVTQLCPVDLLFQRMGRLHRHPR-----ASRPAGYDKPVCTILLPCEC- 686
170018993 618 SDFGKNGERNVGRILVATQVVEQSLDVDFDWLITQHCPADLLFQRLGRLHRHHR-----KYRPAGFEIPVATILLPDGE- 691
288940397 604 EHYGRDAERTQGRILVATQVIEQSLDLDFDWLITQLCPVDLLFQRLGRLHRHSR-----K-RPDDFQVPTCTVLSVETD- 676
259907480 609 EYFGPHGNRRQGRILVATQVVEQSLDVDFDWLITQLCPVDLLFQRGGRLHRHQR-----NRRPAGFSQPLLTVLLPDAE- 682
157162211 618 SNFGKNGKRNVGRILVATQVVEQSLDVDFDWLITQHCPADLLFQRLGRLHRHHR-----KYRPAGFEIPLATVLLPDGE- 691
119945303 559 KNYDKNAKRT-GRLLIATQVIEQSLDLDFDVLISQIAPIEFLMQRMGRLWRHERidsglCPRASCIKAPLFITLLPNEKi 637
218547719 618 SDFGKNGERNVGRILVATQVVEQSLDVDFDWLITQHCPADLLFQRLGRLHRHHR-----KYRPAGFEIPVATILLPDGE- 691
47104065  575 NVYGKNAPRK-GRILIATQVVEQSLDLDFDVMVSQIAPIEFLMQRMGRLWRHDRvdselAKRTISVNEPVFITLIPSTKa 653
16130668  692 -----------GYGRHEHIYSNVRVMWRTQQHIEELNGASLFFPDAYRQWLDSIYDDAEMD-EPEWVGNGMDKFESAECE 759
170082336 692 -----------GYGRHEHIYSNVRVMWRTQQHIEELNGASLFFPDAYRQWLDSIYDDAEMD-EPEWVGNGMDKFESAECE 759
238901898 692 -----------GYGRHEHIYSNVRVMWRTQQHIEELNGASLFFPDAYRQWLDSIYDDAEMD-EPEWVGNGMDKFESAECE 759
292489288 683 -----------GYGRSGYIYGNTRVMWRTQQLIEAQGATPLPFPAAWRQWIESAYRPEADDaEPGWVQEGYQDWEQKEFE 751
292898483 683 -----------GYGRSGYIYGNTRVMWRTQQLIEAQGATPLPFPAAWRQWIESAYRPEADDaEPGWVQEGYQDWEQKEFE 751
39996486  687 -----------NYGYTGKIYADTRVLWRTEQLLASASAGQVTFPAAYREWIESAYQEKSWGtEPDLVIAGFEKFKDKTWS 755
170018993 692 -----------GYGRHEHIYSNVRVMWRTQQHIEELNGASLFFPDAYRQWLDSIYDDAEMD-EPEWVIKGMDKFESAECE 759
288940397 677 -----------DYGLHELIYGDARLLWRTEFLLARHK--QIHFPAAYREWIEPVYGEAPWDdEPGTVYGKHLAWRDDQSE 743
259907480 683 -----------GYGRSGYIYGNTRVMWRTQQLIEAQGATPLPFPAAWRQWIEPVYRPETDDaEPVWVQEGYRAWEQKEFE 751
157162211 692 -----------GYGRHEHIYSNVRVMWRTQQHIEELNGASLFFPDAYRQWLDSIYDDAEMD-EPEWVIKGMDKFESAECE 759
119945303 638 tdltsseqlkhHYQGSGYVYQNSRLLYRTEQYLNQHP--LLHFPDCYREAINYVHEEQSYSeEPQVLTSVADEYSIIADG 715
218547719 692 -----------GYGRHEHIYSNVRVMWRTQQHIEELNGASLFFPDAYRQWLDSIYDDAEMD-EPEWVGNGMDKFESAECE 759
47104065  654 sd------wktHYQGSGFVYRNIRSLYRTEQYLHEHQ--VLTFPDCYREAIEYVHAEQMFAeEPEALESLFNEYQDSNSA 725
16130668  760 KRFKARKVLQWAE-EYSLQDNDETILAVTRDGEMSLPLLPYVQTSSGKQLLDGQVYEDLSHEQQYEALALNRVNVPFTW- 837
170082336 760 KRFKARKVLQWAE-EYSLQDNDETILAVTRDGEMSLPLLPYVQTSSGKQLLDGQVYEDLSHEQQYEALALNRVNVPFTW- 837
238901898 760 KRFKARKVLQWAE-EYSLQDNDETILAVTRDGEMSLPLLPYVQTSSGKQLLDGQVYEDLSHEQQYEALALNRVNVPFTW- 837
292489288 752 KRASARQMLKQAEyATPFSDNDHAVRALTRDGEMSLAVIPYFDSEHGRVLLDGQQLDRLAEFARPEALALNRVNVPHGW- 830
292898483 752 KRASARQMLKQAEyATPFSDNDHAVRALTRDGEMSLAVIPYFDSEHGRVLLDGQQLDRLAEFARPEALALNRVNVPHGW- 830
39996486  756 KTYSAKEMIRKAFeITPFSDSDENVTAVTRDDEMGLTVIPVIDSPKGRRFLDGGLLGDLDEFRRAEELALNSINVPARWs 835
170018993 760 KRFKARKVLQWAE-EYSLQDNDETILAVTRDGEMSLPLLPYVQTSSGKQLLDGQVYEDLSYEQQYEALALNRVNVPFTW- 837
288940397 744 AEKKAHRLTTMN--LSKFRDDEERLTSLTRDGEMSLSVLL---TREDGRLLDGEDPDQMDEYTQAETLMLNTVPAPHSWg 818
259907480 752 KRASARLMLKQAEhATPFSDNDQPVRALTRDGEMSVAVIPYYHSEHGKVLLDGQVLDRLSELARPEALVLNLVNVPHSW- 830
157162211 760 KRFKARKVLQWAE-EYSLQDNDETILAVTRDGEMSLPLLPYVQTSSGKQLLDGQVYEDLSHEQQYEALALNRVNVPFTW- 837
119945303 716 SNYTARSLSKLQ--SKPLNDVDPRCALLTRDGEMSATVVLF--KEDGSLLHGGDFNEQQDRENSTVALAKKHA------- 784
218547719 760 KRFKARKVLQWAE-EYSLQDNDETILAVTRDGEMSLPLLPYVQTSSGKQLLDGQVFEHLSHEQQYEALALNRVNVPSTW- 837
47104065  726 SSYVAKMNANLE--SKPLSDVDPRCALLTREGEMTVSVVLV--DEHGKLLHGGDYQEQQDRELSTVSIAKKHV------- 794
16130668  838 -KRSFSEVVDEDGLLWLEGKQNLDGWVWQG-NSIVITYTGDEGMTRVI 883
170082336 838 -KRSFSEVVDEDGLLWLEGKQNLDGWVWQG-NSIVITYTGDEGMTRVI 883
238901898 838 -KRSFSEVVDEDGLLWLEGKQNLDGWVWQG-NSIVITYTGDEGMTRVI 883
292489288 831 -LGAFLQPMDEQGVIWLPGHFVAGKAGFAGkGQHHFTYSHHEGMEKTG 877
292898483 831 -LGAFLQPMDEQGVIWLPGHFVAGKAGFAGkGQHHFTYSHHEGMEKTG 877
39996486  836 gWLKALCEIDDERRYWLTMTEQGEGCYVREgEKVAFRYHCDTGLERVK 883
170018993 838 -KRSFSEVVDEDGLLWLEGKQNQDGWFWQG-NSIVITYTRDEGMTRVI 883
288940397 819 dRQLAGHVRDEDGRIRLKMHDDGQQ-RWSS-LDGGVCYTTELGLAKAE 864
259907480 831 -QSAFLQPMDEQGIIWLPGHLVDEKTEFTGkGQYHFTYSHHEGMEKTG 877
157162211 838 -KRSFSEVVDEDGLLWLEGKQNQDGWIWQG-NNIVITYTRDEGMTRVI 883
119945303 785 -----------------KGIKDERYYCYKAvVDKDIIYNEMGFITTDL 815
218547719 838 -KRSFSEVVDEDGLLWLEGKQNQDGWIWQG-NSIVIIYTREEGMTRAI 883
47104065  795 -----------------RGIQDADYYCVKAtVGQDIDYTELGVILPKN 825
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