Conserved Protein Domain Family
NHS

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pfam15273: NHS 
NHS-like
This family of proteins includes Nance-Horan syndrome protein (NHS).
Statistics
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PSSM-Id: 464606
Aligned: 18 rows
Threshold Bit Score: 421.133
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_021408781  246 QRSETKDTSCQTEEVKVVP-PSMRRIRAQKGQGIAAQMSQFSSSSGNMSVMSDSAAVIFASRQNNDIGFHSLPRVGARV- 323 
XP_014349971  194 SRRSGTKDSECQTEEILIA-APSRRRIRAQRGQGTVASLSH---SAGNITVLTDESDNMFTTTVSGRVRSHSLPREGARs 269 
XP_005316066  470 NRRSGTRDSECQTEDILIA-APSRRRIRAQRGQSIAASLSH---SAGNISALADKGDTMFTPTVSSRTRSRSLPREGNRg 545 
XP_008105478  123 NRRSGTRDSECQTEEILIA-APSRRRIRAQRGQSVVASLSH---SAGNILVLTDNGDAMFTTSVSNRVRSRSLPREGARa 198 
XP_015219415  376 NGRSTTKDSGCQTDDILIA-APSRRRIRAQRGQGIPTSLSH---STGNITSLPDNSDAMFAATVGSRLRSRSLPREGGRl 451 
XP_025758845   91 ASHLNTRDSGCQTEDFLISgAPSRRRIRLQRGQGVSLSLSH---SAGNISSLPETSDAMFSASVGAHLRSRSLPRDTSRl 167 
XP_023195448   91 ASHLTTRDSGCQTEDFLTSgAPCRRRLRVQRGQGVSLLLSH---SAGNISCLPDSADPMFSSSVEARLRSRSLPRDSSRm 167 
XP_022523944  398 GRNLNTKDSGCQTDDFLIA-APSRRRIRAQRGQGIPASLSH---STGNITSLPDRSDTMYTAASGTRLRSRSLPREGGRl 473 
XP_019686854  264 GQRSETRDSSCQTEEVKVV-PPSMRRIRAQKGQGIAAQMSHFSGSSGNMSVLSDSAGIVFPSRLHSDAGFHSLPRSGAR- 341 
XP_006084480  257 GQRSETRDSSCQTEEVKVV-PPSMRRIRAQKGQGIAAQMSHLSGSSGNMSVLSDSAGIVFPSRLNTDVGFHSLPRSGAR- 334  little brown bat
XP_021408781  324 -----------------SLQSLDQTQSMmSRQTEDIAGTLPHQISKLQVDDSVVHLRN-----------NPMMGTLSRPK 375 
XP_014349971  270 nnlh---------hdigAEVSLYEPEKf-LSSP-ER----TKKEREETVNNQGPPECQpvslt-csqhiHSPEHKLTERG 333 
XP_005316066  546 gdae---------pkvgAKPSTYEEEEP-FVGDHER----TPNDCSEAPSSPSTQEHQpalglacsqhlHSPQHKLSERG 611 
XP_008105478  199 nevd--------hhntsAKVSAYEAEHf-LTSQ-ER----ISAKSKDAINNPCLQEHHpiglk-csqhlHSPDHNSNERG 263 
XP_015219415  452 vded---------hdsdEELSPYETEEf-LPGP-ER----VLKDEEESTDDQAMPDHQlvglk-ckqhvGSPDHNWNERG 515 
XP_025758845  168 ldngh------ndsddeEDLSPFDTEGF-LTGSRKL----TLKDEEESTDDQAMSEHQlgslk-ykqlsQSPERSWMERT 235 
XP_023195448  168 mmilmdn--erndsdeeEELAPFDSEGF-LPGRRER----ILKEEEESADDRAMSERQlgglk-faqlsDSPERSWMERT 239 
XP_022523944  474 rdedhddsddddddeddEELSPYEAEDF-LPGPGQR----ILKDEEESTDDQAMPELQlgslk-rmqhsGSPENSWIERG 547 
XP_019686854  342 -----------------AIIQSLEPRLG-PLGPAEDLDGARPYQSGNPQVDENLGHLG-----------GASRTGTLLRP 392 
XP_006084480  335 -----------------ASIQSLEPRPG-APGPAQDLDGTF----------ENPGQLG-----------GASRTGTLFRP 375  little brown bat
XP_021408781  376 SQEVRSCDSEKSSSPACVvSPHATYSTSIIPNATLSSSSEVILI--HAAQSVGSL-DSKISSSTafpNprDNP-----AA 447 
XP_014349971  334 RSRFPRTAAD--------------------MGSSEISSNSDTFGspIHSISTAGVlLSSQMDQ----------------- 376 
XP_005316066  612 RSRLSRMAAD--------------------SGSCDISSNSDTFGspIHCISTAGVlLSSHMDQ----------------- 654 
XP_008105478  264 RSRLSRM-VD--------------------SGSCDISSNSDTFGspIHSISTAGVlLSSHMDQ----------------- 305 
XP_015219415  516 RSRLPRK-VD--------------------MGSCEISSSSDTFSspIHSISTTGV-LGSQIDH----------------- 556 
XP_025758845  236 RAHLPRK-AD--------------------MGSCEISSSSDTFSspVHCVSAAAV-LGGQIDH----------------- 276 
XP_023195448  240 GAQLPRK-AD--------------------MGSCEISSSSDTFSspVHSVSAAGV-LGSQMDH----------------- 280 
XP_022523944  548 RSRLPRK-AD--------------------MGSCEISSSSDTFSspIHSVSTTGV-LGSQIDH----------------- 588 
XP_019686854  393 KSQELRHFENVISPACVV--SPHATYSTSIIPNATLSSSPEVII--IHTAHSPGQ-LDGKITSSc--S--YLKaksreHL 463 
XP_006084480  376 KSQELRRFESENRASPACvVSPHGTYSTSVIPNATLSSSSEVIA--IQTAQSLGQ-LDSRMTSSs--S--HTKvrprdHL 448  little brown bat
XP_021408781  448 SSAASGkEDHHSSSGNWSESSSTRHSQTSDTIP-SNT------------------------VMML--SLGDSAVSLNTPG 500 
XP_014349971  377 -------KDDHQSSSGNWSGSSSTCPSQTSETIpPAA------------------------SPPLtgSSHCDSELSLNTA 425 
XP_005316066  655 -------KDDHQSSSGNWSGSSSTCPSQTSETIpPAA------------------------SPPLtgSSHCDSELSLNTA 703 
XP_008105478  306 -------KDDHQSSSGNWSGSSSTCPSQTSETIpPAA------------------------SPPLtgSSHCDSELSLNIV 354 
XP_015219415  557 -------KEDHQSSSGNWSGSSSTCPSQTSETIpPAA------------------------SPPLtgSSHCDSELSLNTA 605 
XP_025758845  277 -------KEDHQSSSGNWSGSSSTCPSQTSETLpPAA------------------------SPPLtgSSHCDSELSLNAA 325 
XP_023195448  281 -------KDDHQSSSGNWSGSSSTCPSQTSETIpPAA------------------------SPPLtgSSHCDSELSLNTA 329 
XP_022523944  589 -------KEDHQSSSGNWSGSSSTCPSQTSETIpPTA------------------------SPPLtgSSHCDSELSLNTG 637 
XP_019686854  464 LSRHAS-KEGHQSHGGHWTEGHPTVLSQALDPH-PPS------------------------AAML--SSLCDSAVSLNTP 515 
XP_006084480  449 LPRHSG-EGDR-------------------------PspsgtwsegpstivsrafdphpprAATL--LALCDSAVSLNTP 500  little brown bat
XP_021408781  501 NAEAASQSMSYS----------CRNPAALASPSQDSDGRSESSYSGERAPApvsSTEHWLYKSSENTETP-----SRKVA 565 
XP_014349971  426 PHGNDDSSVFVTdqylyhadksRGHRANSFTSTVADLLDDPNIGN---------ASDSEWGYLHHQHDASchqdfSPEHS 496 
XP_005316066  704 PHANEDTSVFVTeqyndhldkvRGHRANSFTSTVADLLDDPSNSN---------TSDSEWNYLHHHHDASchqdfSPERP 774 
XP_008105478  355 PSANEDSNVFITehytdqidkiRGHRASSFTSTVADLLDDPNNSN---------TSDSEWNYLHHHHDAScrqdfSPERP 425 
XP_015219415  606 PHVNDDPTGFIIdpyq--tdkvRGHRASSFTSTVTDLLDDPGMSN---------VSDGEWNYLHHQHDKScrqdfSPQRS 674 
XP_025758845  326 THTNDDQTGFLLdhy----qglRTQRAGSFSSTAMDILEEVGVST---------PIEGEWSYPNPEPPGSqg--fSPEPS 390 
XP_023195448  330 THTAEDQTSFLLdny----qglRTQRAGSFSSAAMDVLEEAGVST---------PMEGEWDFPNAEPSSSqg--fSPEPG 394 
XP_022523944  638 SHIIDDTTGFIIdpyhmdrtqgQGHRSSSFTSSATDQMDDAGVST---------ASDGEWNCNQDQQDHPcpqdfSPKHS 708 
XP_019686854  516 ASRENGSQAMTY----------DCKNNLGFPAHAQDVDGKSESSFSEGGGH---GSSEPWEYGAAGNGRA-----SPLKA 577 
XP_006084480  501 ANQENGSQAMAY----------TCRRNPNFPAHPQDVDGQSEPSYSGGGGH---GGGEPWEYSASGSGRA-----SPLKP 562  little brown bat
XP_021408781  566 CTTPGCATPGSNLSSSSLE-----RTSVRDDSTSLYSVDQDGYYGSMHMDSRLNADMPCN--STNGFENPRDSVINVFEG 638 
XP_014349971  497 RTD--SLGCPSFTSMATyds-fveKLPSEKAETGSHYSVDTEGYYTSMHFDCGLKDSKSYi-cSYAATGSECRQSAEITS 572 
XP_005316066  775 KAD--SLGCPSFTSMATYDsf-leKSPSDKADTSSHFSVDTEGYYTSMHFDCGLKGNKSYv-cHYAAMGPENSQG--VGP 848 
XP_008105478  426 KTD--SLGCPSFTSMATyds-fieKTPSEKADTSSHFSVDTEGYYTSMHFDCGLKGTKSYi-cNYAAVGSESGQNASVAS 501 
XP_015219415  675 REDESSLECPSFTSMATyes-fmdKPPSEKADSSSHFSVDTEGYYTSMHFDCGLKASKSYi-yNYAAMGTDCGQSANVAP 752 
XP_025758845  391 REPGSSLGCPSFTSMATCEssfsdKPPSEKADTVSHYSVDNEGYYTSMHFDCGLKGSRSFtyNNYAPSGTDCGLS----- 465 
XP_023195448  395 REAESSLGCPSFTSMATCEssfsdKPPSEKADTVSYYSVDTEGYYTSMHFDCGLKGSKSFt-yNYANPGSDCGLS----- 468 
XP_022523944  709 REDESGVSCPSYSSGETYEsf-sgQPPAEKLESSSHYTVDTEGFYTSMHFDCGLKGSRSYy--NYAAIDPDCGPSGNIAP 785 
XP_019686854  578 RAATPGFSTPGSNMSSCSL-----DQTSTKDDARSLYSEEHDGFYASMHPDAGHGSGNLC--NSSDGFGNPRHSVVNVFD 650 
XP_006084480  563 HVATPGCSTPGSNMSSCSL-----DHTCHREGARSLYSEDHDGYYASVHPDAGPGPGSLCssNSSNGFGNPRHSVVNVFD 637  little brown bat
XP_021408781  639 KEKKHQDDHSGQGEKSLARNISLKKAKKPPLPPSRTDSLRRM-------PKKKAQSNGQI-LDETLIATLQHSLQLNLKC 710 
XP_014349971  573 NHSECIQQNFADTGRQG-RQSISLKKPKAKPAPPKRSSSLKKtdngtnvLDKKEPKINSG-QHMT--PSSREIKLQLDLS 648 
XP_005316066  849 GLPDCAWQDYLDHRRQG-RPSISFRKPKAKPTPPKRSSSLRKsdgnadvPEKKEPKISSG-QHLP--HSSREMKLPLDFS 924 
XP_008105478  502 SFTNCTWQDYVNHRRHG-KQSISLKKPKAKPAPPKRSSSLRKpdsstdlPEKKEPKISSGqQHMP--HTSREMKLPLEFA 578 
XP_015219415  753 SMDGYPQQEYQGHRTTG-RQSLSFKKPKVKPAPPKRSSSLKKtssganvPDKKEPKINSG-QPLP--LSSREMKLQLDLA 828 
XP_025758845  466 --------DSSGHMTLG-RRCLSLKKPKVKPSPPKRSSSLRKicsegniPVKKEPKITCG-QQLP--LSAKERKLQLAFS 533 
XP_023195448  469 --------DMSGHLTLG-RRCLSLRKSKAKPSPPKRSSSLRKicseghiPEKREPKITGT-YRHPVSLSSKERRMQLALS 538 
XP_022523944  786 GMGEYPQPDYRGVSTLG-RQCLSLRKPKAKPPPPKRSSSLKEtsssvdvPEQNEPKITNE-LPLP--LSSREMRLQLDLA 861 
XP_019686854  651 GRARKSQGDRPRDHDKSLSRNISLKKAKKPPLPPSRTDSLRR-------VPKKGVQANGQ-ALNESLIASLQHSLQLNLP 722 
XP_006084480  638 GRAPKNQG------DKSHSRNISLKKAKKPPLPPSRTDSLRR-------VPKKNGQANGQ-VLNESLIASLQHSLQLSLR 703  little brown bat
XP_021408781  711 KN--GSSPSQSPCSDYEDPWVLRSRSQSSVSASSSMMSTTAPNLYSICTVTPSQSETSSIKSEYADQWGYYSDYAAVADD 788 
XP_014349971  649 MS--SGRLENSGLSSEQELLW--DNENDNEAKD--DQSSSTD---------APSFKDEGAEQSDYADLWLLN-DLK--SN 710 
XP_005316066  925 NT--PSRMENVNLPTKQEPSW--VNQSEHGMKE--PQLDTSD---------IPPFKDEGAESTHYADLWLLN-DLK--TN 986 
XP_008105478  579 NT--PSRTENANLPSKQELPW--DNQDESGLKE--LSYDTMD---------IPSFKDEGAEQSHYADLWLLN-DLK--SN 640 
XP_015219415  829 SS--PGQLENPTLGDEPAEPW--EVGNAGEVTD-ATLFGSTD---------NHSFKDEGAVQSDYADLWLLN-DLK--SN 891 
XP_025758845  534 GS--PAHTENSSLVRETRVGW--GVEGSADLPD----LVSTD---------THSFKDEGVLQSDYADLWLLN-DLK--ST 593 
XP_023195448  539 GS--PGLMENSSLGREPLEVW--AMEGTSDLTD-LGILSSKD---------AHSFKDNGIVQSDYADLWLLN-DLK--SS 601 
XP_022523944  862 GS--SGQLETAGLCDEPIGAW--GVENVREMLDCSSPFSSSD---------THSFKDEGAVQSDYADLWLLS-DLK--SN 925 
XP_019686854  723 GKarGGSSPSQSPCSDCEEPWLSRSRSQSTVSAGSSMTSATAPNVYSLCGATPSQSDTSSVKSEYADPWGYYIDYTGAQE 802 
XP_006084480  704 GQ--GGLSPSQSPCSDLEEPWLPRSRSQSTVSGGSSLASATAPHGCAPGGVTPSQSDTSSVKSEYTDPWGYYIDYTGLQD 781  little brown bat
XP_021408781  789 QVKSPVTHSASTSSALSDYSISHFSD-------GSRASVPQVPSGLAKPKSASPEKSHRVTSPSSGYSSQSNTPTALTPV 861 
XP_014349971  711 DPYRSLSNSSTATGTTVIECTKSPEGsesqtsqSGSRATSPSLPSVENEFKLASPEKMAGLASPSSGYSSQSETPTSSFP 790 
XP_005316066  987 DPYRSLSNSSTATGTTVIECIKSPESsesqtsqSESRATTPSLPSVDNEFKLASPEKLAGLASPSSGYSSQSETPTSSFP 1066
XP_008105478  641 DPYRSLSNSSTATGTTVIECIKSPESsesqtsqSGSRATTPSLPSVENEFKLASPEKLAGLASPSSGYSSQSETPTSSFP 720 
XP_015219415  892 DPYRSLSNSSTATGTTVIECIKSPESsesqtsqSGSRATTPSLPSVENEFKLASPEKLAGLASPSSGYSSQSETPTSSFP 971 
XP_025758845  594 DPYRSLSNSSTATGTTVIECIKSQDSsesqtsqSGSRATTPSLPSVEGDFKLTSPEKLASLASPSSGYSSQSETPTSSFP 673 
XP_023195448  602 DPYRSLSNSSTATGTTVIECIKSQESsesqtsqSGSRATTPSLPSVESEFKLTSPEKLAGLASPSSGYSSQSETPTSSFP 681 
XP_022523944  926 DPYRSLSNSSTATGTTVIEFVKSPENvettvcrPRSRPTSPTLPPPESDLKLGSPEKLAGLASPSSGYSSQSETPTSSFP 1005
XP_019686854  803 DPGIPGGGCPGGSGAPAGDGPACQVQ-------EGSGTAMPQVPGGSIKPKVTSPEKSHRVTSPSSGYSSQSNTPTALTP 875 
XP_006084480  782 DPASPGGGRAAGSGAPTGNGPGRHVP-------EGCRAAAPHLPGGSVKPKTTSPEKAHRVTSPSSGYSSQSNTPTALTP 854  little brown bat
XP_021408781  862 PVLVKSASSGNGKSKLKPKVPERKSSLLSSVSMSSSSTSLSSNTSAEG 909 
XP_014349971  791 TTFFSGPLSPSSGKR--KPKVPERKSSLSSL--QQTSSRDGNLFIKRD 834 
XP_005316066 1067 TAFFSGPLSPGGSKR--KPKVPERKSSL-----QQPSLKDGTLSLSKD 1107
XP_008105478  721 TAFFSGPLSPGGSKR--KPKVPERKSSL------QQTSKDGSVSLNKD 760 
XP_015219415  972 SAFFPGPLSPTSGKR--KPKVPERKSSLSSLQQQQQP-RDGSTSSKKD 1016
XP_025758845  674 STFFPGPLSPSSGKR--KPKVPERKSSLSSLSLQSLSSRDGATSKRDL 719 
XP_023195448  682 STFFPGPLSPATGKR--KPKVPERKSSLSSLSLQARSSRDVATSKKDL 727 
XP_022523944 1006 SAFFPGPLSPNTGKR--KPKVPERKSSLASLQQQSLALRDPCSSIRRD 1051
XP_019686854  876 VPVFLKSASPANGKGKTKPKVPERKSSLVSSVSVSSSSTSLSSNTSTE 923 
XP_006084480  855 VPVFLKSMSPANGKGKPKPKVPERKSSLVSSVSISSSSTSLSSNTSTE 902  little brown bat
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