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C-terminal allosteric effector domain of the restriction endonuclease Sau3AI Sau3AI is a type II restriction enzyme that recognizes the 5'-|GATC-3' sequence in double-strand DNA (| denotes the cleavage site). The C-terminal domain modeled here does not have catalytic activity, it functions as an allosteric effector domain that assists in DNA binding and cleavage. It belongs to a superfamily of nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.
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Jiyao W et al.(2023). "The conserved domain database in 2023.",