Conserved Protein Domain Family
PRK11749

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PRK11749: PRK11749 
dihydropyrimidine dehydrogenase subunit A; Provisional
Statistics
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PSSM-Id: 236967
Aligned: 250 rows
Threshold Bit Score: 471.586
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
21220460   36 LLPIVGRQADRCMDCGVPFCHEACPLGNLIPEWNDLVSRSDWRAASERLHATNNFPEFTGRLCPAP--CEAGCVLAINQP 113
114800319  36 SPDAAKAQASRCSQCGVPFCQQGCPLQNNIPDWLKLAAEDRLEEAWRVSSATNNMPEICGRICPQDrlCEGICTIEQSGH 115
58040281   36 ARSRAEEQASRCSQCGIPFCSVHCPLGNNIPDWLKLTAEDRLEEAYEMSSATNTFPEICGRICPQDrlCEGNCVINKGFE 115
254292582  36 IDAKAAEQSSRCSQCGVPFCQQHCPLGNNIPDWLKLTAEGRLEEAYQLSSSTNNMPEICGRICPQDrlCEGSCTIEQSGH 115
148553583  37 SDDKAGEQASRCSQCGVPYCSTHCPLHNHIPDWLRLTTEGRLREAYELSNATSTMPEICGRICPQDrlCEGNCVIEFSGH 116
114568852  46 TTEAAAGQASRCSQCGVPFCQSGCPLQNNIPDWLMLAGEDRLREAYDASAATSTMPEICGRICPQDrlCEGSCVVEKSKH 125
294010228  37 ILDKAEEQASRCSQCGVPYCSTHCPLHNHIPDWLRLTAEGRLREAYELSNLTSTMPEICGRICPQDrlCEGNCVIEFSGH 116
103487619  37 SAPDADAQAARCSQCGVPYCSVHCPLHNHIPDWLRLTAEGRLREAYELSNATSTMPEICGRICPQDrlCEGNCVIEFSGH 116
71083139   36 INDKASEQSSRCSQCGVPFCQVHCPLSNNIPDWLKLTAEGRLKEAYELSQSTNNMPEVCGRICPQDrlCEGNCVIEQSGH 115
304321838  32 KERQAEAQASRCSQCGVPFCSSGCPLGNHIPDWLRLAAEDQLEEAWRLSESTSNMPEICGRICPQDrlCEGSCVIEQSGH 111
21220460  114 -AVTIKNVECAIADTAWEEGF---VPPLpperLSGRTVAVIGSGPAGLAAAQQLTRAGHTVAVYERDDRIGGLLRYGIPA 189
114800319 116 gTVTIGSVEKYITDTAWAEGWiqpIKPPr---ERTQSAGIIGAGPGGLAAAEQLRRKGYQVTVYDAYDRGGGLLMYGIPG 192
58040281  116 -SVTIGAVERFITENAFEQGW---VKPAlpdrDLGRSVGIVGSGPAGLACAERLRAQGYEVHVYERQDRVGGLLTYGIPS 191
254292582 116 gTVTIGAVEKYITDTAFENGWvtpVKPPk---ERDQSVGIIGAGPAGFAAAEQLRRLGYQVTVYDRYDRAGGLLIYGIPG 192
148553583 117 gAVTIGSVEKYITDTAWERGWvepVQVGp---ARGQSVGVIGAGPAGLTVAELMRARGYDVHVYDRHDRAGGLLTYGIPG 193
114568852 126 gAVTIGAVEQYITDTAWKEGWvepLKVGp---ERGQSVAVIGSGPAGLAAAERLRESGFAVTVYERADRAGGLLMYGIPG 202
294010228 117 gSVTIGSVEKFITDTAWKEGWvepLVPGa---PLGQSVGVIGAGPAGLTTAEYLRVAGYEVHVYDRHDRAGGLLTYGIPG 193
103487619 117 gAVTIGSVEKYITDTAWAEGWvepLRVGp---ATGQSVGVIGAGPAGLTAAEYLRAAGHDVHVYDRHDRAGGLLTYGIPG 193
71083139  116 gTVTIGSVEKYITDNAWEQGWvnpIKVKn---EKSQSIGIIGAGPAGLAAAEQLRKSGYQITVYDRYDRAGGLMIYGIPN 192
304321838 112 gTVTIGAVEQYITDNAWSKGWikpIAPAr---ERPQSIGIIGAGPAGLSAADELRSLGYRITVYDRYDRAGGLMTYGIPG 188
21220460  190 FKMEKRHLERRVGQMRAEGTRFRTSAAV---GRDVDAAALRTRYDAVVIATGATAWRELTVPGRELAGVHQAMEYLPLAN 266
114800319 193 FKLEKDVVERRIHHLEASGISFRFNTRI---GADMSLADLREQHDTVLIATGVYAAKDLKCPGVGAEGVLPALDYLTASN 269
58040281  192 FKLEKHVVARRHALLEEQGIVFHLSTPVgsgEGETSLEDLRARHDAVFLATGVYRSRDVKVPGAGLEGVVDAIDFLTASN 271
254292582 193 FKLEKEIVLRREQYLKDSGVEFVYNTDV---GNTVTLQELRQKHDSMLIATGVYKARDLNMPGEDAKGVHAALDFLITSN 269
148553583 194 FKLEKPVVQRRVQRLIDAGIVFHQDFEV---GRDATLDELRDRHDAILIATGVYKPRAIKAPGVGAPGIVEALDYLTASN 270
114568852 203 FKLEKHVVQRRIDRLVRGGVAFKLNFEV---GRDATLAEIRSGHHAVLLATGVYNARALTCPGSG-DGVLAALDYLTRAN 278
294010228 194 FKLEKDVVMRRIQRLKDGGIVFHESFEV---GRDASMEELRSRHDAILIATGVYKPRDIKAPGVGAPGVVKALDFLITSN 270
103487619 194 FKLEKDVVMRRIDRLAAGGIQFHLGFEV---GKDATLDGLRQKHDAILIATGVYKAREINVPGNEAEGVIAALDYLVASN 270
71083139  193 FKLEKFVVERRTKLLEEGGIKFVQNFEV---GKDATLEQLRKKHDALLIATGVYKAREIDLPGKDLGNIFPAMEFLTASN 269
304321838 189 FKLEKSVVMRRVKRLADSGVTFVQNADI---GGGVPFSDLREKHDAILIATGVYKARELSVPGVGANGVVRALDYLTASN 265
21220460  267 Rvceg--dlerSPLsa---aGRHVVVVGGGDTGADCLGTAVREGAASVTQL---DIYARPGAERDeraepwptyprlyrL 338
114800319 270 Rvdlgd-tveaYDAgvlnaeGKRVVVIGGGDTAMDCVRTAIRQGAKSVTCLyrrDRVNMPGSQRE--------------V 334
58040281  272 RrgydedpgedAALha---kGRRVVVIGGGDTAMDCVRTSIRQGAERVTCVyrrDRANMPGSRQE--------------V 334
254292582 270 Klslgd-kverFESgelnaeGKRVVVIGGGDTAMDCVRTAIRQGAKAVTCMyrrDRENMPGSQRE--------------V 334
148553583 271 Rkgfgd-avpaFDEgpldakGKNVVVIGGGDTAMDCVRTAIRQGAASVKCLyrrDRANMPGSQRE--------------T 335
114568852 279 Rddlg---dpaANDsvldarGKRVVVVGGGDTAMDCVRTAVRQGARSVTCLyrrDRANMPGSARE--------------V 341
294010228 271 Kagfgd-avpeHEDgslhanGKKVVVIGGGDTAMDCVRTAVRQGATSVKCLyrrDRDNMPGSQRE--------------V 335
103487619 271 Rkgfgd-avpaFDDgrlnaaGKHVVVIGGGDTAMDCVRTAVRQGARSVKCLyrrDRENMPGSQRE--------------V 335
71083139  270 Kkglgd-kvelFDNgtlnaeGKNIVVIGGGDTAMDCVRTSIRQKAKSVKCLyrrDKENMPGSARE--------------V 334
304321838 266 Rkgfgd-evpgFDEghmnahGKRVVVVGGGDTAMDCVRTAIRQDAASVTCLyrrDRENMPGSARE--------------V 330
21220460  339 SAAHEEARDLrsapaadadarLFAASTLRFTGDErghvraLHLVGV------DTGRR---PLPGSERSLPADLVLLALGF 409
114800319 335 QNAEEEGVVF-----------EWLANPEAIIDSKggkvkaVRASRMklgepdASGRQspvK-TGETFDVKADMVIKALGF 402
58040281  335 YNAEEEGAHF-----------EWLGSPEAFLGDSsv--sgVRVLKMrlgapdASGRRs-iEGTGQHDVIEGDLVIKALGF 400
254292582 335 LNAEEEGVKF-----------DWLSAPSSVVEKKtggvkaVKALRMklglpdASGRRspePIEGSEYEVKADIVIKALGF 403
148553583 336 KNAEEEGVEF-----------VWLSAPEAFDGGEtv--ggVRAIRMrlgepdMSGRRtpePDPGSEFRIEADLVIKALGF 402
114568852 342 KHAEEEGVVF-----------EWLSAPLAVLTKGdai-saVRVQGMrlgapdASGRRapeADPGKTWDVEAEMVISALGF 409
294010228 336 ANAEEEGVEF-----------VWLSAPIAFEGTEhv--tgVKVTKMrlgqpdASGRRapePDPGTEHVLEADLVIKALGY 402
103487619 336 ANAEEEGVEF-----------VWLSAPESFTADRhv--keVAVAGMrlgapdASGRRspeVDPGRRFDVPADMVIKALGF 402
71083139  335 ANAEEEGVEF-----------VWLSSPKEFIGTNkv--egLIVDKIklgepdDSGRRkpeIQNNSHFNIKADIVIKALGF 401
304321838 331 VNAEEEGISF-----------RWLSNPKLLLGDAnkl-dgIRVARMrlgppdASGRQspeEIPGEDADLAADMVIKALGF 398
21220460  410 SgpdrhdGLVDGLGLDMEPRGTITRDR-GFATNVPGVFAAGDAARGQSLVVWAIAEGRAVAAAVDRHL----SGGSTR 482
114800319 403 Dped-lpALFNETSLTVNRWGAVRVDYaTLETSLPGVYAAGDIVRGASLVVWAIKDGRDAAEAMHKAM----RAAEAA 475
58040281  401 Dped-lpGQFNEPELAVTRWGTLTVPPgGFETSLPGVFAGGDIVRGASLVVWAIKDGRDAADAIHHYLtetvTGSLEA 477
254292582 404 Sped-lpQLFNEEALTVNRWGALKVNHaNLMTSLDGVFAAGDIMRGASLVVWAVKDGRDAAEHMHKYM----KAQAAS 476
148553583 403 Dped-lpGMFGAPELSVTRWGTLRVDHkTMQTSLEGVFAAGDIVRGASLVVWAIRDGRDVAVRMHAYL----KAKAER 475
114568852 410 Tped-lpVLFEEPDLSVHRDGRVEADRdTRMASLDGVFVAGDLHRGASLVVWAIKDGLDAARSIESYL----DNRMRV 482
294010228 403 Dpee-lpRLFGADDLSVTRWGTLRVDHkTMMTSMDGVFAAGDIVRGASLVVWAIRDGRDVTEHMHRYL----KAKAKA 475
103487619 403 Dpee-lpHLFGAPDLSVTRWGTLRVDHqTMMTSLPGVFAAGDIVRGASLVVWGIRDGRDVSDQMAKWL----KAKAks 475
71083139  402 Dpen-lpKLFGSEDLQVTKWGTLKTNFdTMETNLPGVFAAGDIIRGASLVVWAIKDGRDVAVSIKNFL----ETKELS 474
304321838 399 Sped-lpTAFDEPDLALTRYGTLKVDPsSYETSLPGVFAAGDIVRGASLVVWAIHDARRAAASIHQYF----KGQTVG 471
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