3A3U,1ZBM,2NXO


Conserved Protein Domain Family
VitK2_biosynth

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pfam02621: VitK2_biosynth 
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Menaquinone biosynthesis
This family includes two enzymes which are involved in menaquinone biosynthesis. One which catalyzes the conversion of cyclic de-hypoxanthine futalosine to 1,4-dihydroxy-6-naphthoate, and one which may be involved in the conversion of chorismate to futalosine. These enzymes comprise two domains with alpha/beta structures, a large domain and a small domain. A pocket between the two domains may form the active site, a conserved histidine located within this pocket could be the catalytic base.
Statistics
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PSSM-Id: 426881
Aligned: 84 rows
Threshold Bit Score: 164.645
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3A3U_A          4 LRLGFSPCPNDTFIFYALvhgrvesP-----VPLEPVLEDVETLNRWALEGRLPLTKLSYAAYAQVRDRYVALR--SGGA 76  Thermus thermo...
Q5SK49          4 YVLGLPRYANVAPLHHFLr-----------lEGFRVLHAVPAELNRLLLSGEVGLSLVSSYFYLKHQDSLGLLPdfSVAV 72  Thermus thermo...
WP_011531219    3 YQAGWIHYTNVAPILDPLvl----------pAGVTAITGVPTEMNAALLAGEVDIANISAVEFIRHADVLEALPdfSVAV 72  Deinococcus ge...
BAF59617        4 PRLGQVDQINCLPVYHAL-------EegllpMDIELVKGTPSRLSNLFFSGALAATLISSIEYPRNADNCFILPglSVSA 76 
jgi:Dred_2194   4 IRFGQVDYLNTLPVFHAL-------EdgllpFDGELIKGPPTMLNKMFMEDQLEVASISSVEYARNIDKCIILPnlSVSA 76 
Q8F4K1          1 MKIGIVKHLNARPLTWGFek----------nKKHEIVPENPAILKDYLLNGTIDLGLISSIECIRNDHVLNTYYgtGVCA 70  Leptospira int...
O84434          9 LNIGCVRYVNALPFSSGLs------Qa----PGVSLLMDTPTNLVPKLLSREIDYALTSVAATFS--SPLHRVSsfGIAA 76  Chlamydia trac...
Q7UT25         16 LRLGAVSYLNTKPLIETL-------Prr-lgRSGELRLDLPSRLARDLAAGELDIALIPSVEYFRGGDEYEIISdaAIAC 87  Pirellula sp.
WP_012099028    4 LRAAAVSFLNAHPLTVGLeg----------sDRIELVPAEPSRCAAMLEDGEVDLALVSVAALTK--GEYEIVPgiAIGA 71  Anaeromyxobact...
Q01RN6          9 LRVSAVSFLNTTPLVWGM-------LhgpqrGMFDLEFRIPAGCADQLATGGADIGIVPSFELTR--QDLEIIPgtGIAC 79  Candidatus Sol...
3A3U_A         77 LGRGVGPLVVArg----pLQAleglRVAVPGRHTTAYFLLSLYAQGF------VPVEVRyDRILPMVAQGevEA-GLIIH 145 Thermus thermo...
Q5SK49         73 LGRVYSVNLFHkgalphlA------RVALTTESATSVALLKLLLKEAga--gpRYERRE-GGLE--LLSAy-DG-VLLIG 139 Thermus thermo...
WP_011531219   73 LGPVYSVNLFHtvplselR------RVALTRQSAMSVALLEVLLAARgl--spILERAE-GEAEALLAAGy-DG-VLRIG 141 Deinococcus ge...
BAF59617       77 DGRVASILFFSkipvtelEGK----RVCLTESSDTSAALLKVLFDHYyhv-evQFITAP-PNLDI-MMQKa-DG-ALLVG 147
jgi:Dred_2194  77 DGPVQSILLFSrapivelEGR----KICLTSSSATSVALLKVLFQHYyhl-evEYVTQK-PDLDS-MMAEg-DG-ALLIG 147
Q8F4K1         71 REKVRSILFFknkr-enfPPK----QILTDNGSKTSVALVRVLIYEEsgl-ipYVEPTD-SKLIQEKISNg-IGsHMLFG 142 Leptospira int...
O84434         77 YKKILSVNLHAtsqffakEAP----HIAATKESLSSILLLRVLCENLwnipfpSVTLLS-SDSILTQAEHy-DA-LLLIG 149 Chlamydia trac...
Q7UT25         88 RGPVWSVRVLSrvpmnevR------TLALDEGSRTSAAMSQVLLAEMhgl-rpKTVPFP-IGSSPDEIDA--DA-LLMIG 156 Pirellula sp.
WP_012099028   72 DGPVQTVVLAGeqspaiwD------EVFLDTASRTSHVLAKLVLDAMgv--hpKFTPMH-ADEGLARAKGt-KG-ALVIG 140 Anaeromyxobact...
Q01RN6         80 HGAVRSILLISkcpaeqiR------TLAVDSSSRTSVELARVILARRfga-epRQVAHA-PALEA-MLGIa-DA-ALIIG 148 Candidatus Sol...
3A3U_A        146 ESRF------------------TYPRYGLVQVVDLGAWWEERTGLPLPLGAILARRD-LGE---GLIRALDEAVRRSVAY 203 Thermus thermo...
Q5SK49        140 DRAIkayaallp--evpetphaLPTRFGEVEVADLSTLWFQRTHLPFVFAVWAYRRE-N-----PPPKALVQALREARRE 211 Thermus thermo...
WP_011531219  142 DSALrewyrvagpltpettmtmLPHEGRGITVTDLAEEWFRLTGHPFVFAVWAYRQD-N-----PPPPELVQAMREARRH 215 Deinococcus ge...
BAF59617      148 NDAMlay-------------qrVKEQGLSYYITDLGEAWKLFTGGKMVYALWVVSKS-YARtnrEEINLLNKILLESKEI 213
jgi:Dred_2194 148 DDAMrah-------------lrVKQEKLAYHVTDLGEAWKQFTGERMVYALWVIRKE-FAKenpEVVNNLCHQLVEAKKL 213
Q8F4K1        143 DNALl-----------------AKWNPEFYEVKDLAQWWNELTGLGFIFALWASKKS-LKLdd--------lIFIQSLEY 196 Leptospira int...
O84434        150 DTAL------------------RHPIIPGFHTYDLAASWYDLTAKPFVFAGILSLSS-------TISFQLQQEFSSALNY 204 Chlamydia trac...
Q7UT25        157 DRAM------------------HPAPGKYQEIWDLGDRWCRWTELPFVFAMWVARRSaVADp--QIRQQIEDALNVSRDE 216 Pirellula sp.
WP_012099028  141 DRAFgv---------------------raNHVLDLGREWTHLTGLPMIFALWAARPG-------RVSPEDVQELTRAAQH 192 Anaeromyxobact...
Q01RN6        149 DPALh-----------------IDPARLPWHIYDLGSEWLELTGMPMVFAVWAGRRG-AVT------PEVVAAFGESCRY 204 Candidatus Sol...
3A3U_A        204 ALAHPEEALDYMRAHAQELsdeviWAHVHTYVN-AFSLDVgEEGERAVARLFAEAEA 259 Thermus thermophilus HB8
Q5SK49        212 GLGRLREVAEAEARRLGVH-----PLLLQHYLW-NFRYHLeEPDRLGLKAFAEALGL 262 Thermus thermophilus HB8
WP_011531219  216 GIGHLADVAARHAQKLGLP-----ARVVQHYLW-NFRYHLeAPDRLGLHEFAAQAVP 266 Deinococcus geothermalis
BAF59617      214 GLGQIHALVSKAQKKLSLP-----LQVIEDYFK-TIRLEFdEDCRKALLTFYDYAYK 264
jgi:Dred_2194 214 ADQSLSAVLEKGRRRSGLP-----MEILEEYFN-TINNAFaEDHRRALLTFYDYCYK 264
Q8F4K1        197 GVSHIEEIISHESRLSSA--------LVREYLTkELHYKItEEDQKGFLLFREKCSQ 245 Leptospira interrogans
O84434        205 FQNHKEDITSKAAALLKLP-----ESLMQEYYT-LCRYELsEEDFAGLEQFRDYYdr 255 Chlamydia trachomatis
Q7UT25        217 GLQQFEMIAKREAAGHGLT-----IEDLHRYFAeNLHFQLgNGERSGLAAFREKAEH 268 Pirellula sp.
WP_012099028  193 GLGVRTELAQRFAAQKGGD-----PERFRRYLTqRIRYGLgPHELDGLEAFLGRAAE 244 Anaeromyxobacter sp. Fw109-5
Q01RN6        205 GLTHMDEIVAAESVSRGFP-----AAVVREYLTrYIVHELgEREYRGMELFLNYARR 256 Candidatus Solibacter usitatus Ellin6076
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