2YB5,4ADO


Conserved Protein Domain Family
FusC_FusB
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cd16342: FusC_FusB 
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Fusidic acid resistance protein (FusC/FusB)
The fusidic acid resistance protein FusC (FusB) mediates resistance to the antibiotic fusidic acid. Its C-terminal domain, which contains a zinc-binding site, interacts with EF-G with high affinity, promoting the dissociation of stalled ribosome#EF-G#GDP complexes that form in the presence of fusidic acid, thus allowing the ribosomes to resume translation.
Links
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Statistics
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PSSM-Id: 319974
Aligned: 151 rows
Threshold Bit Score: 183.074
Created: 29-Mar-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding sitedimer interface
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:The C-terminal domain contains a four-cysteine zinc finger with a unique structural fold
  • Structure:2YV5: Staphylococcus aureus fusidic acid resistance protein FusC binds Zinc
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
2YB5_F         8 EVYKFVKVKQLVYQLIKLYRTn-DMNSHKTQKDFLLNEINDIFkekdiDISDFITSIDdvklTKKKAEHLLNELKVYiqd 86  Staphylococcus ...
WP_050614184   6 TNEKYNFIMKQAKQIAAAKHTvnDAGVKQAFIHSALDKVLALFpaigeEERGLLTKMVei-qSDVEMEQYQRTIEEYcip 84  Bacillus sp. SIT10
EIA21203       6 ENHVLNQILRQAKHVLDAEQRvnDMKVKQEFAYYSLNKAEKAFesltnPQLELLKPLVsi-kNEADFNHFKDSLEPYcip 84  Listeriaceae ba...
WP_053582771   7 KNEQFNFISKQVAWIKDSTKQhlPAGVLASVYDLSNEKILNCIpnmtaSQKNILDFSKl--kTVEEYEQALEQLVNYllp 84  Lysinibacillus ...
WP_040285891   7 RNEQYNYISKQVAAMRQSTKPhlTPAVRNSIIALSADRILSCIpgltaEQERLLDFTPy--kTIEEYDHGLSRLAAYrlp 84  Sporosarcina ko...
WP_034780360   7 ENHQFNYIREQVETIRDSRKKslPSSVLQAVIDLANAKIAFLFpeatsAQLAMLDVSKl--qTDEAYDGFIDELRPHvrs 84  Exiguobacterium...
WP_031424141   7 QNEQYNLIKEQVMLVKESRMQslPPSVLRAVIDLAQAKVMYAFpeattEQLKLLQFTTl--qTNEAFDEYMQRLREWvqp 84  Exiguobacterium...
WP_049670285   6 ENHQYVFIREKARQIVHARHTvhDRHVQETFIDNSQFYVYEQFqtltdDQRECLNDLSei-rTEADYERFLSELVKWrip 84  Bacillus sp. FJ...
WP_007203674   6 RNDQYNAIVQYVQVILDTKKKhvAPNVLKATIELAGAKILALFhestaEQQALLDVTAh--tTSEELHRFLEQLRSYvnp 83  Bacillus macaue...
EFI82983      69 ENHTYNTIKKQAKQVLSANRTtnDKKLQKEFAYYILEKATALVse--kEQAELLQDILdl-kKEEEFLQFDDKLKAFvrp 145 Listeria grayi ...

Feature 1                                                                               #  #     
2YB5_F        87 FEIPSSSQLEKIFRKVKKLKRPDinliDTKEIsYLGWNDNssNRKYIVYKNlddkFEGIYGEISPnKVKGFCKICNQESD 166 Staphylococcus ...
WP_050614184  85 FPELTDGKISKLFRKVKKLNHPPfteeDRKHLtYASWIDKgtGRKFIIRELdg-tIVGIHGRFLPsSKKGICHFCNHHSQ 163 Bacillus sp. SIT10
EIA21203      85 FQPITEAQLKKLFKKAKKLHPPHltpdDFLHLtYLSWYDKgsMKKFIVRELgg-sVKGLSGSFVPsPQNGICHFCHHMGA 163 Listeriaceae ba...
WP_053582771  85 FPTVTEQQLKKLFPKSKKLKLPDlsnvDLKRLtYLSWNDSrsNKKYLLYELeg-qLVGIECTFSPsTKKNICSICHCHGE 163 Lysinibacillus ...
WP_040285891  85 FPEVTDPQLKKLFPKRKKLKLPDltefDLEQTtYLGWNDSrsNRKYLLYILdg-rLEGLECSYSPnILHNTCSICHQQGP 163 Sporosarcina ko...
WP_034780360  85 FPQVSEQQVKKMFPKQKKLRLPDaaelNVNRMsYMSWNDLrsNRKYILCEKnh-qLIGIELKASSnAKKNICAFCNQLAE 163 Exiguobacterium...
WP_031424141  85 FPVISAEQLKSLFPKQKKLRLPElsdvDFGRLtYLGWNDGrsNQKLMICQYeg-qLIGIACKPSTnTKKNICAFCNQFTD 163 Exiguobacterium...
WP_049670285  85 FPALSDAQLTKLFRKVKKLQYPLlpqeQMEELtYFGWTHN--ERKFIVKAVdg-sLRGISGRITPsSKQGLCHFCHKQAE 161 Bacillus sp. FJ...
WP_007203674  84 FPPISEPQIKKLFPKAKKLKVPPldsvDWHKLtYLSWNDLgsNKKYIVYPQdg-kWLGIQCSLTPlAKAGYCSLCKCVND 162 Bacillus macaue...
EFI82983     146 FPNIEEQKAKQLFKKIKKLHFPKa--sFPTRAtYISWFDNanNRKFMITERdg-kLAGLAGTFITnHKKSICHLCRQETE 222 Listeria grayi ...

Feature 1                                  #     #                
2YB5_F       167 TSLFLNKTKhnks--sgtYTKKGDYICYDSFKCNQNLDDINNLYEFIVK 213 Staphylococcus aureus
WP_050614184 164 VGLYTVEMKskgn--sdqYKVLGNYICEDAAQCNQQLTSTDKLDEFLHQ 210 Bacillus sp. SIT10
EIA21203     164 VGLFTVDVKtdtk--nhnYKALSNYICQDEANCNAHITDTEKLDFLFDY 210 Listeriaceae bacterium TTU M1-001
WP_053582771 164 VTHFSTVTKakklnnpdyYKSIGNLICVDSSQCNKNITDDSYLKDFLKE 212 Lysinibacillus sp. FSt3A
WP_040285891 164 VTLVTTVTKerkannpdyYRTIGNFICTDSIACNRAITSTDYLERLFKE 212 Sporosarcina koreensis
WP_034780360 164 VSYCVTITKakqaknpdyYKAIGTYICTDSASCNENMTNLDALMTFVET 212 Exiguobacterium mexicanum
WP_031424141 164 VTYCVTITKakqaknpdyYKAIGTYVCVDSKTCNEHITSQEALHTFVHT 212 Exiguobacterium sp. NG55
WP_049670285 162 VGLFSVERKvrgk--smnYQAFAHYICQDSMQCNQHLANVERIDAFMRE 208 Bacillus sp. FJAT-27916
WP_007203674 163 VSYVSTIAKkkqaknsdyYKALGNLICTDSATCNEKITTTMHVEKLFGD 211 Bacillus macauensis
EFI82983     223 VGLFTIKGKvnak--tygYKAMGHYICTDSVACNEHLTDRANIDELFAF 269 Listeria grayi DSM 20601

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