Conserved Protein Domain Family
Pet127

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pfam08634: Pet127 
Mitochondrial protein Pet127
Pet127 has been implicated in mitochondrial RNA stability and/or processing and is localized to the mitochondrial membrane. The Pet127 family is part of the PD-(D/E)XK nuclease superfamily including a full set of active site residues.
Statistics
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PSSM-Id: 430119
Aligned: 92 rows
Threshold Bit Score: 286.307
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q75A95        150 FVPPSRDLRLLERAKEGQARYVSSTSAMSGVLSHLHYLLSNFRPLNGRHLSATL-LR---KDAQVTKCCKMTSSMLLQRr 225  Eremothecium ...
KDE09130      519 YVTSSQDKDLMALAQKEGKKLVGSTSSTVAMLCQIYFWISKGKEVNLDMLSSIW-TK---QNKDFSMGQQLPASVELLY- 593 
EKD01495      268 YITASQDPELTGMATTNNTRYTGSTSTLTQSLSQIYFTLSNARPVDTSTLSAEF-QE---QRPDFTAGAQLPALINIRL- 342 
XP_004361794  376 YMIPSQDPELLTKTSDFKCKFLSSTSSITSVLAAMYLSVFKKYTVNQFGLNSQLq-----SMSKFTPQVLKPTAITLTAv 450 
Q54T03        594 YMRPSEDKRLLDITKEHKAKYLSSTSSITSILTHLYLSLVKGKAPSSSPFSPPIlTRllpLKMGFIPSIVKPTSIHLTPl 673  Dictyostelium...
XP_003292100  409 YMIPSEDQKLIEITEENKCTYFSSTSSITAFLTHLYLAVSKSKAPPSSMYSSSL-TD---LSGSFIPSVLKPSSIHLIPv 484 
Q24CB9        192 YIPPSNDKLLLDFAKQSNIRYVMSTSTISNVLSQIYFLFSSFRNPNFDNISSAY-DQ---EPKKYMISQRKPTSNMLRkl 267  Tetrahymena t...
A0CMI4        139 YVPPSKDITLQQFAKALNLRYCVSTSTFSNVLSQIFYLLSGFHGPDFSSIFEQF-PD---EPRKFMISQRKPTSALLHKv 214  Paramecium te...
EGR34709      157 YIPPSNDQLLLDFAKKSNIKYVVSTSTISSALTQIYYMFSGFRNPLYDNISSNY-EN---EPKKYMISQRKPTTNYLRrl 232 
EFC48349      476 FIPPSQDTTLHKLMDQNPCRYQSSTSSITSPLVSLYLALSNYKPTRARNLENFKy-----LTSSFTPAVRKPVVFILRPk 550 
Q75A95        226 sQa--PPIFSLSSDS----SADR-E--IILSQLGHALEALLTTDQADFA-RIYDKGk-------RAQPgsqplgkghaTS 288  Eremothecium ...
KDE09130      594 -E---DGRYSIDADK----TIDVtSgmNVLADYGHMMEKLLTTDQPEFR-RFLKSSpnpa-aseVDQR-----------Q 652 
EKD01495      343 -Qe--NGTYAIDNDK----THSIdN--NVLSDYGRILEKQLTASPEDFK-RFLNSApesavpesERTE----------RE 402 
XP_004361794  451 kDd----IWAIDINNg---NIPKkN--EVLMELGHSMEKMLTLEEEEFLaKLLKTNnsvpv---------------efdd 506 
Q54T03        674 dGg----IWAIDTNSg---NITQdN--TILMNLGHSMEKMLTLDEEEFNqKLLKSNvgdkp--------------vefpd 730  Dictyostelium...
XP_003292100  485 kDn----IWSIDNNSg---NAEKsN--VILMNLGHSMEKMLTLPEDEFNsKILKSNnpgdp--------------vefpd 541 
Q24CB9        268 d--pknGIYALDSDSglfeTPNQ-----ILMDLGKVMERQLTLDPETFRnGLLKNSpvkeq--------------liddd 326  Tetrahymena t...
A0CMI4        215 dEn----MYALDGDPgifeEELI----ELLMS-GKIVERQLTQDQEEFEnRYIKLDpsmp----------------lved 269  Paramecium te...
EGR34709      233 d--kekGIYAFDSDSgifeAPNK-----ILMDLGKILEKQLTLDEQTFKdALLKTStknil---------------iedd 290 
EFC48349      551 lSklghTFYSIDSYKflfePRSN----QILMDLGKVMEKLFVMEPEDFEkRFVKQYcgeeqt-------------vedee 613 
Q75A95        289 AFRFNK-HGRFLLRSQLDAH--DPKL--P-GTGVFDLKTRAVAAVRHDLDYVSQNgntTGYQLMRRSGQFESYEREISEL 362  Eremothecium ...
KDE09130      653 AYHYMA-TDHMVLRSQLDAH--DPHL--P--NVSFDLKTRGTIAIRQDRLNYIEG---AGYTVDRLRGLWNSFEREYYDL 722 
EKD01495      403 AYAYSK-SGKLLMRSQLDCQ--DSRL--P-GSGTFDIKTRACFPIRQDRANWEKN---AAYTIYKQHGFQESFEREYYDL 473 
XP_004361794  507 SYVFTK-FDNLMYRSQIDCY--SDKIkgKgERMTFDLKTRATRQIRYHVWEHDVH---LDYHLKNVVGLNESYERELSDM 580 
Q54T03        731 SYIFSK-FGSLIYRSQLDCK--SDHL--PeGRNTFDLKTRSTSSIRNNASTSFNY---VSQRISRLSSDKDSFESEYFDL 802  Dictyostelium...
XP_003292100  542 SYIYSK-FDKIIYRSQIDCI--SDNL--PeDRNTFDLKTRATNAIRMNVSETNNF---ISHHINRLFNCNNSFEREYLDL 613 
Q24CB9        327 HHRFMKlNKNICLRSQIDCQaiDPKTgqP---FVFEIKTRAVCPIRYDLNNYLDH---IDYRINTKFGLHSSFEREYYDL 400  Tetrahymena t...
A0CMI4        270 FHRFMElNNEMCLRSQIDCR---NRSenP---IVFEIKARGACPIRYDYPNYRDY---LDYEINQYKGLFQSFEREYYDL 340  Paramecium te...
EGR34709      291 HHRFMKlNGDICLRSQIDCTaiSKETnqP---IVFEIKTRASCPIRYDLENYKDY---LDYRIVQKYGIHSSFEREYYDL 364 
EFC48349      614 VYRYLR-HGSFLLRSQLDCY--HPQY------GVFDIKTRATNPIRINMEKYQKF---TNIKLKMIKGNYNSYEREFYDM 681 
Q75A95        363 VRNAMLKYSFQARIGAMDGIFVAYHNISRIFGFQYIPLEEMDYIIHSsadraaamsltrresalqelfnpveyvtryrfe 442  Eremothecium ...
KDE09130      723 IRSAFLKYQFQARIGHMDGCFVAYHSTRTFYGFQYVPIEEMDVALFG--------------------------------- 769 
EKD01495      474 SRSGMLKYCFQARIGQMDGIFVAYHNTRTFFGFQYLSLAEIDRVLFG--------------------------------- 520 
XP_004361794  581 TRSSGIKYAFQAKIGNMDGLYIAYHNTKKIFGTEYLPLEKLERIVFWgn------------------------------- 629 
Q54T03        803 TKSGAIKYALQAKIGHMAGIFICYHNTKRIFGSEYLDLEELEKSVFWst------------------------------- 851  Dictyostelium...
XP_003292100  614 SRSGGIKYALQAKLGHMAGIFICYHNTRKIFGSEYIDLKELEKSIFWtn------------------------------- 662 
Q24CB9        401 IRGAMLKYAFQLKIGRMDGAFIAYHNTKEIFGFEYVKTKEIETRCFGnq------------------------------- 449  Tetrahymena t...
A0CMI4        341 IRGAFLKWAIQLKIGRMDGAFVAYHNLLEIQGFEYIKSSEIYKRVFGte------------------------------- 389  Paramecium te...
EGR34709      365 IRGGFLKYCFQLKIGRMDGAFIAYHNTLEMFGFEYVKTTEIENRIFGnt------------------------------- 413 
EFC48349      682 VRSVFIKYSMQGRIGGMDGMFLAYHNTVELFGFEYIKLGEIDKHVFGsp------------------------------- 730 
Q75A95        443 ntAREtastLAQAEFNYSMRILEHLFD 469  Eremothecium gossypii
KDE09130      770 --NHE----TGNQIFRLALGFLEQILl 790 
EKD01495      521 --STE----MADQVFQLCVGLMEKLLD 541 
XP_004361794  630 --------hIADDVFRITSTLLDKILt 648 
Q54T03        852 --------dMANRSFLMTNSILEDLLN 870  Dictyostelium discoideum AX4
XP_003292100  663 --------hMADVNFNLTNQLLQNVLD 681 
Q24CB9        450 --------fFADASFVVCSKILTNLLD 468  Tetrahymena thermophila SB210
A0CMI4        390 --------eFSDLSLLVGSRIATKLFd 408  Paramecium tetraurelia
EGR34709      414 --------lFADASFVICSKILTNLLN 432 
EFC48349      731 --------hMAERFFSLLLDLLGEVLD 749 
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