Conserved Protein Domain Family
WBS_methylT

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pfam12589: WBS_methylT 
Methyltransferase involved in Williams-Beuren syndrome
This domain family is found in eukaryotes, and is typically between 72 and 83 amino acids in length. The family is found in association with pfam08241. This family is made up of S-adenosylmethionine-dependent methyltransferases. The proteins are deleted in Williams-Beuren syndrome (WBS), a complex developmental disorder with multisystemic manifestations including supravalvular aortic stenosis (SVAS) and a specific cognitive phenotype.
Statistics
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PSSM-Id: 432656
Aligned: 45 rows
Threshold Bit Score: 63.8019
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001705075 196 LFSGh-KPEQLPAALDGDDPTGDTeAQEQIGYSKVRQ---MSNAE--KRRAGGFLkgkkwq--------------qpakf 255
2_pfamImport   1 LFAGymEQQQIPQGLGTGA------TANQISYEGRAR---NQRQR--RGKGREPVkakyvmpqialcwmancllicyccv 69 
XP_010759668 204 TVGG--------GGLQGDITGVVE-GMDDVDILDARKkamDGQSKgrRRGVDPAHvk----------------------g 252
EDV22658     200 LFTGqtAAAQLPQGL----DTTFSpIANVVQFTNERF---EFSGS--KNKLAAPAhar--------------------kk 250
ESO10747     201 LYTGg-APQAIPHGLGTEEANQRT-VQQQVVCASKRP---KYKDL--KGQSAKLS------------------------- 248
XP_004365347 200 LFAG--VAAEVPKGLDGTEGEDGQ-AGPSMPYSRKDR---DAHFG--KGKGKKAAt-----------------------k 248
EGD83075     201 LFAG--VVGSVPAGKSDMMRDTAS--QSTVAYTRADR---RRQARrkKRAGVK--------------------------- 246
1_pfamImport   1 LFAG--VTGVLPRGLGCETSDRTV--QNQVQFSGQSR---SRF----KNLKGKSAk-----------------------k 46 
XP_022275263 214 LFSG--PSTFMPKPLNDSNESNEE---EEVQESVFTR---ERIPY--RIACRGVVr-----------------------k 260
XP_002129806 202 LFCGv-ASPTLPKALGTEEEAKKK---RQIKYVKERE---QRG----SDKRNKSIk-----------------------k 247
XP_001705075 256 SREWKLHQVVKARLD-GK-DAKPVSRYSGRRRRG 287
2_pfamImport  70 SRDWVMAKKERYRKQ-GK-KVKSDSKFTGRRRPG 101
XP_010759668 253 TKAWITRKKEQMERK-GK-IVKPTSKYTGRKRRI 284
EDV22658     251 SRDWILHKKQRRRRQ-GF-EIRADSKYTGRRRKH 282
ESO10747     249 HREWLLEKKERRKRQ-GR-EVHPDSKYTGRKRAG 280
XP_004365347 249 SRDWIADKKERRKRQ-GK-DVRPDSAYSGRSRGP 280
EGD83075     247 SREWMMKKKESRRKKyGEnSVKRDSKFSGRKRPT 280
1_pfamImport  47 GKDWILEKKERRRRQ-GR-DVRPDTKYTGRQRRP 78 
XP_022275263 261 SREWVLEKKERRRRQ-GK-EVRPDTQYTGRKRKP 292
XP_002129806 248 SRDWIIEKKERRKRQ-GK-EVSINTKYTGRKRKP 279
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