Conserved Protein Domain Family
AKR_Fe-S_oxidoreductase
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cd19096: AKR_Fe-S_oxidoreductase 
Fe-S oxidoreductase and similar proteins
The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Links
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Statistics
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PSSM-Id: 381322
Aligned: 76 rows
Threshold Bit Score: 230.911
Created: 14-May-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative activecatalytic
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Rattus norvegicus voltage-dependent K+ channel beta subunit (3EAU) in complex with cortisone and cofactor NADPH.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          ###                                 #    #                             #   
NP_347403   4 KKLGFGFMRLPlkdqndqgsidlLAVNQMVDTFIERGFTYFDTAYMYHtgkSELAIKEALVKrh---kRNSFTLATKLPT 80  Clostridium
OUP14075   84 SVLGAGTTRFLsadlr--dseglDRCAALLARAVRYGVNYIDNAFSYAeghSEEIVARLLRLv----pRESVHLAVKSNS 157 Anaeromassilibacil...
ETT13593   14 SKIGMGCMRFPeeyir---qrkiENCIELVRYAYSKGINLYDVAPFYChdlSELIVGEALSVf----pRESYYLNSKTNL 86  Fusobacterium sp. ...
EGN33072   14 SAIGLGTMRYDeedik---agrlEKCAEIPLYAFEKGINYWDTAPNYChdkSEIVTGIALSQv----kRSDVYVTSKTNL 86  Lachnospiraceae ba...
SFM16978   15 SRIGFGAQRFEnph-------drDECVETVLHAYKNGINFFDTAMQYCadqSESILGEAIIEmk--kePLPFHISSKCYY 85  Paenibacillus sp. ...
EJP76037   14 SRISMGSHHLKnpq-------diDKHAENFFYAYKQGINFFETGDTYGnncSELILGTAIKEmk--khKKPFYIMSKTHA 84  Campylobacter
OUQ20534   14 SRISMGTHHLDsps-------diDRHVKHFLYAYKKGINFFETSVTYGdgySELILGEAIKEmk--kgTLPFFIMSKTHA 84  Lachnoclostridium ...
OGV37291   14 SAIGMGGMRFEnqe-------dpEACASLMKAAYDSGINYFDTAIGYGk--SEELFGIAIKEmlktrsKKPFYIATKTGG 84  Lentisphaerae bact...
PLX89390   14 SAISFGGMRFPspd-------drAHCHGLIHHAHRAGINYFDTAPAYCndqSEEIFGEALSTl----pRDSYFISSKSSA 82  Desulfuromonas sp.
CCL50722   18 SKIGMGCMRFPekyir---kkdfNNCIELVRYGHSKGINLYDVAPFYChdlSESIVGDALSVf----pRESYYLNSKTNL 90  Clostridium diffic...

Feature 1                                        ##                                  ##       
NP_347403  81 Mflk-----eeGDQERIFNEQLEKCgvDYFDYYLLHALgeknya--taqrfkSFEFIQKKKEEGKIRNIGFSFHDtsELL 153 Clostridium
OUP14075  158 Gsdp-----taDDVLRRVESGLRRTgaEYFDFLYLWSVldaeqlafllrpsgPYEGALEAKKRGWVRHLLVSSHApaRDA 232 Anaeromassilibacil...
ETT13593   87 Stlkh--dfsyDGFMKRLKESLSRLktDYLDFYCLWCMldansc--kenierLYPYFLKAKEEGYIRHIIMSSHMssEEL 162 Fusobacterium sp. ...
EGN33072   87 GtlhvgdhptkEDFRRRLELSLERLktDYIDFYHMWCMlslesw--ekhmdaLYGFFEEAKKDGLIRNIVFSSHMqgNEI 164 Lachnospiraceae ba...
SFM16978   86 Gd--------sANFREMLERSLRRLnlERIDFFTNLWGvksygdwleclrfgAVDQIIKAREEGLIKHVSITTHMpsEDL 157 Paenibacillus sp. ...
EJP76037   85 Gd--------sKTFRKNLENSLKNLgiSCIDSFTCLWGvksfeewrgaknygAIREMEKAREEGLIKHITFSSHLqnKEL 156 Campylobacter
OUQ20534   85 Gd--------hETFRRDLENSLKRLgvECIDAFTCLWGvkssgewdgakaygAIKEMEKAREEGLIRHIAISTHMrnREL 156 Lachnoclostridium ...
OGV37291   85 Gt--------aEAVRKDLEVSLKRMnlDYIDFYHVWCImsldkyr-ervkngVIRELEKMKAEGLVKHICVSTHMagADI 155 Lentisphaerae bact...
PLX89390   83 Hs--------gDALRAELERSLKRLqvEQIDFFHIWHLmnpadwq-qrqqggAIEAALRAKEEGLIGHLVCSSHMqgEEL 153 Desulfuromonas sp.
CCL50722   91 Ntlkn--disyDGFMRRLEQSLKRLkvEYLDFYCLWCMldlssc--nkniekLYSYFLKAKKHGYIRHIIMSSHMssEEL 166 Clostridium diffic...

Feature 1                  #                               #######                      #     
NP_347403 154 DEILLAHpeVDFVQLQINYLDwenesvqSRKCYEVAKKHNkAIVVMEPIKGGKLAQVPKEAEQLFknyhpnlSVPSWAIR 233 Clostridium
OUP14075  233 AQIVDCGa-FEGILLSYNLMSra----eTGPVIDRAAARGmGVLIMNPLGGGILPQNETLFSGARlpg--daSTAEAALR 305 Anaeromassilibacil...
ETT13593  163 EQFLFSDy-FVGVIVGHNPINyk----yRINAIKKAFQNNiATVIMNPLSGGLIPRNQKYFKNIFcqd--nlNVCQSVIR 235 Fusobacterium sp. ...
EGN33072  165 EKVVDSGk-FKGMLIGYNALNyr----fRQSGIEAAYNKGmGVVVMNPLGGGMIPANPDAFRYLTegt--dlTVPQAALR 237 Lachnospiraceae ba...
SFM16978  158 KKVLSEYq-FDINIVGYNVLNap----wRTEGMKATQGMGiGNIAMNPLGTGIIPQYEDVFKAICire--kqSIVDGAIH 230 Paenibacillus sp. ...
EJP76037  157 IEMIGEYk-FDYSLQGFNIINsk----yRLKGIMKTHEKDiGTIAMNPLATGDLLLYEDIFNAIRike--dqTLVQAAYA 229 Campylobacter
OUQ20534  157 KAVMEDYp-FDYNVQGFNAVNsa----yRIDGLRTAWESGaGTIAMNPLATGDILKYAHIFDAIRird--kqSLAQAAYA 229 Lachnoclostridium ...
OGV37291  156 KTLLSDYp-FDGLLLGYSIMNfa----yRTEGVQAAADAKmGVVAMNPLGGGLIPQNPEQFNFVKtrd--deTVVEGALR 228 Lentisphaerae bact...
PLX89390  154 ATVLAEDi-FEGVLLGYNILNfp----yRSAAIELAGTKGlGVMTMNPLGGGVIPQNPERFAFLDand--dcGVVAAALR 226 Desulfuromonas sp.
CCL50722  167 ERILELNy-FEGVIVGHNPINyk----yRISAIKKAFENNvATIIMNPLSGGLIPRNEKYFSKIFcdd--nlNVSQSVIR 239 Clostridium diffic...

Feature 1                ######  #  ##         
NP_347403 234 YVASHDnVMMVLSGMSDMSQLLDNTSYMMEFKP 266 Clostridium
OUP14075  306 FAASRAgVTCVLAGLAGTRDLDQAIHAFDGWEP 338 Anaeromassilibacillus sp. An200
ETT13593  236 FEVAHReITSVLIGFSNIKEIDEAICAIEGVEE 268 Fusobacterium sp. CM21
EGN33072  238 FVASHKeITVTLAGCTTKKHIDDAVKAVEHLEE 270 Lachnospiraceae bacterium 5_1_57FAA
SFM16978  231 YMLSSPyVDSVLVGLRNKSDVQDAIDSFNSFEP 263 Paenibacillus sp. 1_12
EJP76037  230 YILSFPfIDSVLGTFNSKDEINEAIKTLYQEPY 262 Campylobacter
OUQ20534  230 YVLSVPwVHSALGTFNSEEQIDEAVAVLDETPY 262 Lachnoclostridium sp. An14
OGV37291  229 FLLNDKrLTVSLVGLSNKKQLEEAISAADGFRP 261 Lentisphaerae bacterium GWF2_49_21
PLX89390  227 FNVSNPhITAALVGFAATSEIDQALAAMENFTP 259 Desulfuromonas sp.
CCL50722  240 FEVSHKeITSVLIGFSNVDEIDEAMIATEGIVE 272 Clostridium difficile T6

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