4GYF


Conserved Protein Domain Family
hisJ_fam

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TIGR01856: hisJ_fam 
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histidinol phosphate phosphatase, HisJ family
This model represents the histidinol phosphate phosphatase HisJ of Bacillus subtilis, and related proteins from a number of species within a larger family of phosphatases in the PHP hydrolase family. HisJ catalyzes the penultimate step of histidine biosynthesis but shows no homology to the functionally equivalent sequence in E. coli, a domain of the bifunctional HisB protein. Note, however, that many species have two members and that Clostridium perfringens, predicted not to make histidine, has five members of this family; this family is designated subfamily rather than equivalog to indicate that members may not all act as HisJ.
Statistics
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PSSM-Id: 273837
Aligned: 8 rows
Threshold Bit Score: 299.697
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4GYF_A         6 LDYHFHS-HFSADS-EELPRKHVTEAIAHGLEEICFTEHRD-----FYFPGMDFs------------LNLPEYFQEINQL 66  Lactococcus lac...
O34411         4 RDGHIHT-PFCPHGsNDTLRQYAEEALKKGFESITFTEHAPl---pPSFTDPTPlkds-----amaqASLERYIHEISGL 74  Bacillus subtil...
P38635         2 HSHHSHSgDYSAHG-TDPLDSVVDQVVNLNFHTYCLTEHIPrieakFIYPEEQSlgknpeevitkleTSFKNFMSHAQEI 80  Saccharomyces c...
Q02150         4 LDYHFHS-HFSADS-EELPRKHVTEAIAHGLEEICFTEHRD-----FYFPGMDFs------------LNLPEYFQEINRL 64  Lactococcus lac...
Q9RX45         5 CDSHLHT-PLCGHA-TGTPREYAQAALDAGLSGLCFTDHMPm---pRWYDAPWRmk----------lEQLPEYIAEIQAV 69  Deinococcus rad...
EXL20090      31 RDGHTHT-EFCPHGtHDDVEEMILKAIELDFDEYSIVEHAPl---sREFMNNTAgdkeavttasmamSDLPYYFKKMNHI 106 Listeria monocy...
O14059         3 ISSHSHSgQFCLHA-QGKLEDVIQEAIQQGFQSFSFTEHTPrdrveDLYPEELHlqpe------dlfKTFDEYVNEARRL 75  Schizosaccharom...
WP_011064957   2 FDFHMHS-NFSADG-DFEMEAMVQSAIQKGLKEICFTDHLD-----IDYPDKDWdf---------tfDPVR-YTETIEQL 64  Oceanobacillus ...
4GYF_A        67 QAEFKD----KIKIKIGLEMGID-LRFKSEINQFIDSAP--F--DFVIASVHEIG----------DIEVYDGtEFYLQKT 127 Lactococcus lac...
O34411        75 KKEYRG----QLSIRTGLEVDYI-AEFEDEITLFLDTYGpyL--DDSILSVHFLRtdssylcldyDEHTFKE-LISACGS 146 Bacillus subtil...
P38635        81 KTRYADrpdvRTKFIIGMEIESCdMAHIEYAKRLMKENNdiL--KFCVGSVHHVNgip----idfDQQQWYNsLHSFNDN 154 Saccharomyces c...
Q02150        65 QAEFKD----KIKIKIGLEMGID-LRFKSEINQFIDSAP--F--DFVIASVHEIG----------DIEVYDGtEFYLQKI 125 Lactococcus lac...
Q9RX45        70 QQEFAG----RLDVRLGLEADFH-PGTEKFVEKVLGMFD--W--DYVIGSVHYLGaw------gfDNPEFVAeYEER--D 132 Deinococcus rad...
EXL20090     107 KKKYAS----DLLIHIGFEVDYL-IGYEDFTRDFLDEYG--PqtDDGVLSLHFLEgqggfrsidfSAEDYNEgIVQFYGG 179 Listeria monocy...
O14059        76 KQNYGD----QINILIGAETEYIrPESVELLKSLNTKYN--L--DYFVGSVHHVNsip----idfSPELWQKaLQHVGNN 143 Schizosaccharom...
WP_011064957  65 QEKYQN----KITILKGVEVGVQ-PHVLHATADFVNSLQ--P--DFVICSMHATRgt------dlHSGEFFQ-----EKS 124 Oceanobacillus ...
4GYF_A       128 KEEAQREYLLACLDVVQN---FEnYNSFGHLDYVARYGPyt---------------------dKSIKFAENREILFEILR 183 Lactococcus lac...
O34411       147 IEAVYEQYYRSIYSSIVAslgVYkPKRVGHITLVQKFIKl----------------------fPYSMSEHIRGLVSLCLN 204 Bacillus subtil...
P38635       155 LKHFLLSYFQSQYEMLIN---IK-PLVVGHFDLYKLFLPndmlvnqksgncneetgvpvasldVISEWPEIYDAVVRNLQ 230 Saccharomyces c...
Q02150       126 KEEAQREYLLACLDVVQN---FEnYNSFGHLDYVARYGPyt---------------------dKSIKFAENREILFEILR 181 Lactococcus lac...
Q9RX45       133 LGGLYRDYYALVEGAARSg--LF--DAIGHLDLPKKFGHl--------------------------dPDPVYALHA--LD 180 Deinococcus rad...
EXL20090     180 FEQAQLTYLEGVKQSIEAdlgLFkPRRIGHISLCQKFQQffg-------------------adTSNFSGEVMEEFQAILA 240 Listeria monocy...
O14059       144 PEQLFIDYFEHQYDLMQR---LH-PLVIGHFDLICLFAPeda-------------------keVFKNSKSVWELIQRNIK 200 Schizosaccharom...
WP_011064957 125 IETAFRQYFEELYACIQK---FDsYQVLGHVDLVRRYAKq-------------------------tSKDECFDILESILK 176 Oceanobacillus ...
4GYF_A       184 ALASKEKALEINTRLFDDPKT-EQFYSDLLINFKRLG-G-KFITLGTDSHIAKRDWLSIHKART 244 Lactococcus lactis subsp. lacti...
O34411       205 AIEENGMELDFNTSGLRKTYAgGIYIEDWMLNEAKQK-K-IPLVFGSDAHQAGDVGYAYEAFLE 266 Bacillus subtilis subsp. subtil...
P38635       231 FIDSYGGAIEINTSALRKRLE-EPYPSKTLCNLVKKH-CgSRFVLSDDAHGVAQVGVCYDKVKK 292 Saccharomyces cerevisiae S288c
Q02150       182 ALASKEKALEINTRLFDDPKT-EQFYSDLLINFKKLG-G-KFITLGTDSHIAKRDWLSIHKART 242 Lactococcus lactis subsp. lacti...
Q9RX45       181 VVAGQGLALDFNTAGWRKPVA-EAYPAPDLVRAAAER-G-IPFVLGSDAHQPGEVGFRFADAVK 241 Deinococcus radiodurans R1
EXL20090     241 LVKKRDYELDFNTAGLFKSLCgETYPPKEIVTLAREL-K-IPLVYGSDSHGVQDIGRGYNTYCQ 302 Listeria monocytogenes Lm_1889
O14059       201 YAVSYGGIFEINTSAFRKGWK-TAYPQQRLLELMVEQ-G-AQLTLSDDSHGPHQVGLNYHLAKS 261 Schizosaccharomyces pombe 972h-
WP_011064957 177 LVINQRKGIELNTSGFKYGLE-AGLPSKEILELYHQLgG-EILTIGSDAHRPNEISQSFRQSLE 238 Oceanobacillus iheyensis
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