6BOX,1MVH


Conserved Protein Domain Family
SET_SUV39H_Clr4-like
?
cd20073: SET_SUV39H_Clr4-like 
SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 methyltransferase Clr4, and similar proteins
This subfamily contains fission yeast Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (also known as Suv39h), the sole homolog of the mammalian SUV39H1 and SUV39H2 enzymes, that has a critical role in preventing aberrant heterochromatin formation. It is known to di- and tri-methylate Lys-9 of histone H3, a central heterochromatic histone modification, with its specificity profile most similar to that of the human SUV39H2 homolog.
Links
?
Statistics
?
PSSM-Id: 380999
Aligned: 5 rows
Threshold Bit Score: 465.508
Created: 9-Jan-2019
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 31 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens EHMT1 (3HNA) binds SAH and mono-methylated H3k9 peptide.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
6BOX_A        48 LDFQFIsQYRLTQgvippdpnFQSGCNCSsl------gGCDLNNPsRCeCLDDldepthFAYDAQGRvradtgAVIYECN 121 Schizosaccharom...
1MVH_A        44 LDFQFIsQYRLTQgvippdpnFQSGCNCSsl------gGCDLNNPsRCeCLDDldepthFAYDAQGRvradtgAVIYECN 117 fission yeast
KTW26326     334 IDFEFItSYKYGLgieprnplFISGCSCSk-------dGCDLNNPgSCqCLEDsnn-ksFSYDEYGRvhcnssSIIYECN 405 Pneumocystis ca...
XP_007874245 336 IDFEFItSYKYGVgieprnplFISGCSCPk-------dGCDLNNPgSCqCLEDsnn-ksFSYDEYGRvrrnttSIIYECN 407
XP_019027154 274 EKFEFIeRYRFALgitepdsgFSAGCECGikegnvfggHCDLDDPlKCsCLQEmae-peFAYDKHGLlts-tdCPIYECN 351

Feature 1                                     ###                #      #  ## #        ######  # 
6BOX_A       122 SFCSCsmECPNRVVQRGRTLPLEIFKTKeKGWGVRSLRFAPAGTFITCYLGEVITSAEAAKRDKNYDDdGITYLFDLDMF 201 Schizosaccharom...
1MVH_A       118 SFCSCsmECPNRVVQRGRTLPLEIFKTKeKGWGVRSLRFAPAGTFITCYLGEVITSAEAAKRDKNYDDdGITYLFDLDMF 197 fission yeast
KTW26326     406 ENCDCgiNCPNRVVQRGRKIPLNIFKTKhKGWGLQCPRFIKAGTFIGVYLGELISQSEAEIRGKKYDNvGVTYLFDLDLF 485 Pneumocystis ca...
XP_007874245 408 ENCDCgiNCPNRVVQRGRKIPLNIFKTKhKGWGLQCPRFIKEGTFIGVYLGELISQSEAEIRGKKYDHvGVTYLFDLDLF 487
XP_019027154 352 ENCGCalTCPNRVVQRGRQLPLEIFKTPdKGFGLRCPQNIKAGTFLSTYTGEVITNGEAKRREPIYENnGATYLFELDFF 431

Feature 1                    #          #####       # #            #               # #           
6BOX_A       202 DDa------sEYTVDAQNYGDVSRFFNHSCSPNIAIYSAVRNHgfrtIYDLAFFAIKDIQPLEELTFDYAGakdfspvqs 275 Schizosaccharom...
1MVH_A       198 DDa------sEYTVDAQNYGDVSRFFNHSCSPNIAIYSAVRNHgfrtIYDLAFFAIKDIQPLEELTFDYAGakdfspvqs 271 fission yeast
KTW26326     486 EDqv----deYYTIDAQYCGDVTRFINHSCDPNLAIYSVLRDKsdskIYDLAFFAIRDIPALEELCFDYSGrnnddqlgf 561 Pneumocystis ca...
XP_007874245 488 EDqv----deYYTIDAQYCGDVTRFINHSCDPNLAIYSVLRDKsdskIYDLAFFAIKDIPALEELCFDYSGrnnedqlgf 563
XP_019027154 432 ESeleesgqeCYTVDAQCCGDPTRFINHSCDPNLQVRVVLVQMdq-rLYHIAFFAIRDIPAYEELTFDYSPsphhhemsr 510

Feature 1                               #####          
6BOX_A       276 q-----------ksqqnrisklRRQCKCGSANCRGWLF 302 Schizosaccharomyces pombe 972h-
1MVH_A       272 q-----------ksqqnrisklRRQCKCGSANCRGWLF 298 fission yeast
KTW26326     562 ign--------csnskyinlknKKPCYCGSANCRGWLF 591 Pneumocystis carinii B80
XP_007874245 564 ign--------ysnskyinlknKRPCYCGSANCRGWLF 593
XP_019027154 511 sapqrrrgrgrravagpknykaKLSCECKSAKCRGYTF 548

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap