4MZD,1AH2


Conserved Protein Domain Family
Peptidase_S8

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pfam00082: Peptidase_S8 
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Subtilase family
Subtilases are a family of serine proteases. They appear to have independently and convergently evolved an Asp/Ser/His catalytic triad, like that found in the trypsin serine proteases (see pfam00089). Structure is an alpha/beta fold containing a 7-stranded parallel beta sheet, order 2314567.
Statistics
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PSSM-Id: 395035
Aligned: 44 rows
Threshold Bit Score: 131.042
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4MZD_A         91 SKkISVGIIDSGIM-----EEHPDLSNSLgnyfknLVpkggfdneepdetgnpsdivdkmgHGTEVAGQITANGN----- 160 Lactococcus la...
Q0AUR0        267 DAgLSVCILDTGIN-----NGHPLLSPVL------RDedcltveph-------wgeddhdgHGTLMGGIVTFGNleeclv 328 Syntrophomonas...
jgi:Aave_3535 283 DGaPVVCLLDTGVS-----ARHPLIAPALrgawsydeaw------------gvddhglhggHGTPLAGLVLYGDleplmn 345
WP_000253881  276 NItTSVSILDTGVN-----YNNMLLSKVC------CDdfavswdpdwpkydqyqplapfneHGSLQAGLAAFGNlmdvvl 344 Enterobacterales
BAI71454      214 GAaSAVCLLDSGAT-----AGHPLLRPAL------ADadlhtvnpdwg---vadtagrwlgHGTAMAGAALYGDlhaile 279
EDZ95318      274 KHaVSICVLDSGVA-----RIHPLLSPGL------DAndmhavepsw----gvndsafwrgHGTAMAGLCLYSDQlidll 338
WP_013009988  272 KNnVYICLLDTGVN-----NEHILLKEFL------SDkdsisydps-------wstvdkdgHGTNMAGIACYGDmvnile 333 Denitrovibrio ...
EDM37899      296 DDsTLICLLDSGVN-----HHHALISPFL------PDhrlyaynnaw----gthdtwgsegHGTGMAALALYGDltdald 360
WP_004026595  282 TNePTIGVIDTIIVdhtqvYFHEWIDYHYenskelep----------------ilkeenpiHGLEVSSIIVNGPSfnpnl 345 Ureaplasma ure...
P16519        158 GKgVTIGIMDDGID-----YLHPDLASNY------NAeasydfssndpypyprytddwfnsHGTRCAGEVSAAANnn--- 223 human
4MZD_A        161 ----------ILGVAPGITVNIYRV--FGENLSKSEWVARAIRRAA---DDGNKVINISAGqylmisgsyddgTNDYQEY 225 Lactococcus la...
Q0AUR0        329 ----seqtikIPHRLESVKILP-RPphTNSPELWGHITAQAVSKAEiqaPHRIRICCLAIAatdtr---drgrPSSWSGQ 400 Syntrophomonas...
jgi:Aave_3535 346 ----dsryvfLTHDAESMKLLPPRGfpPTKPPSYGVVTQGAVSAVEierPGAKRIFCIACStedl----ppdrPSTWSGA 417
WP_000253881  345 ----ensaiqLSHVIESARILPPQG--NNDPLLYGAITVGTAYKLEvdrPDLNRVYSLAVTsdher---esgrPSSWSAE 415 Enterobacterales
BAI71454      280 ----tadpvtLSHRLESVKILPPDGvpDNEPELYGALTGEAIARAEvqaPFRNRVVCMAVTspsp----srgrPSSWSSA 351
EDZ95318      339 a---tsgqvkLFHRLESVKILPNTG--QNQPELYGAITEQGVSLPEianPHRPRVFCMAVTsssds---tkgtPSSWSAA 410
WP_013009988  334 ----tsepviINHQLESVKVTPDSG--KNPEELLAKITMDSISSIEilePMRRRFFCSSSTsdasl---cvgnPSSWSGA 404 Denitrovibrio ...
EDM37899      361 ----srnsivIRHGLESFKVKQYGV--ENDPELYGAITQMAVDLPViidGQRRRVFCLSITdaatv---frgrPSSWSST 431
WP_004026595  346 ddgcgffrvrHFGVM--------------GQNFTTFELIKKIRSIIe-nNQDIKVWNLSLG------------------T 392 Ureaplasma ure...
P16519        224 --------icGVGVAYNSKVAGIRM--LDQPFMTDIIEASSISHM----PQLIDIYSASWGptdng--ktvdgPRELTLQ 287 human
4MZD_A        226 LNYksainyATAKG----------SIVVAALGNDslniqdnqtminflkrfrsIKVPGKVVDAPSVFE------------ 283 Lactococcus la...
Q0AUR0        401 IDNlasgahEEDNVk---------RLFIVCVGNItdlql---------aldypNAQLTDSVHDPAQSW------------ 450 Syntrophomonas...
jgi:Aave_3535 418 LDQiasgsmPGEASavptalerpkRLLVVATGNVqng-------------mipDVLTSQPLEDPAQSW------------ 472
WP_000253881  416 IDQft--sgMQDGKr---------RLFVISAGNNldirp---------dqdywDQVNLAQIEDPAQAW------------ 463 Enterobacterales
BAI71454      352 IDQlc---fD-ETGr---------RLVVVSAGNIrddld---------paaylDRNDLEPVEDPAQAW------------ 397
EDZ95318      411 VDQlcfndgEF--R----------RLMIISAGNIsqeii---------aedylNINDVETIDNPGQAW------------ 457
WP_013009988  405 IDQlc--fgTLDGHk---------RLFIQAAGNLhdeea----------isypFVNLASKIEDPCQAW------------ 451 Denitrovibrio ...
EDM37899      432 IDKlcfgnsELAAEq---------QLFIISGGNVstakh----------adyySLNDTTSVHDPAQAY------------ 480
WP_004026595  393 KYEikdnfiSIEASilddiqaeydVIFVVSGTNKt-----------------sKESKNYKIGSPADSI------------ 443 Ureaplasma ure...
P16519        288 AMAdgvnkgRGGKG----------SIYVWASGDG---------------------------------Gsyddcncdgyas 324 human
4MZD_A        284 --DVIAVGGID-----------------GYGNISDFSNIGADA-----------IYAPAgttanfkkygqdkfvsqgyY- 332 Lactococcus la...
Q0AUR0        451 --NTLTVGAFTelddiidptledylpvaRSGQLSPFTTTSITWdnkwp--nkpdIVMEGgnlshd-------gqgnydEs 519 Syntrophomonas...
jgi:Aave_3535 473 --NALTIGGFTrkdlpprt-ptglkpavPANHRSPFSRGSQSLpsdlt-pikpeVLFEAgnmlad-------asgfceWg 541
WP_000253881  464 --NAITVGAYTemttnddpyfegwspfaMEGDVAPSSRSSVNWawrkqapfkpdVVAEGgnrllsp-----drkevsnEd 536 Enterobacterales
BAI71454      398 --NALTIGACTdkititdpaydgwaplaPAGDLSPRSRTSVLWdrqwp--ikpeVTFEGgnlagd-------grfppeAi 466
EDZ95318      458 --NPLIVGAYTekiniidsnyqgwlplaPGGDLSPRSRTSVTWdsqwp--irpdVVFEGgnmafd-------genpaaAi 526
WP_013009988  452 --NSVVIGGYTekisidddlyhgcrviaPKGGLCPASKTSSTWtrrwp--ikpdVVFEGgnlavc-------sdmvtkAa 520 Denitrovibrio ...
EDM37899      481 --NAISVGSYTsmdrfdprerpgwrilaARGAMAPSNSTSLLFesqwp--nkpdIVMEGgnmitd-------gadiahHp 549
WP_004026595  444 --NSLVVNAVN-----------------DQQEPAFYTRKGIVLsffn----kpdLAYYGtcy------------------ 482 Ureaplasma ure...
P16519        325 smWTISINSAIndgrta-----lydescSSTLASTFSNGRKRNp------------------------------------ 363 human
4MZD_A        333 ---LKdwlftttNTGWYQYVYGNSFATPKVSGALALVVDKYGI--KNPNQLKRFLLMNS--------------------- 386 Lactococcus la...
Q0AUR0        520 ydlSLlstfydpTRTYFAFHNMTSAATAKAAWLAAQIYSLYPH--SWPETVRALMVHSAewtdqlklqfll------det 591 Syntrophomonas...
jgi:Aave_3535 542 psvSLlstgsnvAHEPLVPMWATSAATGMAGHFLGRLQAALPS--FWPETLRALVVDSArwtepmrkkligtgahwktgt 619
WP_000253881  537 t-vGLlttsgrtTGQVFERGSDTSAACALVSRCAAQLTAEYPE--FWPETIRGLIIHSAewtprmmerfglls--avhsp 611 Enterobacterales
BAI71454      467 ddlQLltthyrpARRLFDTLGDTSGATALAANMAARIMAARPR--LWPETVRGLIVQAAewtpamrarfda------cgg 538
EDZ95318      527 ddlCLltthyrpNIRMFDRMSDTSSATALASYMAARIMSEQPN--YRPETIRALIVHSAewtpamqnhfea------ass 598
WP_013009988  521 d-lSLlttshqpMKRQFDAFYATSAATAEAANFVAKLTNDYPD--AWPETLRGLLVHSAdwteemykqaeadp---snrk 594 Denitrovibrio ...
EDM37899      550 t-lQMltaskrhLDQQFQLFGDTSGAAALTAKMAAEIWTAYPN--LWPETIRALIIHSAqytgemtggfdpa-----emt 621
WP_004026595  483 ---------vfeSNNKVKKVQGTSYAAAWISRKLGYLIN---IlgFSREVAKALLIHAAadsike--------------- 535 Ureaplasma ure...
P16519        364 ---EAgvattdlYGNCTLRHSGTSAAAPEAAGVFALALEANLG--LTWRDMQHLTVLTSkrnqlhdevhqw-------rr 431 human
4MZD_A        387 ---------PEVNG 391 Lactococcus lactis subsp. lactis
Q0AUR0        592 kgsyakllrICGYG 605 Syntrophomonas wolfei subsp. wolfei str. Goettingen G311
jgi:Aave_3535 620 kkqfqaqlrEVGYG 633
WP_000253881  612 kvaketllrTVGYG 625 Enterobacterales
BAI71454      539 krqmqallrRYGYG 552
EDZ95318      599 ktargallrRYGYG 612
WP_013009988  595 sdptrmllrMFGYG 608 Denitrovibrio acetiphilus
EDM37899      622 stqkrnllrRFGYG 635
WP_004026595  536 ----nhdfsFLGYG 545 Ureaplasma urealyticum
P16519        432 ngvglefnhLFGYG 445 human
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