1JL3,1JF8,1JFV,1LJL,1LJU,1LK0,1RXE,1Y1L,2CD7,2IPA,2L17,2L19,2MYU,3T38


Conserved Protein Domain Family
LMWP_ArsC
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cd16345: LMWP_ArsC 
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Arsenate reductase of the LMWP family
Arsenate reductase plays an important role in the reduction of intracellular arsenate to arsenite, an important step in arsenic detoxification. The reduction involves three different thiolate nucleophiles. In arsenate reductases of the LMWP family, reduction can be coupled with thioredoxin (Trx)/thioredoxin reductase (TrxR) or glutathione (GSH)/glutaredoxin (Grx).
Links
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Statistics
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PSSM-Id: 319973
Aligned: 235 rows
Threshold Bit Score: 123.713
Created: 18-Nov-2015
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active site
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1RXE; Staphylococcus aureus arsenate reductase with bound phosphate in active site
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             # ######                                                                   
1JL3_A         5 IIYFLCTGNSCRSQMAEGWAKQYLgd-ewKVYSAGIeah-glNPNAVKAMKEVGIDIsnqTSDIIDsdi---lnnADLVV 79  Bacillus subtilis
1RXE_A         5 TIYFISTGNSARSQMAEGWGKEILge-gwNVYSAGIeth-gvNPKAIEAMKEVDIDIsnhTSDLIDndi---lkqSDLVV 79  Staphylococcus ...
YP_001634941 108 KVAFLCRANSARSQIAEAWLRVLSdg-qvQAMSAGThpq-avHPLAITVMAEVGIPIdqqVSKSITmii---dqrPDLIV 182 Chloroflexus au...
KIE59200       6 HVLFLCTGNSARSIMAEAILNHYSgg-rfHAYSAGSrpkglvHPLALETLQFHGISIdglRSKPLTeflqanapaIDYVV 84  Methylacidiphil...
KPV54906     119 RVLFLCTHNSARSQMAEGILRHFAgs-rvEAFSAGSqps-avHPDAVQVLAAIGIDIsqqRSKHLDqfa---dqsFDYII 193 Kouleothrix aur...
EGF80482       3 SVLFLCTHNSARSQIAEAILRHLDttgkfEAYSAGSeet-fvRPLAIKVMQEWNVDMsshTSKTLEqfl---drkIDFVV 78  Batrachochytriu...
EMH80573       3 KVLFLCTGNSVRSIISECLLNQLGhn-nfQAYSAGSkptgkvNPYTIKVLEKNNINYkntLSKSWDtfi---dtkFDTVV 78  alpha proteobac...
EFH86883     117 RVLFLCTENSARSQMAEALLRQESqg-mvEAYSAGSqpaahiHPLTRRVMEQMGIDMsqaTPKPLHlfe---gqhFDAIV 192 Ktedonobacter r...
AHG89795       9 RVLVLCTGNSARSQIAEALLAVRGag-rvAAASAGSrpaarvNPYAVEVLRDHGIAWegrTPKSIDdva---eerFDLVI 84  Gemmatimonadete...
KQV61439       7 NVLFLSTQNTARSIMAEAMLNAVGgg-rfRAFSAGSqpagklNLFAVEQIRALDDSLnglRSKSLDefsepgapeMDFVI 85  Duganella sp. R...

Feature 1                                  # #                             
1JL3_A        80 TLCGdaa-dkCPmtpphVKREHWGFDDPARaqgteeekwaFFQRVRDEIGNRLKEFAE 136 Bacillus subtilis
1RXE_A        80 TLSSdad-nnCPilppnVKKEHWGFDDPAGke------wsEFQRVRDEIKLAIEKFKL 130 Staphylococcus aureus
YP_001634941 183 TVCDiar-eeCPvwpeaARHIHWSVADPVAiqgtadqrhaAFVAAREELRERVRGLLA 239 Chloroflexus aurantiacus J-10-fl
KIE59200      85 TVCSsaakeaCPlfpkkAIIEHWDLPDPAAvegdigkqkeAFQKIFDALHQRIFLYFL 142 Methylacidiphilum kamchatkense Kam1
KPV54906     194 TVCDrvr-evCPvfpddPECIHWSFADPAAvedaa-arehAFQQTAQQLLTRVRYLLS 249 Kouleothrix aurantiaca
EGF80482      79 TVCDsan-dtCPifpraIKKLHWSFPDPSKavg----tedEQLQAYRTVRNGLAERIT 131 Batrachochytrium dendrobatidis JAM81
EMH80573      79 TVCNraanetCPvypgsPKKLHWELEDPAAfngndeeklnEFQRIFDQIHERIKKEFI 136 alpha proteobacterium HIMB114
EFH86883     193 TVCDrvr-evCPtfsddPERIHWSFPDPATvqgteaeqlhTFEQTALQLTTRIRSFLP 249 Ktedonobacter racemifer DSM 44963
AHG89795      85 TVCDnar-daCPhfpgaTAQVHWGLPDPAEavgal-aarrAFRETYDALAARVDALLA 140 Gemmatimonadetes bacterium KBS708
KQV61439      86 TMCDvaagepCPvwpgqPASANWNFRDPAArqgpvdgirqEFFTVCREIKTRLEIFRN 143 Duganella sp. Root336D2

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