4BFI


Conserved Protein Domain Family
IgV_1_MRC-OX-2_like
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cd05846: IgV_1_MRC-OX-2_like 
First immunoglobulin (Ig) variable (V) domain of rat MRC OX-2 antigen, and similar domains
The members here are composed of the first immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar proteins. MRC OX-2 is a membrane glycoprotein expressed in a variety of lymphoid and non-lymphoid cells in rats. It has a similar broad distribution pattern in humans. MRC OX-2 may regulate myeloid cell activity. The protein has an extracellular portion containing two Ig-like domains, a transmembrane portion, and a cytoplasmic portion.
Links
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Statistics
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PSSM-Id: 409433
Aligned: 12 rows
Threshold Bit Score: 144.024
Created: 11-Jan-2008
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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  next features
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:Ig strand A [structural motif]
Evidence:
  • None
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #####                                                                           
4BFI_B         2 VEVVTQDERKALHTTASLRCSLKTSQEPLIVTWQKKKAVSPENMVTYSKTHGVVIQpay-kdRINVTELGlwNSSITFWN 80  house mouse
P41217        32 VQVVTQDEREQLYTPASLKCSLQNAQEALIVTWQKKKAVSPENMVTFSENHGVVIQpay-kdKINITQLGlqNSTITFWN 110 human
129300        32 VEVVTQDERKLLHTTASLRCSLKTTQEPLIVTWQKKKAVGPENMVTYSKAHGVVIQpty-kdRINITELGllNTSITFWN 110 Norway rat
NP_001025958  20 VVTQTEQRVVKAGNSVTLSCALTEPKDIVQVTWQKDSLKSQSNIATYSKSTGLKIQkpy-qnRMNLTSLMlnNTSITFWN 98  chicken
XP_001517999   3 EVIHRKELSTTVGGNVTLHCQLSQDKEVLQITWQKESGRTSENIATASPSHGFRLMgry-lnRASLRTEGwdSSALTLHS 81  platypus
XP_001233343  14 QVLHKKVQSVQAGGNITFSCQSVTNEDVIQVTWQKEMDGAEDNIATYSTMNGEKIAkay-dgHVSFAHSGleASSISLHR 92  chicken
BAE23034      26 RIKHNTYERAVLGGNISIFCNFTSLENVEQITWQKIQGSLPQNIGTYSHKYGEKILppy-vnRLQCKILEpsTYFMTIQG 104 house mouse
XP_001505921 150 SVRHQRSKIAKTGDSVILNCELRDLAEVLQVTWQKVQHSLLENVGTYSRKYGVKILpqf-erRFSCNSSEfmSSCLIIRD 228 platypus
NP_001025957  31 AVKCESVTEATLGEEANFSCDFLLPMDVFQVTWQKINGSSFQNIVTYSQTRGLRLIgsf-rrKARFARAAlnTSVITLKN 109 chicken
XP_001335657  18 EIVARGDTAVVFGQDASLSCTLPFVSGVRQVTWQRVRAQDVHTLATFSERFKDNVDedf-vrKIIFQASFn-STTIEIKN 95  zebrafish
NP_001013337 115 TVIPEGNTTAVGGKQITLACRYGLPEKVKQVLWKKIVTKAESREIAFFAKQSDPVIeeefveRVSLSPSLs-DTQLTLWP 193 zebrafish
CAM60086     115 CLFDVYPSGQQSGKPVTFLCNYILSMRVRQVLWKKTAEQGDTAIVASYVKYSKPVVtsp-fkGRVSLNPSlgQTRLSIHH 193 zebrafish

Feature 1                                      
4BFI_B        81 TTLEDEGCYMCLFNTFGSQ-KVSGTACLTL 109 house mouse
P41217       111 ITLEDEGCYMCLFNTFGFG-KISGTACLTV 139 human
129300       111 TTLDDEGCYMCLFNMFGSG-KVSGTACLTL 139 Norway rat
NP_001025958  99 ARIDDTGCYLCLFNTFPLG-SFSGRSCLGV 127 chicken
XP_001517999  82 ASLEDEGCYKCIFNVFPSS-PVEGRMCLKI 110 platypus
XP_001233343  93 VTLQDEGCYKCIFNTFPSG-AVTGRMCLKV 121 chicken
BAE23034     105 VTFEDEACYKCLFNTFPHG-SHGGQTCLTI 133 house mouse
XP_001505921 229 VTLEDEACYRCIFNVFPDG-YHMGETCLIV 257 platypus
NP_001025957 110 LTFEDVSCYRCIFSVYPHGsFSSKAMCLNI 139 chicken
XP_001335657  96 TTFEDEACYICSFKVYPTG-PKRETLCVTV 124 zebrafish
NP_001013337 194 VQSEDEACYTCEFHTYPDV-IKSATSCLTV 222 zebrafish
CAM60086     194 AQTEDEGCYTCEYHTYPDG-IKSTTACLSV 222 zebrafish

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