5NTF


Conserved Protein Domain Family
Pdase_M17_N2

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pfam18295: Pdase_M17_N2 
M17 aminopeptidase N-terminal domain 2
This domain is found in the N-terminal region of M17 aminopeptidase (pfam00883) present in Homo sapiens and Mus musculus. M17 aminopeptidases are Zn-dependent exopeptidases that catalyze the removal of unsubstituted amino acid residues from the N-terminus of peptides.
Statistics
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PSSM-Id: 408104
Aligned: 11 rows
Threshold Bit Score: 110.948
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5NTF_A               44 TFVVILGTHAQ-----------------LREDAL-KELPF-YCPAVAEAIQRvkKGETYAVLA-------EGvkneaNER 97 
KPJ08627             78 HPVLIVGQATH-----------------LNTLTW-QDVRCkLEPRVTEEVWQ--RGLTVVSSG-------DS-----CEL 125
XP_009066603         18 NPVLIVGQPRD-----------------LGKLTF-ENVKVkLEPRV--DAETfkMAVTDLTN--------TC-----SLW 64 
1_pfamImport          1 QPVIIVGQLTC-----------------LNKITF-DDVRHkLEPRVTEEVFKnaLSTLHPNTA-------DT-----ISL 50 
XP_001866727         18 APVLIVGQTGH-----------------LKELPF-ERVRCkLEPRVSSEIFEqaKSVLHPAPT-------DS-----CSL 67 
WGS:AAPP:GF18094-PA  45 HPVLIIGQLRH-----------------LNLV------KF-NDLA-SKLSPRvsEETFLNAVAclhpaptDK-----VSL 94 
Q4DZJ3               44 TFVVILGTHAQ-----------------LREDAL-KELPF-YCPAVAEAIQRvkKGETYAVLAegv--knEA-----NER 97  Trypanos...
Q386R3               57 HTILLLGTRQQ-----------------LKSKGLsQLFPY-HKPELDQLIDEidEASFRSDGYr------CG-----TNH 107 Trypanos...
XP_009834651         19 PKVVVIGTKETpatala-----qqiltrLNNGTA-VDTAL-LEHAVAQLSAGldSAASTHLYVs------LG-----ARG 80 
XP_008609698         17 PTVLLIGTTETpgvslaervlahlaggaLEPETV-ALVAH-AIAELSPSTDNaaSAHLYVP---------LD-----DDK 80 
ETW09276             22 PKVVLIGTQETpglelitrvvvrltgspVDPVAA-QILAH-AVMELAPTPDVsaSTHVYLPVG-------NG-----KTD 87 
5NTF_A               98 -FVRV-L-VGEVPSEASRTNCPARPDVVASLLSAALEEIKGPe------tKVDVFV---RSTAALAIAVAAARSAKRnFT 165
KPJ08627            126 wPRGA-S-LAALPARRSRHAAPSRGHALSKIVKNGQRGNVSE--------EFVVLVc--RKQDVLASAVAIARAVPQ-YS 192
XP_009066603         65 -LNNA-T-VAALPSKCSRHNTPSRCHSLSKIVKSCLVGGSE----------FIVLVc--ERKDVLASACAIARTLPL-YS 128
1_pfamImport         51 -YINLaT-LASLPNKCSRHNSSARPHALAGVIKSNSSGASET----------IIVVc--PFSDVLASAAAIARSYPA-FS 115
XP_001866727         68 -YLDL-AkLAVLPTKASRHNSESRGHALTKLVQTHTSGVSES----------IVVVc--DKENLFASGCAVARAFPL-YS 132
WGS:AAPP:GF18094-PA  95 yLDSA-T-VAALPLKASRHNTASRAHAITRLVKSHVMNVPEE---------TVVLVc--ERENLFASACAVVRAFPL-YS 160
Q4DZJ3               98 -FVRV-L-VGEVPSEASRTNCSARPDVVVSLLSAALEEIKGPe------tKVDVFVc---STAALAIAVAAARSAKRnFT 165 Trypanos...
Q386R3              108 -ELRI-T-LGVIAGAFSRHNCPLRPDSITNIVEEAVAYAKKVkgvtaasgALDIYCc--EAENVLCVAAAVARGANQsFS 182 Trypanos...
XP_009834651         81 -VASV-V-VAQLPTFISRYNTLSRPHAISALVRSNVPDNKd---------VIVAFTlpeHATTTVSAGVAVAKGISTaYS 148
XP_008609698         81 -MLSL-V-VAQLPTAVSRHNSEARPHAIMALVKAHAADVEADt-------VVALSLp-nQSATWVAAGTAVAKAMPAyF- 148
ETW09276             88 -VVSV-T-VAQLPTHVSRYNTPARPHAISELVKANASSGAVVva----lsLPDHDFt--FEAAAFGVAKGIPAYAHKsNS 158
5NTF_A              166 AKEGL 170
KPJ08627            193 ARTDS 197
XP_009066603        129 AKSKS 133
1_pfamImport        116 MKTMA 120
XP_001866727        133 RKTSK 137
WGS:AAPP:GF18094-PA 161 RKTGN 165
Q4DZJ3              166 AKEGL 170 Trypanosoma cruzi
Q386R3              183 AKNGY 187 Trypanosoma brucei
XP_009834651        149 HKSSG 153
XP_008609698        149 HKSTK 153
ETW09276            159 PFRGV 163
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