Conserved Protein Domain Family
Vert_HS_TF

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pfam06546: Vert_HS_TF 
Vertebrate heat shock transcription factor
This family represents the C-terminal region of vertebrate heat shock transcription factors. Heat shock transcription factors regulate the expression of heat shock proteins - a set of proteins that protect the cell from damage caused by stress and aid the cell's recovery after the removal of stress. This C-terminal region is found with the N-terminal pfam00447, and may contain a three-stranded coiled-coil trimerization domain and a CE2 regulatory region, the latter of which is involved in sustained heat shock response.
Statistics
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PSSM-Id: 461944
Aligned: 14 rows
Threshold Bit Score: 289.416
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ELV13598     274 YGSSSLFPSD-AVASSGPIISDVTEL-------SPASPAASPGGSIDERPLSSSPLVRVKEEPPSPPQSPRVPATSPGHP 345
Q00613       247 YSSSSLYAPD-AVASSGPIISDITEL-------APASPMASPGGSIDERPLSSSPLVRVKEEPPSPPQSPRVEEASPGRP 318 human
3_pfamImport   1 SGSSNLYSPDsSSANSGPIISDVTEL-------GPSSPSASPGSSIDNGRYAGEPPLR-RKAPSLVPTSRACEAGGTESR 72 
XP_008118339 248 HNRTDGLKQR-EQMSDDIIIYDITDDdigdeekAPDTPETSEDTASDSN---YSPDIVIVEDDCEDDYVPVIQENTNAEP 323
XP_003769453 230 HSRTEGLKPR-EQISEDIIIYDVTDDnid-eenAPVTPETNEDATSDTSNCSQYPDIVIVEDDNEDDYATVIQGGDKSSD 307
XP_016811730 230 HSRTEGLKPR-ERISDDIIIYDVTDDnad-eenIPVIPETNEDVISDPSNCSQYPDIVIVEDDNEDEYAPVIQSGEQNEP 307
XP_009469632 212 YSGSNLYSPD-SSANSGPIISDVTEL-------AQSSPSASPSGSLDE---RSSPVVRIKEEPPSPARSPQIE------- 273 crested ibis
XP_014344337 241 YTGTKLYSSD-SAENLGPIISDVTDL-------AQSSPCVSPSASTREER--SSPVIRIKEEPPSPAHSPQIEEVSVIDT 310 coelacanth
EPQ07036     182 ysssslyspD-AVSSSRPIISDITEL-------TPSSPVASPGRSIDERPLSSSPLVHVKEEPPSPPRSPpVEEASPGLQ 253 Brandt's bat
XP_026344669 247 YSSSSLYSPD-AVASSGPIISDITEL-------APSSPLASPGGSVDERPLSGSPLVRVKEEPPSPPRSPRVEEASPGHP 318 Ursus arctos ho...
ELV13598     346 PSv-DTPLSPTALIDSILRESEPAPAASVLRPERKGhwswehsAHSHPG--------C-RP---CVPASAVpaTQpsapr 412
Q00613       319 SSv-DTLLSPTALIDSILRESEPAPASVTALTDARGhtdtegrPPSPPPts-----tP-EK---CLSVACL--DK----- 381 human
3_pfamImport  73 ASp-DNIYSSTSLVFQPFFRAEKAPLGLYSIFTRKGtq----gRPQCPPpv----hlG-AP---CHALVCLfpPR----- 134
XP_008118339 324 VS-----IPSPESVGPSTDDTSPLMSSAVQLNSQSV-------LTAEDPvsmmdsilN-ENgviSQNINLL--GK----- 383
XP_003769453 308 PT----SVPITDHESSVIESGSSLMSNAVQVNNSSA-------LTSEDPvsmmdsilN-E------NINLL--GK----- 362
XP_016811730 308 AR---------ESLSSGSDGSSPLMSSAVQLNGSSS-------LTSEDPvtmmdsilN-D------NINLL--GK----- 357
XP_009469632 274 -------------------ENEPSTTTAAAGD---S-------TTQPQP--------Q-EK---CLSVACL--DK----- 305 crested ibis
XP_014344337 311 GT--ESCLSPSTFIDSILQENETSGSSNASTSIDPS-------TAQSQP--------E-ER---CLSVACL--DSlvqsp 367 coelacanth
EPQ07036     254 SSivDTPLSPTALIDSILRESEPAPAASATTLPDAG-------GRPPSTpp----tsApEK---CLSVACL--DK----- 312 Brandt's bat
XP_026344669 319 SSvvEIPLSPTALIDSILRESEPAPTTPATPLTDAGgr---hpSPSPPPas-----aP-EK---CLSVACL--DK----- 379 Ursus arctos ho...
ELV13598     413 v------------------tarpwNELSDHLDAMDSNLDSLQSMLSSPGFSVDTSALLDLFSPSVTV-PDMSLPDLDSSL 473
Q00613       382 ------------------------NELSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTV-PDMSLPDLDSSL 436 human
3_pfamImport 135 ------------------------NELNDHLDTMDSSLDNLQAMLSTHGFSVDTSALLDLFSPSVTV-TDMNLPDLDSSL 189
XP_008118339 384 ------------------------VELLDYLESIDCSLEDFQAMLSGRQFSIDPELLVDLFSSSVQMsPTGHINSAKVET 439
XP_003769453 363 ------------------------VELLDYLDSIDCSLEDFQAMLSGRQFSIDPDLLVDLFTSSVQMnPTDYISNTKLEN 418
XP_016811730 358 ------------------------VELLDYLDSIDCSLEDFQAMLSGRQFSIDPDLLVD------------------SEN 395
XP_009469632 306 ------------------------NELNDHLDTIDSNLDNLQTMLTTHGFSVDTSALLDLFSPSMTV-TDMNLPDLDSSL 360 crested ibis
XP_014344337 368 qmsevarlfpspstsslhcrpqqgNDLCDHLDTIDSNLDNLQTMLSAQSFSMDTSTLFDLFNPSLPT-SDMGLPDLDTSL 446 coelacanth
EPQ07036     313 ------------------------AELSEHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTV-PDMNLPDLDSSL 367 Brandt's bat
XP_026344669 380 ------------------------TELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVtvpdmslp-dldssl 434 Ursus arctos ho...
ELV13598     474 ASIQELLSPQEPPRPLEAENSGPDSGKQLVHYTAQPLLLLDPGSVDAG---SGDLPVLFELGEGSYFSEGDDYADDPTI- 549
Q00613       437 ASIQELLSPQEPPRPPEAENSSPDSGKQLVHYTAQPLFLLDPGSVDTG---SNDLPVLFELGEGSYFSEGDGFAEDPTI- 512 human
3_pfamImport 190 ASIQDLLSSQEQQKPSESEDPSADAGKQLVHYTAQPLFLVDSGSVDVGcgvGGELPIFFELGEAPSFTEGDEFLEDPTA- 268
XP_008118339 440 KGIETVKTNGAQRTTQDVPNSKLKADKQLIQYTAFPLLALLDGSPGSA----------VESTN--VATEPVSSLDKPLEv 507
XP_003769453 419 KGSETNKNNEVQPTSEDGKNSKPKSDKQLIQYTAFPLLAFLDGSPSST----------VENGS--ATSEAASSLDKPLGv 486
XP_016811730 396 KGLETTKNNVVQPVSEEGRKSKSKPDKQLIQYTAFPLLAFLDGNPASS----------VEQASTTASSEVLSSVDKPIEv 465
XP_009469632 361 ASIQDLLSSQEQQKPTETEASTADTGKQLVHYTAQPLFLVDSSAVDMG---SGDLPIFFELGEGPYFTDGDEYSEDPTI- 436 crested ibis
XP_014344337 447 DTIQDLLSSQE-QKPTDTDSNTADTGKQLVHYSAQPLFLLDSGSGDMG---SGDLPILFELGDAPYFAEGDES-EDPTI- 520 coelacanth
EPQ07036     368 ASiqellspqEPPRPLEAENSSPDSGKQLVHYTAQPLLLMDPGPMDVG---SSDLPVLFELGEGSYFSEGDNYADNPTI- 443 Brandt's bat
XP_026344669 435 asIQELLSPQEPPRPLEAENSSPDSGKQLVHYTAQPLFLVDPGSVDMG---SSDLPVLFELGEGSYFSEGDDYTDDPTI- 510 Ursus arctos ho...
ELV13598     550 -SLLTGSEPSKAKDPTVS 566
Q00613       513 -SLLTGSEPPKAKDPTVS 529 human
3_pfamImport 269 -SLFSGTEDPKPPDPAVS 285
XP_008118339 508 dELLESSLDPQPTQSKLV 525
XP_003769453 487 dELLDSSLDPEPTQSKLV 504
XP_016811730 466 dELLDSSLDPEPTQSKLV 483
XP_009469632 437 -SLLSGTEQSKPKDPAIS 453 crested ibis
XP_014344337 521 -ALLSSTDESKPKDPAIS 537 coelacanth
EPQ07036     444 -SLLTGSEPPKAKDPTVS 460 Brandt's bat
XP_026344669 511 -SLLTGSEPSKAKDPTVS 527 Ursus arctos horribilis
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