Conserved Protein Domain Family
DUF4504

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pfam14953: DUF4504 
Domain of unknown function (DUF4504)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 253 and 329 amino acids in length. There are two conserved sequence motifs: LLGYP and SFS.
Statistics
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PSSM-Id: 464399
Aligned: 21 rows
Threshold Bit Score: 212.525
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002533364  14 DSSLSHI--KWRLKSHAKHRLQIDVLALCTEMRPVIMVDY-GGKMPELQEHLCALlrlcqQESP-I-------------- 75 
CBI36690      14 STSLSRT--KWRLKASSKRRLEIDILALCTGMRPVVMVDY-GGKMPELQERLCAVlklsqKASS-I-------------- 75 
ERN20362      14 ENSIFRV--QWRLRAASKRRLILDVLALCTGLRPVVMVDY-GGKVPELQERLCSVlnlvhKESS-F-------------- 75 
XP_003576730  18 EACAARI--RWRLRPQSKRRLLNDILFLCAGLRSVILMDY-GGTMPLLQENLCSLlhhaqQEAS-I-------------- 79 
XP_020147922  18 EACAARI--RWRLRPQSKRRLLNDITFLCTGLRPVILMDY-GGTMPQLQENLCSLlhharQEAS-I-------------- 79 
EFC48273      26 FNINVSKigSTTNKKQNNYSLGRDLFHLWSGLRDTILLDY-----AVLKDSDCTDlqnlsKQLSiLennnsellnnfpht 100
XP_015462602  15 FLCCGNK--KKRLSSLSCLDVAVQILAVDLGLKPAFLYDCnAASAEQLLQYLNSL-----QDAGlL-------------- 73 
Q567C3        14 QKCLCSR--KKRLSPSSCLEVTIHIIAVDLGVKPALLYDSnGASPDQLQLYLHSL-----QESSvV-------------- 72  zebrafish
KRH10124      15 DSCLANI--NWRLKPSSKRRLQLDVLALITRMRAVVMVDY-GGIMPQLQHHLSSLlqlalRDSPsI-------------- 77 
NP_001118858  14 SSCLSQI--KWRLKSNSKRRLEIDVLALCTGMRPVVMIDY-GGKMPELQNRLLSLlelirEGLP-V-------------- 75 
XP_002533364  76 ---------FEHLKVMII----------EDMI--YLIHVKGLVEYVKSSLNsEVD-LVFVNLEQDPPKMVTQAENSSLNA 133
CBI36690      76 ---------FYHLRIMVI----------EDMI--YLIHVKELAEHVRSSLNsEPE-LHFVDLEHNPPKMIVQAEKSSVAM 133
ERN20362      76 ---------FLPLRVMII----------EEMV--YLVHIEGFSQHVLSSLSlQWQ-LQFVDLDQDPPKIISYQGQNSVAS 133
XP_003576730  80 ---------LNPLRVMVI----------KDML--YLIHVKGLAEHVSPNARsRHQ-PAFVDLEKSCCELLVNTEENGTVL 137
XP_020147922  80 ---------LNPLRVMVM----------KDML--YLIHAEGLAEHVSPNARsQHQ-LAFVDLEKSCCELLANTEKNETMV 137
EFC48273     101 shenvnklnFGNIGVMIIkfwmffdgkrEEMIfnYLINTEKLKQRLEKLQScDLN-LIFIDIDALDRKEPYLECGEKIQN 179
XP_015462602  74 ---------TTILQVVSI----------DGNN--LVVNSELMKSHLAELIS-ERR-IITVDVCPWKEQPAICDMESRSVE 130
Q567C3        73 ---------SNSLRIMSI----------NDNT--FIINPDIMKSHLGELLK-SKS-LPLIDVCSSRKRPVLCAFERSAEE 129 zebrafish
KRH10124      78 ---------FEHIRVMVI----------QDMI--YLIHITEIAHFVRSSFNsQQHpLLFVDLEHQPPKMITQIEESQLAM 136
NP_001118858  76 ---------FKDLKVMVI----------EDMI--YLINVRSLPKFVSSSLDsEPE-LFFIDLEQDPPKMVTQSKESNLGM 133
XP_002533364 134 ALVRVQKLFSLYLPVNenvspchltetaanasdnvanaadsvanaadsvasaessinkpiISQSSEFIDFSSCMQDSEVT 213
CBI36690     134 QLISVQKWFSLLFPVDeinndllpsitte------------------vmsiakpsisepvASQSSEIIDLSSGIQGTQVA 195
ERN20362     134 QLIAVQNLFSVAFSSEgtnnlfmga---------------------------tpsrdvlvPSQPSQCIDLSSCLENSKVV 186
XP_003576730 138 ELLSIQDGFSGKFPLEaafepgttkqeskl----------------aekataveytdihvANRTSLVLDLSAILENTQIA 201
XP_020147922 138 ELLSIQDRFAATFPLEadvepettqqksrl----------------peratdvertgisiPDTTSLVVDLSAFLEGTQMA 201
EFC48273     180 NIQPFIQLISNQIIENfn----------------------------------------ngNGKCVFEIDFSSHLTPSLPF 219
XP_015462602 131 MIKAISELFLNKADKD-------------------------------------------------SSVCMLPEQMYDQWN 161
Q567C3       130 MVRSFLEVFMNGLD-----------------------------------------------------LVVLEEELYKDWN 156 zebrafish
KRH10124     137 QLVSIQRLFLTVFSPEepksaddpkan-----------------------ananaacqssSSPSAHCIDLSNCMDNTDIT 193
NP_001118858 134 QLRSIQKLFSSTFPLDdsntdtt------------------------------tvldeanSSQTSLCIDLSCCLQDTKVT 183
XP_002533364 214 VP----TLNGWLLGYPVVYL----FSKEHIADaiYNLS------TKYLRIFQILVSRNISPNKASr-pEELMSFSVPYEL 278
CBI36690     196 VP----TLNGWLLGYPVVYL----FSTEHISDaiFNLS------TKSLRIFKILICRNDAYKGSGk--EELLSFSVPYDL 259
ERN20362     187 IP----TLNGWLLGYPVVYL----FSKEHTSHavCNLS------TRPLHIFKILVCRKGASARENsqeEELMSFTVPYEL 252
XP_003576730 202 LP----SLNGWLLGYPVTYL----FRNESAEAatQNLS------KHSLHIYRIYVVRSPHSDAKPs-eEELLSFSVPCEM 266
XP_020147922 202 LP----SLNGWLLGYPVTYL----FRNESGETatQNLS------KHSLHIYRIYVVRNRHSDSKQs-eEELLSFSVPCDI 266
EFC48273     220 LPfdatLMNGILLNYPIILFygsrFPIQQTSN--KNLKfyanhvLNNIDLYRYTLSCTQEHQ------ETLLQFIIPQSI 291
XP_015462602 162 LC----TLFGIILGYPATYW----FDQSQNFE--NCLK------MTPLVVYKVWVCWEAGDKKHC---SCLYSFSVPEIL 222
Q567C3       157 LC----TFFGILLGYPASYW----FEQTQGFE--NCLS------MTPLVVCTVWVRWQIHEIKQR---CCLYSFSVPEEL 217 zebrafish
KRH10124     194 VP----TLNGWLLGYPVVYL----FGKDHISDaiYHLS------TKYLHIFQVFVCRNSTLKKGTq-aEELLSFSVPYDL 258
NP_001118858 184 IP----TLNGWLLDYPVVYL----FGTDHIEEaiYNLS------TKSLRLFKVLVCRNGTTEKDSh-lEELTSFSVPYDL 248
XP_002533364 279 S------MGGSKEPWAEAFLAQMQSRwekskQIWRTLQMEVSECYPQAiVL 323
CBI36690     260 S------MGGSNEPWAKAFMAHLEAKwekckQVWSSLQMEESDLATYS-RW 303
ERN20362     253 S------TGGRNEAWAQEFLTHMLLKiakckNIWRHLRMEVIECSPQSiAL 297
XP_003576730 267 S------VRRDEEPWAKSFLACMNEKlercnHVWASMRLEIDVFRSQSgVI 311
XP_020147922 267 S------MKREEEPWAKSFLARVNGKlercsQVWASVRLEIEVFQSQSgVI 311
EFC48273     292 YsensqmIDSTIEQWLSTQQQSNKKP---------HLQLSKETIQYDNiVL 333
XP_015462602 223 Ws----eVHAYIQQWTELLSDRFSKQ-----KVLTELSFSQETVVLPSvAL 264
Q567C3       218 Ws----dVQSHIQRWTDHLRERFSKQ-----TVLTDICFSRDTVTLPSvTL 259 zebrafish
KRH10124     259 S------MRGSNEQWAEAFLAHMQAKwercaSAWKSLKMEVSECHPQAiVL 303
NP_001118858 249 S------MEGSKEVWAEKFLERMSSRweeckHIWRSLDLQVSECYPQAiVL 293
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