Conserved Protein Domain Family
CTNNB1_binding

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pfam08347: CTNNB1_binding 
N-terminal CTNNB1 binding
This region tends to appear at the N-terminus of proteins also containing DNA-binding HMG (high mobility group) boxes (pfam00505) and appears to bind the armadillo repeat of CTNNB1 (beta-catenin), forming a stable complex. Signaling by Wnt through TCF/LCF is involved in developmental patterning, induction of neural tissues, cell fate decisions and stem cell differentiation. Isoforms of HMG T-cell factors lacking the N-terminal CTNNB1-binding domain cannot fulfill their role as transcriptional activators in T-cell differentiation.
Statistics
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PSSM-Id: 462440
Aligned: 18 rows
Threshold Bit Score: 183.898
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003224258  19 GGGSGD-DLGAPDELIPFQDEGdEQDKGA-GG--RGSAHGDLDELKSSLVHESESRGAgggggSSSESEAErppp--ppr 92 
EEN52158      30 NGSGGD-DLGASDETISFKDEG-EQEEKS-----AENVSNDLSDIKSSLVNESESSQSgavpsEGSKPPLQs-------- 94 
Q9W7C0         7 GGGGGDpELCATDEMIPFKDEGdPHKEQIfAEisHSEEEGDLAEIKSSLVNETEISPN-----SNS-------------- 67  zebrafish
3_pfamImport   1 SGGGGDpELCATDEMIPFKDEGdPHKEQIfAElsHSEEEGDLADIKSSLVNESESSPN-----SNS-------------- 61 
4_pfamImport   1 SGGGGDpELCATDEMIPFKDEGdPHKEQIfAElsHSEEEGDLADIKSSLVNESESSPN-----SNS-------------- 61 
9_pfamImport   1 GGGGGDpELCANDEMIPFKDEGdPQKEKIfAEisHPEEEGDLADIKSSLVNESEINPS-----TIS-------------- 61 
XP_003410438   9 GGGGGDpELCATDEMIPFKDEGdPQKEKIfAEisHPEEEGDLADIKSSLVNESEIIPA-----SNG-------------- 69 
AAI42318      10 GAGGGD-DLGAPDELLAFQDEGeEQDDKSrDS--AAGPERDLAELKSSLVNESEGAAG-----DAGVPGAGagargeaev 81 
Q8JHX2         5 GSGGGD-DLGATDEMLAFKDEG-EQEEKI-PE--NAFTERDLADLKSSLVNESEGSGSpaaaaD---------------- 63  chicken
XP_016283178   7 GGGSGD-DLGATDEMLAFKDEG-EQEEKI-PQ--GGFPERDLADLKSSLVNESEG-AG-----SSGQAGSGpg------- 68  gray short-tail...
XP_003224258  93 pRESF-QKPRDspaSVAEVLRRQQD-G---------GFFKG-TPYPSYP-FLMIPELG---SPYLQSGALS--------- 147
EEN52158      95 --------------YPREDSRRGDE-Gskae--svpVVSRG-PAYLTPG-GVIVSNMGvypHP---NGSLA--------- 143
Q9W7C0        68 -HDAArQSQITpdsYHEKHRDHPDD-Gkl-----qdLYSKG-HPYPSYPgYIMMTNMNn--EPYMNNGSLS--------- 128 zebrafish
3_pfamImport  62 --HGVrQSQIPd-sYHEKHRDHQEDgSkihnnv---tnccghAPYTVTPvPVLP-------EPYLRQEPISi-------- 120
4_pfamImport  62 -HEIVkQH------FSSTYKGHRES-----------VYHKHfPPHPSGPcYTAPRSFYpfsFPCLPFSSLSv-------- 115
9_pfamImport  62 -HEAArRSQVPqdsY-DKAREHPDEaGkhp---dgvLYNKG--PYQGYPgYIMMPNMN---DPYMSNGSLS--------- 122
XP_003410438  70 -HEVArQAQTSqesYHDKAREHPDE-Gkhp---dggLYNKG-PSYSGYSgYIMMPNMNn--DPYMSNGSLS--------- 132
AAI42318      82 gAEALgREHTSqrlFPDKLPESLED-Glkap-ectsGMYKD-TVYSAFN-LLM---------HYPP-------------- 134
Q8JHX2        64 -PEAIrRVQDPqrvYQEKLPDHMDDaGmkh---qdpGMYKG-SAYSGYP-FLMLSD------PYLPNGSMS--------- 122 chicken
XP_016283178  69 qTETLrRASNSqrlYQDKLPDALEE-GlkaqdsssvGMYKE-SVYSGYN-LLV---------HYPANGVSAgtgagtgag 136 gray short-tail...
XP_003224258 148 -------PgGARTylqvkwPLldvpagatlkdtrspSPAHL-SNKVPVVQHAHHMHPLTPLITYSNDHFSPG-SPPSHL- 217
EEN52158     144 --------------------------------------ASAtSNKVSVVHGPPHPGPLTQLMMYSNEHFAPG--TPPHIg 183
Q9W7C0       129 ------------------------------------PPIPRtSNKVPVVQPSHAVHPLTPLITYSDEHFAPG-PHSGHH- 170 zebrafish
3_pfamImport 121 -----------------------------------sLPQ---SNKVPVVQPSHAVHPLTPLITYSDEHFAPG-SHSGHH- 160
4_pfamImport 116 -----------------------------------sPP----SNKVPVVQPSHAVHPLTPLITYSDEHFAPG-SHSGHH- 154
9_pfamImport 123 ------------------------------------PPIARtSCQLSVVQPAHVLHALGEFFTYTEQGFKPGvSHPSFL- 165
XP_003410438 133 ------------------------------------PPIPRtSNKVPVVQPSHAVHPLTPLITYSDEHFSPG-SHPSHI- 174
AAI42318     135 -------PsGAGQhpqpqpPL---------------------HNKAS--QPSHGVPQLSPLY----DHFS-S-PHPTPA- 177
Q8JHX2       123 -------------------PL---------------------SNKVPVVQPSHGVHPLTPLIPYSNDHFSHG-SHSPHL- 160 chicken
XP_016283178 137 agtgpgaVsGAGQ------PL---------------------HTKPG--QPSHGVPQLTPLY----EHFS---SHPTHV- 179 gray short-tail...
XP_003224258 218 ----SPEIDPKT--GIPRPPHPSELSPYYPLSPGAIGQIPHPLGW 256
EEN52158     184 vppnSIEVDPKT--GIPRPRHPADLPPMYAIPPNQLPQLGPSYPK 226
Q9W7C0       171 ----PQDVNPKQa-GMPRHHPGPDIPNFYPLSPGGVGQMTPPLGW 210 zebrafish
3_pfamImport 161 ----PHDGSSKQgrGMPRQHPGPDMPNFYSLSPGGVGQITPPLGW 201
4_pfamImport 155 ----PHDGSSKQgrGMPRQHPGPDMPNFYSLSPGGVGQITPPLGW 195
9_pfamImport 166 ----PSRKNVRQ--GMPRHPPGPDIPTFYPLSPGGVGQITPPLGW 204
XP_003410438 175 ----PSDVNSKQ--GMPRHPPAPDIPTFYPLSPGGVGQITPPLGW 213
AAI42318     178 ----PADISQKQ--GVHRPLQTPDLSGFYSLTSGSMGQLPHTVSW 216
Q8JHX2       161 ----PADISQKQ--AVHRPSQTSDIPGFYPLPPAGVGQITPSMGW 199 chicken
XP_016283178 180 ----SADINQKQ--GVHRPLQTTDLSSFYSLSPGGVGQISHTMGW 218 gray short-tailed opossum
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