5YFP


Conserved Protein Domain Family
Sec5

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pfam15469: Sec5 
Exocyst complex component Sec5
This entry represents the Sec5 component of the exocyst complex which is an octomeric complex that mediates the tethering of post-Golgi secretory vesicles to the plasma membrane during exocytosis.
Statistics
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PSSM-Id: 464733
Aligned: 45 rows
Threshold Bit Score: 335.487
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5YFP_B               80 RDPLnG-------QEMSKELQ-H-LPndsmrlnylVNSKQFNVKAFLRDMHKQDSFNDLNNSLDRLDSDIQDQ-SIHLKQ 149  Sacchar...
EEN68501            126 EDPL-GmsmegncNEVSVYICsipg-------sgdPSNEKFLSEWFLIENHHHTSFDDLKTGLSYLKRKSSQR-SEGPLA 196 
XP_002746327        132 ANPL-Giei--ekSKFSQKDLe-mLFhgm---sadFTSENFSAAWYLIENHSNTSFEQLKMAVTNLKRQANKK-SEGSLA 203 
XP_002436201         81 EDPL-Gisd-esvRRFPEEELr-qLFpeg---sgnLLSENFNPTWYLLENYNSTSFSDLKAGLMSLKRKVGQL-QEGPSS 153 
EFN62457            126 EDPL-GlsvegndKKFPEDELt-eLFgdg---sgdLTSEKFHPGWFLLQHHHATTLEDLKAGLAYLRRKVNSQ-KEGQLS 199 
WGS:AAPP:GF21589-PA 126 EDPL-GlsiegneQKIPEDLRd--LFpda---cgdLSQENFSPAWFLLENHLATSFEDLKAGLSYLKRKVESQ-KEGQLS 198 
XP_001843214        126 EDPL-GlsiegndKKFPEDLRd--IFpdg---sgdLSQENFLPGWFLLENHHATSFEDLKAGLSYLRRRVESQ-KEGQLS 198 
EFA11086            125 EDPL-GlsvegndKKFPEDDLm-tYFpdk---sgdIASGNFSPGWFLLENHHATSFNDLQAGLNFLRRKVEGQ-KEGQLS 198 
XP_002936472        132 ANPL-Giei--dkQKIQSQAIeS-LFpgm---sgdFNCENFSATSYLITNHSTASFEQLKTAANNLRKQASKK-NEGNVA 203  tropica...
XP_002127048        129 TDPL-GlnseelgHKTQAYMQladLFgkg---spdPTDQNFEPSWFLLERHCNTSFSKLKEGHAYMKRKANRNtNNAPLN 204  vase tu...
5YFP_B              150 LVGKNFTKYVKIKNKLDQIYKEFDEKTneknqcdspkenqinVESLNKKVDEVIRTTTFKLKPLMDNYQKILNYQATKKF 229  Sacchar...
EEN68501            197 FMKGNLTSIMDCQDALAAMHQDLLKDEstseg-------gsitEKLETLLNNANDKANAMYQDVLGRKDKADATRNALNV 269 
XP_002746327        204 YVKGGLSTFFEAQDALSAIHQKLEADGtekve-------gsmtQKLENVLNRASNTADTLFQEVLGRKDKADSTRNALNV 276 
XP_002436201        154 FLKSNVNAIVICLDVLHELQKAMEKDKqemg--------sdltEKLSEAVLRSKEEAENIFESILARKDQADSTRNALSI 225 
EFN62457            200 FLKANVGAVMEQLDTIMSLKDQFEADMksyg--------sdptEKLEKAIRQSMSEANKLFDDVLARRDRADATRNALAV 271 
WGS:AAPP:GF21589-PA 199 FLKSNAGSVIDQLDTLMNIRDKLQEDVklhg--------neplNILEASIENSITESQKIFTDVLVRKEKADSTRSVLFA 270 
XP_001843214        199 FLKSNAGSVMDQLDTLMALRDRVSQDTklyg--------kdqvKDLEVAIQKSIDASHELFKDVLSRKEKADATRAALSA 270 
EFA11086            199 FLKANIGSVMDQIDTLVNLKEKIEGDVakfg--------teptLKLEKSIKESEREGRKLFDDVLARRDRAEKTRNALNV 270 
XP_002936472        204 YVKGGLSTFFEAQDALAAIHQKLEADGtekv-------egsmTQVLEKVLKSASTTADTLFQEVLGRKDKADSTRNALNV 276  tropica...
XP_002127048        205 HVKDSLPVFFEVHETLSGIHHKMQRDEggrkn-------gnltDKLESTLNEASENANKLFDTVLSCKDRADSIRNTLNV 277  vase tu...
5YFP_B              230 IELNKFYFNLPKSLKRCLTNNDFNEFIIEYSKGLTLRRRfnqssdaSQSLVIKRIWTQIENLLVTYKDLIWNSLINsnfn 309  Sacchar...
EEN68501            270 LQRFRFLFSLPGSIERNIQNGDYDIVINDYAKAKSLFAD-------TEVQVFKRVYLEVEKQIETFRGQLTEKLMQlpss 342 
XP_002746327        277 LQRFKFLFNLPLNIERNIQKGDYDVVINDYEKAKSLFGK-------TEVQVFKKYYAEVETRIEALRELLLDKLLEtpst 349 
XP_002436201        226 LQKFRFLFNLPVTIEKNIQKGDYDVVINDYNRAKSVFQD-------TEVAVFRRVFQDVEQRVQRFRNALMDSLKQlpmp 298 
EFN62457            272 MQRYKFLFCMPINIERNIKRGNYDLVINDYARVKNLFKN-------TEVDVFRKVLEEIDDRINNFKVLLRKRLEEmsfs 344 
WGS:AAPP:GF21589-PA 271 LSRHKFLFCLPNSVDRRAKAGEYDIVVNDYSRAKNLFGK-------TEIPIFRKVLEEVDQRILSIRKQLHEKVVKmpqs 343 
XP_001843214        271 LSRHKFLFCLPNSVEKSAARNEFDIVVNDYARVKNLFGK-------TEVPIFKKVLEEVDLKILGIRQQLHGKIKEmpqg 343 
EFA11086            271 LARFRFLFCLPCVIDRNIKKGEYDIVINDYIRVKNLFNK-------TDVPIFKSALNEVDKRIADLKKKLLTDLQTmpit 343 
XP_002936472        277 LQRFKFLFNLPLNIEKNIQKGDYDVVINDYEKAKSLFGK-------TEVQVFKKVYAEVETRIESLRNLLLDKLLEtpst 349  tropica...
XP_002127048        278 LQRFKFLFNLPLNIEKNIQRGDYGVVINDYEKAKSLFSE-------TDVDVFKKVFAEVEKRIEKFREQLKQEVQElpsp 350  vase tu...
5YFP_B              310 idqpqetILSLFSKLLNLeNfINNnqresesgnkntTsssnenPILRWMSIKMNGFQNELNELSGHMISKIIHSQRL--I 387  Sacchar...
EEN68501            343 ----ldeQSKLIRYLMDL-G-EPG------------D------PAWDCLVNQQKWLLQLLFSCKEEHIKQGLCYSQAtfp 398 
XP_002746327        350 ----lhdQKRYIRYLSDL-H-APG------------D------PAWQCIGAQHKWILQLMHNCKEGYVKDLKGSPGLhsp 405 
XP_002436201        299 ----veeQKRLIRYLISL-E-VPG------------S------PAWDAVRHNYNWLLNSVETCKQKHLSVCKSLHVYlsv 354 
EFN62457            345 ----leeRKKIIRNLVNL-D-AEG------------D------PAWDAIVSHANYLEKCIVNVVPEHLDAVNYEDTSktc 400 
WGS:AAPP:GF21589-PA 344 ----veqQKKLIKALTSL-E-LQQsgtpigdklrniD------PAWDAIEARAKYLEATFRQTFEQHANKDAGPQEKsks 411 
XP_001843214        344 ----veqQKKLVKALISL-E-AQQagtsvasrlkieD------PAWDAIEARAKYLEDTFLKSYEQYTGKEGTPESKsrs 411 
EFA11086            344 ----veqQKRLIRYLVNL-D-CTE------------D------PAWRAIESRSAYINKNIKQIYGEHNVEKPDPRSKsns 399 
XP_002936472        350 ----lhdQKRYIRYLSDL-H-APG------------D------PAWQCIGAQHKWIVQLMHSCKEGYVKELKGTPVLqsP 405  tropica...
XP_002127048        351 ----lhrQKKLIRYLLGL-G-ESG------------D------PGWECLVHQHGWIQESMIKCKDRHIKT---------- 396  vase tu...
5YFP_B              388 LQNNTNQDksqgcVELSYYLkinqlfqiisdtgkdseglkstvepnkvntisgTSYLNLNCQPSSQGLTDSPTIIEMWLL 467  Sacchar...
EEN68501            399 -----------mlLCLQRFLislh-------------------------lpsgHSSVKRMPSFGSTQSPDQAGWKFKTPQ 442 
XP_002746327        406 -----------mlDLDNDTRpsv---------------------------lghLSQTASLKRGSSFQSGRDDTWRYKTPH 447 
XP_002436201        355 ------------------------------------------------------------akGDEDERKRSEESHPDLPR 374 
EFN62457            401 ----------------------------------------------------------ksISLNIKHLRLEKTNGNNPPT 422 
WGS:AAPP:GF21589-PA 412 ----------------------------------------------------------------------rdRDSSQAPS 421 
XP_001843214        412 -------------------------------------------------------------------------dpNATPV 418 
EFA11086            400 ------------------------------------------------------------tsKYSKYNPPPQNDLNTVPA 419 
XP_002936472        406 LLDIDSDGrpsplGRLSQN-----------------------------------TSLQRG---SSFQSGRNDTWRYKTPH 447  tropica...
XP_002127048        397 -AFKCTENldeagKVQ-----------------------------------------VCH-------------------- 414  vase tu...
5YFP_B              468 ILKYINDL-WKICDQFIEFWEHIEKFLDGTYQNsiinekrkeniligdsniiESYQKSLILKEEQINEVR---------- 536  Sacchar...
EEN68501            443 RVQFVDDLtDVLLENFPDLWKLWEGYSTGSLLN-------------------EAAEKTDVANQEKESKFK---------- 493 
XP_002746327        448 RVAFVEKLtKLVLSQLPNFWKLWISYVNGSLFSeta-------------eksGQIERS-KNVRQRQNDFK---------- 503 
XP_002436201        375 QVLFVEEVtALFQKHLCDFWKLGLSYFAGDFLV---------------------EDASVNDRERDEKELR---------- 423 
EFN62457            423 QISCIETIcDIVVEQLPDLWRLGQSYFTGQLHV--------------------------AVDVEKQGHFK---------- 466 
WGS:AAPP:GF21589-PA 422 RVNFCEELcDIAASQLPDLWRLGQLYFTGELRG---------------------------PHDPKPGDFK---------- 464 
XP_001843214        419 RVQFCEEMtEIAASQFPDLWRLGQAYFTGELRG---------------------------AGQPKPGNFK---------- 461 
EFA11086            420 NVNFIDEIcLSISETFPDLWKIGQAYFSGELRV--------------------------KIEPGRHVEFK---------- 463 
XP_002936472        448 QVSFVDKLtKVVVGQLPNFWKLWISYVNGSLFS------------------------------------Etaeksgqmek 491  tropica...
XP_002127048        415 --QYLEELtSIATSQIPEHWNLWQHYSTGVILSetg-------------eksSDVENLKEMASKHSKQMK---------- 469  vase tu...
5YFP_B              537 -------------LKGEEFITSVSQNLISFFTsSQSSLPsslkdSTGDITrsnkdsgSPLDYGFIp-------------- 589  Sacchar...
EEN68501            494 -------------KMVEEVMSVYSKLL---RA------------------------------AFLpetlsslpkeqraky 527 
XP_002746327        504 -------------KMIQEVMHSLVKLT---RG------------------------------ALLplsirdgeakqyg-- 535 
XP_002436201        424 -------------EMVASLVGQLSWEV---RV------------------------------ALLppthhslakqahrvs 457 
EFN62457            467 -------------NLVLSSMQRAMEAIKSICShdvd-------------------------------------------- 489 
WGS:AAPP:GF21589-PA 465 -------------RIILNAIEKYCVYL---RV------------------------------AILiaadqralrqssgln 498 
XP_001843214        462 -------------RIILTVIEQFCSYL---KA------------------------------ALLpagnqrtllastmkg 495 
EFA11086            464 -------------HIVMTIMESFCKSI---RS------------------------------SLIpntldkadksalg-- 495 
XP_002936472        492 skknarqrqndfkKMIQDVMQTLVKLI---RG-ALLPFSl----EEEELKhfg--gwEVKSELFGp-------------- 547  tropica...
XP_002127048        470 -------------GLLRDTVILFVNLL---RA------------------------------AFLpatlhvdddedlher 503  vase tu...
5YFP_B              590 ----------------pNCNGLSCLRylpkivepilKFSTELAQLNITTNGITICRNTLSTIINRCVGAISSTKLRDISN 653  Sacchar...
EEN68501            528 ---gvwpegkydnmahwLPQFVRTIR----------SCNSTLSGMNLPDETTHDVRDVAQDTRVHCVTTLLQQATEDVKA 594 
XP_002746327        536 -----gwevkcelsgqwLAHAVQTVR----------LTHESLTALEIPNDLLQTIQDLILDLRVRCVMVTLQHTAEEIKR 600 
XP_002436201        458 ---awpghktneklgpwLPQCLRSIR----------QCYLSLLKLDIPEENTSLVQRLIFDLRVHSMTCLFGQAAEDVRN 524 
EFN62457            490 --------------akwLLHILRCVR----------QMYASLIHLDLPSEALDIFGAFILNLRIQCLIALFKQGADNIIA 545 
WGS:AAPP:GF21589-PA 499 --wpigsasathqflpwIPQCLRYTR----------IAYATLITLDLPSEALDIIQKLIDEVRLFCFSIIFKRATDRCKK 566 
XP_001843214        496 lptwpasnlslnylitwLPHCLRYVR----------VSYATLIRLDLPGEALDIVLKFIDELRLYCLSTILKKANEKVKK 565 
EFA11086            496 ----swtipeleevapfLPEILRCVR----------STYIALIKLDLPSEALDIVSSLLLDLRIHCMSTLFKQAAEQIKQ 561 
XP_002936472        548 ----------------wLMHVVQTVR----------LSHESLTALEIPNDMLQTIQDLILDLRVRCVMVTLQHATEEVKR 601  tropica...
XP_002127048        504 e-sygvwpsevplpatvLYDCVRAAR----------QCLIELSSLTLPHGTLQSLNDVIHDLRVLSLSTFLQEATDDIRG 572  vase tu...
5YFP_B              654 FYQLENWQVYETVtfssksqdssknltfEYGVTQFPEIVTSFQEVSIKTTRDLLFAYEKLPIINGISVvSYPSKQLLTGI 733  Sacchar...
EEN68501            595 LNDRETWTVERDD---------------RGGITALPLLFENIITELIQHLKEVVQSRAEESE--IFRR--ADTRMKVSKL 655 
XP_002746327        601 LAEKEDWIVDN------------------EGLTSLPCQFEQCIVRSLQSLKGVLECK--PGEASVFQQ--PKTQEEVCQL 658 
XP_002436201        525 LLKSEVWRLEKDDr--------------CGGTTQLPLMFENRVVETLQLVRENILQSG-PREMEVFEQ--INVQGTIKQY 587 
EFN62457            546 LNREETWQIEYLNe--------------DGGVTKLPYLFEETVVKISRHARETVIACG-PREGPLFNN--PTHQLLYHNT 608 
WGS:AAPP:GF21589-PA 567 LGSQETWEMGVEE---------------YPGATLLPGALEALLIETLDEVQSVCMQTE-SREGNLLEP-QSDGQREVSQR 629 
XP_001843214        566 LHEKETWEFPVAD---------------FAGATGLPSKLEEILTEAIDDAQVICLTPE-IRETSLLEP-QSDGQREMSKR 628 
EFA11086            562 LN--ENWKIDFSGn--------------HVGITELPIKFERIIQDVIQIVKESVLSTE-QRETPLLEN--PTAHKELDKQ 622 
XP_002936472        602 LADKEDWIVDNEG------------------LTSLPSQFEQCIIQALQSLKGVIECK--PGETSIFQQ--QRIQDDLCYL 659  tropica...
XP_002127048        573 LRMKETWEVSN------------------KGVTALPSQFHNITVALVSVVRDVLESL--PGEEPVFAR--VAVQSRVTQD 630  vase tu...
5YFP_B              734 EIQQIISMEAVL-EAILKN-------AAK-----------DKD-----N---------PRNSHTILTLTNLQYFRECAFP 780  Sacchar...
EEN68501            656 CEDMLSVISLGLgPPLPTQppstfpgTLLgletgstflihGLHvh-------------fqERRLVTVLSNCSHTREKVLP 722 
XP_002746327        659 SINIMQVFIYCL-EQLSTKpdadidtTHLsvdvsspdlfgSIHedfslT----------SEQRLLIVLSNCCYLERHTFL 727 
XP_002436201        588 AQAVLQAFVETL-EKCALSpdrlspiIDAigsnveilppgQRAksfkqKreds-lttpPLEKRLLIVLSNCSFTSRVVIP 665 
EFN62457            609 VKMLFTSFTRCL-EQLAFSgcedndeTSvsqli--gspsgYKSktnkhKg-------pTWEQCLLISLSNIRYTLNIVLP 678 
WGS:AAPP:GF21589-PA 630 LQEFLSAFSGVI-EELAFHshdeetpTHNvsqll-gfpnaQQPdsvagGaga----tvTWEQRMLCCLANFAYCNKSFFP 703 
XP_001843214        629 IQELLGTFCGVI-ETLALQrsdedpqQAPmlsqligfpaaLLQqqisgGtdkswgssiTWEQRMLCCLSNCIYCNKVFFP 707 
EFA11086            623 IEAVLVSFHNVLnNLSSDEscdddedTSPvvsqligtpinGYRtnytnNnm------pIWEHRLLITLSNCLYAKNVVFD 696 
XP_002936472        660 CINLIQVFITSL-EYLSTKpaggvdiMHIsadvsspdlfgSIHedttvS----------PEKRLLIVLSNCHFIERHTLL 728  tropica...
XP_002127048        631 FTRLFTTFSSCL-ERCVFIeesesdsSKV-------------------Pqesl----pplEQRLVIGISNLSYTKQNLLH 686  vase tu...
5YFP_B              781 NILQYFDDAFEWNLASKNLELFS--LLSKMESSIFGNYLSDLKINLRDTLEEKF--HEINWPMYTSNSfRVGDYIIEALM 856  Sacchar...
EEN68501            723 KLIDLLEKNGYPEVQ-KVQKVGTniCFSALDEKLFDAYLEQKADPLVGALEPGVyaGYFMWNDCLPPR-GVRNYVKEALM 800 
XP_002746327        728 NIAEHFEKHNFQGIEKITQVSMA--SLKELDQRLFENYIELKADPIVGSLEPGIyaGYFDWKDCLPPT-GVRNYLKEALV 804 
XP_002436201        666 RLQESFERHGYPDMSLVIQTTLS--RLAELDRKLFQKLLEAKCDPIVGAIEPNMyaGAFDWKKCAEPM-GVSSYIKEALM 742 
EFN62457            679 RIEDALKTQGYPELSTAVGWNSDwtQMETLDSAVLEAYLERRCDPLVGTIEPSMylGGLEWDFDIEPT-HLKPYAQEILA 757 
WGS:AAPP:GF21589-PA 704 KIGDIFVLYGYPLPTLAIETARY--TVNQLFTNLLEEYVEHKGDPLVGTIEPSMylGRFQWDHEMEIG-QLRPYAHECCD 780 
XP_001843214        708 KLAGLFTKHNYPVPSIAIENSRS--TVNTLFSSLLDMYVEHKSDPLVGTIEPSMyiGRFQWDQVGPSD-KLSPYAHECCD 784 
EFA11086            697 TILRKFKESGFPAPETPVKNAKD--KLDVLEKTILEKYLEQKSDPLVGTIEPSMylGRFDWDIEITPN-NIRPYAKECIN 773 
XP_002936472        729 NIAEHFEKYGFQAIEKITRASTD--SLKELDFRLFECYIENKADPIVGSLEPGIyaGYFDWKDCPTPT-GVRNYLKEALV 805  tropica...
XP_002127048        687 PLIDHFRQLHFPNIEVTEKTCDS--EFSKLDEKFFEAYVEHRVEPLTGALEPGMyaGSFDWNECLRPE-GVRPYIKTALM 763  vase tu...
5YFP_B              857 ILIVVHSECFRIGPQLIHKILIETQIFIARYlFEAFKPYvgNLSNDGSLQIIVDLEFFQKVMGPLLEKDTEATLRACLQN 936  Sacchar...
EEN68501            801 NLIAVHAEVFSISPLLVERVLSRLLQALAEE-MLRLMECvtGWSADGAIQARLELCALQDALALYKTPESSKSFHDALQM 879 
XP_002746327        805 NIIAVHAEVFTVSKELVPRVLSKVIEAVSEE-LSRLMQCvsSFSKNGALQARLEICALRDTVAVYLTPESKSSFKQALEA 883 
XP_002436201        743 SMIEVHAEVYTISPPLVSRIMTPLAQNVAEE-ISRLYECteKFTKHGNMQATLDLRALEEAVDSYRTQNTGKFFMICRSR 821 
EFN62457            758 NLIAVHAEVRRVAPALLQRILSHIIETIAEE-LARLMSCvtQFRPAGIIQARTDITLLRNALQAYSTTRAKSFFEEALDA 836 
WGS:AAPP:GF21589-PA 781 NLVGVYSEIYSISPALLRPILESIVQTISEE-LARLMSCvqRFSFTGAIQAHVDIRLLRDALEGYVNETAKNYFMEALEA 859 
XP_001843214        785 NLVSVYSEIFSISPVLLRPVLEPIVQTVAEE-LARLMTCvqKFNVNGALQAKVDINVIRDAVRVYSNDTAKSFFVEALEA 863 
EFA11086            774 NVIHVHSEVNSISSSLLESVLPQVVLTIAEE-LYRLMSCvqKFSKGGAQQARADISALQIFFDHYSTPKARSYFQEALDI 852 
XP_002936472        806 NIIAVHAEVFAVSKELVPRVMARIVEAVGDE-LSRLMQCvsSFSRNGALQARLELYALRDAIAIYLTNDSKSSFKHAVEA 884  tropica...
XP_002127048        764 SIITIHAEVYSINPDLVPRFLIQVIQMTSEE-VLRLIQCirKIGTNGSMQARLDIEALQQATAAFESTQSSTNFVEALDS 842  vase tu...
5YFP_B              937 CFqndtnrlqkcineinPIVSANLKRTAIQFAAF 970  Saccharomyces cerevisiae S288C
EEN68501            880 VPpvksaa---drknleELMNKFKSNMQLQLTCF 910 
XP_002746327        884 LPqlssga---dkklleELLNKFKSSMHLQLTCF 914 
XP_002436201        822 LDpfsstk---dkelvdELLKRFRNQMRLQLLCF 852 
EFN62457            837 IPqpvntv---drmridALLSKVTTCMRLQLSCL 867 
WGS:AAPP:GF21589-PA 860 INpplnae---qkrkadEILERVKGNMRLQLLCF 890 
XP_001843214        864 IPqvaes-----edriqDTVRQIKNNMRLQLMCL 892 
EFA11086            853 IPplense----atvvqDILRQCRARMRIQLLCL 882 
XP_002936472        885 LPqlpsgs---dkklleELLNEFKSSMHLQLTCF 915  tropical clawed frog
XP_002127048        843 IPdmssaa---drrfldENINKFKSLLIFQLRCF 873  vase tunicate
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