Q9HU38 1 MKAFGKVLGLFFLGLLLLVvalgFALTHLFDPNDYKDEIRQIARDKANLELDLKGDIG------------WSLFPWLGLE 68 Pseudomonas aeruginosa Q9ZDI1 1 MPKALKYSLIIFITIILLL----IIIPFFIPLNNYKGVLIDKVKEATNRNLTINGDIK------------LSLLPTPTIS 64 Rickettsia prowazekii Q9JY87 8 HKYRLKYAVAVLTILLLAAvglhASVYRTFTPENIRSRLQQSIA-HTHRKISFDADIQ------------RRLLPRPTVI 74 Neisseria meningitidi... Q87TE2 1 MKTARRILILLLVVLIVLP----ATIIALLTTSYANSTWQW-VSPYLGLPIQAERV--------------HYDFPY-HLS 60 Vibrio parahaemolyticus Q9KNJ9 1 MRKILAIGVAGIALLLILV----LAGFGIMHTRYFTPSAQWIVQQLWPETLRFAKI--------------EYLYPF-KLR 61 Vibrio cholerae Q9HUT4 1 MTRGRKILTWSLASLVLLLaa-lVVFIATFDWNLIKPTLNEKVSAALNRPFAINGNLAvawrreegeegwRAWIPWPRFS 79 Pseudomonas aeruginosa P37645 1 MSKAGKITAAISGAFLLLIvv-aIILIATFDWNRLKPTINQKVSAELNRPFAIRGDLGvvwerqkqetgwRSWVPWPHVH 79 Escherichia coli K-12 Q9KT66 1 MKK----LFISLLGLVVLIvgalLALVLLVNPNQFKPLIVEQAKKQTGLDLVIEGDIG------------WQFFPSIGFE 64 Vibrio cholerae
Q9HU38 69 LHDTSIASAATPTKP-----FADLQMLGLSVRVLPLLRKDVQMSAIRVEGLSLDLVRDKQGKGNWENIGKPAQPQAPAap 143 Pseudomonas aeruginosa Q9ZDI1 65 LSEIKLSSINGAKVPh----LVSVEAVKASLRLFPLFRGVIEVALIELQKPTISLEVLDNGQKSWQLYISNNNNTINN-- 138 Rickettsia prowazekii Q9JY87 75 LKNLTITEPGGDQT------AVSVQETKIGLSWKNLWSDQIQIEKWVVSSAELALTRDGKGVWNIQDLIDSQKRQASV-- 146 Neisseria meningitidi... Q87TE2 61 LQNVRSQDAQ----------LPYIEQVDVWLNPDIRRDGKWIIDSLLIDGVSLKKGIPTQPNL---ESIQFHQIALKNid 127 Vibrio parahaemolyticus Q9KNJ9 62 LSGVQIASEP----------TIELQQMDLWLNPYGLLEQQLEIDSVLIDGANLAHGL---PNFTLPESVHLNQLALHNid 128 Vibrio cholerae Q9HUT4 80 AEDITLGNPEWTAGKtkaseFASLERIEFRLAPLPLLWQTIRIPQIKLTQPRAELLRLADGRANWDFDLPASDSDEPS-- 157 Pseudomonas aeruginosa P37645 80 AEDIILGNPPDIPEVt----MVHLPRVEATLAPLALLTKTVWLPWIKLEKPDARLIRLSEKNNNWTFNLANDDNKDAN-- 153 Escherichia coli K-12 Q9KT66 65 LGKTELKNPQGFASPn----LFKVESVGIDVSVMPLLDKQLKIGNIRLDGAEFHLETLKDGRSNLDALTQAQSKPASApa 140 Vibrio cholerae
Q9HU38 144 setppaadgkgaqaqAPEQAPQNDSPRTPIKLDIDSLNVNNARVTYTDEASGKQYNVEGIELSTGAIREGSsiplklna- 222 Pseudomonas aeruginosa Q9ZDI1 139 ---------------NNTVQSNYTQTVLELPILISHLKIKGGKVIYIEKNNEKIFNDINLETKMKSIKGPIdftialnal 203 Rickettsia prowazekii Q9JY87 147 ----------------------------------NRIIVENSTVRLNFLQEQLILKEINLNLQSPDSSGQP--------- 183 Neisseria meningitidi... Q87TE2 128 yagp-----rfsvtgLSIQIQDPTWLNAQQLWPYGAIQASAEQMYWHGEAIQKVLVDVDYQAQNSTLYGTS--------- 193 Vibrio parahaemolyticus Q9KNJ9 129 wadq-----giiargVSLQIKQPVWDSPQQQLPYGKIQLAADQITIDGEAFNQVLVDANYQAQDSTVYGFS--------- 194 Vibrio cholerae Q9HUT4 158 ----------------------------AWQLDIREIGFDKGSVSLDDQRLKT-----RLEVLVDPLGKP---------- 194 Pseudomonas aeruginosa P37645 154 ------------------------AKPSAWSFRLDNILFDQGRIAIDDKVSKA-----DLEIFVDPLGKP---------- 194 Escherichia coli K-12 Q9KT66 141 t-----------tdsAPASQPSSSEPAAAWSIELGGVSVSNAVLEITDKKAGSHTKLYDVQLSVAEFVP----------- 198 Vibrio cholerae
Q9HU38 223 -----------------ylgtnqpVVRVKTELTGNLRFDTALRRYQLEDAR-LSGEASGEPLQGKTATFSAq-------- 276 Pseudomonas aeruginosa Q9ZDI1 204 qqqihidghvkeigkiiplstninLAGAKIKIDGKFDSKNNSFIGNANIKG-NTKTLGMPYDLNNDYTLTMsisacskni 282 Rickettsia prowazekii Q9JY87 184 ------------------------FESSGILVWGKLSVPWKSRGLFLSNGI-GPPEISPFHFEASTSLDGHg-------- 230 Neisseria meningitidi... Q87TE2 194 ------------------------FKWRNSQISGQGEQYPQGW-SLVNVTI-DKLAITNAQRQSLLS------------- 234 Vibrio parahaemolyticus Q9KNJ9 195 ------------------------FNWRNSPISGQAEQYPQGW-SLINVTL-SRLNLNLDEWRHH--------------- 233 Vibrio cholerae Q9HUT4 195 ------------------------VPFGQLAGKALATGDAANAQDYVFGWK-VKGTYKGQALAGSGKVGGM--------- 240 Pseudomonas aeruginosa P37645 195 ------------------------LPFSEVTGS-KGKADKEKVGDYVFGLK-AQGRYNGEPLTGTGKIGGM--------- 239 Escherichia coli K-12 Q9KT66 199 ------------------------DNWTKATFAAKGDKDQQKFAAQGEAEVrLSADFKQYALRNI--------------- 239 Vibrio cholerae
Q9HU38 277 --------gQLLLDQSAQIAEWNGLKLSVNQLRA-LGEL------KARELDKDTKFSGGLSIAP----------MNLREF 331 Pseudomonas aeruginosa Q9ZDI1 283 nirdarlhyPNIELLANTNYDMERNNLESNIIVN-PGNLitkiqsNLDKTNILLQADSLKPILDalklk-tdelPPIINQ 360 Rickettsia prowazekii Q9JY87 231 ---------ITISTTGSPSVRFNAGGADAAGLGLrADTSfrnlhlTAQIPALALRNNSIKIETVngaftaggeyARWDGS 301 Neisseria meningitidi... Q87TE2 235 ---------KPWQELPFTINHINSLDLLNADIEW-GEWHwq--nlELSIEDASLPASLWNA-TAkvslq-adsvRFQEQT 300 Vibrio parahaemolyticus Q9KNJ9 234 ---------SLWQTIAPSIYHINSLDLLNSQLTL-NGVAwe--nlNLSVEDYDLRHSLWQQQQAylsln-adsaQWLATQ 300 Vibrio cholerae Q9HUT4 241 ---------LALQDASKPFPLQAEVSAGSTRAAV-VGTLtd--plNLGALDLRLKLSG----------------TSMANL 292 Pseudomonas aeruginosa P37645 240 ---------LALRGEGTPFPVQADFRSGNTRVAF-DGVVnd--pmKMGGVDLRLKFSG----------------DSLGDL 291 Escherichia coli K-12 Q9KT66 240 ---------NLDASFSDPSNQIDSAKLKLDTFEF-DKANaltfsvAGKAADMKLNAQGSASLMVnqais-kvglDALKLQ 308 Vibrio cholerae
Q9HU38 332 LAGIGVTLPAMADANTLGKFELNTRLAGSRNSLNLEDLKLGL-------------------------------------- 373 Pseudomonas aeruginosa Q9ZDI1 361 KLILTTNVIRDPQAIKLQNINLSATNSNITGEIVLKNLTENIiilhnlkinnfelfmsligvnnlskigilqlngevqkv 440 Rickettsia prowazekii Q9JY87 302 FKLDKANLHSGIANIGNAEISGSFKTPRHQTNFSLNSPLVWT-------------------------------------- 343 Neisseria meningitidi... Q87TE2 301 AIEPRLNAIFTPENIQLQELSLDWQQGRVQVSGQFKPTHWQL-------------------------------------- 342 Vibrio parahaemolyticus Q9KNJ9 301 WVEPSAELTLTPQGIELDGHSQVWQ-GDVQVKGHITETSLNL-------------------------------------- 341 Vibrio cholerae Q9HUT4 293 YPLTGITLPDTPAYSTDGHLLARLKEEGGALF------------------------------------------------ 324 Pseudomonas aeruginosa P37645 292 YELTGVLLPDTPPFETDGRLVAKIDTEKSSVF------------------------------------------------ 323 Escherichia coli K-12 Q9KT66 309 AELEGAALPQSPMKLSLDS-QIAFDLTQNHLSVLLNKLTA---------------------------------------- 347 Vibrio cholerae
Q9HU38 374 -------DDTAFSGR--FGIADF----------ARQSLRAQLKGDKLDLDRYLPAKAKqaqdAASATRKAEVDATVASAA 434 Pseudomonas aeruginosa Q9ZDI1 441 kdtfninNKISVLNTniSIKGDInlanqkpkanQKPNFNLKLYSPLVNLDKIFSSNSA----INTSNKTNNPSNHNIDTD 516 Rickettsia prowazekii Q9JY87 344 -------ENKGLDAPrlYVSTLQdtvnrlpqprFISRLDGSLSVPNLQNWNAELNGTFdrqtVAAKFRYTHEDAPHLEAA 416 Neisseria meningitidi... Q87TE2 343 -------DTASVQGLkwVIQSDDnkdw---wkaATSALQ-EVDIQELDIERSQIIQLA---------HEPFWQLSGLNVE 402 Vibrio parahaemolyticus Q9KNJ9 342 -------AQLTITGVkwIAEQPQdllp---fsqPLPAWQ-NLQIEHLDINNLQMIQTV---------NRPFWQASGLNAD 401 Vibrio cholerae Q9HUT4 325 -------RYENFNGK--VGASDLhgsltfvarqPRPKLSGKLTSEQLRFADLGPLIGA-------DSNAEKQKRGQTSRQ 388 Pseudomonas aeruginosa P37645 324 -------DYRGFNGR--IGDSDIhgslvyttgkPRPKLEGDVESRQLRLADLGPLIGVdsgkGAEKSKRSEQKKGEKSVQ 394 Escherichia coli K-12 Q9KT66 348 -------NALSFDGKadVTLADI------------PKVRFNLHSPEIDLDAFLGTKAQ----ESQPAPAKEAAASSSSAP 404 Vibrio cholerae
Q9HU38 435 QGNTPLPEKPT-RQAWSDAPLlpiatlrkldlDVA--LNFGRLTV-EKLPIDDASLKLRGQGGVISLDDMRGGLYNGRFN 510 Pseudomonas aeruginosa Q9ZDI1 517 KNNSPWSNNRInLGFLNEIEG-----------QLS--ANIDKVTN-NSLIINNLKAKLNIIGGKLNINAVNGSIYGGELN 582 Rickettsia prowazekii Q9JY87 417 VALQKLNLTPYlDDVRQQNGKifpdtlaklsgDIEahLKIGKVQL-PGLQLDDMETYLHADKGHIALSRFKSGLYGGHTE 495 Neisseria meningitidi... Q87TE2 403 GKALKLKRQHRfWGVWHG--------------SLD--ASVVNASY-DQVLSSHAAISTQSEQGLWQLSRLFAPLEQGYIE 465 Vibrio parahaemolyticus Q9KNJ9 402 GKNLQWVKESQ-WGFWQG--------------QLS--VTANSASY-AGVLSTQGVLNMRSEQGVWQLTRAFLPLERGYVE 463 Vibrio cholerae Q9HUT4 389 PGDKVLPVEEFrTERWRDMDA-----------DVE--FTGKRIVHsDQLPISDLYTHLVLNDGLLRLEPLRFGVAGGKLE 455 Pseudomonas aeruginosa P37645 395 PAGKVLPYDRFeTDKWDVMDA-----------DVR--FKGRRIEHgSSLPISDLSTHIILKNADLRLQPLKFGMAGGSIA 461 Escherichia coli K-12 Q9KT66 405 ATNAPAEVEPDlSALKAL--------------DVAgeISIDKFKA-SNAHLQNVKANFAVNRGVVDLKSFTANLYQGSVQ 469 Vibrio cholerae
Q9HU38 511 AKANLDvRQDSAVLTATKHIANVPVERLLEAQGKKPPVKGLLDLDADIRTSGNSEKSWIDHLNGNARFSLINGVLP---- 586 Pseudomonas aeruginosa Q9ZDI1 583 STGYIN-SGKEQDVAIKINLKNAYLKRLTAQSSKIKITDGLLSFTIDLTSHGNSVYTYVNNLNGQFNINSDNGEIS---- 657 Rickettsia prowazekii Q9JY87 496 GGISIA-NTRPATYRLQQNASNIQIQPLLQDLFGFHSFSGNGDAVIDLTAGGETRKELIRSLQGSLSLNISNGAWH---- 570 Neisseria meningitidi... Q87TE2 466 GFGQLDlSTASQPWALNLSADGIPLKLLHPYLPDAFAVDGFSDLNLDLQGLSGDNNMLAYSLTGQVEANLRETTLR---- 541 Vibrio parahaemolyticus Q9KNJ9 464 AHAKWDlTSLSAPWQLSLDADSLPIGPLQSWFKLPFGLEALADISLTAQGIAGDRTMLAHSLDGQLQLNLRQGLLS---- 539 Vibrio cholerae Q9HUT4 456 SDIRLDgGKQPMQSRVKMSARGFKLKQLFPGFAPMQTSFGELNGDASLSGSGNSVAKILGGADGELKMLINDGAISkglt 535 Pseudomonas aeruginosa P37645 462 ANIHLEgDKKPMQGRADIQARRLKLKELMPDVELMQKTLGEMNGDAELRGSGNSVAALLGNSNGNLKLLMNDGLVSrnlm 541 Escherichia coli K-12 Q9KT66 470 ASAQVDaRKTPATYSVKKQIKGVQVKPLLKDVLNNEMLEGTGNIDVNVQGQSLTPSGIQKNLVGTVAINFADGAVK---- 545 Vibrio cholerae
Q9HU38 587 ---DANLEQQLCQGIATlnr----kaLAGTHGGKDTPFRELKGSLNFTNGVASNPDL 636 Pseudomonas aeruginosa Q9ZDI1 658 ---GFDLNQIAHAIDNAkniegvlslINSSFRTGSTSFKNLIVHGNLKQGNLNLNKC 711 Rickettsia prowazekii Q9JY87 571 ---GIDMDNILKNGISG---------KTADNAAPSTPFHRFTLNSEISDGISRHIDT 615 Neisseria meningitidis serogroup B Q87TE2 542 ----------------------------SQADKSLKSITFSPIRVHAQRGAVSLKPV 570 Vibrio parahaemolyticus Q9KNJ9 540 --------------------------LRSDNTLIIQPFELDDLAVSADRGRITITPT 570 Vibrio cholerae Q9HUT4 536 eiaGLNVGNYLV---------------TKLFGDDEVKINCAAADFGLQKGLMTSRLF 577 Pseudomonas aeruginosa P37645 542 eivGLNVGNYIV---------------GAIFGDDEVRVNCAAANLNIANGVARPQIf 583 Escherichia coli K-12 Q9KT66 546 ---GINVAHLIRTHYAKikg----qnVEEADAVKKTDFSAMTTTLKLNKGEVTTNDL 595 Vibrio cholerae
Jiyao W et al.(2023). "The conserved domain database in 2023.",