Conserved Protein Domain Family
TroA_f

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cd01139: TroA_f 
Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind their ligands in the cleft between these domains.
Statistics
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PSSM-Id: 238559
Aligned: 12 rows
Threshold Bit Score: 405.152
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative ligand
Feature 1:putative ligand binding residues [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                               ##                       #                           #  
AAM05546     44 ITVTDMEGRSVTVKvPVERIVLMESSKTHELAAIDGaaIVDKIVGWDNDFKdnAGDGYVKFIERYPKLAdVPNVGsLDDN 123 Methanosarcina a...
NP_670175    39 ATVTDMAGRTVTIPaKVERILLGEGRLFYAVSLLEGnkPLDRIVGWQGDFRklDPQTYAIYKAKFPQIDqIPLIGnTTAD 118 Yersinia pestis KIM
NP_357214    27 VTVKDVTGRDVEVNvPVSHVILGEGRQIYFLAALDKenPFQHVVGWRDDLAkaDPETYAAYLAKYPDIAkLPTFGgMKDG 106 Agrobacterium tu...
CAE16110     28 ITVKDVAGRKVKIDaPVSRVMLADSRILIALNILHPdnPLKGIVAWDNALEikSPDLATTYEKDFPQLRdIPVFPnPYHS 107 Photorhabdus lum...
NP_617071    37 ITVTDLAGRTVSLKvPAERVVLGSSRDLHEFAAVEGenFSNKIVGWGPDLRksDKDTYDKFGEKYPEIKnIPEVGyYGSQ 116 Methanosarcina a...
NP_357215    24 GEITDVTGRKVELDlPAKRVIVGEARQVHVIAALRGdhTFDTIVGWRDDLLkkDPDSYAAYVERFPEIEkLPRFGyVPQG 103 Agrobacterium tu...
NP_901159    24 AAVTDIAGRKVEVPaKVNRILLGEGRLFYSLALLEGkqPLARIAGWQGDFRqlDPQTYAQYKKRFPEIDrIPLIGqTSEN 103 Chromobacterium ...
NP_670641    21 KTITDITGQRIEIPdNPQRIVLGESRMLYTLALLEPgyPAARVVGWPLDLKkyDPQSWALYTDKFPQMThIPALGsTGLR 100 Yersinia pestis KIM
NP_386377    35 MTVTDAVGRQVTIPaPPKAVLLGTGFNLVALSLIHPd-PVSLLAGWSGDMKadNPEIYESYLRKFPKLAdVPLIDdGSGP 113 Sinorhizobium me...
NP_938504    43 LTVTDVAGRTVEFDkQPERVLLGEGRAMFAASILDKenPGEHIVALGEDLHqgAPSFEAKLFEAHPEIKdIPVIGhIAKG 122 Corynebacterium ...
NP_404936    38 IHLKDVDGREVTLAaPAQRVYIGFYYEDFLAINGPDs-YQHVVAFSKSDWSl-RTSQWPRYQAALRRLSqLVDVGsLYNQ 115 Yersinia pestis ...
ZP_00099025 166 ITIKDVKGREVTLDlPISSYAISTMDVIDYIIPLKGeeAFAMLVASGQDGGggIQKYAQLYKPIVGDYTqHLGQIsDHNA 245 Desulfitobacteri...
Feature 1                       # #                                                             
AAM05546    124 TFSVEKVIAlNPDVVIMHNWEfmwsgdatkeALVKLEQAGIPVIFVDFYme-pMTNSTKSMLLLGQILGKEQRAKDIVEF 202 Methanosarcina a...
NP_670175   119 SISPEKVLTlNPDIAIFGLSGhgpg--kgseLVKQLEKAGVPVVFVDFRns-pLKNTLPSMRLLGKALHREQQAENYINF 195 Yersinia pestis KIM
NP_357214   107 TFDIEQAISlKPDVILMNIDAktat--qeagYIEKLEKVGIPLVYVDFRek-pMENTEPSMRLMGKLTGKEKIAEDFIKF 183 Agrobacterium tu...
CAE16110    108 DFNVEKALTyKPDLVIFDIGLqtkl--ndsgTIMLLEKAGIQVIFIDFHqy-pLTNTIPSMILLGKVFNEEENAQKFIEF 184 Photorhabdus lum...
NP_617071   117 DFSIEKVVSlKPDLVIFPMFDydr----akdDLSKFEQAGIPVVFTDFYqd-tLENSTKSITLLGKLLGKEKRAKEITDF 191 Methanosarcina a...
NP_357215   104 DFSLETAITlSPDVITLNLEAeksa--kesgFEDKAAAAGIKVIYLDFRid-pEKNSEASIEILGKLFGAEERAKEFIAY 180 Agrobacterium tu...
NP_901159   104 SVSAEKVLTlKPDIAIFSISGhgpg--lnnpIVQQLQAAKVPVVFVDFRna-pLEHTVPSLRIMGKALQREAEAERFIRF 180 Chromobacterium ...
NP_670641   101 DINPEKVLElAPDLVILPVLAktth--eeiaLISLLKQAHIPVIRVDLRvd-lLNHTIPSLRLLGEALNRQDRAEAFISL 177 Yersinia pestis KIM
NP_386377   114 GLSFETILTlKADLAVLANWQadte--agrrAMEYLESTGVPVIVVDFNne-vLKNTPDNMRLLGKVFEREEQAEDFARF 190 Sinorhizobium me...
NP_938504   123 NVSVENLLAfNPDVVVMTLDHkkaa--eqngFLAKMDQAGMKYVFTDFRqk-pLENTTKSVEVLGAVLGEQDKAKEFNEF 199 Corynebacterium ...
NP_404936   116 SFDFERLLAtRPDLLILAKWQleg----fanYLPVLQQLSIPYVVVDFNq--gEDAKLTSIRVMGQALGHGERAERLAIA 189 Yersinia pestis ...
ZP_00099025 246 PFDLEMVLSmNPDVLIVNSAMaahk--yaleIEEQLTAAGISIVLIDVPgktlDKSVQETMKLLGKIFQEGEKAAEVAAF 323 Desulfitobacteri...
Feature 1                   #                                       #                           
AAM05546    203 YNQHVEAVYSRLEts-dgLKPGVYIETGy--nGPETYGITE-GDVGWGSIVKKAGGENIAepllgnTSKALSPEYLIn-Q 277 Methanosarcina a...
NP_670175   196 YQDNVDKVTDITNkipedKKPSVFIELRa--gASEECCGTA-GKGNMGDFIDQAGGNNIAknllpgSLGTVNLEKVLa-A 271 Yersinia pestis KIM
NP_357214   184 RADSIAKVTDTLEka-npKKPVVFVERAg--gYSDDCCMSF-GNENFGKMVELAGGINMAkdiipgTFGNVNPEQIIa-S 258 Agrobacterium tu...
CAE16110    185 YQERMKIINQRVGtlgkeQRPPVFIERHagmlGAEHCCKTF-GNGNFGEFVTAAGGDNLGarwfsgIDGEVNEKQLIv-S 262 Photorhabdus lum...
NP_617071   192 YDEQTDIVYSRLSki-nkTKPKVYIESGw--kGASEYGRTY-SSLGWGPIVDKAGGDNIArnf-tsESATVAPEFLId-A 265 Methanosarcina a...
NP_357215   181 RRAEIARVTDRLAgvkdlKRPKVFIERApgisGEDNCCRTF-GPVNFGAMVDLAGGHNIAdgiiktTFGDLNPEQLVi-A 258 Agrobacterium tu...
NP_901159   181 YQSRIDAIRNTVAaipaqQKPKVFLDLRa---AAFPNVTSA-GKGSLGELVDAAGGVNIGdklipgAVGEVNMEHVLa-A 255 Chromobacterium ...
NP_670641   178 YQSHMDRIHQRIAay-qgPHPSVLLQLHl--gRGDECCTTT-LKGNLGQLLEFAGGNNIAaaqvkgVFGQLSEEYVLa-R 252 Yersinia pestis KIM
NP_386377   191 YEERLARIRERVAgs-sePGPKVLMEAFp---APDRCCWAY-GVGGLGEFIAITGSRNIAegalprPGGMMNAEAVMa-E 264 Sinorhizobium me...
NP_938504   200 YTKKRDDIIARAKkl--eNKPRTLLWRAa---GLKDCCNTV-KNSNLGDLVNAAGGVNIGdtlidtESGDLTAEKVIa-E 272 Corynebacterium ...
NP_404936   190 YQQGIADIRRRITqa-nlPSPKTYIELGd--kGPGEYSSSY-GSSIWGPLLQQAGANNIAtgv-vtTPSPLRAEYVLs-Q 263 Yersinia pestis ...
ZP_00099025 324 IDKQYELLAAKNLaq-rqNKPKVYYEKSg---YSEVYGSTGtSVSGWGLPIAIAGGDNIAda---vLLDKASAGGSSntL 396 Desulfitobacteri...
Feature 1                                                                                       
AAM05546    278 NPDIIILTGRNWs--TPGSIRMGy----tSTAADTKDTMDa---YIARPGWNtINAVNTHQVYGIYHGYCFSIYNFvaLE 348 Methanosarcina a...
NP_670175   272 KPDIYIASGGKSpgsDAPGVVLGa----qVTPEQAQASLQk---ILGRKGINtLSAVNTGHSYAIWHNYYNSPYNVlaIQ 344 Yersinia pestis KIM
NP_357214   259 NPEQIIITGGNWn-gYVPGGNWVg----vGYGADLKEAHRklenLTKRPAFTgVQAVKDGNVHAIWHQFYNNPYQFvaIQ 333 Agrobacterium tu...
CAE16110    263 NPEFYLMTAANWd--KVRSGSFSvp---lGYTGDLKQSQErlkkLLTRPKLSvLRAFREKQVIALYHQYYDTPFNIiaVE 337 Photorhabdus lum...
NP_617071   266 DPDIIIITGSNWv-tTPDSVKLGy-----YANQDSSKDLLk--aYLQRPGWDsLQAVENQEVYSIFHTYDSRIYSFagLQ 337 Methanosarcina a...
NP_357215   259 DPDYVIVTGSNWa--AESDINQFvp---vGRGADMALSRErlanLMKRTPFPeLNAVKRGNVHAVWHQFYGAPYEFfpIQ 333 Agrobacterium tu...
NP_901159   256 RPDWYIGTGSADa-aDKIGVQFGa----dISPAQARASLAr--aAARKPVSA-LAAVRDGRTFGAWHHFYNTPYHIvlLE 327 Chromobacterium ...
NP_670641   253 SPEIYIATGMATagsQAKTLALGp----qVSTAQAQESFRr--vIATQSKLQhLPAIQNGHAWGLWHNFYLSPLHVvaAE 326 Yersinia pestis KIM
NP_386377   265 NPDVYIATSSPGg--KYSGFSIGp-----GVTAEEAETTLt--eSVDKPVMAsIAAVRNGRVHGLWNFFNAVPLNIvaAE 335 Sinorhizobium me...
NP_938504   273 QPEKIIATGGAWa-kDPKKPEVLphvelgYTATDDVAERTle-gLLKTPGFSaLEAPKKGDLHAVFHQFYDSPYNIfaLE 350 Corynebacterium ...
NP_404936   264 KPEVIFLAGGDWp-kMPNAVSMGf-----GAKPETLQQSMt--qYAQRPGWSqFPAIKQTRFYALYHGGVRTLYDYifVQ 335 Yersinia pestis ...
ZP_00099025 397 DPEYVIKADPDYi--ILSGVNDGwl---dSLKQKKEPPQYd---IINRTGWSnLQAVKNNNVYEFAHSTSRSIYAFypCL 468 Desulfitobacteri...
Feature 1                                            
AAM05546    349 AFAKWFYPEEFKDLDPnttIREYHEKFMPIEYSGTFM 385 Methanosarcina acetivorans C2A
NP_670175   345 SFAKWFYPEQFADLDPkktMDSLYSQFLAVEPSGTYW 381 Yersinia pestis KIM
NP_357214   334 EIAKWLHPDLFKDLDPeatFKELHARFLPLDYKSGYF 370 Agrobacterium tumefaciens str. C58 (Cereon)
CAE16110    338 IIAKFLHPKLFEDIDPqadNLYLHKTFTALDGNGVFW 374 Photorhabdus luminescens subsp. laumondii TTO1
NP_617071   338 ILAKWFYPEEFSDVDPeagIKEFHARFMPIDYSGTWM 374 Methanosarcina acetivorans C2A
NP_357215   334 QFAKWFHPDLFADLDPeknFEEFHRKFLPVTYKPGYF 370 Agrobacterium tumefaciens str. C58 (Cereon)
NP_901159   328 AFAKTLQPARFAKLDPdasWQQLHRDFLAIPPQGTYW 364 Chromobacterium violaceum ATCC 12472
NP_670641   327 FFAKTLYPHLFADVSPqdtLQTIYQQFLPLDFTGTFW 363 Yersinia pestis KIM
NP_386377   336 AFASWLRPDLFPDVDPaatLAEINRRFAAVPFEGSYW 372 Sinorhizobium meliloti
NP_938504   351 QFAQWLHPEEFKDLDAvkdFQEFHKKWMPFEFSGVFF 387 Corynebacterium diphtheriae
NP_404936   336 FVAKALFPSAFEDVNPqhnLETFYEEYLPIKADGVFM 372 Yersinia pestis CO92
ZP_00099025 469 KMAKLFYPEEFKDLNPeavLDEFFDQFMLVGSDISTW 505 Desulfitobacterium hafniense

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