Conserved Protein Domain Family
Haem_oxygenas_2

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pfam14518: Haem_oxygenas_2 
Iron-containing redox enzyme
The CADD, Chlamydia protein associating with death domains, crystal structure reveals a dimer of seven-helical bundles. Each bundle contains a di-iron centre adjacent to an internal cavity that forms an active site similar to that of methane mono-oxygenase hydrolase.
Statistics
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PSSM-Id: 434009
Aligned: 125 rows
Threshold Bit Score: 69.7249
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ACR31016      37 QNFVIHRFPIKNHWTRNILGIASRIPd---------HQLRVELVENVFeEETGHFSHSKR-----HLETFVDFGKALGVT 102
Q83DQ9        58 QIFAQQFYYYGYHFPRFLGIIIWRSFd---------DKIRSSVASNLI-DELGIISSENIdpeqsHINVFIQFAKAVGLN 127 Coxiella burnetii
Q117R9        46 QEYAQEYYLQVHYFPTYVSATHAACDd---------LEIRKMLLENLIeEEMGATN---------HPELWLRFAEGLGVK 107 Trichodesmium e...
EKQ70814      36 KHYAIQYFQNVLAFPTYVSAVHFNTPhfg-----tsIAVRQEILENLIeEERGNQN---------HPELWRRFAISLGAT 101
Q2Y5P8        40 RGYAEQYFHNVLAEPTYLSAVHFNTPhfhsednsgdISVRQEVLNNLIsEEHGDKN---------HPALWKNFALALGSS 110 Nitrosospira mu...
Q82UP8        39 RHYAEQYFYNVLAEPTYLSAVHFNTPhfhnvensgdISIRQEVLKNLIdEEHGEKN---------HPALWKAFAFALGAD 109 Nitrosomonas eu...
WP_016483262  47 QDYACQYYRHVAAFPTYLSALHSRIAd---------PELRKPILQNLMeEEGGSPN---------HPELWLRFAEGLGLT 108 Chthonomonas ca...
WP_011520885  39 AAYAGDYYHHVAAFPAYLSAFHSRLEd---------GETRRTVLRNLAdEEISGRA---------HSDIWLDFAAGMGAD 100 Candidatus Kori...
WP_025333868  49 ARWVEQHYAYVGPFADYLAYIYANCPh---------EDAKDFLLQNMWeEELGGDR---------HTDLLIRFGEACGTT 110 Paenibacillus
Q0K012        43 ARWAENHYHYVGPFADYLGYIYARTPdr-------yTEAKDFLLANMYeEEIGGDR---------HTDLLIRFAEACGTT 106 Cupriavidus nec...
ACR31016     103 QRDIDTAPML-PQTQAVIDHnveacnttvhFT---------AGVASVLLLMEGQPpvvSAGNQSMLSVMRDvYRLPPEG- 171
Q83DQ9       128 EADLKNSCPR-DYTRETLNK----------IEnllvhapfmEAMGCMSPGLENAL---SHYSYNIYKGLQNqHRFTEES- 192 Coxiella burnetii
Q117R9       108 RKAVQERQHL-AKTQESVKI----------LQqlshse-ntakgLAALYAYESQI---PEVATTKIAGLKKfYGINSEAa 172 Trichodesmium e...
EKQ70814     102 DTELTDTPAL-PTTTNLVST----------FRniclnt-pfyagLAALYAYESQI---PSVATTKIDGLKRfYGMTDANe 166
Q2Y5P8       111 DKDLARASAL-PGTARLVST----------FRdiclnq-pfyagLAALHAFESQV---PSIASVKIDGLEKyYGMSDPSs 175 Nitrosospira mu...
Q82UP8       110 DASLTQADAL-PETENLVAT----------FRdicine-pfyagLAALHAFESQV---PDIAAVKIDGLAKfYGMKDPDs 174 Nitrosomonas eu...
WP_016483262 109 KSQVLNTAVQ-RETAACVAT----------FQalcgrg-hftrgLAALYAYESQI---PEVSETKIEGLKQhYGIRDVEt 173 Chthonomonas ca...
WP_011520885 101 CDTVRSSQPM-DSVANAIAW----------FRniaatg-traeaLAAFYAYESQV---PRVAEEKSKGLKErYGADRKT- 164 Candidatus Kori...
WP_025333868 111 REKVEAMENLlPETIGLQSW----------CYrmafrenflYATAALVVGLESQV---PAIYRRQTPTLREkYGFTDEE- 176 Paenibacillus
Q0K012       107 RERVIDPDNMsPTTRGLQSW----------CYavamredpiVAVAGLVVGLESQV---PSIYRKQTPTLRDkYQFTDEE- 172 Cupriavidus nec...
ACR31016     172 YEFFVHHASaveraggdhtaVSDLeedHAETA-EILLDTYCTTDELRIQAHRYLDRAIDRRH 232
Q83DQ9       193 LYHFKLHSV-----------LDKE---HGNNLkQSLLPHLKESKINRELLRKGALTAAKAQR 240 Coxiella burnetii
Q117R9       173 LAFFKVHEK-----------ADEI---HSKVTrEALVKLCETN-AQKQEALTAAATAVDALN 219 Trichodesmium erythraeum IMS101
EKQ70814     167 YRFFTVHQS-----------ADEY---HSAAElKLIEEHADTA-EKQSEVLKAAAQAADALW 213
Q2Y5P8       176 YEFFSVHEE-----------ADVY---HSQAEwMLIERFADTP-EKQAEVLAATMRACEALW 222 Nitrosospira multiformis ATCC 25196
Q82UP8       175 YEFFSVHQT-----------ADIF---HSQAEwAIIEKFADTP-EKQAEVLAATRRACDALW 221 Nitrosomonas europaea
WP_016483262 174 LRYFAVHVE-----------ADRA---HRAQEkQLLAQTVCDE-AMAEEALDAAQQALEALW 220 Chthonomonas calidirosea
WP_011520885 165 CGYFDLHKY-----------ADVE---HSRVWgDLLAQELEAHPEQREAALAASEQAAKVLW 212 Candidatus Koribacter versatilis
WP_025333868 177 VEFFDLHIV-----------SDEI---HGERGyQIVLEYART-AEEQQRCIEIVEEATKMRR 223 Paenibacillus
Q0K012       173 VEFFDLHIV-----------SDEI---HGERGyQIVLEHANT-PELQQRCLKICEIGAQMRL 219 Cupriavidus necator H16
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