Conserved Protein Domain Family
DIP1984_fam

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NF038048: DIP1984_fam 
DIP1984 family protein
Members of this family, including the Corynebacterium diphtheriae protein DIP1984, which has a solved crystal structure, are uncharacterized with respect to function. Some members of this family previously have been annotated, incorrectly, as septolysin. This model was constructed to overrule and correct such errors. Note that septolysin O, and other members of the family of cholesterol-dependent cytolysins such as listeriolysin O (WP_003722731.1), are unrelated.
Statistics
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PSSM-Id: 411640
Aligned: 83 rows
Threshold Bit Score: 123.791
Created: 11-Oct-2024
Updated: 3-Dec-2024
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WGS:AACQ:CaP19.715   2 KLAEALNLKKNLERDAGELKSLILKCCQAQTGENPPFDPNELFEQYEEIDKLITDITIKIQRTNNEIKFa--------yD 73 
XP_001525344         2 KLANALKLRANLQTDLKQQESEIRSNLVQQEGLTPSHDSNEQYQKYVLKLGELEKLIVAINYTNTKLRHey-------nG 74 
CCE39645             2 KLASALKLRSNLKKQLSDLRSIISDGLVVQEGMTKP-NPNENYTKYVAKLDELEQLIININDTNIHTTVcf-------kD 73 
WGS:AACQ:CaP19.716   6 KLATALKQRAILTKELSELDDKIQSSLISQVGMKKINDPDKLYLDYVAKSQELAKLVSSINYTNNITPIeldltmgkydN 85 
EDK45094             3 SLGELLKQRSCLTNRASDIRLILYKSCKKQEGDDLPFEVDELYEQYEFLQTRIMELSAQIQAANIGLEF----------- 71 
EER35876             2 NLIEALKLQSQLTKQTNELSVLIEKCCQAQEGDEPPFDPNQLFQEYEDLLQELIELSIRIQTTNNIIKFkyl-----dnP 76 
WP_012671300         2 KLGEALLKKDEYVKKIDNLKKRVKNNVVMKEDNENNEDPNDLIKEYIETNNELSDLIMKINNKENTTRL----------E 71  Brachyspi...
WP_010747700         2 KLAEALLLRRDLNNRLFQLRNEISSSVLVQEGDTLDRSITELFKEYDEINQQYSELVVAINRKNATASL----------A 71  Enterococcus
WP_002310932         2 KLAEALLLRRDLESKLTLLREEIASSAVIQEGDTLDRSIDDLLLDYETTNQEFAQLVIAINQRNAVAKI----------G 71  Enterococcus
WP_004651061         2 KLAEALLLRNDLQTKLASLQQRINNNVLVQEGDQPSEEPNVLLSNTFAVNIELHDLIKRIHSTNAQAKS----------I 71  Acinetoba...
WGS:AACQ:CaP19.715  74 DNksneeplRSMTQAIADIDDLERQINVTDDIIHNGIITK-SYSTKKIADVSHVDVVAYDKTRKKMNERLDKLKLRIQSA 152
XP_001525344        75 QQ-------KSITELILRIKEIKQMISLTELVISRGKAPT-INTASDIRILSCVDMKKYDDKLEQLKLELLNLEMKLEEI 146
CCE39645            74 QN-------VSISELILLKDEVISVIDILNSILQRSEEQR-IDDVACIRMVSVVDRDLYQTKLDAAKDEKLAIEMVLEEA 145
WGS:AACQ:CaP19.716  86 TI-------KTINDALICRDRIFKKLQFVKKISTAGKEQP-LDSKDEIKFVSFIDVDKYDTLAQELNTQFENLNLKLQEI 157
EDK45094            72 DG-------KTMMEHIIEKDILRQHGDFLRDIIRESFPST---HTKEIRDVPTVDGKHYYDKYITISDRLNEVELKIQEH 141
EER35876            77 TP-------RSMTQALADVSKLEALRYSASRIVNNGIITR-GYSNKKIKDVAYADVVKYHKISNEFDKQLNSLSLSIQNA 148
WP_012671300        72 IG-------ISISEAINIKDKLTREIDIYKSILKEVNSKDfRTAKNELKMKVLINVKDIQNEFDKLSKALNDIDIMIQSA 144 Brachyspi...
WP_010747700        72 DSa------LLLMEALEQREQLRRKHALLTQALDETKAAP-RMGRNEIRLVRTIDTKTLTEQLNTTAKQLRELDGKIQQT 144 Enterococcus
WP_002310932        72 EQ-------ETIAAALEKREALRRSHAMLTATLEAAKVAP-RMGRNEIRMIRTIDTKQITDRLNHTAKALRELDGQIQQT 143 Enterococcus
WP_004651061        72 NG-------SSLLEVLNARDRLISQHRIVQQAIDNSRRENaRYSSSEIRWVKVISVSELQKQADEISAKLRQNNLEIQAS 144 Acinetoba...
WGS:AACQ:CaP19.715 153 NWEFDL 158
XP_001525344       147 NWQVDL 152
CCE39645           146 NCQVDL 151
WGS:AACQ:CaP19.716 158 NWQVDL 163
EDK45094           142 NWRDQV 147
EER35876           149 NHEFEL 154
WP_012671300       145 NWNTDL 150 Brachyspira hyodysenteriae
WP_010747700       145 NWLVDL 150 Enterococcus
WP_002310932       144 NWLVDL 149 Enterococcus
WP_004651061       145 NWQIDL 150 Acinetobacter bohemicus
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