4I6P


Conserved Protein Domain Family
Par3_HAL_N_term
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pfam12053: Par3_HAL_N_term 
N-terminal of Par3 and HAL proteins
This domain is about 150 amino acids in length found associated with pfam00595 in eukaryotes. It has a conserved GILD sequence motif. Family members have been found to be essential for cell polarity establishment and maintenance such as Par3 (partitioning defective) and involved in conversion of histidine into ammonia (a crucial step for forming histamine in humans) such as Histidine ammonia lyase (HAL). This N-terminal domain is found to mediate oligomerization critical for the membrane localization of Par-3. It is also found to possess a self-association capacity via a front-to-back mode in Par-3 and HAL proteins. However, unlike the Par-3 N-terminal domain which self-assembles into a left-handed helical filament, the HAL N-terminal domain does not tend to form a helical filament but rather self-assembles into circular oligomeric particles. This has been suggested to be likely due to the absence of equivalent charged residues that are essential for the longitudinal packing of the Par-3 N-terminal domain filament.
Links
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Statistics
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PSSM-Id: 463446
Aligned: 12 rows
Threshold Bit Score: 123.598
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4I6P_A          7 KVTVCFGRTRVVVPCGDGRMKVFSLIQQAVTRYRKAVAKDPNYWIQVHRLEH-GDGGILDLDDILCDVADDKDRLVAVFD 85  
XP_014966258    2 KVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEY-TDGGILDPDDVLADVVEDKDKLIAVFE 80  
XP_002936439    2 KVTVCFGKTGIVVPCKDGKMSVRELIQQAAQRFIKAKEKEPGYWVKVHHLEY-QDGGILDPDDIVADVVEDKDKIIAVFD 80  
XP_015215079    2 KVTVNFGKTGVVVPCKDG-WTVRDLIQQATQRYMKLLEQDGSCFVKIHHLEY-SDGGILDPDDILADLVDDKDKLIALYE 79  
XP_005998452    2 KVTVLFGKSGVVIPCGDGRLTVGELIHQATQRFIKNSEKDSSYCMKVHHLEY-VDGGILDPDDVLADVVDDKDKLIAVYD 80  
XP_021026274    2 KVTVCFGRTRVVVPCGDGRMKVFSLIQQAVTRYRKAVAKDPNYWIQVHRLEH-GDGGILDLDDILCDVADDKDRLVAVFD 80  
EKC37796      126 KVTVCFDRVRVIVPCGDGDLLVKELTEKAILRYKKATGKSNDHWVSVHNLRTiNDGGILDPDDQLNDVVDDREQLIADYE 205 
XP_001943183    2 KVTVCFGSTRVIVPCGRGEILVRDLIQQAITRYKKATGKSSNSWVTVHSLQSqSDGGILDPDDRLRDVADDREQIVALYD 81  
XP_002426515    2 KVTVCFGPVRVVVPCGDGFITVRDLIRQATLRYKKATGKGADSWVVVQSLQT-SDGGILDPDDRLNDVADDREQIVATFS 80  
XP_002110754    2 KITVIFGEIRILVPCSSGDLRISDLIKKAVDRYRKVTKKLPGEGVYVRSVEDaKDHAILDDDDLVNEVLDDRDMVIANYE 81  
XP_014864217    2 KVTVCFGRTRVVVPCGDGNVKVQNLIEQAAMRYKKAIAKDPSYWVQVHRLEH-GDGGILDLDDMLCDVVDDKDRLVAVYE 80   Poecilia mexi...
XP_029695977    2 KVTVTFGDTSVVVPCKSG-WTVRDLIDQATRRYRRILEQHGESAVKTHHLEY-AEGGILDMDDMLSDLVEDRDKLVAIFD 79   torafugu

4I6P_A         86 EQD 88  
XP_014966258   81 EQE 83  
XP_002936439   81 EQE 83  
XP_015215079   80 EQE 82  
XP_005998452   81 EQQ 83  
XP_021026274   81 EQD 83  
EKC37796      206 EQG 208 
XP_001943183   82 DGD 84  
XP_002426515   81 DGD 83  
XP_002110754   82 EDR 84  
XP_014864217   81 EQD 83   Poecilia mexicana
XP_029695977   80 EVH 82   torafugu
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