Conserved Protein Domain Family
HCR

?
pfam07111: HCR 
Alpha helical coiled-coil rod protein (HCR)
This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.
Statistics
?
PSSM-Id: 284517
Aligned: 3 rows
Threshold Bit Score: 1012.36
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_027294751  84 MAPTWASDIPQFQSTFDQDVLERRqLDSQRPTVTMREQDVYGDGQGPGQRGRSLELRVSGALSQQAELISRQLQELRRLE 163
Q8K2I2        27 MAPTWASDVPLVQSPASQDVLERR-LDAQRSTVTTWGQDFCGDGQGLGRRGRSLELGFSSALSQQAELISRQLQELRRLE 105 house mouse
Q8HZ60        27 MAPTWLSDIPLVQPPGHQDVSERR-LDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIARQLQELRRLE 105 chimpanzee
XP_027294751 164 EEVRMLRETSLQQKMRLEAQAMEMDALAVAEKAGQAEAEGLRAALAGAEMVRKNLEEGNQRELQEIQTLHQEQLSSMTQA 243
Q8K2I2       106 EEVRSLRETSLQQKMRLETQAVELDALAVAEKAGQAEAEGLRTALAGAEMVRKNLEEAKHKELEEIQSLHQEQLSSLTQA 185 house mouse
Q8HZ60       106 EEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQA 185 chimpanzee
XP_027294751 244 HEMALASLTSKAEGLERALNSLEMKRAGEIKQLSVAQKETELLRGQLSKTQEELEAQVTLVESLRKYVGEQVPPEVHRQA 323
Q8K2I2       186 HQKALDSLASKAEGLEKSLNSLETKRAGEAKQLAMAQKEADMLRNQLSKTQEELEAQVTLVESLRKYVGEQVLPEFPSQE 265 house mouse
Q8HZ60       186 HEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQT 265 chimpanzee
XP_027294751 324 WEPEREELLDTVQHLREDRADLQATVELLQVRVQSLTHMLALQEEELTRKIQPSDVLEPEYPKKCRSLLSSWREKVFVLM 403
Q8K2I2       266 WELERKELLDTLKHLKEDRADLQATVELLQVRVQSLTHMLALQEEELTRKIQPLDPLEPEFPKKCRSLLRNWREKVFALM 345 house mouse
Q8HZ60       266 WELERQKLLETMQHLQEDRDSLQATVELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALM 345 chimpanzee
XP_027294751 404 VQLKAQDLEHRDSMKGLRDQVAELQEQVMAQSQEQAILQQALQDKAAELEVERMSIKTLQMELNRAQEARRRQKQRTDSV 483
Q8K2I2       346 VQLKAQDLQHRDSTSQLRIQVAELQEQVTSQSQEQAILQRALQDKTAQVEVERMSTKSLQMELDQAQEARRRQEQQIASA 425 house mouse
Q8HZ60       346 VQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASA 425 chimpanzee
XP_027294751 484 EEQLKFVVSAMKSTQDSIHGTMTRLNQTVARIPSLSNRLSYAIRKVHTIKGLMARKVSLAQLRLQSCPPPPPAPPVDADL 563
Q8K2I2       426 EEQLKFVVGAMNSTQAKLQSTMTRMDQAVARIPSLSNRLSYAVRKVHTIKGLMARKVALAQLRVESSPPSEAAPPLDTDL 505 house mouse
Q8HZ60       426 EEQLRLVVNAVSSSQIWLETTMAKVEEAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLP---PPV-ADV 501 chimpanzee
XP_027294751 564 SLELEHLREERNRLDAELQLSAHIIQQEVGRAREQGEAERLQLNEVAQQLEQELQRAQESLVNVGQQLESALQGQQESTE 643
Q8K2I2       506 SVELEQLREERNRLDAELQLSAHLIQQEVGRAREQGEVERRRLIEVAQQLEQELQRAQESLASVGQQLEAARRGQQESTE 585 house mouse
Q8HZ60       502 SLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTE 581 chimpanzee
XP_027294751 644 EAANLRQELTQQQQIYGQALQEKVAEVETRLREQLSDTKRRLNEARREQAKAVVSLRQIQHRATREKERNQELRRLQDEA 723
Q8K2I2       586 EAASLRQELTQQQEIYGQALQEKVAEVETRLREQLSDTKRRLNEARREQAKAVVSLRQIQHKATQEKERNQELRRLQDEA 665 house mouse
Q8HZ60       582 EAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEA 661 chimpanzee
XP_027294751 724 RKEEAQRVARRVQELERDKNLMLatlrqegllsrykqQRLLAMLPLGTD-KKTvrfSPQ-PEVSPEHGCPAASPPRECTK 801
Q8K2I2       666 RKEEGQRLTRRVQELERDKNLML--------------QRLLAVLPSGVN-KKC---SPR-SVESSSSESPAAASCKESVK 726 house mouse
Q8HZ60       662 RKEEGQRLARRLQELERDKNLMLatlqqegllsrykqQRLLTVLPSLLDkKKSvvsSPRpPECSASAPIAAAVPTRESIK 741 chimpanzee
XP_027294751 802 ESLTALFENLQGLSEAISREEATCPEDKQYTQ 833
Q8K2I2       727 GSLTVLLDNLQGLSEAISRDEDICVEDNQNTK 758 house mouse
Q8HZ60       742 GSLSVLLDDLQGLSEAISKEEAVCQGDNLDRC 773 chimpanzee
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap