5N0B,7L6V


Conserved Protein Domain Family
Peptidase_M27

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pfam01742: Peptidase_M27 
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Clostridial neurotoxin zinc protease
These toxins are zinc proteases that block neurotransmitter release by proteolytic cleavage of synaptic proteins such as synaptobrevins, syntaxin and SNAP-25.
Statistics
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PSSM-Id: 396347
Aligned: 2 rows
Threshold Bit Score: 691.378
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5N0B_A   25 IN-NFRYSDPVNNDTIIMMEPPYCKGLDIYyKAFKITDRIWIVPERYEFGTKPE-DFNPPSSLIEGASEYYDPNYLRTDS 102  Clostridium tetani
7L6V_A    9 VNkQFNYKDPVNGVDIAYIKIPNAGQMQPV-KAFKIHNKIWVIPERDTFTNPEEgDLNPPPEAKQVPVSYYDSTYLSTDN 87   Clostridium botulinum
5N0B_A  103 DKDRFLQTMVKLFNRIKNNVAGEALLDKIINAIPYLGNSYSL--LDKFDTNSNSVSfnlleqDPSGATTKSAMltNLIIF 180  Clostridium tetani
7L6V_A   88 EKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDteLKVIDTNCINVI------QPDGSYRSEEL--NLVII 159  Clostridium botulinum
5N0B_A  181 GPGPVLNKNEvrgiVLRVDNKNYFPCRDGFGSIMQMAFCPEYVPTFDNVIENITSLTIGKSKYFQDPALLLMHELIHVLH 260  Clostridium tetani
7L6V_A  160 GPSADIIQFE----CKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGH 235  Clostridium botulinum
5N0B_A  261 GLYGMQVSSHEIIPSK-QEIYMQHTYPISAEELFTFGGQDANLISIDIKNDLYEKTLNDYKAIANKLSQVTSCNDPNIDI 339  Clostridium tetani
7L6V_A  236 RLYGIAINPNRVFKVNtNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASL 315  Clostridium botulinum
5N0B_A  340 DSYKQIYQQKYQFDKDSNGQYIVNEDKFQILYNSIMYGFTEIELGKKFNIKTALSFFSMNHDPVKIpNLLDDTIYNDTEG 419  Clostridium tetani
7L6V_A  316 QYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKI-NIVPKVNYTIYDG 394  Clostridium botulinum
5N0B_A  420 FNIESKDLKSEYKGQNMRVN 439  Clostridium tetani
7L6V_A  395 FNLRNTNLAANFNGQNTEIN 414  Clostridium botulinum
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