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Phosphate transport (Pho88) Members of this family of proteins are involved in regulating inorganic phosphate transport, as well as telomere length regulation and maintenance. Family members such as SND3 (SRP-independent targeting protein 3, encoded by PHO88, also known as YBR106W) is localized to the endoplasmic reticulum (ER). SND3 works together with SND1 and SND2; these proteins function in parallel with the SRP and GET pathways to target a broad range of substrates to the ER. The SND proteins constitute an alternative targeting route to the ER. SND3/PHO88 was first identified as a Saccharomyces cerevisiae protein involved in inorganic phosphate transport. Functional analysis revealed that Loss of SND3 has been shown to affect secretion of the yeast acid phosphatase. |
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Jiyao W et al.(2023). "The conserved domain database in 2023.",