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polar granule component Polar granule component (pgc) is implicated in primordial germ cell specification in Drosophila, which require transcriptional quiescence and three genes: pgc, nano (nos) and germ cell less (gcl), that act to down-regulate Pol II transcription. The microprotein pgc inhibits transcription elongation factor b (P-TEFb), which phosphorylates the C-terminal domain of the largest Pol II subunit. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",