1DXQ,3F2V,3HA2,5JRO


Conserved Protein Domain Family
Flavodoxin_2

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pfam02525: Flavodoxin_2 
Click on image for an interactive view with Cn3D
Flavodoxin-like fold
This family consists of a domain with a flavodoxin-like fold. The family includes bacterial and eukaryotic NAD(P)H dehydrogenase (quinone) EC:1.6.99.2. These enzymes catalyze the NAD(P)H-dependent two-electron reductions of quinones and protect cells against damage by free radicals and reactive oxygen species. This enzyme uses a FAD co-factor. The equation for this reaction is:- NAD(P)H + acceptor <=> NAD(P)(+) + reduced acceptor. This enzyme is also involved in the bioactivation of prodrugs used in chemotherapy. The family also includes acyl carrier protein phosphodiesterase EC:3.1.4.14. This enzyme converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine residue from ACP. This family is related to pfam03358 and pfam00258.
Statistics
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PSSM-Id: 426816
Aligned: 240 rows
Threshold Bit Score: 52.721
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1DXQ_A         3 RRALIVLAHSEK-TSFNYAMKEAAVEALKKRg-----wEVLESDLYAMnFNPIISRNDITgelkdsknfqypSessLAYK 76  house mouse
ABN07907       1 MKITVIYGTNRTeKSSTYNIARQFIEELADGd------tVTEFHLPRD--MPVFCTGCLTc-----------L---SDST 58 
ABN07897       1 MKITVIYGTSRTeKSSTYNIAQQFLAELADGd------pVTEFHLPKD--MPEFCTGCFNc-----------F---SDPA 58 
Q5WD38         1 MKVMALFGSARI-EGNTEQLADIALRGINHRr----------IHLLKCgFDPIIDER--------------------HAP 49  Bacillus clausi...
Q7WAP8         8 NPVLVLVGSPRRd-GNSALLAQAVAEGARQSg------aVATLLFLDD-YIAGFLTd---------------E---KEAd 61  Bordetella para...
XP_001287462   6 AKVLILNASFNFl-HSGGKLNTSLTEEAKKYles-kghEVKVTNMAEG-------------------------------- 51 
XP_001322702   6 SKVLIIIAGFSNpPMSQGMLNESLGLEAKKYleh-kghQVKVTQIAKG-------------------------------- 52 
EAY07038       6 AKVLILNAGYNQpPMAKGKLNEALANDMEKYlqg-kghETKITHMEQG-------------------------------- 52 
EAY15747       8 GTVLIIDGGCEFe-MSKGNLNHYLAEVAKNQles-fgwNVITTAVDKG-------------------------------- 53 
WP_008243378   1 MKVLIINGGQVFg-HSGGRFNATVTNETISFfsqqegvEIRITNINDV-------------------------------- 47  Pedobacter sp. ...
1DXQ_A        77 EgrlS-PDIVAEH--KKLEAADLVIFQFPLQWFGVPAILKGWFERVLVAGF----AY--------TYaamYdnGPFQ--- 138 house mouse
ABN07907      59 K---CpHYKYVQPieEAMESADLIIFTTPVYLLHVPGQVKALLDHF---------GFqw----maHK---Pk-DVYF--- 115
ABN07897      59 K---CpHYAYIKPisDAMLNADLIIISAPVYVFHMPGQVKALLDHF---------GYqw----iaHR---Pi-EAFF--- 115
Q5WD38        50 NgftAvNDGYKEVl-DDFLNQDIVLFVTPLYWFGMSGQMKGFFDRWSQYMQ---------------DqrlGfhERIR--- 110 Bacillus clausi...
Q7WAP8        62 a--rRpDDRYGELffDHFLPARAVVLCTPVYWYGMSAQAKAFFDR----------SFtyysashpRHaevL--RRMT--- 124 Bordetella para...
XP_001287462  52 ------YNIEEEV--SKIMWSDVVILQTPGWWMGLPWGAKKYIDEVFAHGVm---YRndgrtrkdPSkkyGsgGLCQ--- 117
XP_001322702  53 ------YKVEEEI--EKFKWADVIIFQSQTWWIGLPNPAKKYIDEVLTAYIpl-iEQyk--------------------- 102
EAY07038      53 ------YKVEEEV--AKFNWADVIIVQTPTWWLGLPGPAKTYIDSVLSAYM------------------------MNpdk 100
EAY15747      54 ------YDIKEEV--DKIVKCDVAILQVPGWWMGLPWKVKQYIDTVFQSGRgv-lFNsdgrtrkdPSkkyGtgGCLS--- 121
WP_008243378  48 ------YDPAEEV--KKYVWADLIIYHTPIWWFQLPHEFKKYLDVVFSAGHrngiYRsdgrsnenPTanyGtgGMLQ--- 116 Pedobacter sp. ...
1DXQ_A       139 --NKKTLLSITTGGSgSMySlqgV--HG-DMNVILWPiQSGILRFCGFQVL----EPQLVYS-I--GHTP-PDARMQILE 205 house mouse
ABN07907     116 --HKQALVISTGARI--------------GIRQTVRD-VRNSLDWWGVGRIyrfkKTVGMKGwRglSDKRkAAFAQEIKQ 178
ABN07897     116 --HKQGLVITTAAGA--------------GMRHAAKD-AQDSFNWWGVGRTytfkKAVQASEwSqvSEKKrEKITKEVKA 178
Q5WD38       111 --GKKAYVIVVGENPhPRiAa----------lPLIQQ-FHAIFEYTGMEFS----DYIIGKGnR--PGTIkQDQLALEKA 171 Bacillus clausi...
Q7WAP8       125 --GKRLALAVSSEET--------Y--PGaALGIVHQ--LQEFTRYTHSQFV----GMVHGAGnRrgEVAHdPRRPLQAAH 186 Bordetella para...
XP_001287462 118 --GRYIMISSTWNAPeESfDdpsQffEGrHAEGVWFN-VYKAFEFCGFEKL----KPVTFHD----VMK--MPDFNMYIE 184
XP_001322702 103 -gkKKIMVSATFGALeETiHdknTcyEGlGAEQVWWP-LYAAFVYSGFEKL----PMVAYFN----SFSR-HFVYQERVD 171
EAY07038     101 kdGK--KVSATFAATeETmVdpkSayQGlGADQVWWT-LYQNFFFCGIGKL----PIVTVNN----VLNP-SFKFDEAVS 168
EAY15747     122 --GKRFMVSSTWNAPeIAfTeegQfyADlGKKKHWAT-VEKAFRFIGFDVL----EGMYFFD----VHK--DPHVEQEVE 188
WP_008243378 117 --GKKYMVTTSWNAPkEAfTlpgEffMEtSVDQGPLFgFHRMNAFIGLKPL----QSMHFHD----VEK--NADIEQDML 184 Pedobacter sp. ...
1DXQ_A       206 GWKKrL 211 house mouse
ABN07907     179 TSKKiR 184
ABN07897     179 TSRKiL 184
Q5WD38       172 DFWNkT 177 Bacillus clausii KSM-K16
Q7WAP8       187 RLGHgL 192 Bordetella parapertussis
XP_001287462 185 HLHQhL 190
XP_001322702 172 KLHAhL 177
EAY07038     169 KLHAhL 174
EAY15747     189 QYKQlL 194
WP_008243378 185 VYKAhL 190 Pedobacter sp. BAL39
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