1ZP7,2FCO,5FDK


Conserved Protein Domain Family
RecU-like

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cd22354: RecU-like 
Holliday junction resolvase RecU (recombination protein U) and similar nucleases
Holliday junction (HJ) resolving enzyme RecU is involved in DNA repair and recombination. It belongs to a superfamily of nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.
Statistics
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PSSM-Id: 411758
Aligned: 60 rows
Threshold Bit Score: 141.515
Created: 14-Feb-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:2FCO: Geobacillus kaustophilus RecU active site binds divalent cation; contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                              #            # #          
1ZP7_A        34 TLEDDLNETNKYYLtnQIAVIHKKPTPVQIvnvhypkrsaavikEAYFKQSStTDYNGIYkGRYIDFEAKETKNkTSFPL 113 Bacillus subtilis
2FCO_A        32 TLEDDLNATNEYYRerGIAVIHKKPTPVQIvrvdypkrsaavitEAYFRQAStTDYNGVYrGKYIDFEAKETKNkTAFPL 111 Geobacillus kau...
WP_098572950  10 SFEELIKNSCEFYKysGVALIHKIPTPWSVsydkk----yhrviRAHPEEKSsVDFEGIWhGRSVAFEAKSTRErKRFDL 85  Bacillus sp. AF...
WP_098600335  20 EFEGYIMQANARYAirGIASIDKVATPVKVlklaatgpkkgriiDGYFEEKStVDFSGIArGRSVYFDAKETENkTSFPL 99  Bacillus megate...
WP_053963925   8 GFEEIINLANLSYKrkEIALVQKIATPMKPirrg------kqivSAYYEEKStLDYIGIYgGVPIAFDAKETKEeTRFPL 81  unclassified Cl...
WP_052470530  10 GLQLLVNQTNAVYKhkGWALVDEVATPTKNir-----------gRIVYEKKStVDYVGIAqGRGIAFDAKATQInTRFEL 78  Bacillus subtilis
WP_043935988  14 ALEIAIGTANAQYDarGIALIDKVATPVKVkkldq----rgqieNGWYDHKStVDYKGLTnGVSIAFDAKSSMNkTNFPL 89  unclassified Ba...
OAS19340       2 GLETLIEYANQQYAakGIAQIQKVATPWKVvrng------krivSAFPEKKStVDFLGVYkGMAIAFDAKQTENkTRFPL 75  Paenibacillus s...
WP_100523383  11 SFEQLIEHSNKQYLakGKALVQKVPTPWTVirrg------kqivSAHPAEKStVDFVGVAdGKPIAFDAKSTRElTRFPL 84  Mycobacteroides...
AJD91562       2 TLQFYIDEANAMYErrDQAKVVRQHPEVKVtgmkn-----kkvtDGFYKAKGaPDYIGLAgHIPVCFDAKETKE-KSFPL 75  Jeotgalibacillu...
Feature 1           #  #                                                                         
1ZP7_A       114 QNFHDHQIEHMKQVKAQDgiCFVIISaf--dQVYFLEa-dKLFYFWDrke-----kngRKSIRKDELEETAYPISLGYap 185 Bacillus subtilis
2FCO_A       112 KNFHAHQIRHMEQVVAHGgiCFAILRfs-llNETYLLdasHLIAWWNkqe-----aggRKSIPKQEIERHGHSIPLGYqp 185 Geobacillus kau...
WP_098572950  86 KNIKQHQIDYLQQHQEQGglSFFLIEfakigEVYLVWf-dQVNEWWEgmk-----eggRKSIPYTWIEINCDVVVPGRt- 158 Bacillus sp. AF...
WP_098600335 100 DNIGDHQYEALREKHVHQaiSFLLIRfkahqEVFILLf--EDLDKCWkeam----tggRKSIPYQFFKENCVKCEPGRnv 173 Bacillus megate...
WP_053963925  82 NNVQLHQIKFMKEWDKHGgiTFLLIYft-klGAVYRLd-wTTLDWYWnryqenrgkrgYGSIPLNEFECNCKQLKSRDgi 159 unclassified Cl...
WP_052470530  79 KNVHDHQVEYLKRFMDQGgiSFLLIEfsklrEFYFVRm-pFFLKYWEaak-----dngPKSIPYQDIYLNCDPIRTRRgv 152 Bacillus subtilis
WP_043935988  90 KNVKSHQISYLRKHQQQKgvSFLLIEfs-iyQEHYILm-fDQLAEWWsesv----qggRKSIPYQYFVENCIRCGPGRgi 163 unclassified Ba...
OAS19340      76 ANIEQHQIDFMIDWEKNGgiAFVIIDfk-shGQIFLM---NLQEFVIass------lyGSSIPYKHFTQCIREVHHENgi 145 Paenibacillus s...
WP_100523383  85 SNIEVHQMVFLQNFHDQGgqAFVLIEfakiyEVYLVPf-pKLREYWNnar-----kggRKSIPYDEMKHFPKISSGNGi- 157 Mycobacteroides...
AJD91562      76 ENVHHHQIKDLKQWEEQGgfSFLIIRfv-sqRETYLLp-fKAFNRCIeecq----tkgIKSIPYQIIQERGKLITAGSni 149 Jeotgalibacillu...
Feature 1                    
1ZP7_A       186 RIDYISIIEQLY 197 Bacillus subtilis
2FCO_A       186 RIDYISVVDNVY 197 Geobacillus kaustophilus HTA426
WP_098572950 159 YLDFIRVLEKEK 170 Bacillus sp. AFS073361
WP_098600335 174 AIDYMAALDKAT 185 Bacillus megaterium
WP_053963925 160 ILDYLEGIENVK 171 unclassified Clostridiales
WP_052470530 153 PLDYLELCFQNV 164 Bacillus subtilis
WP_043935988 164 ALDYLASLPQVN 175 unclassified Bacillus
OAS19340     146 VFDYLKHVEAIA 157 Paenibacillus sp. 1ZS3-15
WP_100523383 158 ALDYLSVFDKSL 169 Mycobacteroides abscessus
AJD91562     150 TLDWLTAAWEAR 161 Jeotgalibacillus malaysiensis

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