2CV8,2ZYZ,2OHC,3IEY,5X89,1A79,3P1Y,3AJV,4FZ2,2ZYZ,5X89,3P1Z,3IF0,2GW6


Conserved Protein Domain Family
tRNA-intron_lyase_C
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cd22363: tRNA-intron_lyase_C 
catalytic C-terminal domain of the tRNA-intron lyase
This C-terminal catalytic domain of tRNA intron endonucleases cleaves pre tRNA at the 5' and 3' splice sites to release the intron (EC:3.1.27.9). It belongs to a superfamily of nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.
Links
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Statistics
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PSSM-Id: 411767
Aligned: 282 rows
Threshold Bit Score: 50.1769
Created: 28-Mar-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:The role of the conserved histidine has been confirmed by mutational studies
  • Comment:the tetramer contains four active sites with conserved His-Tyr-Lys triads, but only two of them are thought to be involved in tRNA cleavage
  • Citation:PMID 9535656
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                    #         #                              #       
2CV8_B     86 RFRILYSVYEDLREkGYVVRSGIkygADFAVYtigp--gieHAPYLVIALDEnsqisSNEILGFGRVSHstRKELILGIV 163 Sulfolobus tokodaii
3AJV_B     94 RFSMLYNIYRDLRErGFVVRSGLkfgSDFAVYrlgp--gidAAPFIVHAYSPednidPVEIVRAGRLSHsvRKKFVFAVT 171 Aeropyrum pernix
KXH76420  109 DLWINYLVFRDLRSrGYAVRQGFgggIGFRVYargnrpgaaTANQLIYVLKEgdaisLHDLDMVTETASaaRKKLVFALV 188 Candidatus Thorarc...
OLS13303  125 DLWIKYLVYRDLRTrGYIVRKGIgdgIEYRVFkrgakkgedEAKYRISIVIEgkpveLRVLDKITKYSVssRKKLVLAVV 204 Candidatus Lokiarc...
SPC34076   96 SIWTKFLIYRDLRSrGYVAREGFgfgNDFRVYerge-ysikSARYIVFGLNEgrevkIDDLSRMVEQIWsmGKEPIVAVI 174 Candidatus Nitroso...
PMP94583   83 GFLTKYIVYRDLRNrGYVVREGYgigNDLRVYrrge-ygreDARYLVMALEEggrmpASRLTRNYLRALnlGKDLILAVV 161 Nitrososphaera sp.
RPJ30479   88 EIVTRFLVYRDLRSrGYVVKEGFgfgADFRVYerge-yekkRAKYVVFCINEginvkVGELSKNVREIEtmGKNAIAAVV 166 Nitrosopumilales a...
AIF11738   81 NAWTKFLIYRDIRTrGYVAKEGFgfgADFRVYdkgn-fgtkAAKYIVFAMNEgneinVKSLTDSVKQISrmGKVPIIAVV 159 uncultured marine ...
ABK77764   82 DVLTKFLIYRDLRIrGYVAKEGFgfgTDLRAYdrgr-fgekASKYVVFGLKEgtqekIGALQKKVAKITqmGKEPIIAVI 160 Cenarchaeum symbio...
RLE50203   80 NIWIKYLIYSDLRKrGYIVKPGFgtkISFRVYrrgaeigkePAKYLVYGIVEgkpieLSELSEMVKEARstRKELILAIV 159 Candidatus Verstra...

Feature 1                   
2CV8_B    164 nltngkIRYIXFKW 177 Sulfolobus tokodaii
3AJV_B    172 rg--gdVSYLMIDW 183 Aeropyrum pernix
KXH76420  189 dqn-geVNYYRVAQ 201 Candidatus Thorarchaeota archaeon SMTZ-45
OLS13303  205 drl-geITYYSIDQ 217 Candidatus Lokiarchaeota archaeon CR_4
SPC34076  175 err-geVIYYSVER 187 Candidatus Nitrosocaldus cavascurensis
PMP94583  162 esr-gdVVYYSIAQ 174 Nitrososphaera sp.
RPJ30479  167 err-geVIYYKLTN 179 Nitrosopumilales archaeon
AIF11738  160 err-geVIYYHLAK 172 uncultured marine thaumarchaeote KM3_53_E01
ABK77764  161 err-geVIYYKVSR 173 Cenarchaeum symbiosum A
RLE50203  160 drq-geVTYYDVTC 172 Candidatus Verstraetearchaeota archaeon

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