Conserved Protein Domain Family
ASKHA_NBD_NTPDase6
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cd24115: ASKHA_NBD_NTPDase6 
nucleotide-binding domain (NBD) of ectonucleoside triphosphate diphosphohydrolase 6 (NTPDase6) and similar proteins
NTPDase6 (EC 3.6.1.6), also called CD39 antigen-like 2 (CD39L2), catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner. It has a strong preference for nucleoside diphosphates, preferentially hydrolyzes GDP, IDP, and UDP, with slower hydrolysis of CDP, ITP, GTP, CTP, ADP, and UTP and virtually no hydrolysis of ATP. The membrane bound form might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides.
Links
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Statistics
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PSSM-Id: 466965
Aligned: 6 rows
Threshold Bit Score: 744.328
Created: 26-Jan-2023
Updated: 27-Apr-2023
Structure
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Aligned Rows:
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Feature 1: catalytic site [active site], 1 residue position
Conserved feature residue pattern:EClick to see conserved feature residue pattern help
Evidence:
  • Comment:The catalytic residue Glu functions as a general base to deprotonate a water nucleophile for direct attack of the terminal phosphate group.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
O75354       100 VFYGIMFDAGSTGTRVHVFQFtrppretptLTHETFKALKPGLSAYADdVEKSAQGIRELLDVAKQDIPfdfWKATPLVL 179 human
NP_001017862  59 FQYGIMIDAGSTGTRIHIFKFqmepneapkLAHETFRAIKPGLSAYADePEKSKEGILELLNVAKDTVPevlWSSTPLML 138 zebrafish
OCT79765      87 IFYGIMFDAGSTGTRIHIYQFsrtpsgapnLDHEEFRALKPGLSSYADnPIKCAPGINELLNIAKKEIPqklWASTPLVL 166 African clawed ...
XP_006003708  46 VLHGIMFDAGSTGTRIHVFKFtqasneppkLAHETFKAIKPGLSAYSDePDKCTEGIQELLEIAKEAVPsgfWKATPLVL 125 coelacanth
XP_007892535  49 VFYGIMFDAGSTGTRIHVFKFtqkpneslkLTEEIFKALKPGLSAYSDePHLCMKNIQDLLDVAKNSIPsdfWANTPVAL 128 elephant shark
ELV12970      72 VFYGIMFDAGSTGTRVHIFHFarppgetptLTHETFKALKPGLSAYADdVEKSSQGIQELLDVAKQDIPfdfWKATPLVL 151 Chinese tree shrew

Feature 1                                                    #                                   
O75354       180 KATAGLRLLPGeKAQKLLQKVKKVFKAspFLVGDDCVSIMNGTDEGVSAWITINFLTGslktpggsSVGMLDLGGGSTQI 259 human
NP_001017862 139 RATAGLRLLPGeKATILLDKVREVFSEslFLYKPDSVSIMDGTDEGMSAWITINFLIGalhgtetpTVGMLDLGGGSTQI 218 zebrafish
OCT79765     167 KATAGLRLLPGeKAHKLLDMVRELFKAspFLIGKDSVSIMNGTDEGIFAWITVNFLTGslnnagkkHSGMLDLGGGSTQI 246 African clawed ...
XP_006003708 126 KATAGLRLLPGkKAQDLLNKVKEVFRAspFFVRDDCVSIMDGTDEGISAWITVNFLIGtlhgterrTVGMLDLGGGSTQI 205 coelacanth
XP_007892535 129 KATAGLRLLPAeKAEGLLDKVKEAFKTspFLVRDDSVRIMDGTDEGISAWITVNFIKDylhmskpsSIGILDLGGGSTQI 208 elephant shark
ELV12970     152 KATAGLRLLPGeKAQKLLQKVEEVFKAspFLVGDDCVSIMNGTDEGVSAWITVNFLTGslktpgrsSVGVLDLGGGSTQI 231 Chinese tree shrew

Feature 1                                                                                        
O75354       260 AFLPrvegtlqasp------------pgyltalrmFNRTYKLYSYSYLGLGLMSARLAILGGVEGQPakdgkeLVSPCLS 327 human
NP_001017862 219 TFALqdeitiqtsp------------idyvtsfqmFNISHALYSHSYLGLGLMSARLAVLGGIEGQPlagpqeLVSPCLA 286 zebrafish
OCT79765     247 TFYPyskntltssp------------pgymtkfelFGNTYSLYSHSYLGYGLMSARLAIMGGEEGKPlqegeqLVTSCLT 314 African clawed ...
XP_006003708 206 TFSPhdektvqtsp------------veyitsfqmFQKIHTLYSHSYLGLGLMSARLAILGGTEGQPlqegeeLISPCLA 273 coelacanth
XP_007892535 209 TFSPhsdmtlqtsp------------idyitsiqlFNRTKTLYSHSYLGLGLLSARLAILGGVESKPlkngqeLVSACLA 276 elephant shark
ELV12970     232 TFLPrvegtlqtsppgyltalqvfnrtyrlysyrsGATLTQMLLHSYLGLGLMSARLAILGGVEGKPakdgkeLVSPCLP 311 Chinese tree shrew

Feature 1                                                                                        
O75354       328 PSFKgEWEHAEVTYRVSGqkaaaslHELCAARVSEVLqnrvhrteEVKHVDFYAFSYYYDLAAGVGLIda---------- 397 human
NP_001017862 287 PDYSgQWEHAEVLYTVKGqkpgepiYESCLRKVEKMIykqvrkaeEVKNMDFYAFSYYYDRAVDLGLIde---------- 356 zebrafish
OCT79765     315 PEFVtEFKHAEITYKIKGqkndeplFVSCYKRVLALLggkvehskEIPNLFFYAFSYYYDRAVDAHLIda---------- 384 African clawed ...
XP_006003708 274 PDYKsNWEHAEITYSIKGqkageplYESCYNKVEKMLykkvhkaeEVKDLDFYAFSYYYDRAVDVGLIde---------- 343 coelacanth
XP_007892535 277 PEYKgEWEHAEIVYKIKGqkpeeplYNSCRARIEKILykklhkpeEVNNLLFYAFSYYYNRAVDAGLIde---------- 346 elephant shark
ELV12970     312 PGFKgEWEHAEVTYRLSGttaeaslHALCASRVSEVLrdrvhrteDVKHVDFYAFSYYYDLAAHVGLIgpyqhgehlptt 391 Chinese tree shrew

Feature 1                                                                                        
O75354       398 ----------------------------------------------------ekGGSLVVGDFEIAAKYVCrtle-tqpq 424 human
NP_001017862 357 ----------------------------------------------------rtGGTVRVSDYIEGAKKVCnnmsaggik 384 zebrafish
OCT79765     385 ----------------------------------------------------elGGSLKVKDFDMAAKKECklie-eapg 411 African clawed ...
XP_006003708 344 ----------------------------------------------------eeGGSLKVEDFEVAAKRVCksme-sepg 370 coelacanth
XP_007892535 347 ----------------------------------------------------ekGGTIKLQDYETAAKQVCqrme-ssst 373 elephant shark
ELV12970     392 vttvsedggpwkpgicnsqcpgalsgpspamglsgsvchasadgraisppdaekGGSLTVGDFEIAAKYVCrtle-tqpr 470 Chinese tree shrew

Feature 1                                                         
O75354       425 SSPFSCMDLTYVSLLLQEFGFPRsKVLKLTRKIDNVETSWALGAIFHYI 473 human
NP_001017862 385 ESPFLCLDLTYISVLLQELDFPPdKELKLARQINNAETSWALGAAFHCI 433 zebrafish
OCT79765     412 ENPFLCMDLTYITLLLQESGFPMeKELKLVKKIDNVETSWALGATFYYT 460 African clawed frog
XP_006003708 371 VKPFLCLDLTYITVLLQEMGFPKdTVFKLARRIDNVETSWALGATFHYI 419 coelacanth
XP_007892535 374 EKPFLCMDLIYINVLLEELGFQKdAVIKLARKIDNVEASWALGASLHYV 422 elephant shark
ELV12970     471 HGPFTCMDLTYISTLLQEFGFPRtTELKLTRKIDNVETSWALGAIFHYI 519 Chinese tree shrew

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