2E6R


Conserved Protein Domain Family
PHD
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smart00249: PHD 
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PHD zinc finger
The plant homeodomain (PHD) finger is a C4HC3 zinc-finger-like motif found in nuclear proteins thought to be involved in epigenetics and chromatin-mediated transcriptional regulation. The PHD finger binds two zinc ions using the so-called 'cross-brace' motif and is thus structurally related to the RING finger and the FYVE finger. It is not yet known if PHD fingers have a common molecular function. Several reports suggest that it can function as a protein-protein interacton domain and it was recently demonstrated that the PHD finger of p300 can cooperate with the adjacent BROMO domain in nucleosome binding in vitro. Other reports suggesting that the PHD finger is a ubiquitin ligase have been refuted as these domains were RING fingers misidentified as PHD fingers.
Links
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Statistics
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PSSM-Id: 214584
Aligned: 183 rows
Threshold Bit Score: 30.643
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2E6R_A         18 ICQVCSRgd-------eDDKLLFCD--GCDDNYHIFCLLPPLp-----EIPRGIWRCPKC 63   human
Q24459        426 MCVACKRsd-------iEDVVEICE--RCGRGYHRGCTVEIVt-------GSGIWSCKRC 469  fruit fly
AAC23623      545 GCVFCRShdfsi-gkfdDRTVILCD--QCEKEYHVGCLRENGfcdlkeIPQEKWFCCSNC 601  thale cress
EDL41175     1490 TCFVCKQs---------gEDVKRCLlpLCGKFYHEECVQKYPp----tVTQNKGFRCPLH 1536 house mouse
XP_002729900  228 hCAVCEGpg-------eLCDLFFCT--SCGHHYHGACLDTALt-----ARKRAGWQCPEC 273  Norway rat
XP_002200144  159 YCDFCLGdskinkktgqPEELVSCS--DCGRSGHPSCLQFTPvm--maAVKTYRWQCIEC 214  zebra finch
AAC34383      214 CCAVCDSag-------eLSDLLFCT--GCGQHYHAACLEIGAt-----PIQRAGWQCPEC 259  torafugu
XP_003252537 1391 MCVVCGSfgr-----gaEGHLLACS--QCSQCYHPYCVNSKIt----kVMLLKGWRCVEC 1439 White-cheeked Gibbon
XP_003357368  247 FCHVCGRqh------qaTKQLLECN--KCRNSYHPECLGPNYpt--kpTKKKKVWICTKC 296  pig
NP_055542    1251 FCHVCGRkg------rgSKHLLECE--RCRHAYHPACLGPSYpt--raTRKRRHWICSAC 1300 human
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