3C90,1YXB


Conserved Protein Domain Family
NTP-PPase_HisE
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cd11547: NTP-PPase_HisE 
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Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs
This family includes M. tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs. M. tuberculosis HisE is encoded by the hisE gene, which is a separate gene presenting in many bacteria and archaea but is fused to hisI in other bacteria, fungi and plants. HisE is responsible for the second step in the histidine-biosynthetic pathway. It can irreversibly hydrolyze phosphoribosyl-ATP (PRATP) to phosphoribosyl-AMP (PRAMP) and pyrophosphate. HisE dimerizes into a four alpha-helix bundle, forming two inferred PRATP active sites on the outer faces. M. tuberculosis HisE has been found to be essential for growth in vitro, thus making it a potential drug target for tuberculosis.
Links
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Statistics
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PSSM-Id: 212154
Aligned: 6 rows
Threshold Bit Score: 106.416
Created: 9-Dec-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative metalhomodimer
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: putative metal binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:E E E QClick to see conserved feature residue pattern help
Evidence:
  • Comment:Based on sequence similarity to other superfamily members.
  • Comment:Most members of the NTP-PPase superfamily contain the well-conserved divalent ion-binding motif, EEED, instead of EEEQ present here.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                #  #               #  #                
3C90_X        7 KTFEDLFAELGDRArtr-padSTTVAALDGGVHALGKKLLEEAGEVWLAAEHESNDALAEEISQLLYWTQVLMISRGLsL 85  Mycobacterium tu...
1YXB_A        4 KTFEELFTELQHKAangdpatSRTAELVDKGVHAIGKKVVEEAAEVWXAAEYEGKDAAAEEISQLLYHVQVXXVARGIsL 83  Streptomyces coe...
Q2S4L5        2 KRFEELFAELADKVdrq-dpdSGTVQAVQEGRHAIGKKVIEEAGEVWMAAEHEGPDRTAEEISQLLYHLQVLMIACDLdL 80  Salinibacter rub...
ZP_01874667   2 KTFEELFEELSKKAaag-dpnSGTVKELNKGTHFIGKKIVEEAAEVWMAAKFETDDDTALEISQLLYHLQVMMIDQKLtL 80  Lentisphaera ara...
YP_003249229  1 MTFEEMYALACQRKkdm-pegKGTTELFKKGPHGIGKKLVEEAAESWMAARFESRDAQCLELSQVLYYVAVMMAEKGLtL 79  Fibrobacter succ...
YP_003719512  2 NNFEELYEIIESRKner-pegSRTVEELDRGVHGIGKKIVEEAAEVWMACEYESDEAAQIEISQLIYHLQVMMVAKGFtP 80  Mobiluncus curti...

Feature 1              
3C90_X       86 DDVYRKL 92  Mycobacterium tuberculosis H37Rv
1YXB_A       84 DDVYAHL 90  Streptomyces coelicolor
Q2S4L5       81 EDVYEHL 87  Salinibacter ruber M8
ZP_01874667  81 EDIYKKL 87  Lentisphaera araneosa HTCC2155
YP_003249229 80 EEVYAKL 86  Fibrobacter succinogenes subsp. succinogenes S85
YP_003719512 81 QDIYQHM 87  Mobiluncus curtisii ATCC 43063

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