Conserved Protein Domain Family
7TM_GPCR_Srd

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pfam10317: 7TM_GPCR_Srd 
Serpentine type 7TM GPCR chemoreceptor Srd
Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.
Statistics
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PSSM-Id: 402094
Aligned: 55 rows
Threshold Bit Score: 211.64
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O17240        19 FKIIGYIVNPLGILFNTLLIILISTKTPKLLQSYSMLHLNFALCDLFSCLAGMLALQKIV--FSGWSLTYIFHGACGQIS 96  Caenorhabditis ...
O01608        10 YISYAAVVSTLGIIFNGFLLFLIFFKSPSCLTPYTVFLANTSITQLGYCICFLLTVPRVI--SINLRIVNIYLGFSQFLG 87  Caenorhabditis ...
Q22594         5 FVIFHSVLSAIGCVLNSMLCHVAAWKSPTVIKTYSIITVNFAITNLTICGVNFILQMRMV--PIEKTMIFVSYGPCQWLT 82  Caenorhabditis ...
Q17760         8 FIGINSILTLLGCFINLFLCYLAIFQSPKAIRTYSLVLINITLTNVGACVTGFLLDQRII--QSGKSMLYVSYGYCSLLG 85  Caenorhabditis ...
Q9XWA0         6 YQIIHAILSIFGVGINIFLLFLALTKSPKIMRPCSALITNKSLTDIMSSVANFFVMQRIL--TDGSSVTIIPTGPCTMIG 83  Caenorhabditis ...
XP_002638128   3 YQVIHTIFSSLGVVFNAFMMFLALTKSPPIMRLCSVVITIKTTTDIMTSLINAFVMMRIV--TDGIHVFLIPSGPCTYFG 80 
P92001         5 FEIWHWSWALLGCYLNLLLAYLAIFKSPKAIKSYATLIINYAATDFVECALDSFLQTRLLavPGEAELVYIFNGPCKYIG 84  Caenorhabditis ...
Q9U2P4         5 FEIWHCIWALLGCSFNLMLIYMAIYKSPKTIRSYATLIINFAVTDFFECALDLFIQIRLMpaPGDVTVIYILNGSCKYIS 84  Caenorhabditis ...
O01468        11 VKSWHIFFGITGVILNLVLILLVVFKSPNAIRVYSRLITNFAVTDFLACLLDIFIEIRVLpsPNEATITYILNGFCTYFG 90  Caenorhabditis ...
O01466        11 FRILHAIFGGTGCILNAVLILLVIFETPKHIRLYSILILNFAIFDLAACILDIFIEIRVLpyPNEDSMAHIMNGVCKHFG 90  Caenorhabditis ...
O17240        97 SYFCYFLHVFVCHCLAHSQWILMISFLYRYYILDQISPDTVKIVRICILTYLPSLLFv-----IVYWSDVANEDALKRIV 171 Caenorhabditis ...
O01608        88 HWWSYMIFTTMLHFAVNSFLSIMLSMVFRCISLKTLRFPTSGAFAMCILAYMIPLSMvvsirgIEITSNFTINSKYTLWQ 167 Caenorhabditis ...
Q22594        83 DRTCFNLYSVLVHVYTHTIWLLLISFCYRYYVMIRSEPSKRQVELLLLIIYLPSFIQm-----ILLFFDFTDPLILLDIQ 157 Caenorhabditis ...
Q17760        86 EGFCFNIFAAYLHFHTHALWLLFLSFVYRYYVIIRQEPTKKVLQISVVIVYIPSLIQl-----ISMCLQEMNFDELRSLS 160 Caenorhabditis ...
Q9XWA0        84 PTACYAGHMFMGSFLEHNLIWLIACYLFRYYILYVCDPSIKSIIFAAFLVYTPSFVHm----aMWIKLFDAEQMEIKMNE 159 Caenorhabditis ...
XP_002638128  81 PVACYAGHMFMTCFLEHNLIWMICSYIFRYYILYVRDPKARTLFLTAFCLSIPSFFHmt--twISFFNLKTNTIAPEELG 158
P92001        85 SISCKVGLSFFLHCLTHSVWSLLLSFGYRFYILHNPSLSRLVLLKLILVFYIPSLIQa-----LTYWTIFASREEILPLA 159 Caenorhabditis ...
Q9U2P4        85 QFACKIGLSLFLPCITHSVWSLLLSFGYRYYILHYSALTRLKLVKIVLLILIPSLFQg-----LTFWTSFAPLEIILPLA 159 Caenorhabditis ...
O01468        91 LSTCAIGLSMYIHTLTHSLWSLFISFVFRYLILYKVSLKEKHILLALFVFYIPSFVQa-----ATYWTSFVDSSTILPIT 165 Caenorhabditis ...
O01466        91 LTACAVGFSLYLHTLTHSIWSLLISFAYRYLILFKTTFKRNNILLVILAFYFPSFLQa-----VTYWTNFVERFEILPIL 165 Caenorhabditis ...
O17240       172 NSFHPEYIYDSK-EiwgdlvIAGNMSCWSAATFSAIVYMTIPCFPIYGVIVFFRHKTLKSLDGrGRITMSETTRSSHKQL 250 Caenorhabditis ...
O01608       168 LENLDKYRT-----------VVG-TTMAQLSTLWVACCVSILCIPIYSVMFWCRYRILRMLER-PGYMFNTTTTLQIKRL 234 Caenorhabditis ...
Q22594       158 QNLVPQYNFTDL-M------IFGVADSTSFNAMYSIVHVAVMSTPIVLCIVVLRKKILRKMEF-KGVQVNANTRSLQLQL 229 Caenorhabditis ...
Q17760       161 KEVVPQYNLTGL-T------ITGSLDFFTFAPFYCLVHMAIISFLIAIGIHILRKMIINRMVL-NGVDVTIRSRNLHAQL 232 Caenorhabditis ...
Q9XWA0       160 TELFANELEFPEmQ------LTG--RIVYWSSIVVYVQLVFTALLVVIAYTWIRNVLINFLIS-MGVSLSKDVKIINRQL 230 Caenorhabditis ...
XP_002638128 159 LDEAPNI------I------LTG--SLIYYSTITVFVQLAITAFLVLLTYIWLRDVLLNYSLR--MGAVTSDTKKLNRVL 222
P92001       160 RQWFPYYDLDAE-Tg----vLTGIIDLTNFVAIYSIGHICLPFFPVYITIFILRQKIINQLHV-KQHVMSPDTKAAHSQL 233 Caenorhabditis ...
Q9U2P4       160 KKWFPQYNFEAE-Tg----vLTGIVDITHWAATYAVFNICLPIFPIYIAIFILRQKIITFLGA-KTQSMSPDTKAAHSQL 233 Caenorhabditis ...
O01468       166 KRIYPQYNFELE-Tg----lITGITNLFSVSAIYAVLHMTIPVTPVYITIFILRRKILKTLMM-SYNVMSKETKAIHAQL 239 Caenorhabditis ...
O01466       166 MRVHPDYDFSDS-Si----lITGITNLYTPSVVYGMLHTTLPVTPIYIAIFITRWKIIKVLKK-NQSSMSKGTRAQHDQL 239 Caenorhabditis ...
O17240       251 IKALTIQAIVPIFWLT-ASTFYLLALFQVVGRVIVENMPFRIMECMPMITPLISLYFVRPYRSALTG 316 Caenorhabditis elegans
O01608       235 VKALTVQSLIPVFTLFpASLIFLSTQFHVIETTKFGYIIISLLSLSPTIDPLVTIYYVQPYRKYIVD 301 Caenorhabditis elegans
Q22594       230 LRALTFQAVIPGFYLI-GVASYFVSRLEIYRDPFFEYLIFSAFLFVPVLTPISSFIFVTPYRKWFLK 295 Caenorhabditis elegans
Q17760       233 LRTLSFKATVPIIYYF-GCIFFILGR--IWINPIFEFSIFVPTVIVPVLTPLSAFIHVAPYRDFVSK 296 Caenorhabditis elegans
Q9XWA0       231 VKILTFQVCIPIWIFL-GVFFFLAMYTQSTRPDTLQYAITISFMLAPVVSPFAYIFFVPHYWNFCIG 296 Caenorhabditis elegans
XP_002638128 223 VKIITFQVFLPIFIFT-GVTIFALQYSGWVQQEYLDYMISLVFMCSPILSPFSYMLFVPHYRNFFAI 288
P92001       234 LKALTIQAFIPIFVGI-AVTFYFLSQSGLVRSPILEYSIYAVAILAPALSPITYLYFVRPYRQNVKR 299 Caenorhabditis elegans
Q9U2P4       234 LKALTIQAFIPIFMGI-GVIFYLIAQSGLIVSPIVENAIFSIAILMPALSPLTYFYFVRPYRQFLKR 299 Caenorhabditis elegans
O01468       240 MKALTFQAFIPVAAWA-AVYVYIGMQFGIISGIFFEYMVFSTVIFMPLLSPVAYLVYVRPYRLYILR 305 Caenorhabditis elegans
O01466       240 LKILTIQAILPSTSFF-TSWLFMGLRFGLFQGQVYEHLVFSCAIFMPVISPIIYIVFIKPYREFFVR 305 Caenorhabditis elegans
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