2F46,3GXH


Conserved Protein Domain Family
PTP-bact
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cd14503: PTP-bact 
bacterial tyrosine-protein phosphataseS similar to Neisseria NMA1982
This subfamily is composed of bacterial tyrosine-protein phosphatases similar to Neisseria meningitidis NMA1982, which displays phosphatase activity but whose biological function is still unknown.
Links
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Statistics
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PSSM-Id: 350353
Aligned: 34 rows
Threshold Bit Score: 106.947
Created: 11-Jul-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitecatalytic site
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 6 residue positions
Conserved feature residue pattern:C x x x x RClick to see conserved feature residue pattern help
Evidence:
  • Structure:3GXH: Shewanella putrefaciens putative phosphatase binds a phosphate ion in the active site; contacts at 4A
  • Comment:also based on structures of cys-based phosphatase superfamily members with bound substrates (both peptide and non-peptide)
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
2F46_A     16 AILKLDEHLYISPQLtkaDAEQIAQLGIKTIICNRPDREeesqpdfAQIKQWLEqagVTGFHHQPVtardiqKHDVETFR 95  Neisseria meningit...
3GXH_A     14 ALQQQAPQLLSSGLPneqQFSLLKQAGVDVVINLXPDSSkd---ahPDEGKLVTq-aGXDYVYIPVdwqnpkVEDVEAFF 89  Shewanella putrefa...
ABO12136    2 ELKRVNQDFYVAGQItanDIVKIADQGIKTLICNRPDGEgadqpnvIEIEEAAQq-yGLNVIYQPVisgkitDQQVTEFK 80  Acinetobacter baum...
CBW44751    2 DIRKIDDSISVAPQIaieDVAEIARLGFRTLVANRPDHEeygqpamADIEAAAKa-eGLEWVYMPVesgnitDQDVERFA 80  Marinobacter hydro...
AAB82053    2 DLRTLTPDFAVAPQIaldDIAEAARLGFRTLINNRPDEEves-glnAALQAAAAa-aGLSYVHLPYypgeltPDLIAGFE 79  Rhodobacter capsul...
YP_353241   2 SFRPLTDRYAVSPQIsqeELPALRAAGFTTIIDNRPDGEipphlqtEEMRRAAEa-eGFTFIANPViggavtLENVERQR 80  Rhodobacter sphaer...
NP_869826   3 NRMKFNDQLTVGPQPsqdELKSLPDDGFRSVINFRTAGEdeq-plsPEEEGEAVratGLKYLHVPVsmdgmdEKKVDQFR 81  Rhodopirellula bal...
AAM48691    2 SMKKLSDQFYVGPQIevdDIEDIQISGIKSVICLRPDGEgpdqpafDTLKIQAAt-lELAAHYLPIilgqisEEQIAEFA 80  uncultured marine ...
NP_435818   2 PITAISDKLSVSPQLsveDIPSLRDKGFKTLINNRPHKEdtfqpntQAERQEVKh-cGLTYAFIPVtadtitEADVRAFQ 80  Sinorhizobium meli...
NP_357144   2 KAVRINERLTIAGQPmiaDFPSLSAQGFKSIINARPDGEepgqpgnTQEKSAAGa-aGMDYGFIPVsgptitEADIRAFQ 80  Agrobacterium tume...

Feature 1                   ######                                           
2F46_A     96 QLIGQAEy-PVLAYCRTGTRCSLLWGFRRAAEgx-pvDEIIRRAQAAgvn---lenFRERLDN 153 Neisseria meningitidis Z2491
3GXH_A     90 AAXDQHKgkDVLVHCLANYRASAFAYLYQLKQgq--nPNXAQTXTPWndelaiypkWQALLTE 150 Shewanella putrefaciens CN-32
ABO12136   81 QLYQNAQk-PVLAYCRSGMRAISLWALAEVAPqd--aALLVESGNKLgfn---lkgLVPRILK 137 Acinetobacter baumannii ATCC 17978
CBW44751   81 PMIRDAEk-PVLAFCRSGTRCTVLWALSSARDhq--pEEILSRARNAgyd---itgLIPRLMQ 137 Marinobacter hydrocarbonoclasticus
AAB82053   80 AALAAADa-PVLAWCRSGTRSSHLWALSQAGQrp--lEEIVQTAQNAgyd---lsaLVPMLRA 136 Rhodobacter capsulatus
YP_353241  81 EAIDQAGg-PVLAYCASGNRSSVVWALANAGRmp--tDELIGLPARHgyq---legLRHEIDR 137 Rhodobacter sphaeroides
NP_869826  82 EQYQSLPk-PVFAHCKSGKRAGAMMMMHTAVEqglsgDQALEQAKEMgfec-dkpeLEKFVKQ 142 Rhodopirellula baltica SH 1
AAM48691   81 DMVSKSTg-PIFAYCRSGMRATALWALHQAQIgq-svDEILAAAKSAghd---ltaLTPRLSA 138 uncultured marine proteobacterium
NP_435818  81 RAVDESDg-PVLAHCQTGGRSLNLYLIGEVLDgrmsaDEADAFGRSRgfd---tsvAAAWLKQ 139 Sinorhizobium meliloti 1021
NP_357144  81 QKMAEAEg-PVFAHCKGGTRALTLYVLGEALDgriqrSDIEDFGKTHgfd---lcaATRWLER 139 Agrobacterium tumefaciens str. C58

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