3BUL,2O2K


Conserved Protein Domain Family
Met_synt_B12

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pfam02965: Met_synt_B12 
Vitamin B12 dependent methionine synthase, activation domain
Statistics
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PSSM-Id: 460767
Aligned: 289 rows
Threshold Bit Score: 116.801
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3BUL_A          289 SIETLRNYIDWTPFFMTWSLAGK-Y-----PRILE------------------DEVVGV--EAQRLFKDANDMLDKLSAE 342 
Q8AAX0           40 LLKRVIPLL--RPRFAFFFMEGTlDieketLSVQSihpptvnpiqdtiptrspEQNTFStqSKSTVFSVGKTIARQ---- 113  Bacteroides...
WP_068690498    926 DLGELAERIDWTPFFHFWGFKGK-F-----PEIIY---------------------TRE--EAEKTYQAALEMLGRIIAG 976  Culturomica...
jgi:Odosp_3416  927 DLQDLIAKIDWTPFFHFWGFKGK-F-----PEIIH---------------------QHE--EADRTYQAALEMLGTVIAG 977 
CDA96507        950 SIDEILPYFDWRMFLAIWGIKYG-------GDLPD------------------DP------IIEKTVKDGKAVLERFKTR 998 
WP_014623889    931 GVAEVRPYLDWRMFYKGWGLPARtpe-------------------------rmREAERA--EAVRLREEAEGVLARMEGR 983  Spirochaeta...
WP_071424985    931 PICDVIPYIDWSYFISSWGLKGR-W-----PEILF------------------SSDKGE--EARKLVDDAQTMLYRIGRE 984  Tidjanibact...
WP_004328825    931 SIADVEPLIDWNFFFPAWGLKGR-V-----PEIFE------------------NPEHGA--EARKLYDDAQKMLARIREE 984  Alistipes p...
WP_015706351    940 ALERVIPFIDWEGFLRIWEL----------DREQH------------------SPEKDV--AKEKLLEDARKILDQVRTE 989  Treponema p...
WP_013970204    978 PLESLVPYIDWSYFFYGWDLGHG-F-----ERILE------------------DPEKGE--AARKLYDDAQVLLDRLVSE 1031 Treponema c...
3BUL_A          343 KTLNPRGVVGLFPANRVGDD-IEIYrDEtrt-------hvINV--SHHLRQQ--TEKtgFAN---YCLADFVAPKlsgka 407 
Q8AAX0          114 --LRGSEAFVFFAATA-GTE-FEVF--------------------QHTLQQE----------------EDMVKI------ 147  Bacteroides...
WP_068690498    977 QEFDASLVVRFFNAHTE-NDtIIL----------------DNGhrLPMLRQQ-------SDSpvcLCLSDFISPQadq-- 1030 Culturomica...
jgi:Odosp_3416  978 NEFEASIVVNFFDAYAE-DDeIVL----------------DNGhrLPMLRQQ-------KAGqecLSLSDYICPKayg-- 1031
CDA96507        999 HEVIIRLSERIMNARREGND-IVIS---------------GEStrFPMLRQEniDAHge----srLSLADFVPSGhd--- 1055
WP_014623889    984 V--RIEGVVGFFPARDVGED-CIGvlgwg-------gegvIRR--LPMLRQQ--AVkegEPT---RSLVDFLPHEg---h 1043 Spirochaeta...
WP_071424985    985 KLLTLNAVVGIFPAFSRGDD-IVV--ERe-----------GRKvvLPQLRCQsaST---AEN---LSLADYVLPEge-gn 1043 Tidjanibact...
WP_004328825    985 KLLTLQGVAGIFAAVSRGDD-IVVT-GPk-----------DKKyiLPMLRSQapVRE--AQA---RCLADFIADEkagrt 1046 Alistipes p...
WP_015706351    990 KLLQLRGVAGIFPACADGDD-VLVYgsg---------pepV-R--FAFLRNQ--EKK--RAGganLCLADFLPSGhsggg 1052 Treponema p...
WP_013970204   1032 HILTAHGVAGFFSAQSLGDD-ILLFsadpsgadlngfgtpIAR--FSFLRNQ--EKK--LAGgfnPCLSDFIAPEssgrt 1104 Treponema c...
3BUL_A          408 D-------------------------YIGAFAVTG--------------------------GLEEDALADAF-EAQH--- 432 
Q8AAX0          148 --------------------------YIA--------------------------------------------------- 150  Bacteroides...
WP_068690498   1031 ------------------------psTIGVFCLKV--------------------------------------SDRHncp 1048 Culturomica...
jgi:Odosp_3416 1032 ------------------------tsTIGLFALKV--------------------------------------ADKQggc 1049
CDA96507       1056 -------------------------gPMGTFAISVvtnhgpactcgcqaglpdffarrvygRASGEDITSQLpETAT--- 1107
WP_014623889   1044 D-------------------------YLGLFVITA--------------------------GKDIERFLA-----EEgpg 1067 Spirochaeta...
WP_071424985   1044 D-------------------------YVCLFAASA--------------------------GFGLHELVTGL-RESG--- 1068 Tidjanibact...
WP_004328825   1047 D-------------------------YIGAFALTG--------------------------GIGLKELTEKF-RAEG--- 1071 Alistipes p...
WP_015706351   1053 NpgasprdgnpgvssgdgnpgvsgggWLGLFALSA--------------------------GFGLEEAAAAF-RSRN--- 1102 Treponema p...
WP_013970204   1105 D-------------------------WIGLFAVTA--------------------------GHGLETFVADC-KARG--- 1129 Treponema c...
3BUL_A          433 D--DYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQGIRPAPGYPACPEH-TEKATIWELLEV 509 
Q8AAX0          151 D--SLGSIIAEKTADCMEVALAEYIRE----KNWKH-----------------TNRYSPGY--CGWHvSEQQKLFPLFPI 205  Bacteroides...
WP_068690498   1049 DcrDFEHLLRESLCARLTEALAVWMQEQVND---------GLQM----------IRPAFGYPACPDH-SLKKEVFELLDA 1108 Culturomica...
jgi:Odosp_3416 1050 DchDFSHLLRESLCARLTEALAEWMQEQLSE---------GLSL----------IRPAFGYSACPDH-SLKKDVFDLLDA 1109
CDA96507       1108 K--DYNSMMDRAVRVTLAEAASLWLDDFLKK---------RMHCGR--GRNVRIVKPAAGYASCPDH-TLKKDILDILPE 1173
WP_014623889   1068 E--PYRELMVRLLADRLAEAASEYLHMLVRTTLWGYAPEEHLSPEEVLAGRYRGIRPAPGHAACPDH-SLKQDIFELLGA 1144 Spirochaeta...
WP_071424985   1069 D--EYGAILAKLLADRLAEAFAEALHVAVRRDLWGFEAGETMPVQEVLAGNYQGARMAFGYPAVPDH-SLKKEVFRLLDA 1145 Tidjanibact...
WP_004328825   1072 D--DYNAILSKLLADRLTEALCEWVHIFIRRQMWGYETGPALTPEQIIRSKYRGRRMAFGYPACPDH-SLKREVFDLLAA 1148 Alistipes p...
WP_015706351   1103 D--DYGALLLGTLADSLAEAFAEEVHLRIRREWWGYGEGETLSVEDVFKGKYSGIRPAFGYPPCPDH-QDKRIAFDLLEA 1179 Treponema p...
WP_013970204   1130 D--DYTALLAASLADRLAEAFAEKLHALVRTELWGYVAEENLNAKELFEGKYRGIRPAFGYPACPDH-HDKRIACKVLEA 1206 Treponema c...
3BUL_A          510 EKHTGMKLTESFAMWPGASVSGWYFSHPDSK--YYAVAQIQRDQVEDYARRKG 560 
Q8AAX0          206 AAPCGIRLTDSSLMVPIKSVSGVIGTGTNVRklEYTCGLCTYENC--YRKRKH 256  Bacteroides thetaiotaomicron
WP_068690498   1109 PEKIGVTLTPSYAITPSTSICGMLIAHPEAR--YFGIGEIGPDQFAAYCKNKG 1159 Culturomica massiliensis
jgi:Odosp_3416 1110 PSKIGVSLTTSYAIYPTTSLCGMLIAHPAAR--YFSIGKIGADQLTDYCTKRA 1160
CDA96507       1174 SGKLGIRLTESFAMIPDASICGFIFFHPDAT--YPEIRHISKEQFDDYASRRG 1224
WP_014623889   1145 EARLEVRLTESFMMVPPSSVAGFYFSHPESR--YFAVGRITEEQLRDYARRRE 1195 Spirochaeta thermophila
WP_071424985   1146 ERITGMKLTDSYMIDPGESLCGMILADRHLK--YFDVGKIDAEQLADYARRRR 1196 Tidjanibacter massiliensis
WP_004328825   1149 DKTTAMRLNDNYMITPEEALCGLFFAD--AE--YFSVGRIDREQLADYAARRN 1197 Alistipes putredinis
WP_015706351   1180 QKRCGLTLTESAMIIPAASVCGMVFSNPEAR--YFSAAPVGDDQLQDWAKRKG 1230 Treponema primitia
WP_013970204   1207 EQRCGIKLTESSMMQPAASVCGMYFAHPASY--YFGVGRVGEDQLEDWARRKG 1257 Treponema caldarium
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