4MLZ


Conserved Protein Domain Family
F420-O_ABCperi

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TIGR03868: F420-O_ABCperi 
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proposed F420-0 ABC transporter, periplasmic F420-0 binding protein
This small clade of ABC-type transporter periplasmic binding protein components is found as a three gene cassette along with a permease (TIGR03869) and an ATPase (TIGR03873). The organisms containing this cassette are all Actinobacteria and all contain numerous genes requiring the coenzyme F420. This model was defined based on five such organisms, four of which are lacking all F420 biosynthetic capability save the final side-chain polyglutamate attachment step (via the gene cofE: TIGR01916). In Jonesia denitrificans DSM 20603 and marine actinobacterium PHSC20C1 this cassette is in an apparent operon with the cofE gene and, in PHSC20C1, also with a F420-dependent glucose-6-phosphate dehydrogenase (TIGR03554). Based on these observations we propose that this periplasmic binding protein is a component of an F420-0 (that is, F420 lacking only the polyglutamate tail) transporter.
Statistics
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PSSM-Id: 274826
Aligned: 7 rows
Threshold Bit Score: 441.586
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4MLZ_A         36 PLTVDNCGTTATFDSVPERVVTLKSSTTELLLALGRGDRIVATSYLDGPVAP-WLEDEAAqvpavSAPLDERLPSLEKVL 114 Jonesia denitr...
EEW83931       79 PVTVDNCGFEVTFGSAPQRVLTVKSSTTEMLLALGLSDRVVATAFPDGPVPA-WLADAAAgndavATPLTMQAPGPEAVT 157 Sanguibacter k...
jgi:Bcav_2582  51 AFTADNCGTDVAVDAAPQRIVTIKSSTTELVLALGAGDRIVGTAYPDGPVPDeYADVMAD-----VPVLSDRVPSHEAVL 125 Beutenbergia c...
EAR25994       51 PLTIDNCGTELTLDAAPARVVTIKSSTLELLLALGLGDRIVGSAFTDGPVPEeFTTIASD-----IPLISDKVPSQEVTL 125 marine actinob...
EAR23868       73 PVALSNCGFDVSFDSAPERVITIKSSTTEMLLALGLGDRIIGTAFQDGPVPAeWATAAAA-----LTSIAERVPSEEAVL 147 marine actinob...
EEN36562       17 PVTVDNCGTRVTFDAPPQRVVAIKSSTTEMLLALGLSDVLVGTAFADGPVPErWAADVAD-----VPVLSEKVPGPEAVL 91  Cellulomonas f...
EEJ12725       61 PLTVDNCGTTATFDSVPERVVTLKSSTTELLLALGRGDRIVATSYLDGPVAP-WLEDEAAqvpavSAPLDERLPSLEKVL 139 Jonesia denitr...
4MLZ_A        115 ETEPDLIFAGWESXVTTEGLADRDRLTQLGVNTLVAPSACKEDGYRPDPLTWESLAQEITTVGTIFDAHSEAQSLVDTXN 194 Jonesia denitr...
EEW83931      158 EVEPDLVYAGWESNLTAESAGDRGTLATLGVSSYVSPSACKGEAYMPDPLTFDDVFADITEVGTVFDVPAAAEELVAQQR 237 Sanguibacter k...
jgi:Bcav_2582 126 ELEPDLVYAGWESNLAADGAGERSSFSSLGITTFVSPSACQEPGYQPDPLTFDDVFAEIEQVGALLGEPDAAADLVEEQR 205 Beutenbergia c...
EAR25994      126 ATEPDFIYAGWESNLTAEGAGERADLAKLGVDTYVAPAACKGDGYMPDPLEFSEVFREFAEVGVVFNVPDAADSLISEQE 205 marine actinob...
EAR23868      148 DLEPDLVFAGWESTFSADGAGARADLTSLGINTFVAPSACQSSG-QPAKLSFDDVFSDIETVASIFRV--DASELIADQS 224 marine actinob...
EEN36562       92 EAEPDLVYAGWESNLSADGAGERETLAGLGIATYVSPSACKAPGYQPDPLTFDDVLDEIREVGEIFGVPDAAADVVAEQQ 171 Cellulomonas f...
EEJ12725      140 ETEPDLIFAGWESMVTTEGLADRDRLTQLGVNTLVAPSACKEDGYRPDPLTWESLAQEITTVGTIFDAHSEAQSLVDTMN 219 Jonesia denitr...
4MLZ_A        195 EQLAAISPDSRGLSALWFSSGSDTPFVGGGSGSAQLVXDTVGLRNIGSDIDDTWGPXSWEAIIDANPDVIVLVDSSWSSA 274 Jonesia denitr...
EEW83931      238 SELDAVVPDDRGLTVLWYSSGTDIPYVGAGIGAPQMIMDAAGLTNIAADVHDTWTPFGWEDVVAADPDVIVLVDAAWNTA 317 Sanguibacter k...
jgi:Bcav_2582 206 AALSDVTPSDAGLSAVWYSSGSDTPFVGAGIGAPQMVMDAAGLENIAADVHDTWTSLSWEAVADAEPDVIVLVDSEWNTA 285 Beutenbergia c...
EAR25994      206 AALAEIEPNTDGLTALWYSSGKDTPFVGAGIGSPQMIMGAAGLVNIGAEVKDSWTSMSWEVIVDENPDVIVLVDSSWNTA 285 marine actinob...
EAR23868      225 AQLASIDANGAGRTALWFSSGSDTPYVGAGIGAPQLLLETVGLTNVAADVDATWAPYNWEAVVDVDPDFIVLVDAAWNSA 304 marine actinob...
EEN36562      172 ATLDAIEPVE-GVTAVWWSSGTDTPYVGAGIGAPQMLLQTAGLTNVFADVHDTWTSVGWEQVVAADPDVLVLVDSAWNSA 250 Cellulomonas f...
EEJ12725      220 EQLAAISPDSRGLSALWFSSGSDTPFVGGGSGSAQLVMDTVGLRNIGSDIDDTWGPMSWEAIIDANPDVIVLVDSSWSSA 299 Jonesia denitr...
4MLZ_A        275 QKKKDILTSHPVASTLDAVVNDRYLVIDFPPTEPGVRTADGAVALADQLAAL 326 Jonesia denitrificans DSM 20603
EEW83931      318 DSKIEMLEENAATANLTAVREQRYVVVPFAATEAGVRNVSAVVDLVERLGEV 369 Sanguibacter keddieii DSM 10542
jgi:Bcav_2582 286 ENKIEVLESNPVTAALPAVQDARYVVVPFAATEAGVRSVDAARTIADQLADL 337 Beutenbergia cavernae DSM 12333
EAR25994      286 ESKIEYLESNPITSILTAVQEKRYVILDFAATEAGVRNVGAVASTVEQLKEL 337 marine actinobacterium PHSC20C1
EAR23868      305 EKKIGVLEANPATANLSAVKAGRYLVVPFAASEAGVRSVEAAASLSAQIAEL 356 marine actinobacterium PHSC20C1
EEN36562      251 QKKKDYLAAHPAASQLTAVREQRYAVVPFAASEAGVRNAQAAADLADAVRAL 302 Cellulomonas flavigena DSM 20109
EEJ12725      300 QKKKDILTSHPVASTLDAVVNDRYLVIDFPPTEPGVRTADGAVALADQLAAL 351 Jonesia denitrificans DSM 20603
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