Conserved Protein Domain Family
Myc_N

?
pfam01056: Myc_N 
Myc amino-terminal region
The myc family belongs to the basic helix-loop-helix leucine zipper class of transcription factors, see pfam00010. Myc forms a heterodimer with Max, and this complex regulates cell growth through direct activation of genes involved in cell replication. Mutations in the C-terminal 20 residues of this domain cause unique changes in the induction of apoptosis, transformation, and G2 arrest.
Statistics
?
PSSM-Id: 460045
Aligned: 21 rows
Threshold Bit Score: 375.278
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_008115538   2 P----GMVSKNPDLEFDSLQPCFY--PDEDDFY---LCgpDSAPPGEDIWKKFELL-PTPPLSPSPAGLQENPpggvags 71 
P52160         2 Pvs-aSLACKNYDYDYDSIQPYFYfdNDDEDFYhhqQGqtQPSAPSEDIWKKFELL-PTPPLSPSRRQSL---------- 69  zebrafish
3_pfamImport   1 Pld-sSLASKNYDYDYDSFQPLFY--DNEEDFY---AQqlQPPAPSEDIWKKFELLpPTPPLSPSRRPSLSSL------- 67 
XP_006634423   2 Pln-sSLSSKNYDYDYDSIQPYFYidNDDEDFYqqqHSqlQPPAPSEDIWKKFELL-PTPPLSPSRRPSLSSL------- 72 
XP_005319419   6 VstmpRMICRNADLEFDWLQPCFY--PDEDDFY---FSgpNSTPPGEDIWKKFELL-PTPPLSPSCAFLELST------- 72 
Q9Z304        10 P----GMICKNSDLEFDLLKPCFY--PEEDDIY---FGghNSTPPGEDIWKKFELL-PTPRLSPDSALAEHSL------- 72  house mouse
XP_009235806  10 P----GMICKNPDLEFDSLQPCFY--PDEDDFY---FGgpDSTPPGEDIWKKFELL-PTPPLSPSRGFAEHSS------- 72 
Q63379        10 P----GMICKNPDLEFDSLQPCFY--PDEDDFY---FGgpDSTPPGEDIWKKFELL-PTPPLSPSRAFPEHSP------- 72  Norway rat
P18444         2 P----GMISKNPDLEFDSLQPCFY--PDEDDFY---LCgpDSAPPGEDIWKKFELL-PTPPLSPSRAGLQEPPpgggsia 71  chicken
NP_001006874   2 P----GLVSRNLDLEFDSLQPCFY--PDEDDFY---LCgpDSAPPGEDIWKKFELL-PTPPLSPSRSGLHGDPlsp---- 67  tropical clawed...
XP_008115538  72 wgaavaalgGFRTSDPLDWASELLLlppeADLWG------NNDGGDSFeiglgesinsnLNAIIIQDCMWSGISASEKLE 145
P52160        70 -----------STAEQLEMVSEFLG----DDVVSqsficdDADYSQSF-----------IKSIIIQDCMWSGFSAAAKLE 123 zebrafish
3_pfamImport  68 ---------FPSTADQLEMVTEFLG----DDAVSqsi-icDADYSQTF-----------LKSIIIQDCMWSGFSAAAKLE 122
XP_006634423  73 ---------VPSTADQLEMVTEFLG----DDVVSqsf-icDADYSQSF-----------LKSIIIQDCMWSGFSAAAKLE 127
XP_005319419  73 --------------EPSDWASEMMLs--eADLWD------NPDEEDVFgpegl--gsltPNPVILRDCMWSGFSAREKLE 128
Q9Z304        73 --------------EPVNWATEMLLp--eADLWS------NPGEEEVFgqggl--rgctSNPIILQDCMWSGFSNPGKPE 128 house mouse
XP_009235806  73 --------------EPPSWVTEMLLe---NELWG------SPAEEDAFglggl--ggltPNPVILQDCMWSGFSAREKLE 127
Q63379        73 --------------EPSNWATEMLLp--eADLWG------NPAEEDAFglggl--ggltPNPVILQDCMWSGFSAREKLE 128 Norway rat
P18444        72 --vgrggpgECRPVDPLDWASELLLlppeAELWG------STDGADFFetglg--asnnLNSIIIQDCMWSAFSAREKLE 141 chicken
NP_001006874  68 -------glPGDYGDSLDWASELLLlppeTDLLGgsg-wgELGLSPCN-----------VKSIIIQDCMWSGFSAREKLE 128 tropical clawed...
XP_008115538 146 RVVHEKLQGKGGGLPATAagsatlavgtatavssttPSSTGNNGSS---QAELNNS-VSECVDPAVVFPFPIKREMKREL 221
P52160       124 KVVSERLASLHAERKELMs-------------------DSNSNRLNasyLQDLSTS-ASECIDPSVVFPYPLTECGKAGK 183 zebrafish
3_pfamImport 123 KVVSERLASLHAARKESPar--------------dcAGPEVGGALNssyLQDLNTSrGRECIDPSVVFPYPMAETAQAGA 188
XP_006634423 128 KVVSERLASLQAARKEAAc-------------------EIPGNKLNatyLQDLNTS-ASECIDPSVVFPYHMSESPKAGG 187
XP_005319419 129 RAMSEKMQHGHEPAATGPatqvpgaga-aspagrghSGTTGAa-----lPAELAHP-AAKCVDPAVVFLLPVSKQNPAPV 201
Q9Z304       129 SVVSEKLPGGYRSLAVGAgtlapgaaaaassagherSGTAGVGRGKaawLTELSHL-DLECVDPAVVF-FPANKREPM-- 204 house mouse
XP_009235806 128 RAVSEKLQHGRGPPTAGStaqspgaga-aspagrghGGAAGAGRAGaalPAELAHP-AAECVDPAVVFPFPVNKREPAPV 205
Q63379       129 RAVNEKLQHGHGPPGASSscpapgvga-sssggralGGSASAGRTGatlPTDLSHP-AAECVDPAVVFPFPVNKRESASV 206 Norway rat
P18444       142 RAVSEKLQSKPPAAAPPPpppvvpta---acrrreqPQRGPG-------RAELGGS-VPECVDPAVVFPFPVNKREAA-- 208 chicken
NP_001006874 129 RAVSEKLGKASCTAEPAIp----------------hPPSSTVGSTVsgrGVDMNNP-AAHCVDPAVVFPFPFNKGESCRT 191 tropical clawed...
XP_008115538 222 GTTIapsctaggeagiTGALAPA-APAQrnsnsrhpgAANDCRANNnncsssgddtlsDSD-------EEEEE--DDEEE 291
P52160       184 VASP------------QPMLVLDtPPNS----------SSSSGSDSedeee--edeeeEEE-------EEEEEeeEEEEE 232 zebrafish
3_pfamImport 189 P------------------GRSP--------------SRDLGTGDAafpgrsltcyvvDRF--------------EIRSR 222
XP_006634423 188 TLA--------------LPSSLDtPPGTss-----ssGSSSSGSDS-------------------------EDneEDDEE 223
XP_005319419 202 RVAPapapanapavgsAVARAAA-PASAavaappglsNRPPNSGDHkvlsts----------gedalsDEVDEeeDEEEE 270
Q9Z304       205 ------------------------PVPTipt----stGSAISLGDHqglsssledflsNSG-------SVEEGg----EE 245 house mouse
XP_009235806 206 PAAPasapaa-gpavaSGAGIAA-PAGApgvapprpgGRQTSGGDHkalstsgedtlsDSD-------DEDDEeeDEEEE 276
Q63379       207 PAAPtsap----atsaVVTSVSV-PAVApvaapargsGRPANSGEHkalstsgedtlsDSD-------DEDDEeeDEEEE 274 Norway rat
P18444       209 --------------------------VPsggetprggRRPGPAGESrassssgddtlsDSD-------DEDEEeeDDEEE 255 chicken
NP_001006874 192 APAG------------SAASSAN-PPPCtttsvpaaaTARSCTQPCstscssgeeshsDSDddeeeeeEEEEEedDEEEE 258 tropical clawed...
XP_008115538 292 IDVVTVEKRRsSSY-KSvstltiavrpknatsfASGRtQPSEVILKRCAPIHQQHNYAAPs-PYIENEEv-PPQKKLKSE 368
P52160       233 IDVVTVEKRQ---KrHEtd-------------aSESR-YPSPLVLKRCHVSTHQHNYAAH--PSTRHDQ--PAVKRLRLE 291 zebrafish
3_pfamImport 223 IDVVTVEKRH-GVKrSDpt------------spAETR--HSPLVLKRCHVSTHQHNYAAH--PSMRQEQ--PAVKRLKLG 283
XP_006634423 224 IDVVTVEKRH-SIKrSEsse-----------sgVSHRpHHSPLVLKRCHVPIHQHNYAAP--PSTRHEQ--PAVKRIKLE 287
XP_005319419 271 IDVVTVEK----SCkTGgntftltv-spkntalGLKReQSRELILQRSVPIYQQHNYAAPs-PYVESEDa-PPQKKIKRE 343
Q9Z304       246 IYVVMLEETQfS---KTvsrlptaa-hqenaalSPGCaQSSELILKRYDLIQEQHNYAAPplPYVDREDa-RPQKKPRSH 320 house mouse
XP_009235806 277 IDVVTVEKRRsSSNtKAvttftitv-rpknaalGPGRaQSSELILKRCLPIHQQHNYAAPs-PYVESEDa-PPQKKIKSE 353
Q63379       275 IDVVTVEKRRsSSNnKAvttftitv-rpktsalGLGRaQPGELILKRCVPIHQQHNYAAPs-PYVESEDa-PPQKKIKSE 351 Norway rat
P18444       256 IDVVTVEKRRsSSN-KAvttltitv-rpknttfPSVRtQQNELILKRCAPIHQQHNYAAPs-PYMESEDv-PPQKKLKAE 331 chicken
NP_001006874 259 IDVVTVEKRRnSSN-KSvtsltitv-rpkntilVSAKtTQNEVILKRCAPVHQQHNYAAPs-PYVETEEvaPPQKKQKNE 335 tropical clawed...
XP_008115538 369 A-----------SRPVKPVAQPkLKSSSP 386
P52160       292 AsnnhsinssssNRHVKQ-----RKCASP 315 zebrafish
3_pfamImport 284 Gsg-------ahRRVLKQISSN-RKCSSP 304
XP_006634423 288 Ts----------TRVLKQISNN-RKCTSP 305
XP_005319419 344 Vs----------PRPLKSVIHPkGKSFSP 362
Q9Z304       321 T-----------SLALKCVFRPkAPRLGS 338 house mouse
XP_009235806 354 As----------PRPLKSVIPPkAKSLSP 372
Q63379       352 As----------PRPLKSVVPPkAKSLSP 370 Norway rat
P18444       332 V-----------PRPVKPMIQPkSKSSSP 349 chicken
NP_001006874 336 L-----------PRLVKSVVPTkAKSSSP 353 tropical clawed frog
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap