6AR0


Conserved Protein Domain Family
FHA_SLMAP

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cd22679: FHA_SLMAP 
Click on image for an interactive view with Cn3D
forkhead associated (FHA) domain found in sarcolemmal membrane-associated protein (SLMAP) and similar proteins
SLMAP, also called sarcolemmal-associated protein (SLAP), is a tail-anchored protein involved in fundamental cellular processes, such as myoblast fusion, cell cycle progression, and chromosomal inheritance. It is a cardiac membrane protein that plays an important role in E-C coupling and the adrenergic response of the heart. Overexpression of the SLMAP gene has been associated with diabetes and endothelial dysfunction of macro- and micro-blood vessels. SLMAP contains an N-terminal FHA domain, which is a small phosphopeptide recognition module.
Statistics
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PSSM-Id: 438731
Aligned: 26 rows
Threshold Bit Score: 167.83
Created: 4-Sep-2020
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:putative phosphopeptide binding site [polypeptide binding site]
Evidence:
  • Comment:the pT-binding site in the SLMAP FHA-pMST2 complex.
  • Comment:also based on structures of other FHA domains with bound phosphopeptide
  • Comment:GR at the C terminus of strand beta3, SRxH just preceding beta5, and motif SxNG in the beta6-beta7 turn indicate a canonical mode of pThr recognition.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                       ###                 #### #                  #### 
6AR0_A         3 SALAIFTCRPnsHPFQERHVYLDe---PIKIGRSVARCRPAq-NNATFDCKVLSRNHALVWFDhktGKFYLQDTKSSNGT 78  human
NP_001036399 208 AAKIVLLCEPksHKFETRSILLQpn-qDCKVGRLIAKSKAGe-GNAIFDCKVLSRNHAILWYTp-dGKFWVKDTKSSNGT 284 fruit fly
XP_019848758   8 VPKIVLIPHSrsHPFAQRECVLSe---PLKVGRPVDKKKISq-NNLIFDCRVLSRNHALIWFEn--GKFFIKDTKSSNGT 81  Amphimedon quee...
XP_002118063   6 NILVSFKYCGhsHLFNDRLIDVNk---PVKIGRSTYRVKPTd-NNLIFTCKVLSRNHAILWYEd--NKLWLKDTNSSNGT 79  Trichoplax adha...
NP_001294341   3 FGWVSLVATPksHPFEERRIKVNgsndPVKIGRAVARIQATa-ENAVFDCKVLSRNHAILWFRd--GEFWLKDTKSSNGT 79  Caenorhabditis ...
XP_019643699   2 TSMAILTCRPnsHPFQERRVLLTe---AMKIGRSVARARPAp-NNCIFDCKVLSRNHALLWFEn--SKFFLQDTKSSNGT 75  Belcher's lancelet
XP_012566814   1 MAFALLSARPnsHPFQERHISLKe---VVKIGRAVAKTKPSs-NNAVFDCKVLSRNHAIMWYEn--GKFLLQDTKSSNGT 74  Hydra vulgaris
KAB8356421   155 PAMLNLMPMN--GTFERKTITVPhspeVLRIGRQTNAKTVPtpLNGYFDSKVLSRQHAEVWAEr-dGKIWIRDVKSSNGT 231 Carpinus fangiana
XP_018226278   6 LVCLILAPIN--DTFERKCLWLPswpqTLRIGRQINSRTAPapNNGFFDSKVLSRAHAEVWADpktGSVFIRDIKSSNGT 83  Pneumocystis ca...
O74388         2 SAVITLTPLN--ESFQTKKLVISps-tIYKIGRHTNKSTSPspSNLFFNSKVLSRQHAELWLDkdtLSVYIRDVKSSNGT 78  Schizosaccharom...
Feature 1                                      ###                      
6AR0_A        79 FINSQRLSRgse--esPPCEILSGDIIQFGVDVTENtrk-vtHGCIVSTIKLFLP 130 human
NP_001036399 285 FINDNKLGS-------DPAELHYGDIVKFGVEVIENsrq-evHGCILARVALFLP 331 fruit fly
XP_019848758  82 FVNECRLSPsge--esSPTEMRTRDIVQFGVNVNVEkk--vtHGCIIATVKLFID 132 Amphimedon queenslandica
XP_002118063  80 FVNNARIVTd-----vEAKELHNGDLLQFGIDVVDAdkn-vnHNCIIGSLEWPIE 128 Trichoplax adhaerens
NP_001294341  80 FVNNEKLQQtvsgrdtDVRRVFSGDIIQLGVEIVENank-vvYGCIYAVINCFNA 133 Caenorhabditis elegans
XP_019643699  76 FVNNQRLSKgse--esPAHEIHSGDIIQFGVDVMENsrk-vtHGCIIAQIHLYNP 127 Belcher's lancelet
XP_012566814  75 YVNSVRLSRgse--esEPYEIKSNDILQFGVEVVENskn-vtHGCIIGLVTLFHE 126 Hydra vulgaris
KAB8356421   232 FVNGKRLSQenr--dsEPHPLKENDIVELGIDIISEdqktvvHHKVAARVEHAGP 284 Carpinus fangiana
XP_018226278  84 FLNGRRLSQenq--tsEPFELYVGDVLELGIDILNEedrsilHYKVASRVEHAGW 136 Pneumocystis carinii B80
O74388        79 FVNETRLSPenk--psAPCKLNSGDIVDFGVDIYNEde--ivHQKVSAQVRIVVR 129 Schizosaccharomyces pombe 972h-

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